CN100392079C - 蛋白c或活化的蛋白c-样分子 - Google Patents

蛋白c或活化的蛋白c-样分子 Download PDF

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Publication number
CN100392079C
CN100392079C CNB018175716A CN01817571A CN100392079C CN 100392079 C CN100392079 C CN 100392079C CN B018175716 A CNB018175716 A CN B018175716A CN 01817571 A CN01817571 A CN 01817571A CN 100392079 C CN100392079 C CN 100392079C
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China
Prior art keywords
polypeptide
protein
leu
conjugate
gly
Prior art date
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Expired - Fee Related
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CNB018175716A
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English (en)
Chinese (zh)
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CN1535313A (zh
Inventor
金·V·安德森
安德斯·H·佩德森
珀·O·弗雷斯克加尔德
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Perseid Therapeutics LLC
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Maxygen Holdings Ltd
Maxygen Inc
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Publication of CN1535313A publication Critical patent/CN1535313A/zh
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Publication of CN100392079C publication Critical patent/CN100392079C/zh
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB018175716A 2000-10-18 2001-10-15 蛋白c或活化的蛋白c-样分子 Expired - Fee Related CN100392079C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200001560 2000-10-18
DKPA200001560 2000-10-18
DKPA200100970 2001-06-21
DKPA200100970 2001-06-21

Publications (2)

Publication Number Publication Date
CN1535313A CN1535313A (zh) 2004-10-06
CN100392079C true CN100392079C (zh) 2008-06-04

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CNB018175716A Expired - Fee Related CN100392079C (zh) 2000-10-18 2001-10-15 蛋白c或活化的蛋白c-样分子

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CN (1) CN100392079C (pt)
BR (1) BR0114771A (pt)
IL (1) IL154999A0 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906435A (zh) * 2009-06-05 2010-12-08 苏州泽璟生物制药有限公司 一种真核细胞中重组糖蛋白高水平表达的载体系统pSA
CN108159399B (zh) * 2017-12-29 2020-07-24 华中科技大学同济医学院附属同济医院 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005824A1 (en) * 1987-12-23 1989-06-29 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides to facilitate covalent linkages to a hydrophilic moiety
JPH0372877A (ja) * 1989-08-10 1991-03-28 Teijin Ltd 活性化ヒトプロテインｃ誘導体
EP0575054A2 (en) * 1992-05-21 1993-12-22 Eli Lilly And Company Protein C derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005824A1 (en) * 1987-12-23 1989-06-29 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides to facilitate covalent linkages to a hydrophilic moiety
JPH0372877A (ja) * 1989-08-10 1991-03-28 Teijin Ltd 活性化ヒトプロテインｃ誘導体
EP0575054A2 (en) * 1992-05-21 1993-12-22 Eli Lilly And Company Protein C derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecu. Rezaie AR et al.The Journal of Biological Chemistry,Vol.268 No.27. 1993
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecu. Rezaie AR et al.The Journal of Biological Chemistry,Vol.268 No.27. 1993 *
Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va.. Gale A et al.Protein Science,No.6. 1997
Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va.. Gale A et al.Protein Science,No.6. 1997 *

Also Published As

Publication number Publication date
CN1535313A (zh) 2004-10-06
BR0114771A (pt) 2004-07-27
IL154999A0 (en) 2003-10-31

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