CN100413518C - Capsule for treating cirrhosis ascites and its preparation technology - Google Patents

Abstract

The present invention provides a medicine for treating hepatic cirrhosis ascites, and a manufacture technique thereof, particularly a capsule for treating hepatic cirrhosis ascites and a preparation technique thereof. The traditional Chinese medicine preparation is prepared from twelve kinds of medicinal materials, such as red sage root, tuckahoe, radices saussureae, etc. The capsule for treating hepatic cirrhosis ascites is processed by five technical procedures of animal medicine powder preparation, vegetable seed medicine extraction by alcohol, thick extract decoction by grass root class medicines, pelletization and capsule filling. The capsule for treating hepatic cirrhosis ascites has the advantages of scientific and novel formula, simple preparation technique, convenient oral administration and complementary medicine effect. The capsule for treating hepatic cirrhosis ascites has the efficacy of diuresis, body fluid elimination, blood forming, tissue regeneration, swelling relief, water dispersal, pain alleviation and purulent discharge. The capsule for treating hepatic cirrhosis ascites can effectively accelerate liver cell regeneration, can prevent liver cell fibrosis, can increase urinary flows, can reduce ascites and can promote the healing of patients with hepatic cirrhosis ascites.

Description

Treatment cirrhotic ascites capsule and preparation technology thereof

Affiliated technical field

The present invention treats cirrhotic ascites capsule and preparation technology thereof, belongs to treatment because of hepatopathy and preparation technology thereof that hypofunction of liver causes, relates in particular to medicine and preparation technology thereof with pure Chinese prescription treatment liver cirrhosis disease.

Background technology

Cirrhotic ascites is a commonly encountered diseases, mostly be cardiac cirrhosis, on form, be micronodular cirrhosis, being enlargement of liver upright stone tablet and serum albumin amount reduces, cause albumin and globulin out of proportion, impel hepatocyte distortion widely and progressively downright bad, fibrous tissue diffusivity hypertrophy, at the liver function injury initial stage, causing gradually that the abdominal cavity is poly-stays hydrops, and involves other system in the body, as untimely treatment or malpractice, ascites stagnates for a long time and ties in the abdominal cavity, liver function promptly further goes down, and it is impaired to cause liver to be out of shape gradually with more organs, treats the cirrhotic ascites operative treatments that draw water from the abdominal cavity that adopt at present more, operative treatment not only exists the patient suffering to add, defectives such as wound easy infection and complication are many, and albumen excretes with ascites in the interior ascites of body, and it is out of proportion to have aggravated interior albumin of patient's body and globulin, and the treatment phase is prolonged, cure the symptoms, not the disease, relapse rate is higher.

Summary of the invention

The objective of the invention is: carry the pure Chinese medicinal preparation of scientific formulation novelty for the cirrhotic ascites patient, reach diuresis and wet discharging, hemopoietic granulation promoting, detumescence aproll, dense effect is arranged in pain relieving, improve the abnormal metabolism of protein, fat and glucose, prevent the hepatocyte fibrosis, accelerate liver cell regeneration, promote albumin and globulin ratio and total serum protein level to improve, increase the urine flow, reduce abdominal circumference and ascites, impel the cirrhotic ascites patient complete rapidly.

In order to realize the foregoing invention purpose, the technical scheme that the present invention takes is: treatment cirrhotic ascites capsule is according to the main etiology and pathogenesis of cirrhotic ascites, with inducing diuresis to remove edema, invigorate blood circulation moisturize, the hemopoietic granulation promoting is principle of treatment, the crude drug total amount is 1230 grams in the prescription, is made up of Radix Salviae Miltiorrhizae 150 grams, Poria 50 grams, the Radix Aucklandiae 75 grams, Radix Et Rhizoma Rhei 75 grams, Semen Pharbitidis 60 grams, Radix Stephaniae Tetrandrae 150 grams, Semen zanthoxyli 150 grams, Semen Lepidii (Semen Descurainiae) 150 grams, Semen Plantaginis 100 grams, Endothelium Corneum Gigeriae Galli 60 grams, Oletum Trogopterori 60 grams, Concha Ostreae 150 grams.Treatment cirrhotic ascites capsules preparation technique is divided into animal drugs powder process, the alcohol extraction of seed medicine, grass roots class medicine decocting to thick ointment, granulate, dress capsule five road technologies, get Endothelium Corneum Gigeriae Galli earlier, Oletum Trogopterori, Concha Ostreae three flavor animal drugs were pulverized 80 mesh sieves, and to make the fine powder medicine standby, get Semen zanthoxyli again, Semen Plantaginis, Semen Lepidii (Semen Descurainiae), Semen Pharbitidis four flavor plant seed medicines mix the pulverizing back and add 7 times of amount 95% alcohol refluxs 2 times at every turn, merging filtrate recovery ethanol gets medicinal residues and ethanol extract is standby, getting all the other Chinese crude drugs and standby medicinal residues again merges, decoct with water 2 times, add for the first time 10 times of water gagings, soak after 1 hour and decocted 2 hours, adding for the second time 8 times of water gagings decocted 1 hour, collecting decoction filters, filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.32 (60 ℃), to mix thoroughly repeatedly in standby fine powder medicine and the standby ethanol extract adding thick paste at last, be dried and crushed into fine powder through 60 ℃, add an amount of 75% ethanol and make soft material, cross 16 mesh sieves and granulate, 14 mesh sieve granulate are crossed in 60 ℃ of dry backs, are sub-packed in No. 0 capsule and get patent medicine.The cirrhotic ascites clinical manifestation has the branch of the deficiency of YIN, yang deficiency, the cause of disease descends from patient's immunity of organisms, to mend during treatment and attack combination, in treatment cirrhotic ascites capsule, Radix Salviae Miltiorrhizae has protective effect to hepatic injury, can promote liver cell regeneration and increase protein content by anti-hepatic fibrosis, improve body immunity; Poria has diuresis, can improve body immunity, can impel leukocyte increasing to quicken; The Radix Aucklandiae has intestinal stasis relieving effect in capable Liver Channel gas, the accent, cures mainly fullness and distention in the chest and hypochondrium, abdominal distention; Radix Et Rhizoma Rhei has significant protective effect to hepatic injury, can reverse hepatic tissue fatty infiltration and fibrosis, and significant diuresis is arranged; Semen Pharbitidis has intensive rushing down down and diuresis, cures mainly edema, ascites; Radix Stephaniae Tetrandrae has and strengthens body immunity and tangible diuresis, can inducing diuresis to remove edema, cure mainly edema, dysuria; Semen zanthoxyli has the effect of hepatoprotective effect and warming YANG tonify deficiency; Semen Lepidii (Semen Descurainiae) has inducing diuresis to remove edema, expels the heat-evil by evil effect, cures mainly edema, breast abdomen hydrops, dysuria; Semen Plantaginis has the clearing away heat and promoting diuresis effect, cures mainly dysuria, edema distension; Endothelium Corneum Gigeriae Galli has spleen invigorating Sal Nitri, diuresis effect; Oletum Trogopterori can improve body immunity, can significantly improve the peritoneal macrophage phagocytic function; Concha Ostreae can be improved body immunity, has suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving effect.More than all medicines share, each medicine has complementary functions, and plays clearing away liver-fire, smooth QI and blood, the clear swollen merit of diuretic altogether, strengthens body immunity, stop courses of infection, increase the urine flow, accelerate the hydrothorax excretion, prevent the hepatocyte fibrosis, promote liver cell regeneration, avoid protein loss, promote albumin globulin ratio value and total serum protein level to improve, impel the cirrhotic ascites patient complete rapidly.

Instructions of taking: per day for adults 3 times, each 2-3 grain.

The invention has the beneficial effects as follows: the scientific formulation novelty, the prescription medication is imitated complementary, preparation technology is easy, convenient oral has diuresis and wet discharging, hemopoietic granulation promoting, detumescence aproll, pain relieving evacuation of pus effect, can effectively accelerate liver cell regeneration, prevent the hepatocyte fibrosis, increase the urine flow, reduce abdominal circumference and ascites, it is complete rapidly to impel liver just to change patients with ascites.

Specific embodiments

1, get crude drug roguing well sifted respectively by existing prepared slices of Chinese crude drugs standard after weighing standby.

2, getting Endothelium Corneum Gigeriae Galli, Oletum Trogopterori, Concha Ostreae three flavor animal drugs earlier pulverized 80 mesh sieves and becomes the fine powder medicine standby.

3, get Semen zanthoxyli, Semen Plantaginis, Semen Lepidii (Semen Descurainiae), Semen Pharbitidis four kind of plant seed feed medicines again and mix and pulverize that the back is each to add 7 times of amount 95% alcohol reflux secondaries, merging filtrate reclaims that ethanol gets medicinal residues and ethanol extract is standby.

4, getting the merging of all the other Chinese crude drugs and standby medicinal residues again decocts with water 2 times, add 10 times of water gagings the 1st time, soak after 1 hour and to decoct 2 hours, add 8 times of water gagings and decocted 1 hour for the 2nd time, collecting decoction filters, and it is that 1.30-1.32 (60 ℃) thick paste is standby that filtrate decompression is concentrated into relative density.

5, with standby fine powder medicine, ethanol extract adds thick paste to be mixed thoroughly repeatedly, becomes fine powder through 60 ℃ of crushed after being dried.

6, fine powder is added an amount of 75% ethanol and make soft material, cross 16 mesh sieves and granulate, 14 mesh sieve granulate are crossed in 60 ℃ of dry backs, be sub-packed in No. 0 capsule patent medicine.

Claims (2)

1. treat the cirrhotic ascites capsule for one kind, it is characterized in that: the crude drug total amount is 1230 grams in the prescription, is made up of Radix Salviae Miltiorrhizae 150 grams, Poria 50 grams, the Radix Aucklandiae 75 grams, Radix Et Rhizoma Rhei 75 grams, Semen Pharbitidis 60 grams, Radix Stephaniae Tetrandrae 150 grams, Semen zanthoxyli 150 grams, Semen Lepidii (Semen Descurainiae) 150 grams, Semen Plantaginis 100 grams, Endothelium Corneum Gigeriae Galli 60 grams, Oletum Trogopterori 60 grams, Concha Ostreae 150 grams.

2. treat the cirrhotic ascites capsules preparation technique according to claim 1, it is characterized in that: get Endothelium Corneum Gigeriae Galli earlier, Oletum Trogopterori, Concha Ostreae three flavor animal drugs were pulverized 80 mesh sieves, and to make the fine powder medicine standby, get Semen zanthoxyli again, Semen Plantaginis, Semen Lepidii (Semen Descurainiae), Semen Pharbitidis four flavor plant seed medicines mix the pulverizing back and add 7 times of amount 95% alcohol refluxs 2 times at every turn, merging filtrate recovery ethanol gets medicinal residues and ethanol extract is standby, getting all the other Chinese crude drugs and standby medicinal residues again merges, decoct with water 2 times, add for the first time 10 times of water gagings, soak after 1 hour and decocted 2 hours, adding for the second time 8 times of water gagings decocted 1 hour, collecting decoction filters, relative density was the thick paste of 1.30-1.32 when filtrate decompression was concentrated into 60 ℃, be dried and crushed into fine powder with mixing thoroughly repeatedly through 60 ℃ in standby fine powder medicine and the standby ethanol extract adding thick paste at last, add an amount of 75% ethanol and make soft material, cross 16 mesh sieves and granulate, 14 mesh sieve granulate are crossed in 60 ℃ of dry backs, are sub-packed in No. 0 capsule and get patent medicine.