CN100408078C - Medicinal composition for treating hyperplasia of prostate and its preparing method - Google Patents
Medicinal composition for treating hyperplasia of prostate and its preparing method Download PDFInfo
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- CN100408078C CN100408078C CNB2005100850740A CN200510085074A CN100408078C CN 100408078 C CN100408078 C CN 100408078C CN B2005100850740 A CNB2005100850740 A CN B2005100850740A CN 200510085074 A CN200510085074 A CN 200510085074A CN 100408078 C CN100408078 C CN 100408078C
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Abstract
The medicinal composition for treating hyperplasia of prostate includes two separately packed components. The component A is prepared with 15 kinds of Chinese medicinal materials, including lysimachia, Japanese felt fern frond, patrinia, etc. The component B is prepared with 5 kinds of Chinese medicinal materials, including pearl, pangolin scales, amber, etc. clinical application shows that the medicinal composition has obvious curative effect on hyperplasia of prostate, clinical use safety and no toxic side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate in particular to a kind of main be the Chinese medicine composition and preparation method thereof of the treatment prostatic hyperplasia that forms of feedstock production with the Chinese herbal medicine, belong to the field of Chinese medicines.
Background technology
Hyperplasia of prostate is a kind of commonly encountered diseases of elderly men, age of onset is mostly after 50 years old, its sickness rate also constantly raises with age, has become the commonly encountered diseases of Urology Surgery, and it carefully is main feature that its symptom increases (especially night), dysuria, urine rheology with number of micturitions.As climate change, fatigue, drink, inducement such as sexual life or infection, very easily cause urine retention, even urine can not arrange fully, cause very big misery to the patient.
Androgen and estrogenic dysequilibrium are in close relations in prostatic hyperplasia and the body.Testosterone is the main androgen of male, under the effect of enzyme, becomes two hydrogen testosterones, and two hydrogen testosterones are active hormones that androgen stimulates prostatic hyperplasia.Estrogen also has certain influence to prostatic hyperplasia.Be used for the treatment of at present prostatic hyperplasia in, the curative effect of Western medicine drug is all not ideal enough, main because Western medicine is cured the symptoms, not the disease more, with relief of symptoms, it is main suppressing further increase of prostate, or dwindled with male inhibitor prostate, but side effect is lost more than gain more greatly.And pure Chinese medicinal preparation because of blood drug level at the bottom of, relief of symptoms is difficult to allow the patient persist slowly.
Summary of the invention
The present invention's technical problem at first to be solved is to overcome the deficiencies in the prior art, and a kind of pharmaceutical composition of treatment prostatic hyperplasia evident in efficacy is provided.
The present invention's technical problem at first to be solved realizes by following technological approaches:
A kind of pharmaceutical composition for the treatment of prostatic hyperplasia is made up of two kinds of components of A, B, and two kinds of components are packed separately; Wherein the A component is made by following bulk drugs: Herba Lysimachiae 10-20 part, Folium Pyrrosiae 10-20 part, Herba Patriniae 10-20 part, Herba Lycopi 10-20 Fen, Herba Polygoni Avicularis 10-20 part, Pheretima 10-20 part, Herb Gynostemmae Pentaphylli 15-30 part, Herba Lophatheri 5-15 part, rhizoma sparganic 5-10 part, Radix Paeoniae Rubra 5-15 part, Spina Gleditsiae 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Glycyrrhizae 3-10 part, Radix Astragali 10-30 part and Radix Rehmanniae Preparata 5-15 part; Be preferably: 10 parts in 20 parts of Herba Lysimachiaes, 15 parts of Folium Pyrrosiaes, 20 parts of Herba Patriniae, Herba Lycopi's 15 15 parts of Fen, Herba Polygoni Avicularis, 15 parts of Pheretimas, 20 parts of Herb Gynostemmae Pentaphylli, 10 parts of Herba Lophatheris, 6 parts of rhizoma sparganic, 12 parts of Radix Paeoniae Rubra, 15 parts of Spina Gleditsiae, 12 parts of Radix Salviae Miltiorrhizaes, 6 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali and Radix Rehmanniae Preparata.
The B component is made by following bulk drugs:
Margarita 20-40 part, Squama Manis 20-40 part, succinum 50-70, Talcum 200-230 and Hemiculter lcucisculus (Basil.) 20-40 part; Be preferably: 30 parts of 30 parts of Margaritas, 30 parts of Squama Maniss, 60 parts of succinums, 210 parts in Talcum and Hemiculter lcucisculus (Basil.)s.
Modern medicine thinks that prostatic hyperplasia is increasing of elderly patient hormone in vivo dihydrotestosterone, stimulates the hyperemia of prostata tissue, due to the fibrosis hypertrophy, compressing urethra, Chinese medical discrimination, primary disease belongs to " difficulty in urination ", " lump in the abdomen " category, and its sick position relates to liver,spleen,kidney three warmers etc. at bladder, the primary disease deficiency in origin and excess in superficiality, worn with age, healthy energy is lost empty, be the basis that primary disease takes place, diseases caused by exogenous pathogenic factor six evil, eating and drinking without temperance, the overstrain internal injury, risk factor such as feelings will stimulation and cause damp invasion of lower energizer is pented up bladder; Disturbance in functioning of QI, QI and blood block up resistance bladder, the blood stasis phlegm-damp loses essence stasis and forms piece, the compressing urethra forms the difficulty in urination, the disease of lump in the abdomen, therefore treatment is gone up to tonify Qi of the kidney, blood stasis-eliminating and stagnation-dissipating, clearing away heat and eliminating dampness is the rule of treatment, in the medicine side of the present invention with the Radix Astragali, Radix Rehmanniae Preparata is monarch, and vital energy benefiting and the kidney invigorating makes visceral-qi vigorous, gasification function is normal, water pure and impure its road of respectively walking that wets, simultaneously annoying again prosperous capable with short blood, and inducing diuresis to remove edema, with Talcum, Herb Gynostemmae Pentaphylli, Herba Lysimachiae, Folium Pyrrosiae, Herba Patriniae Herba Polygoni Avicularis, Herba Lophatheri is a minister, clearing away heat-damp and promoting diuresis, the dissipating blood stasis that relieves internal heat, assistant is with the Herba Lycopi, Squama Manis, Pheretima, rhizoma sparganic, Radix Paeoniae Rubra, Spina Gleditsiae, Radix Salviae Miltiorrhizae, succinum, blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, impel lump to dissipate, alleviate pressure symptom, tonneau urine, Margarita contains the multiple essential amino acids of human body in the side, and having the merit of heat-clearing and toxic substances removing, Hemiculter lcucisculus (Basil.) that effects such as the medicine of promotion is absorbed by the body are arranged, the two is messenger drug altogether.
The concocting method of Margarita: get Margarita and clean, wrap, boiled altogether about 2 hours, take out, clean, smash to pieces with bean curd and water with cloth, add water a little, be ground into superfine powder, drying.
Hemiculter lcucisculus (Basil.) [Hemiculter leucisculus (Basil.)], the Cyprinidae animal, it is very wide to distribute, and in China south, river, north, the lake distribution is arranged all, and property is sweet, and temperature is nontoxic, and the effect of have warming the stomach, ending cold diarrhea has effects such as the medicine of promotion is absorbed by the body.
The used raw material of the present invention all can be bought from common pharmacy and obtain, and its specification meets national medical standard.
Another technical problem to be solved by this invention provides a kind of method for preparing aforementioned pharmaceutical compositions.
Another technical problem to be solved by this invention realizes by following technological approaches;
A kind of method for preparing aforementioned pharmaceutical compositions, step is as follows:
One, preparation A component:
1) takes by weighing each raw material by following weight portion: Herba Lysimachiae 10-20 part, Folium Pyrrosiae 10-20 part, Herba Patriniae 10-20 part, Herba Lycopi 10-20 part, Herba Polygoni Avicularis 10-20 part, Pheretima 10-20 part, Herb Gynostemmae Pentaphylli 15-30 part, Herba Lophatheri 5-15 part, rhizoma sparganic 5-10 part, Radix Paeoniae Rubra 5-15 part, Spina Gleditsiae 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Glycyrrhizae 3-10 part, Radix Astragali 10-30 part, Radix Rehmanniae Preparata 5-15 part;
2) said medicine is mixed be placed on and add water in the marmite and do not have powder, soak after 20-40 minute and decoct, decoct altogether three times, merges three times decocting liquid, filtration is got filtrate and is promptly got the A component;
Two, preparation B component:
1) takes by weighing each raw material by following weight portion: forge Margarita 20-40 part, Squama Manis 20-40 part, succinum 50-70, Talcum 200-230 and Hemiculter lcucisculus (Basil.) 20-40 part;
2) will forge and mix the back after Margarita, Squama Manis, succinum and Talcum are pulverized and cross 500 mesh sieves; With Hemiculter lcucisculus (Basil.) smash to pieces the back with more than after sieving powder mixes together, promptly get the B component.
Three, A component and B component are packed separately, place same medicine box, promptly.
Drug usage of the present invention and consumption: during use, get B component 6g at every turn and be dissolved in the A component of 200-250ml, oral; Every day twice, sooner or later respectively once.One week was a course of treatment, and state of an illness the lighter need take the 1-2 course of treatment, and weight person need take the 2-3 course of treatment.
Further describe beneficial effect of the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never limit the scope of the invention.
The specific embodiment
Embodiment 1
1, preparation A component:
Take by weighing each raw material (unit: g): Herba Lysimachiae 20, Folium Pyrrosiae 15, Herba Patriniae 20, Herba Lycopi 15, Herba Polygoni Avicularis 15, Pheretima 15, Herb Gynostemmae Pentaphylli 20, Herba Lophatheri 10, rhizoma sparganic 6, Radix Paeoniae Rubra 12, Spina Gleditsiae 15, Radix Salviae Miltiorrhizae 12, Radix Glycyrrhizae 6, the Radix Astragali 20, Radix Rehmanniae Preparata 10 by following weight portion; Said medicine mixed to be placed on add water in the marmite and do not have powder, soak after 30 minutes and decoct three times, merges three times decocting liquid, filtration is got filtrate and is promptly got the A component.
2, preparation B component:
Take by weighing each raw material (unit: g): forge Margarita 30, Squama Manis 30, succinum 60, Talcum 210 and Hemiculter lcucisculus (Basil.) 30 by following weight portion; To forge and mix back 500 mesh sieves of crossing after Margarita, Squama Manis, succinum and Talcum are pulverized; With Hemiculter lcucisculus (Basil.) smash to pieces the back with more than after sieving powder mixes together, promptly get the B component.3, A component and the independent packing of B component are promptly got medicine of the present invention.
Embodiment 2
1, preparation A component:
Take by weighing each raw material (unit: g): Herba Lysimachiae 10, Folium Pyrrosiae 10, Herba Patriniae 10, Herba Lycopi 10, Herba Polygoni Avicularis 10, Pheretima 10, Herb Gynostemmae Pentaphylli 15, Herba Lophatheri 5, rhizoma sparganic 5, Radix Paeoniae Rubra 5, Spina Gleditsiae 10, Radix Salviae Miltiorrhizae 10, Radix Glycyrrhizae 3, the Radix Astragali 10, Radix Rehmanniae Preparata 5 by following weight portion; Said medicine mixed to be placed on add water in the marmite and do not have powder, soak after 40 minutes and decoct three times, merges three times decocting liquid, filtration is got filtrate and is promptly got the A component.
2, preparation B component:
Take by weighing each raw material (unit: g): forge Margarita 20, Squama Manis 20, succinum 50, Talcum 200, Hemiculter lcucisculus (Basil.) 20 by following weight portion; To forge and mix back 500 mesh sieves of crossing after Margarita, Squama Manis, succinum and Talcum are pulverized; With Hemiculter lcucisculus (Basil.) smash to pieces the back with more than after sieving powder mixes together, promptly get the B component.
3, A component and the independent packing of B component are promptly got medicine of the present invention.
Embodiment 3
1, preparation A component:
Take by weighing each raw material (unit: g): Herba Lysimachiae 20, Folium Pyrrosiae 20, Herba Patriniae 20, Herba Lycopi 20, Herba Polygoni Avicularis 20, Pheretima 20, Herb Gynostemmae Pentaphylli 30, Herba Lophatheri 15, rhizoma sparganic 10, Radix Paeoniae Rubra 15, Spina Gleditsiae 20, Radix Salviae Miltiorrhizae 15, Radix Glycyrrhizae 10, the Radix Astragali 30, Radix Rehmanniae Preparata 15 by following weight portion; Said medicine mixed to be placed on add water in the marmite and do not have powder, soak after 20 minutes and decoct three times, merges three times decocting liquid, filtration is got filtrate and is promptly got the A component.
2, preparation B component:
Take by weighing each raw material (unit: g): forge Margarita 40, Squama Manis 40, succinum 70, Talcum 230, Hemiculter lcucisculus (Basil.) 40 by following weight portion; To forge and mix back 500 mesh sieves of crossing after Margarita, Squama Manis, succinum and Talcum are pulverized; With Hemiculter lcucisculus (Basil.) smash to pieces the back with more than after sieving powder mixes together, promptly get the B component.
3, A component and the independent packing of B component are promptly got medicine of the present invention.
The clinical observation on the therapeutic effect of [test example] Drug therapy prostatic hyperplasia of the present invention
One, physical data
Accepted 116 routine prostatic hyperplasia patients altogether for medical treatment, be the out-patient, age 36-78 year.54 years old mean age.36-40 year wherein, 8 examples; 41-50 year 12 examples; 51-60 year, 36 examples; 61-70 year, 35 examples; 71-78 year, 25 examples.
Two, trial drug
Supply the reagent thing: the embodiment of the invention 1 drug prepared.
Three, Therapeutic Method
Use the embodiment of the invention 1 drug prepared to treat, get B component 6g at every turn and be dissolved in the A component of 200-250ml, oral, every day twice, sooner or later respectively once.One week was a course of treatment, and state of an illness the lighter takes the 1-2 course of treatment, and weight person takes the 2-3 course of treatment.
Four, curative effect determinate standard
1. clinical recovery: disappear with interior clinical symptoms and sign three courses of treatment with interior sx a course of treatment in medication, and integration reduces 〉=95%.
2. produce effects: medication obviously improves with interior symptom, Signs three courses of treatment, and integration reduces 〉=70%.
3. effective: medication makes moderate progress with interior symptom, sign three courses of treatment, and integration reduces 〉=30%.
4. invalid: medication does not have obvious improvement with interior symptom and sign three courses of treatment, or integration reduces less than 30%.
Five, observed result
The 116 routine prostatic hyperplasia patients that accepted for medical treatment, cure rate 82%, obvious effective rate 12%, effective percentage are 6%, total effective rate is 100%.Untoward reaction appears in none routine patient among the 116 routine prostatic hyperplasia patients of use Drug therapy of the present invention, and clinical drug drug safety of the present invention is described.
The explanation of clinical trial observed result, medicine of the present invention is evident in efficacy for prostatic hyperplasia, and clinical drug safety, has no side effect.
Claims (4)
1. a pharmaceutical composition for the treatment of prostatic hyperplasia is made up of two kinds of components of A, B, and two kinds of components are packed separately; Wherein the A component is made by following bulk drugs: Herba Lysimachiae 10-20 part, Folium Pyrrosiae 10-20 part, Herba Patriniae 10-20 part, Herba Lycopi 10-20 part, Herba Polygoni Avicularis 10-20 part, Pheretima 10-20 part, Herb Gynostemmae Pentaphylli 15-30 part, Herba Lophatheri 5-15 part, rhizoma sparganic 5-10 part, Radix Paeoniae Rubra 5-15 part, Spina Gleditsiae 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Glycyrrhizae 3-10 part, Radix Astragali 10-30 part and Radix Rehmanniae Preparata 5-15 part; The B component is made by following bulk drugs: Margarita 20-40 part, Squama Manis 20-40 part, succinum 50-70, Talcum 200-230 and Hemiculter lcucisculus (Basil.) 20-40 part.
2. according to the pharmaceutical composition of claim 1, it is characterized in that the A component is made by following bulk drugs: 10 parts in 20 parts of Herba Lysimachiaes, 15 parts of Folium Pyrrosiaes, 20 parts of Herba Patriniae, Herba Lycopi's 15 15 parts of Fen, Herba Polygoni Avicularis, 15 parts of Pheretimas, 20 parts of Herb Gynostemmae Pentaphylli, 10 parts of Herba Lophatheris, 6 parts of rhizoma sparganic, 12 parts of Radix Paeoniae Rubra, 15 parts of Spina Gleditsiae, 12 parts of Radix Salviae Miltiorrhizaes, 6 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali and Radix Rehmanniae Preparata; The B component is made by following bulk drugs: 30 parts of 30 parts of Margaritas, 30 parts of Squama Maniss, 60 parts of succinums, 210 parts in Talcum and Hemiculter lcucisculus (Basil.)s.
3. method for preparing the pharmaceutical composition of claim 1, step is as follows:
1) preparation A component:
A. take by weighing each raw material by following weight portion: Herba Lysimachiae 10-20 part, Folium Pyrrosiae 10-20 part, Herba Patriniae 10-20 part, Herba Lycopi 10-20 part, Herba Polygoni Avicularis 10-20 part, Pheretima 10-20 part, Herb Gynostemmae Pentaphylli 15-30 part, Herba Lophatheri 5-15 part, rhizoma sparganic 5-10 part, Radix Paeoniae Rubra 5-15 part, Spina Gleditsiae 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Radix Glycyrrhizae 3-10 part, Radix Astragali 10-30 part, Radix Rehmanniae Preparata 5-15 part;
B. said medicine is mixed to be placed on and add water in the marmite and do not have powder, soak after 20-40 minute and decoct, decoct altogether three times, merges three times decocting liquid, filtration is got filtrate and is promptly got the A component;
2) preparation B component:
A. take by weighing each raw material by following weight portion: Margarita 20-40 part, Squama Manis 20-40 part, succinum 50-70, Talcum 200-230 and Hemiculter lcucisculus (Basil.) 20-40 part;
B. mix the back after Margarita, Squama Manis, succinum and Talcum being pulverized and cross 500 mesh sieves; With Hemiculter lcucisculus (Basil.) smash to pieces the back with more than after sieving powder mixes together, promptly get the B component;
3) A component and B component are packed separately, place same medicine box, promptly get pharmaceutical composition of the present invention.
4. claim 1 or 2 described arbitrary pharmaceutical compositions are preparing the purposes for the treatment of in the prostatic hyperplasia medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100850740A CN100408078C (en) | 2005-07-20 | 2005-07-20 | Medicinal composition for treating hyperplasia of prostate and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100850740A CN100408078C (en) | 2005-07-20 | 2005-07-20 | Medicinal composition for treating hyperplasia of prostate and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1899548A CN1899548A (en) | 2007-01-24 |
| CN100408078C true CN100408078C (en) | 2008-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100850740A Expired - Fee Related CN100408078C (en) | 2005-07-20 | 2005-07-20 | Medicinal composition for treating hyperplasia of prostate and its preparing method |
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| Country | Link |
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| CN (1) | CN100408078C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341064B (en) * | 2013-06-26 | 2014-12-10 | 威海高科医疗设备有限公司 | Chinese medicine composition for treating urine retention |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116937A (en) * | 1994-08-18 | 1996-02-21 | 王耀强 | Chinese herb medicine preparation for treating prostate hyperplasia and its preparing method |
| CN1163761A (en) * | 1996-04-26 | 1997-11-05 | 李建平 | Qianliehuixiao pill for treating prostatitis and prostatic hyperplasia |
| CN1753682A (en) * | 2003-01-16 | 2006-03-29 | 利盛私人有限公司 | The herbal-composition that is used for prostatosis |
-
2005
- 2005-07-20 CN CNB2005100850740A patent/CN100408078C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116937A (en) * | 1994-08-18 | 1996-02-21 | 王耀强 | Chinese herb medicine preparation for treating prostate hyperplasia and its preparing method |
| CN1163761A (en) * | 1996-04-26 | 1997-11-05 | 李建平 | Qianliehuixiao pill for treating prostatitis and prostatic hyperplasia |
| CN1753682A (en) * | 2003-01-16 | 2006-03-29 | 利盛私人有限公司 | The herbal-composition that is used for prostatosis |
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| Publication number | Publication date |
|---|---|
| CN1899548A (en) | 2007-01-24 |
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