CN100386095C - Medicine for treating gout - Google Patents
Medicine for treating gout Download PDFInfo
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- CN100386095C CN100386095C CNB2006100107381A CN200610010738A CN100386095C CN 100386095 C CN100386095 C CN 100386095C CN B2006100107381 A CNB2006100107381 A CN B2006100107381A CN 200610010738 A CN200610010738 A CN 200610010738A CN 100386095 C CN100386095 C CN 100386095C
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Abstract
The present invention provides a medicine for treating uarthritis. The present invention is characterized in that the medicine is composed of the raw materials by the following mass percentage: 80 to 90% of homonoia root, 5 to 10% of beautiful sweetgum fruit and 5 to 10% of mulberry twig. The medicine provided by the present invention can effectively treat uarthritis, primary hyperuricemia and secondary hyperuricemia caused by damp-heat stasis obstruction, and has stronger functions of regulating purine metabolic disturbance and supporting excretory functions. The medicine can treat both the symptom and the cause of a disease; thus, a patient can comprehensively restore independent metabolism when the blood uric acid content of the patient is reduced. The medicine has the advantages of healthy essence, clear source, no adverse reaction in medicine taking period or no toxic or side effect in medicine taking period and no influence on gastrointestinal tract functions, liver functions and kidney functions. The content of uric acids does not recover after medicine administration is stopped, and a healed patient does not need to take the medicine for a lifelong time and does not need to control diet either. The present invention is a good medicine for treating lithemia and uarthritis at present.
Description
Technical field
The present invention relates to a kind of medicine, especially a kind of pure Chinese medicine medicine that is used for the treatment of goat belongs to biological technical field.
Background technology
Gout be since in the blood of human body uric acid increase unusually, and make urate crystal be deposited on intraarticular and cause the joint to have an intense pain, simultaneously with a kind of disease of redness distortion.Often occur in foot metatarsophalangeal joints, big toe joint or heel, instep, ankle joint or other joints, make the joint of getting involved that twinge take place, skin heating and congested in short time until arthroncus, can peak in 24 hours, sharp ache, the lighter can be in a few hours free disappearing, weight person will continue many days or a few week, most gouts all can recur.As untimely treatment, then easily form chronic, chronicity disease, and permanent lesion is caused in the joint, not only influence patient's orthobiosis, working and learning, more serious harm patient's body health.In addition, gout is high from blood uric acid, symptom shows needs a long slowly process, had plenty of several years, what have then is decades, and body is in the improper slant acidity environment that uric acid causes for a long time, infringement to Liver and kidney is very big, therefore, not only to treat gout, will prevent that more uric acid is too high.The medicine of existing treatment gout is as: benzbromarone (upright markon's celestial being), and its main mechanism is to suppress the heavily absorption of renal tubules to uric acid, increases the drainage of renal tubules to uric acid; Allopurinol suppresses the generation of uric acid; This class medicine often with gastrointestinal reaction as diarrhoea, gastrointestinal upset, erythra, leukocyte and thrombocytopenia, liver function damage, toxicity, side effects such as toxicity epithelium necrosis, and, in case left alone without help medicine can recur again, can not effect a radical cure.Compound recipe is stretched the muscle capsule, though can treat gout causes due to the dampness and heat stasis redness and swelling of joints, burning pain, diseases such as joint stuffiness, but the necessary fasting raw food of period in a medicine is sour and astringent and the food of purine-containing, as seafood, bean product and other nutriment or the like, cause the health malnutrition easily, resistance, immunity degradation and cause adverse consequencess such as other disease.Up to the present, still there is not the medicine appearance of radical cure.Therefore, be necessary fully prior art is improved.
Summary of the invention
Big for overcoming the toxicity, side effect that existing medicine exists, because of the multiple food of fasting causes the body malnutrition, resistance, immunity degradation such as can not effect a radical cure at deficiency, the invention provides a kind of medicine for the treatment of gout.
The present invention realizes by following technical proposal: a kind of medicine for the treatment of gout is characterized in that being made up of following raw materials by weight percentage:
Radix Homonoiae Ripariae 8090%, Fructus Liquidambaris 5-10%, Ramulus Mori 5-10%.
Described Radix Homonoiae Ripariae is the root of euphorbia plant water willow Homonoia riparia Lour, and its nature and flavor hardship is cold, has diuresis, heat clearing away, function of gallbladder promoting, antiinflammatory, the antidotal effect can be treated traumatic injury, ulcer, hemorrhoid, gonorrhea, syphilis, wing light calculus, cholelithiasis, and acute and chronic hepatitis.Fructus Liquidambaris is the fruit of Hamamelidaceae plant sweetgum Liquidambar formoana Hance, its nature and flavor hardship, and flat, 12 warps of going into to pass through have dispelling wind and removing obstruction in the collateral, and effects such as diuretic dehumidifying can be treated the limbs arthralgia pain, contracture of the limbs, stomachache, edema, diseases such as distension.Ramulus Mori is the twig of moraceae plants Mulberry Morus alba L, and its nature and flavor hardship is flat, goes into Liver Channel, has wind-damp dispelling, sharp joint, row aqueous vapor, promoting fluid production, strong lung qi, dampness, kidney nourishing water, the effect of stimulating the menstrual flow can be treated anemofrigid-damp arthralgia, spasm of the limbs, limb air supporting is swollen, the human body pruritus due to wind pathogen, the cough-relieving relieving restlessness, reducing swelling and alleviating pain, diseases such as numb hand and foot.
Medicine provided by the invention makes by following method: adopt Herb and be used as medicine, through pulverizing of the prior art, decocting in water lixiviate, filtration, concentrate, after the drying, make preparations such as existing capsule, tablet, pill, electuary or oral liquid.
The present invention compared with prior art has following advantage and remarkable result: adopt said medicine prescription provided by the invention, can effectively treat because of the goat due to the dampness and heat stasis, constitutional and secondary hyperuricemia, to adjusting purine metabolic disturbance, the strengthening body's resistance and regulating excrement function has stronger effect, and treating both the principal and secondary aspects of a disease, can make the patient when reducing blood uric acid, recover autonomous metabolic function comprehensively, radically reform, period in a medicine does not have any untoward reaction or toxic and side effects, to gastrointestinal tract, liver function, the kidney merit all has no effect, uric acid does not go up behind the left alone without help medicine, need not after the healing to take medicine all the life, more need not to keep a diet, is to treat hyperuricemia at present, the potion good medicine of goat.
For showing effect of the present invention, the present invention is through 106 routine clinical observations, and its result is as follows:
1, clinical data
1.1 physical data
All case is the out-patient, and the uric acid index is extraordinary in the serum, and symptom is obvious.The patient is divided into two groups of matched group and test group at random, all cases totally 106 examples, wherein test group 66 examples: male 42 examples, women 24 examples, 23～64 years old age, average 43 years old, the course of disease 3～10 years; Matched group 40 examples: male 25 examples, women 15 examples, 21～65 years old age, the course of disease 2～10 years.Learn by statistics and handle, there not being significant difference (P＞0.05) aspect age, sex, the course of disease, have comparability between two groups.
1.2 diagnostic criteria
All patients all meet the diagnostic criteria of " the hyperuricemia classification of diseases scheme and the diagnostic criteria " of China's formulation.
2, treatment and observational technique
2.1 Therapeutic Method
Test group: oral medicine provided by the invention, every day 2 times, each 1.2～1.8 grams;
Matched group: oral allopurinol, every day 2-3 time, each 50mg, maximal dose 300-600mg/ day;
Two groups was a course of treatment with 15 days all, and each outpatient service course of treatment is followed up a case by regular visits to once, the relevant situation of itemized record.Treat 60 days 4 courses of treatment altogether, treatment finishes to carry out therapeutic evaluation.
2.2 observing, safety comprises general physical examination, electrocardiogram, blood, urine, just conventional, hepatic and renal function.2.3 efficacy evaluation method
2.3.1 efficacy assessment standard: formulate with reference to " new Chinese medicine clinical research guideline "
Clinical recovery: treatment back uric acid index is normal, the somatization disappearance, and diet is good, need not to avoid food, the sleep rule, work, life, study can reach the preceding level of disease, continue 6 one years.The total score value of symptom accumulative total reduces 〉=95%;
Produce effects: treatment back uric acid index is a little more than normal value, and somatization is obviously improved, but not complete obiteration, diet is general, suitably avoids foods such as Fish, Hepar Bovis seu Bubali, Ren Bovis seu Bubali, brain, soup stock, and work, life, learning capacity improve, and continue 3 months.The total score value of symptom accumulative total reduces;
Effectively: treatment back uric acid index is a little more than normal value, and clinical symptoms has at least more than 2 to be improved, taboo Fish, shellfish, animal livers, meat, brain and the high purine vegetable of part, and work, life, learning capacity have raising slightly.The total score value of symptom accumulative total reduces 35%～70%;
Invalid: treatment back uric acid index height, somatization does not have improvement, and work, life, learning capacity do not have raising.The total score value of symptom accumulative total descends＜35%;
3, therapeutic outcome
The treatment group is totally 66 examples, 25 examples of fully recovering (37.87%), and produce effects 28 examples (42.42%), effective 8 examples (12.12%), invalid 5 examples (7.58%), total effective rate (61 example) is 92.42%.Matched group is totally 40 examples, produce effects 20 examples (50%), effective 6 examples (15%), invalid 14 examples (35%), total effective rate (26 example) is that 65%, two group of result learns by statistics to handle significant difference is arranged, and gout medicine clinical efficacy of the present invention is significantly higher than matched group (P＜0.01).
4, discuss
Uric acid is the catastate of purine nucleotides in the human body, and 80% purine nucleotides is to be produced by the human body cell metabolism, and 20% obtains from food, and human kidney can be got rid of uric acid and keep the normal concentration level of uric acid in blood under the normal condition.Because congenital uric acid metabolism obstacle or because some disease or factor cause uric acid to increase.Uric acid increases and is meant in the blood: the uric acid content male in the time of 37 ℃ in the serum surpasses 417 μ mol/L, the women surpasses 357 μ mol/L, because this concentration is the saturated concentration of uric acid in blood, when surpassing this concentration, urate can be deposited on and cause multiple infringement in the tissue.Gout be exactly since in the blood of human body uric acid increase unusually, and make urate crystal be deposited on intraarticular and cause the joint to have an intense pain, simultaneously with a kind of disease of redness distortion.Sickness rate is in rising trend in recent years, and untimely treatment then easily forms chronic, chronicity disease, and permanent lesion is caused in the joint, not only influences patient's orthobiosis, working and learning, more serious harm patient's body health.Traditional method mainly is to rely on Western medicine such as benzbromarone (upright markon's celestial being), allopurinol, and not only toxic and side effects is big, and in case left alone without help medicine can recur again, therefore, does not still have the active drug of radical cure goat at present.Can effectively treat because of the goat due to the dampness and heat stasis, constitutional and secondary hyperuricemia, to adjusting purine metabolic disturbance, the strengthening body's resistance and regulating excrement function has stronger effect, and treating both the principal and secondary aspects of a disease, can make the patient when reducing blood uric acid, recover autonomous metabolic function comprehensively, radically reform, back intravital urate crystal of patient and the tophus of taking medicine is softened, dissolving, neutralize, and the raising kidney is to the excretory function of uric acid, and period in a medicine does not have any untoward reaction or toxic and side effects, to gastrointestinal tract, liver function, the kidney merit all has no effect, and uric acid does not go up behind the left alone without help medicine, need not after the healing to take medicine all the life, more need not to keep a diet, is to treat hyperuricemia at present, the potion good medicine of goat.
The specific embodiment
Embodiment 1
Get former medicine by following prescription: 80 kilograms of Radix Homonoiae Ripariaes, 10 kilograms of Fructus Liquidambaris, 10 kilograms of Ramulus Moris.
Through pulverizing of the prior art, decocting in water lixiviate, filtration, concentrate, after the drying, make existing capsule.
Embodiment 2
Get former medicine by following prescription: 90 kilograms of Radix Homonoiae Ripariaes, 5 kilograms of Fructus Liquidambaris, 5 kilograms of Ramulus Moris.Make tablet through existing process method.
Embodiment 3
Get former medicine by following prescription: 85 kilograms of Radix Homonoiae Ripariaes, 7 kilograms of Fructus Liquidambaris, 8 kilograms of Ramulus Moris make pill through existing process technology.
Embodiment 4
Get former medicine by following prescription: 82 kilograms of Radix Homonoiae Ripariaes, 8 kilograms of Fructus Liquidambaris, 10 kilograms of Ramulus Moris make electuary through existing process technology.
Embodiment 5
Get former medicine by following prescription: 88 kilograms of Radix Homonoiae Ripariaes, 6 kilograms of Fructus Liquidambaris, 6 kilograms of Ramulus Moris make oral liquid formulations through existing process technology.
Claims (1)
1. medicine for the treatment of gout is characterized in that being made by the following raw materials by weight percentage medicine:
Radix Homonoiae Ripariae 80-90%
Fructus Liquidambaris 5-10%
Ramulus Mori 5-10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100107381A CN100386095C (en) | 2006-03-10 | 2006-03-10 | Medicine for treating gout |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100107381A CN100386095C (en) | 2006-03-10 | 2006-03-10 | Medicine for treating gout |
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|---|---|
| CN1857413A CN1857413A (en) | 2006-11-08 |
| CN100386095C true CN100386095C (en) | 2008-05-07 |
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| CNB2006100107381A Expired - Fee Related CN100386095C (en) | 2006-03-10 | 2006-03-10 | Medicine for treating gout |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401888B (en) * | 2008-11-07 | 2011-02-02 | 张洪磊 | Chinese medicament preparation for treating gout |
| CN108186932A (en) * | 2018-03-16 | 2018-06-22 | 天津聚成广达科技有限公司 | A kind of Chinese medicine for treating gout |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192916A (en) * | 1997-03-12 | 1998-09-16 | 李航海 | Chinese medicine for treatment of gout |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192916A (en) * | 1997-03-12 | 1998-09-16 | 李航海 | Chinese medicine for treatment of gout |
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