CN100394935C

CN100394935C - Method for extracting injection medicine from Chinese herb medicines for intravenous drip

Info

Publication number: CN100394935C
Application number: CNB2003101105680A
Authority: CN
Inventors: 熊得胜
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-11-21
Filing date: 2003-11-21
Publication date: 2008-06-18
Anticipated expiration: 2023-11-21
Also published as: CN1618440A

Abstract

The present invention relates to a method for extracting injection medicine from Chinese herb medicine for intravenous drip, which comprises the steps: firstly, the Chinese herb medicine screened and ground into powder according to a formula is packaged to be delivered to a container, and after a right amount of pure water is blended, the powder of the Chinese herb medicine is soaked for certain time at the normal temperature in the state of complete sealing; then, strong fire is firstly used for heating at 1.2 of atmospheric pressure, so that the Chinese herb medicine in the container is heated to a boiling point, and subsequently, soft fire is used for boiling for certain time to carry out distillation so as to obtain a base solution; the Chinese herb medicine which treats certain diseases and is ground into the powder, on which the formula is adjusted, is packaged to be delivered to the container, a right amount of base solution is blended, and the powder is soaked for certain time at normal temperature in the state of complete sealing; then, the strong fire is firstly used for heating at 1.2 of the atmospheric pressure, so that the medicine in the container is heated to the boiling point, and subsequently, the soft fire is used for boiling for certain time; after the Chinese herb medicine is fully dissolved into physic liquor, distillation, concentration and filtration are carried out on the physic liquor repeatedly so as to obtain the injection medicine with high purity and high grade. The injection medicine produced by the method of the present invention can be used for clinics, and is widely suitable for the field of medical products.

Description

The extracting process of Chinese herbal medicine drop injection raw material

Technical field

The present invention relates to a kind of method of extracting Chinese herbal medicine effective ingredients, particularly a kind of extracting process of Chinese herbal medicine drop injection raw material.

Background technology

Chinese herbal medicine is an important component part in China's Chinese medicine, has played active and effective effect in preventing and treating diseases.For the use of Chinese herbal medicine, normally adopt the method that decocts, soaks or concoct to be processed, supply for oral administration or external to obtain medicinal liquid, thereby reach the purpose of prevention and treatment disease.But said method is difficult to extract to greatest extent the active ingredient in the medicine, and this certainly will cause the significant wastage of the valuable Chinese herbal medicine resource of China.Above-mentioned processing method technology is original, coarse simultaneously, is difficult to medicine is carried out refine.So certainly will contain more impurity in the active drug composition that extracts, be difficult to guarantee optimum medicine efficacy, and this method also is difficult to guarantee the sterile working, be difficult for stopping the pollution of antibacterial to medicinal liquid, thus might produce negative effect, so the scope of application is restricted.And the Western medicine preparation in field of medicaments, in particular for the preparation of muscle, intravenous drip injection, its processing technique complexity, extraction process are lengthy and tedious.Pure Chinese herbal and crude drugs preparations is used for the fluid infusion in western modern medicine field, and it is impossible to be considered as in Western European countries' medical circle! Have extensive use Chinese herbal medicine traditional China, Japan and Korea three states that cure the wound of curing the disease, Chinese herbal medicine generally only is used for oral and external application is cured the disease cures the wound.Even in populous, the formal China of a specified duration of Chinese herbal medicine medical history, the injection of Chinese herbal medicine processing is used for clinical, also phoenix feathers and unicorn horns just is as (production technology are as shown in Figure 1) such as processing of ephedrine.But its extraction process is very complicated, and needed production equipment is many, the production cost height, and purity and precision are all lower.

For solving above-mentioned technical barrier, Chinese patent CN1278445A discloses the application for a patent for invention of the applicant in " the extracting the method for Chinese herbal medicine active ingredient " of application on November 23rd, 1999, its technical scheme is: the Chinese medicinal herbs that at first will necessarily fill a prescription grinds and is powder, adding suitable quantity of water again soaks, pack into afterwards in the airtight distillator, adopting distillatory method to heat under room temperature, atmospheric pressure boils, make it evaporation, after the steam cooling liquid, promptly get Chinese herbal medicine fluid (as shown in Figure 2).This technical scheme novelty, reliable, the good method of extracting the Chinese herbal medicine active ingredient really.But there is following weak point in its production technology, is difficult to reach the target that fully extracts high-purity, the active ingredient of high-grade Chinese herbal medicine:

One, soak at room temperature under unsealed condition might cause active ingredient to be run off;

Its two, under non-air-tight state, boil evaporation, evaporate the part active ingredient unavoidably;

Its three, under non-air-tight state, distill, its active ingredient vapors away unavoidably;

Its four, begin to drug packaging from feeding intake, whole process of production is not a full closeding state, has a small amount of active ingredient loss and trace impurity and occurs.

Summary of the invention

The extracting process that the objective of the invention is to overcome the above-mentioned deficiency of prior art and a kind of Chinese herbal medicine drop injection raw material is provided.

Technical scheme of the present invention is: at first will after parcel is handled, render in the container through screening and the Chinese herbal medicine that is crushed into powder by prescription, mix pure water by the volume ratio of a medicamental pulverata, two parts of water after, soak at room temperature is 1 hour under complete airtight state; Then, first intense fire is heated under 1.2 atmospheric pressure, and the medicament in the container is heated to boiling point, distills after slow fire decocts 24 hours subsequently promptly to get base fluid; The Chinese herbal medicine of suiting the medicine to the illness that to adjust prescription again and be crushed into powder is rendered in the container after parcel is handled, and mixes base fluid by the volume ratio of a medicamental pulverata, two parts of base fluids, and soak at room temperature is 1 hour under airtight fully state; Then, first intense fire is heated under 1.2 atmospheric pressure, and the medicament in the container is heated to boiling point, and slow fire decocts subsequently, treats that medical material fully is dissolved as behind the medicinal liquid distill repeatedly again, concentrates, filters, and promptly gets Chinese herbal medicine drop injection raw material.This raw material process is routinely made the drop injection.

The present invention since directly with Chinese herbal medicine through screening, grind end, prescription, adjust prescription, technology extracting high purity, high-grade drop injections such as immersion, steam-cured i.e. distillation and infusion, can be applicable to cure the disease, it is promptly clinical to cure the wound, not only started the beginning of the universal fluid infusion of Chinese herbal medicine history, filled up the blank of pharmaceutical formulation, more raised " the Chinese medicine west is used " new page, thereby changed the conventional use that Chinese herbal medicine is confined to Orally taken and externally, widen the Chinese herbal medicine medical market, and reduced equipment investment and production cost significantly.Has advantage easy and simple to handle, stable, that efficacy component is difficult for the segregation loss.That product has is colourless, as clear as crystal, efficacy component concentration is big, of high grade, purity is high, pollution-free, free from admixture, not emulsifying, anti-storage, and safe in utilization, reliable, the characteristics that curative effect is high can be widely used in the medical product field.

Description of drawings

Accompanying drawing 1 is existing ephedrine technological process of production figure;

Accompanying drawing 2 is the technological process of production figure of prior art;

Accompanying drawing 3 is technological process of production figure of the present invention.

Below in conjunction with embodiment detailed content of the present invention is further described.

The specific embodiment

Embodiment: the extraction process of hepatoprotective drop injection as shown in Figure 3:

The first step, Radix Isatidis 30g after at first will screening, Rhizoma Polygoni Cuspidati 20g, Herba Abri 20g, Endothelium Corneum Gigeriae Galli 10g, Herba Hedyotidis Diffusae 20g, Radix Bupleuri 10g, Poria 10g, Herba Hyperici Japonici 20g, Semen Coicis 50g, Herba Artemisiae Scopariae 20g, Radix Glycyrrhizae 5g, Herba Rabdosiae Lophanthoidis 20g, Galla Chinensis 20g is a secondary dosage, be crushed into powder and after parcel is handled, render in the sealable container, by a medicamental pulverata, after the volume ratio of two parts of water is mixed pure water, soak at room temperature is after one hour under airtight fully state, under 1.2 atmospheric pressure, heat with high heat earlier and make in the container medicament to boiling point, move back then to slow fire decocts about 24 hours, promptly get base fluid after concentrating through distilling.Base fluid is used to soak the medicinal powder of adjusting prescription, and residue then discards.

Second step, with selected Herba Cassiopes selaginoidis, Radix Ginseng, natural Broneolum Syntheticum, Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Salviae Miltiorrhizae is crushed into powder after the parcel processing, by a medicamental pulverata, the volume ratio of two parts of base fluids is rendered in the sealable container, soak at room temperature is after one hour under airtight fully state, under control evaporation and volatilization and aseptic condition, intense fire is heated under 1.2 atmospheric pressure and medicament to boiling point is retreated to slow fire decoct, steam-cured more i.e. distillation and infusion, redistillation concentrates after making medicamental pulverata fully be dissolved as medicinal liquid, the first liquid and the tail washings that generate use as Recycling Mother Solution, and the pure liquid that quality is high concentrates through repeatedly distilling again, be drop injection raw material of the present invention after the filtration.This raw material is colourless, as clear as crystal, and process is made the drop injection routinely.

Certain monarch suffered from hepatitis B more than 20 year, the multi-treatment state of an illness still, behind the hepatoprotective drop injection and medicinal liquid combined treatment for oral administration of the inventive method extraction, the state of an illness take a favorable turn at present (seeing the following form)

Annotate: be week age a course of treatment.

The pure Chinese herbal and crude drugs preparations that the inventive method is produced shows through clinical use, forceful drug effect, and curative effect is showing, effective percentage and cure rate height.

By pure Chinese medicine eye drop of refreshing light that the inventive method is produced, character: clear, colorless liquid has the fragranced of Chinese medicine.Main Ingredients and Appearance: Herba Cassiopes selaginoidis, Radix Ginseng, natural Broneolum Syntheticum, Calculus Bovis, Stigma Croci, Herba Hieracii Umbellati, Radix Scrophulariae etc., clinical for many years this medicament that shows is better than similar drug, and it is high to control the rate of fullying recover from an illness." refreshing light " serial medicinal liquid and the drop injection thereof produced by the inventive method, through " Hong Kong standard and calibrating " center " be respectively to heavy metal or poisonous element test, microbial limit test, the persticide residue test, and conclusion is qualified.

The different medicaments of the inventive method extraction use for many years in folklore, and to ophthalmic, wound, hepatitis, gastric ulcer, the curative effect of preventing and treating of disease such as suffer from a deficiency of the kidney is showing, and person's network post is without cease to ask the medicine to the doorstep.

Claims

1. the extracting process of a Chinese herbal medicine drop injection raw material, Radix Isatidis 30g after it is characterized in that at first will screening, Rhizoma Polygoni Cuspidati 20g, Herba Abri 20g, Endothelium Corneum Gigeriae Galli 10g, Herba Hedyotidis Diffusae 20g, Radix Bupleuri 10g, Poria 10g, Herba Hyperici Japonici 20g, Semen Coicis 50g, Herba Artemisiae Scopariae 20g, Radix Glycyrrhizae 5g, Herba Rabdosiae Lophanthoidis 20g, Galla Chinensis 20g is a secondary dosage, be crushed into powder and render in the sealable container, by a medicamental pulverata, after the volume ratio of two parts of water is mixed pure water, soak at room temperature is after one hour under airtight fully state, heat with high heat earlier and make the interior medicament of container to boiling point, move back then to slow fire decocts about 24 hours, promptly get base fluid after concentrating through distilling; With selected Herba Cassiopes selaginoidis, Radix Ginseng, natural Broneolum Syntheticum, Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Salviae Miltiorrhizae is crushed into powder, by a medicamental pulverata, the volume ratio of two parts of base fluids is rendered in the sealable container, soak at room temperature is after one hour under airtight fully state, under control evaporation and volatilization and aseptic condition, intense fire is heated and medicament to boiling point is retreated to slow fire decoct, steam-cured more i.e. distillation and infusion, redistillation concentrates after making medicamental pulverata fully be dissolved as medicinal liquid, the first liquid and the tail washings that generate use as Recycling Mother Solution, and the pure liquid that quality is high concentrates through repeatedly distilling again, be drop injection raw material of the present invention after the filtration.

2. the extracting process of Chinese herbal medicine drop injection raw material according to claim 1 is characterized in that intense fire heats under 1.2 atmospheric pressure.

3. the extracting process of Chinese herbal medicine drop injection raw material according to claim 1 and 2 is characterized in that and will render in the container after parcel is handled through the Chinese herbal medicine that screens and be crushed into powder.