CN100398546C - 碳青霉烯类抗生素法罗培南钠的制备方法 - Google Patents
碳青霉烯类抗生素法罗培南钠的制备方法 Download PDFInfo
- Publication number
- CN100398546C CN100398546C CNB2005100272469A CN200510027246A CN100398546C CN 100398546 C CN100398546 C CN 100398546C CN B2005100272469 A CNB2005100272469 A CN B2005100272469A CN 200510027246 A CN200510027246 A CN 200510027246A CN 100398546 C CN100398546 C CN 100398546C
- Authority
- CN
- China
- Prior art keywords
- compound
- reaction
- sodium
- ethyl acetate
- thf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
分析项目 | 测定值(%) | 理论值(%) |
C | 40.72 40.85 | 40.90 |
H | 5.43 5.41 | 5.43 |
N | 4.03 4.02 | 3.98 |
S | 8.88 9.04 | 9.08 |
溶剂 | λmax(nm) | ε(×104) | E | 归属 |
H2O | 306 | 0.64 | 183.0 | 双键 |
0.1mol/L HCl | 320 | 0.77 | 218.2 | 双键 |
0.1mol/L NaOH | 218 | 0.61 | 174.3 | 双键 |
序号 | δH | 质子数 | 多重性(J/Hz) | COSY(位) |
9 | 1.37 | 3 | d 6.4 | 8 |
12 | 1.97 2.44 | 2 | m | 13 |
13 | 2.07 2.11 | 2 | m | 12 |
14 | 3.90 4.01 | 2 | q | 13 |
6 | 3.93 | 1 | dd | 5 |
8 | 4.29 | 1 | quintet 6.4 | 9 |
11 | 5.59 | 1 | t6.8 | 12 |
5 | 5.66 | 1 | d0.4 | 6 |
序号 | δC | 碳原子数 | DEPT | HMQCδH δC | HMBC(位) |
9 | 15.02 | 1 | ↑ | 1.37-15.02 | |
13 | 20.59 | 1 | ↓ | 2.07 2.11-20.59 | |
12 | 28.08 | 1 | ↓ | 1.97 2.44-28.08 | |
5 | 57.00 | 1 | ↑ | 5.66-57.00 | |
8 | 59.66 | 1 | ↑ | 4.29-59.66 | |
6 | 63.50 | 1 | ↑ | 3.93-63.50 | |
14 | 69.47 | 1 | ↓ | 3.90 4.01-69.47 | |
11 | 69.67 | 1 | ↑ | 5.59-69.67 | |
2 | 119.92 | 1 | 11 14 | ||
3 | 147.51 | 1 | 12 | ||
10 | 161.00 | 1 | |||
7 | 170.74 | 1 | 568 |
d-value | 2Theta | I/I。 |
16.23 | 5.43 | 100 |
8.86 | 9.96 | 20.7 |
8.09 | 10.91 | 29.0 |
4.67 | 18.98 | 43.2 |
3.26 | 27.25 | 20.3 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100272469A CN100398546C (zh) | 2005-06-29 | 2005-06-29 | 碳青霉烯类抗生素法罗培南钠的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005100272469A CN100398546C (zh) | 2005-06-29 | 2005-06-29 | 碳青霉烯类抗生素法罗培南钠的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1887886A CN1887886A (zh) | 2007-01-03 |
CN100398546C true CN100398546C (zh) | 2008-07-02 |
Family
ID=37577168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100272469A Active CN100398546C (zh) | 2005-06-29 | 2005-06-29 | 碳青霉烯类抗生素法罗培南钠的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100398546C (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101235044B (zh) * | 2008-03-03 | 2010-11-03 | 南京华威医药科技开发有限公司 | 法罗培南酯的制备方法 |
CN104165957B (zh) * | 2014-08-15 | 2016-02-17 | 珠海联邦制药股份有限公司 | 一种法罗培南钠原料中二聚物杂质含量的测定方法 |
CN107337684B (zh) * | 2017-08-10 | 2019-10-18 | 沈阳三九药业有限公司 | 一种法罗培南钠的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030236265A1 (en) * | 2002-05-23 | 2003-12-25 | Sayada Chalom B. | Methods of treating bacterial infections and diseases associated therewith |
AU2003268330A1 (en) * | 2002-08-29 | 2004-03-19 | Activbiotics, Inc. | Methods and reagents for treating infections of clostridium difficile and diseases associated therewith |
EP1404398A1 (en) * | 2001-06-02 | 2004-04-07 | Astrazeneca AB | Antibiotic drug delivery system |
CN1171639C (zh) * | 1999-10-12 | 2004-10-20 | 第一三得利制药株式会社 | 口服药物组合物 |
WO2004089378A1 (ja) * | 2003-04-04 | 2004-10-21 | Sankyo Company, Limited | ピロロピリダジン誘導体を含有する医薬組成物 |
-
2005
- 2005-06-29 CN CNB2005100272469A patent/CN100398546C/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1171639C (zh) * | 1999-10-12 | 2004-10-20 | 第一三得利制药株式会社 | 口服药物组合物 |
EP1404398A1 (en) * | 2001-06-02 | 2004-04-07 | Astrazeneca AB | Antibiotic drug delivery system |
US20030236265A1 (en) * | 2002-05-23 | 2003-12-25 | Sayada Chalom B. | Methods of treating bacterial infections and diseases associated therewith |
AU2003268330A1 (en) * | 2002-08-29 | 2004-03-19 | Activbiotics, Inc. | Methods and reagents for treating infections of clostridium difficile and diseases associated therewith |
WO2004089378A1 (ja) * | 2003-04-04 | 2004-10-21 | Sankyo Company, Limited | ピロロピリダジン誘導体を含有する医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN1887886A (zh) | 2007-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100422184C (zh) | 美罗培南的制备方法 | |
ES2218328T5 (es) | Derivados de epotilón, su preparación y utilización. | |
Kametani et al. | Studies on the syntheses of heterocyclic compounds. 800. A formal total synthesis of (.+-.)-thienamycin and a (.+-.)-decysteaminylthienamycin derivative | |
CN100398546C (zh) | 碳青霉烯类抗生素法罗培南钠的制备方法 | |
CN102127024A (zh) | 一种利用1,1-二溴-1-烯烃合成4-芳基-1h-1,2,3-三氮唑的方法 | |
CN101024649A (zh) | 口服非酯型抗生素头孢丙烯的制备方法 | |
CA1246546A (en) | 2-alkylthiopenem derivatives | |
CN101720781A (zh) | 一种防治作物真菌病害的新磷氮霉素a及其制备工艺 | |
CN112500347B (zh) | 一种苯并氮杂七元环化合物、其制备方法及用途 | |
CN105348242B (zh) | 天然产物(‑)‑(6S,2’R)‑cryptocaryalactone的合成方法 | |
CN110041161A (zh) | (3r)-2,4-二碘代-3-甲基丁-1-烯化合物及其制备方法和应用 | |
CN102250080B (zh) | 一种1-(4,5-二氢-2-噻唑啉基)-3-巯基吖丁叮盐酸盐的制备方法 | |
CN107513056A (zh) | 一种含四氢呋喃基团的喹啉类化合物的合成方法 | |
Del Buttero et al. | The [2+ 2] Staudinger cycloadditive route to enantiopure azetidino [4, 1-d][1, 4] benzooxazepines | |
Nicoll-Griffith et al. | Introduction of a chiral centre on C-6 of a carbohydrate unit: Application to the synthesis of the C-2 to C-15 fragment of lonomycin | |
Fujioka et al. | Facile formation of tetrahydrofurans with multiple chiral centers using double iodoetherification of σ-symmetric diene acetals: short asymmetric total synthesis of rubrenolide and rubrynolide | |
CN103030608A (zh) | 一种n-(5-脱氢枞基-[1,3,4]噻二唑-2-基)-芳酰胺衍生物、其制备方法及其应用 | |
CN102875578B (zh) | 一种头孢拉宗钠的合成方法 | |
EP0633266A1 (en) | 16-Membered macrolide derivatives and process for producing the same | |
CN111592536B (zh) | 单环β-内酰胺化合物及其制备方法和应用 | |
CN111848665B (zh) | 一种索氟布韦杂质的合成方法 | |
CN111675641B (zh) | 单环β-内酰胺类化合物、单环内酰胺类化合物盐及其制备方法 | |
CN113651847A (zh) | 氮杂环丁酮类化合物的制备方法和4-酰氧基氮杂环丁酮化合物的制备方法 | |
CN110627811B (zh) | 一种以顺式-联噻吩环为构筑单元连接的八元卟啉的合成方法及应用 | |
CN101891666B (zh) | 一种β甲基碳青霉烯类抗生素中间体的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai New Asiatic Pharmaceuticals Minhang Co., Ltd. Assignor: Shanghai Medicine Science-Technology Development Co., Ltd. Contract record no.: 2010310000196 Denomination of invention: Prepn of carbapenum type antibiotic Faropenum sodium Granted publication date: 20080702 License type: Exclusive License Open date: 20070103 Record date: 20101019 |
|
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI XINYA PHARMACEUTICAL INDUSTRY CO. LTD. Free format text: FORMER OWNER: SHANGHAI MEDICINE SCIENCE + TECHNOLOGY DEVELOPING CO., LTD. Effective date: 20130228 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20130228 Address after: 201203 No. 978, Chuansha Road, Shanghai, Pudong New Area Patentee after: Shanghai Xinya Pharmaceutical Industry Co., Ltd. Address before: 201203 Zhangjiang Road, Zhangjiang hi tech park, Shanghai, Pudong New Area, No. 58 Patentee before: Shanghai Medicine Science-Technology Development Co., Ltd. |
|
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: 201209 Chuansha Road, Shanghai, No. 978, No. Patentee after: SHANGHAI PHARMA NEW ASIA PHARMACEUTICAL CO., LTD. Address before: 201203 No. 978, Chuansha Road, Shanghai, Pudong New Area Patentee before: Shanghai Xinya Pharmaceutical Industry Co., Ltd. |