BR0114771A - Moléculas de proteìna c ou semelhantes a proteìna c ativada - Google Patents

Moléculas de proteìna c ou semelhantes a proteìna c ativada

Info

Publication number
BR0114771A
BR0114771A BR0114771-4A BR0114771A BR0114771A BR 0114771 A BR0114771 A BR 0114771A BR 0114771 A BR0114771 A BR 0114771A BR 0114771 A BR0114771 A BR 0114771A
Authority
BR
Brazil
Prior art keywords
protein
conjugates
molecules
present
vivo
Prior art date
Application number
BR0114771-4A
Other languages
English (en)
Inventor
Per Ola Freskgaard
Kim Vilbour Andersen
Anders Hjelholt Pedersen
Original Assignee
Maxygen Aps
Maxygen Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Aps, Maxygen Holdings Ltd filed Critical Maxygen Aps
Priority claimed from PCT/DK2001/000679 external-priority patent/WO2002032461A2/en
Publication of BR0114771A publication Critical patent/BR0114771A/pt

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MOLéCULAS DE PROTEìNA C OU SEMELHANTES A PROTEINA C ATIVADA". A presente invenção está relacionada a novos conjugados entre variantes de polipeptídeos de proteína c e uma porção não polipeptídica, tal como PEG ou porções de açúcar. Em particular, a presente invenção fornece novos conjugados de proteína C tendo uma resistência aumentada à inativação por, por exemplo, plasma humano e alfa-1 antitripsina. Conseq³entemente, tais conjugados possuem uma meia-vida in vivo aumentada. Exemplos de preferência incluem conjugados de proteína C, onde pelo menos um sítio de N-glicosilação adicional in vivo foi introduzido. Os conjugados da invenção são úteis para tratamento de uma variedade de doenças, incluindo choque séptico.
BR0114771-4A 2000-10-18 2001-10-15 Moléculas de proteìna c ou semelhantes a proteìna c ativada BR0114771A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001560 2000-10-18
DKPA200100970 2001-06-21
PCT/DK2001/000679 WO2002032461A2 (en) 2000-10-18 2001-10-15 Protein c or activated protein c-like molecules

Publications (1)

Publication Number Publication Date
BR0114771A true BR0114771A (pt) 2004-07-27

Family

ID=32598630

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114771-4A BR0114771A (pt) 2000-10-18 2001-10-15 Moléculas de proteìna c ou semelhantes a proteìna c ativada

Country Status (3)

Country Link
CN (1) CN100392079C (pt)
BR (1) BR0114771A (pt)
IL (1) IL154999A0 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906435A (zh) * 2009-06-05 2010-12-08 苏州泽璟生物制药有限公司 一种真核细胞中重组糖蛋白高水平表达的载体系统pSA
CN108159399B (zh) * 2017-12-29 2020-07-24 华中科技大学同济医学院附属同济医院 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
JP2774154B2 (ja) * 1989-08-10 1998-07-09 帝人株式会社 活性化ヒトプロテインｃ誘導体
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives

Also Published As

Publication number Publication date
CN1535313A (zh) 2004-10-06
CN100392079C (zh) 2008-06-04
IL154999A0 (en) 2003-10-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A E 10A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.