CN100382826C

CN100382826C - Traditional Chinese medicine composition for treating mammary gland hyperplasia

Info

Publication number: CN100382826C
Application number: CNB2005100019494A
Authority: CN
Inventors: 赵志全
Original assignee: Lunan Pharmaceutical Group Corp
Current assignee: Lunan Hope Pharmaceutical Co., Ltd.
Priority date: 2005-01-13
Filing date: 2005-01-13
Publication date: 2008-04-23
Anticipated expiration: 2025-01-13
Also published as: CN1803175A

Abstract

The present invention discloses a traditional Chinese medicine composition for treating mammary gland hyperplasia, which is prepared from the following raw medicinal materials: nutgrass galingale rhizome, deglued antler, epimedium herb, tree peony bark, red sage root, peach seed, cowherb seed, white mustard seed, dandelion, hawthorn fruit, paniculate swallowwort root and seaweed. The traditional Chinese medicine composition can be made into various clinical dosage forms, and have nice therapeutic effect on mammary gland hyperplasia.

Description

A kind of Chinese medicine composition for the treatment of cyclomastopathy

Technical field

The present invention relates to a kind of Chinese medicine composition, a kind of specifically is raw material with the Chinese crude drug, through processing the Chinese medicine composition with treatment mastitis effect of purifying and obtaining.

Background technology

Female mammary gland proliferation disease is a kind of commonly encountered diseases, frequently-occurring disease.It is characterized by the one or both sides breast can touch differ in size, soft or hard differs, boundary is not clear lump, as if there is granule on the surface, does not have adhesion with skin, fascia, press...with one's finger promptly to feel pain after pressing.Simultaneously with distending pain of the breast or ache, individual patients is also to oxter and upper limb radiation.Pain the lighter can not cause that patient notes, weight person can influence work and life.In recent years, this disease sickness rate increases year by year, and women of child-bearing age's sickness rate is up to 28-40%.Meanwhile, age of onset descends.This disease originally is more common in the women in 30-50 year, the maiden's morbidity about 20 years old is also arranged now, and symptom is apparent in view; The pathogenic factor of cyclomastopathy is still not fully aware of.It is generally acknowledged relevant with the ovary endocrine dysfunction.Lutein hyposecretion, estrogen relatively or too much absolute so that mammoplasia and restoration of old ways process get muddled in the menstrual cycle, make breast duct or acinus epithelial proliferation, comedomastitis becomes cryptomere, forms lump.

Treatment cyclomastopathy Western medicine commonly used has hormones, Operand and other symptomatic treatment medicines.Traditional hormones preparation mainly is to come estrogen antagonist with androgen, as oral methyl testosterone in preceding 10 days of menstrual phase; Or intramuscular injection testosterone propionate 3～4 days.Use the androgen treatment and some side effect can occur, if any some manlike performances: hirsutism, voice chap, acne etc.; Also may have in various degree liver injury, dizziness in addition, feel sick etc.Development along with medical science, people recognize gradually, cyclomastopathy is not that simple estrogen secretion increases, but because ratios female, progestogen are unbalance, progestogen hyposecretion luteal phase in the menstrual cycle particularly is due to estrogen increases relatively, so advocate to treat primary disease with Progesterone, female to correct, progestogen are excretory unbalance, can 2 weeks begin usefulness before menstruation, oral Progesterone 7～8 days; Or the intramuscular injection Progesterone is injected weekly 2 times.Also the someone advocates at intermenstrual period orally with low dose of estrogen (1mg), obeys for 3 weeks altogether, obeys in later intermenstrual period again, but successively decreases gradually, promptly reduces dosage and medication number of times, 6 menstrual cycle of shared medicine.Take side effect such as feeling sick also can appear in estrogen, vomiting, headache, some conditions of patients instead can increase the weight of.

In recent years, because breakthrough progress has appearred in the research of hormone receptor, people recognize that the generation of cyclomastopathy is female with the mammary gland tissue part, the content of progesterone receptor and sensitivity increase relevantly, therefore, bring into use hormone receptor antagonists to treat primary disease.As the estrogen receptor antagon tamoxifen, also can produce certain side effect but take tamoxifen, as amenorrhea, hectic fever, feel sick etc.In addition, people recognize that also the cyclomastopathy that endocrine regulation causes not merely is that the ovary endocrine hormone is unbalance, but also are subjected to the influence of multiple endocrine hormones such as hypothalamus, hypophysis, as prolactin antagonist and other promoting sexual gland hormone.Use bromocriptine can suppress the secretion of prolactin antagonist, and reach the effect of treatment primary disease; As seen its side effect feels sick, vomiting, dizzy, orthostatic hypotension etc.; The use danazol can suppress the secretion of promoting sexual gland hormone and ovarian hormone, available its oral medication primary disease, the visible amenorrhea of side effect, menostaxis, weight increase, acne etc.

The general traditional Chinese medical science thinks that the main diseases of cyclomastopathy is because of causing by suffering from a deficiency of the kidney, so the Chinese medicine of treatment cyclomastopathy is main treatment means with kidney invigorating and YANG supporting mostly now, be aided with means such as dispersing the stagnated liver-QI and dredging collateral, but because the restriction of clinical treatment experience, so that curative effect all is difficult to is satisfactory.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition that can treat cyclomastopathy effectively, another object of the present invention provides the preparation method of this Chinese medicine composition.

For achieving the above object, we have adopted following technical scheme.The technical program is in a large amount of testing programs, comes out through selection, optimization.

We according to theory of Chinese medical science to the argumentation of cyclomastopathy and to this disease to controlling, from a large amount of prescriptions and hundreds of flavor Chinese medicine,,, and technology groped this Chinese medicine composition that obtains at last repeatedly in conjunction with clinical verification through repetition test.

According to theory of Chinese medical science, " nodules of the breast " described in cyclomastopathy and the document is similar, it is characterized in that mastalgia and lump, is cyclically-varying, increase and decrease with the fluctuation of feelings will, according to the relation of Basic Theories of Chinese Medicine and breast and meridians, internal organs, think that breast and Liver and kidney taste dash and appoint etc. in close relationsly that feelings will is not smooth, depression of liver-QI, qi depression to blood stasis is pented up in newborn network, stagnation of QI and blood may bring about pain.Kidney unit loses empty, the mechanism of qi retardance, the stagnation of QI, blood stasis, expectorant coagulate etc. pathological product hinder in newborn network then mammary gland thicken block.Therefore, stagnation of liver-QI is suffered from a deficiency of the kidney and is the main pathogenesis of primary disease, and the stagnation of QI expectorant stasis of blood of Sheng Chenging is the mark reality of primary disease therefrom.

In view of the above, establish soothing the liver kidney tonifying, phlegm reduction of blood circulation promoting is the Therapeutic Method of primary disease.

In a large amount of Chinese prescriptions, we have selected following flavour of a drug, Rhizoma Cyperi, Cornu Cervi Degelatinatum, Herba Epimedii, Cortex Moutan, Radix Salviae Miltiorrhizae, Semen Persicae, Semen Vaccariae, Semen Sinapis Albae, Herba Taraxaci, Fructus Crataegi, Radix Cynanchi Paniculati, Sargassum.And the combination between each flavour of a drug a large amount of experiments and clinical research have been done.

The little hardship of Rhizoma Cyperi acrid in the mouth, property is flat, returns liver, tri-jiao channel.Effect: promoting QI circulation for relieving depression.Be applicable to distending pain of the breast due to the stagnation of QI due to depression of the liver, disease such as do not relax uncomfortable in chest.

The Cornu Cervi Degelatinatum salty in the mouth, warm in nature, go into Liver and kidney two warps.Effect: temperature compensation Liver and kidney, promoting blood circulation and detumescence.

The Herba Epimedii sweet in the mouth, warm in nature, return the Liver and kidney warp.Effect: reinforcing the kidney and supporting YANG.

Cortex Moutan acrid in the mouth hardship, cold nature is gone into the heart, liver, kidney channel.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.

The Radix Salviae Miltiorrhizae bitter in the mouth, cold nature, GUIXIN, pericardium, Liver Channel have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing effect.

Semen Persicae bitter in the mouth, sweet, property is flat, GUIXIN, liver, large intestine channel.

The Semen Vaccariae bitter in the mouth, property is flat.Return liver, stomach warp.Function: promoting the circulation of blood is stimulated the menstrual flow, dissipating blood stasis for subsidence of swelling, is used for amenorrhea due to stagnation of blood, agalactia, distending pain of the breast.

Semen Sinapis Albae flavor acrid in the mouth, warm in nature, return lung stomach warp, effect: warming the lung to eliminate phlegm, promoting the circulation of QI cold expelling, removing obstruction in the collateral to relieve pain.Be applicable to the disease of the sluggish meridians of cold-phlegm." book on Chinese herbal medicine covers bamboo fish trap " cloud: " ... the outer sputum of flesh side film must reach with drawing." the shallow table in cyclomastopathy position, with the Semen Sinapis Albae eleminating phlegm and freeing channels, its institute can go directly.

The Herba Taraxaci bitter in the mouth, cold in nature, return liver, stomach warp, effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Ancients Yun Qi " housewife's human milk carbuncle." modern age pharmacological research confirm that Herba Taraxaci has antitumor action.

The acid of Fructus Crataegi sweet in the mouth, slightly warm in nature is returned spleen, stomach, Liver Channel, effect: invigorating the stomach and promoting digestion, blood circulation promoting and blood stasis dispelling.Compendium of Material Medica cloud: sour sweet tepor, dissipating fluid-retention food, the inner product that disappears, mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, stagnant blood distending pain.

The Radix Cynanchi Paniculati acrid in the mouth, warm in nature.Return liver, stomach, spleen channel.Function: antalgic and sedative is applicable to multiple pain disease.

The Sargassum bitter in the mouth is salty, and is cold in nature, and the merit of hard masses softening and resolving is arranged, and cures mainly goiter scrofula note of the ancient Chinese abdominal mass and aqueous vapor, and salty-coldly goes into Liver and kidney two warps, but both vanishing sputum and dispelling knot treatment primary disease, again with the kidney invigorating warming YANG compatibility of drugs, simultaneously using both cold and hot drugs, the property of medicine is gentle, and drug effect is helped each other.

For above flavour of a drug, at curative effect we preferred wherein the number flavor so that all form prescription, obtained having the Chinese medicine composition of treatment cyclomastopathy.This Chinese medicine composition is made by following proposal:

Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion.

Chinese medicine composition of the present invention also can be formed by the feedstock production of following weight parts:

Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion.

Chinese medicine composition of the present invention can also be formed by the feedstock production of following weight parts: Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 70 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions.

Perhaps the feedstock production by following weight parts forms: Rhizoma Cyperi 60 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Herba Epimedii 40 weight portions, Cortex Moutan 60 weight portions.

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 3-10 times of water gaging, soak water vapour distillation 4-10 hour 1-3 hour, collect volatile oil, Cortex Moutan adds 3-10 times of water gaging, soaks 1-3 hour, water vapour distillation 4-10 hour, collect volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 3-10 and doubly measures the ethanol extraction secondary, refluxes 1-3 hour at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 3-12 times of water gaging and decoct twice, each 1-3 hour, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount at 30%-90%, leave standstill and be no more than 72 hours, filter, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, add adjuvant or directly be prepared into clinical applicable dosage form.

This Chinese medicine composition also can be prepared from by following flavour of a drug:

Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion.

This Chinese medicine composition also can be got by the following proposal preparation:

Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion.

This Chinese medicine composition can also be got by the following proposal preparation:

Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 110 weight portions, Semen Persicae 70 weight portions, Semen Vaccariae 50 weight portions.

Perhaps the feedstock production by following weight parts forms:

Rhizoma Cyperi 50 weight portions, Cornu Cervi Degelatinatum 70 weight portions, Herba Epimedii 40 weight portions, Cortex Moutan 60 weight portions, Radix Salviae Miltiorrhizae 50 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 40 weight portions.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 3-10 times of water gaging, soak water vapour distillation 4-10 hour 1-3 hour, collect volatile oil, Cortex Moutan, add 3-10 times of water gaging, soaked 1-3 hour, water vapour distillation 4-10 hour, collect volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 3-10 and doubly measure the ethanol extraction secondary, reflux 1-3 hour at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 3-12 times of water gaging and decoct twice, each 1-3 hour, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount at 30%-90%, leave standstill and be no more than 72 hours, filter, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, add adjuvant or directly be prepared into clinical applicable dosage form.

Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion, Semen Sinapis Albae 10-100 weight portion, Herba Taraxaci 20-120 weight portion, Fructus Crataegi 10-100 weight portion.

Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion, Semen Sinapis Albae 30-80 weight portion, Herba Taraxaci 40-100 weight portion, Fructus Crataegi 30-80 weight portion.

Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 100 weight portions, Semen Persicae 50 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 40 weight portions, Herba Taraxaci 60 weight portions, Fructus Crataegi 60 weight portions.

Perhaps the feedstock production by following weight parts forms:

Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Herba Epimedii 50 weight portions, Cortex Moutan 40 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 50 weight portions, Herba Taraxaci 80 weight portions, Fructus Crataegi 40 weight portions.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 3-10 times of water gaging, soaks water vapour distillation 4-10 hour 1-3 hour, collect volatile oil, Cortex Moutan, add 3-10 times of water gaging, soaked 1-3 hour, water vapour distillation 4-10 hour, collect volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 3-10 and doubly measure the ethanol extraction secondary, reflux 1-3 hour at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 3-12 times of water gaging and decoct twice, each 1-3 hour, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount at 30%-90%, leave standstill and be no more than 72 hours, filter, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, add adjuvant or directly be prepared into clinical applicable dosage form.

Rhizoma Cyperi 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion, Semen Sinapis Albae 10-100 weight portion, Herba Taraxaci 20-120 weight portion, Fructus Crataegi 10-100 weight portion, Radix Cynanchi Paniculati 10-100 weight portion, Sargassum 10-100 weight portion.

Rhizoma Cyperi 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion, Semen Sinapis Albae 30-80 weight portion, Herba Taraxaci 40-100 weight portion, Fructus Crataegi 30-80 weight portion, Radix Cynanchi Paniculati 30-80 weight portion, Sargassum 30-80 weight portion.

Rhizoma Cyperi 40 weight portions, Herba Epimedii 70 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 100 weight portions, Semen Persicae 50 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 40 weight portions, Herba Taraxaci 60 weight portions, Fructus Crataegi 60 weight portions, Radix Cynanchi Paniculati 60 weight portions, Sargassum 30 weight portions.

Perhaps the feedstock production by following weight parts forms:

Rhizoma Cyperi 40 weight portions, Herba Epimedii 50 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Cortex Moutan 40 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 50 weight portions, Herba Taraxaci 80 weight portions, Fructus Crataegi 40 weight portions, Radix Cynanchi Paniculati 50 weight portions, Sargassum 40 weight portions.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 3-10 times of water gaging, soaked 1-3 hour, water vapour distillation 4-10 hour, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 3-10 times of water gaging, soaked 1-3 hour, water vapour distillation 4-10 hour, collect volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 3-10 and doubly measure the ethanol extraction secondary, reflux 1-3 hour at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, adding 3-12 times of water gaging decocts twice, each 1-3 hour, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount at 30%-90%, leave standstill and be no more than 72 hours, filter, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, add adjuvant or directly be prepared into clinical applicable dosage form.

Drug therapy cyclomastopathy of the present invention has better curative effect.For showing the therapeutical effect of medicine of the present invention to cyclomastopathy, we have done a large amount of experimentatioies, below experimental example be used to further specify the present invention.

1. Chinese medicine composition of the present invention is to estradiol (E ₂) influence of inductive cyclomastopathy

1.1 experiment material

1.1.1 animal

The Wistar rat, Shandong University's Experimental Animal Center.

Kunming mouse, Shandong University's Experimental Animal Center.

1.1.2 medicine and reagent

Chinese medicine composition of the present invention, Shandong Lunan Pharmaceutical Co., Ltd.

Tamoxifen Citrate, Yangtze River Medicine Industry Group Co Ltd, Jiangsu

Estradiol benzoate (E ₂), Shanghai General Pharmaceutical Co., ltd.

Estradiol radioimmunoassay, RIA medicine box, Beijing North technical research institute

1.1.3 instrument

SN-682, radioimmunity r enumerator, Shanghai nuclear good fortune photoelectric instrument company limited

1.2 experimental technique:

1.2.1 medicine preparation:

Rat: Chinese medicine composition intermediate of the present invention is a brown ceramic powder, designing requirement according to dosage, take by weighing 400g powder (9.8g crude drug/g powder), with distilled water diluting to 500ml (7.83g crude drug/ml), heavy dose for Chinese medicine composition of the present invention, get heavy dose of medicinal liquid 160ml and be diluted to 480ml for three times with distilled water, be (the 2.61g crude drug/ml) of dosage in the Chinese medicine composition of the present invention, dosage medicinal liquid 140ml in getting, with distilled water diluting to 420ml (0.87g crude drug/ml), be the low dose of Chinese medicine composition of the present invention, medicine prepares and places wide mouthed bottle, room temperature was placed 0.5 hour before 4 degrees centigrade of preservations, administration.More than three dosage groups all irritate stomach and give rat by the 1ml/200g volume, its dosage is respectively 39.15g crude drug/kg, 13.05g crude drug/kg, 4.35g crude drug/kg.

Mice: Chinese medicine composition intermediate of the present invention is a brown ceramic powder, designing requirement according to dosage, take by weighing the 69.3g powder, with distilled water diluting to 120ml (5.655g crude drug/ml), heavy dose for Chinese medicine composition of the present invention, get heavy dose of medicinal liquid 40ml and be diluted to 120ml for three times with distilled water, be (the 1.885g crude drug/ml) of dosage in the Chinese medicine composition of the present invention, dosage medicinal liquid 40ml in getting, with distilled water diluting to 120ml (0.628g crude drug/ml), be the low dose of Chinese medicine composition of the present invention, medicine prepares and places wide mouthed bottle, room temperature was placed 0.5 hour before 4 degrees centigrade of preservations, administration.More than three dosage groups all irritate stomach and give mice by the 0.2ml/20g volume, its dosage is respectively 56.55g crude drug/kg, 18.85g crude drug/kg, 6.28g crude drug/kg.

1.2.2 Chinese medicine composition of the present invention is to E ₂Induce the inhibitory action of rat mammary gland cyclomastopathy

Get 60 of Wistar rats, female, body weight 180-200g, be six groupings at random, every group 10: normal control group, model group, the positive group of Tamoxifen Citrate 3.6mg/kg, Chinese medicine composition 4.35g crude drug of the present invention/kg group, Chinese medicine composition 13.05g crude drug of the present invention/kg group, 39.15g crude drug/kg group.Except that the normal control group, all the other organize intramuscular injection estradiol benzoate (E equal the next day ₂) 0.5mg/kg, continuous 30 days, intramuscular injection began to irritate stomach and is subjected to the reagent thing after two weeks, and the normal control group gives normal saline, with the volume variable concentrations, 1ml/200g, inferior on every Saturdays once a day, intramuscular injection E ₂Two weeks again after the end is plucked eyeball and is got blood at last administration next day, and 3000rpm 10 minutes is centrifugal, gets serum, puts the method for exempting from and measures estradiol content in the serum.Change with second pair of breast diameter of vernier caliper measurement rat, every rat is chosen 2 of maximum mammary gland tissues, 10% formalin fixed, the routine paraffin wax embedding, slice thick 4～5 μ m, HE dyeing, the professional reads sheet by pathology, and light microscopic is observed down and had or not tissue pathologies change and pathological changes light and heavy degree.

1.2.3 Chinese medicine composition of the present invention is to E ₂The inhibitory action of inducing mouse cyclomastopathy

Get 60 of Kunming mouses, female, body weight 20 ± 2g, be six groupings at random, every group 10: normal control group, model group, the positive group of Tamoxifen Citrate 5.2mg/kg, Chinese medicine composition 6.28g crude drug of the present invention/kg group, Chinese medicine composition 18.85g crude drug of the present invention/kg group, Chinese medicine composition 56.55g crude drug of the present invention/kg group.Except that the normal control group, all the other organize intramuscular injection estradiol benzoate (E equal the next day ₂) 0.8mg/kg, continuous 30 days, intramuscular injection began to irritate stomach and gives relative medicine after two weeks, and the normal control group gives normal saline, with the administration of volume variable concentrations, 0.2ml/20g, inferior on every Saturdays once a day, intramuscular injection E ₂Two weeks again after the end, last administration next day, every mice is chosen 2 of maximum mammary gland tissues, 10% formalin fixed, routine paraffin wax embedding, slice thick 4～5 μ m, HE dyeing, the professional reads sheet by pathology, and light microscopic is observed down and is had or not tissue pathologies change and pathological changes light and heavy degree.

1.2.4 pathological diagnosis standard:

Mammary gland tissue is divided into I～IV level Four according to pathology hypertrophy situation, and scoring is 1 minute, 2 minutes, 3 minutes, 4 minutes respectively again, and each grade standard is as follows.The I level: (normal galactophore tissue), lobules of mammary gland is hypertrophy (-) not, and acinus quantity is few, and acinus and conduit are not expanded, and are in state resting stage.The II level: slight hypertrophy (+), lobules of mammary gland does not have obvious hypertrophy, and indivedual acinuses and conduit have slight hypertrophy, do not have expansion.The III level: moderate hypertrophy (++), the most of hypertrophy of lobules of mammary gland, part acinus and conduit are obviously expanded.IV: obvious hypertrophy (+++), the obvious hypertrophy of lobules of mammary gland, acinus and conduit are in extremely expansion state, and glandular epithelium is flat, in the acinus and in the conduit a large amount of secretions is arranged.The every treated animal mammary gland scoring of accumulative total, and (X ± SD), the high more prompting hyperplasia degree of score value is heavy more to calculate average ± standard deviation.

13 experimental results:

Table 1-1. Chinese medicine composition of the present invention is to E ₂Induce rat mammary gland cyclomastopathy model papilla diameter, serum E ₂Influence

^*# ##p＜0.05 p＜0.01 is compared in p＜0.01 with the normal control group, compare with model group.

By table 1-1 as seen, rat mammary gland hamartoplasia model has successfully been duplicated in this research.Papilla diameter enlarges markedly, serum estradiol content significantly improves, light microscopic undertissue pathology show as that the acinus volume increases, alveolar lumen expansion, acinus quantity increase, simultaneously can be with ductal ectasia, the secretions that more or less is arranged in the alveolar lumen of expansion and the conduit.Chinese medicine composition 13.05g crude drug/kg of the present invention can significantly reduce the content of serum estradiol, reduce papilla diameter, outgrowth mammary gland there is certain inhibitory action, outgrowth mammary gland acinus volume is reduced, quantity reduces, and the ductal ectasia degree is alleviated, and secreting phenomenon reduces (p＜0.05, p＜0.05, p＜0.05); 39.15g crude drug/kg also can significantly reduce the content of serum estradiol, reduce papilla diameter, suppress outgrowth mammary gland, effect is better than 13.05g crude drug/kg group, (p＜0.01, p＜0.01, p＜0.01), do not observe 4.35g crude drug/kg the hypertrophy situation of the content of serum estradiol, papilla diameter, mammary gland is had tangible influence (p＞0.05).

Table 1-2 Chinese medicine composition of the present invention is to E ₂The influence of inducing mouse cyclomastopathy model cyclomastopathy situation

By table 1-2 as seen, mice mammoplasia model has successfully been duplicated in this research, and the pathology performance of light microscopic undertissue has the secretions that more or less based on the expansion of conduit sample in the conduit of expansion.Chinese medicine composition 56.55g crude drug/kg of the present invention has certain inhibitory action (p＜0.05) to the outgrowth mammary gland of mice, outgrowth ductal ectasia degree is alleviated, secreting phenomenon reduces, 18.85g crude drug/kg group also has slight inhibitory action to outgrowth mammary gland, but no difference of science of statistics, not observing 6.28g crude drug/kg has tangible influence (p＞0.05) to the cyclomastopathy situation.

2. the analgesic activity of Chinese medicine composition of the present invention

2.1 experiment material

2.1.1 animal

Kunming mouse, Shandong University's Experimental Animal Center

2.1.2 medicine and reagent

Chinese medicine composition of the present invention (intermediate), Shandong Lunan Pharmaceutical Co., Ltd.

Glacial acetic acid, Shanghai reagent four factories

Pethidine, Qinghai Pharmaceutic Plant

2.1.3 instrument

Constant water bath box Beijing Medical Equipment Plant, the quality certification: 1987.3

2.2 experimental technique

Medicine is prepared same 1.2.1

2.2.1 hot plate method

Get 18～20g female mice number, each one is placed on 55 ± 0.5 ℃ of hot plates, and mice makes this Mus pain threshold from being placed on the hot plate to occurring licking metapedes required time (second).Lick the metapedes time less than 5 seconds or give it up greater than 30 seconds or leaper.50 of qualified mices are divided into 5 groups at random: normal saline, pethidine 0.013g/kg, Chinese medicine composition 6.28g crude drug/kg of the present invention, 18.85g crude drug/kg, 39.15g crude drug/kg, matched group is irritated stomach and is given normal saline, with volume variable concentrations gastric infusion.Behind the gastric infusion 30 minutes, survey its pain threshold behind the pethidine lumbar injection 10min, survey 30,60,90,120,180 minutes pain threshold respectively,, take out, calculated by 60 seconds if animal is reactionless in last 60 second from being placed on hot plate.By formula calculate the threshold of pain and improve percentage rate, the results are shown in Table 2-1, table 2-2.

2.2.2 writhing method

Get 50 of mices, male and female half and half, be divided into 5 groups at random, 10 every group: normal saline, pethidine 0.013g/kg, Chinese medicine composition 6.28g crude drug/kg of the present invention, 18.85g crude drug/kg, 39.15g crude drug/kg, matched group gives the normal saline of equal volume, behind the gastric infusion 30 minutes, behind the pethidine lumbar injection 10min, 0.2 milliliter in lumbar injection 0.6% glacial acetic acid/is only observed the number of times that writhing response appears in mice in 20 minutes, calculate the analgesia percentage rate, the results are shown in Table 2-3.

2.3 experimental result

Table 2-1 Chinese medicine composition of the present invention is to the influence (hot plate method) of mice pain threshold

^*, ^*Compare with the normal saline group p＜0.05 p＜0.01

Table 2-2 Chinese medicine composition of the present invention improves percentile influence (hot plate method) to the threshold of pain of mice

By table 2-1,2-2 as seen: the pain that Chinese medicine composition 6.28g crude drug/kg of the present invention caused hot plate at 60 minutes has tangible antagonism (p＜0.05), the pain that Chinese medicine composition 18.85g crude drug/kg of the present invention caused hot plate at 60,90,120 minutes has tangible antagonism (p＜0.05, p＜0.05, p＜0.05), the pain that Chinese medicine composition 56.55g crude drug/kg of the present invention caused hot plate at 60,90,120,180 minutes has significant antagonism (p＜0.01, p＜0.01, p＜0.05, p＜0.05).

Table 2-3 Chinese medicine composition of the present invention is to the analgesic activity (writhing method) of mice

^{* *}P＜0.05, compare with the normal saline group p＜0.01

By table 2-3 as seen: Chinese medicine composition 18.85g crude drug/kg of the present invention, 56.55g crude drug/kg, the pain that Dichlorodiphenyl Acetate causes has tangible antagonism (p＜0.05, p＜0.05), do not observe the pain that Chinese medicine composition 6.28g/kg Dichlorodiphenyl Acetate of the present invention causes significant analgesic activity (p＞0.05) is arranged.

3. the antiinflammatory action of Chinese medicine composition of the present invention

3.1 experiment material

3.1.1 medicine and reagent

Dimethylbenzene, Beijing Hongyueshun Chemical Factory

Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.

3.1.2 animal

Kunming mouse, Shandong University's Experimental Animal Center

The WISTAR rat, Shandong University's Experimental Animal Center

3.2 method

1.2.1 is seen in the medicine preparation

3.2.1 Chinese medicine composition xylol of the present invention causes the influence of Mice Auricle inflammatory swelling

Get 50 of the male mices of body weight 20 ± 2 gram, be divided into 5 groups at random: normal saline, prednisolone acetate 0.0078g/kg, Chinese medicine composition 6.28g of the present invention, 18.85g, 56.55g crude drug/kg, each organizes continuous gastric infusion three days, gastric infusion was after 30 minutes in the 4th day, dimethylbenzene is applied to two sides, ear front and back, a mice left side, every 0.1ml, put to death mice after 4 hours, punch in left and right sides auricle same area with the 9mm card punch, the both sides auricle is weighed respectively,, by formula calculates as the swelling level index with the swelling rate, difference between comparative drug group and matched group the results are shown in Table 4.

3.2.2 Chinese medicine composition of the present invention is to the bullate influence of rat granuloma

Get 50 of the male rats of body weight 200 ± 20 gram, make abdominal incision under ether light anaesthesia aseptic condition, with the cotton balls (50mg) of having weighed, oven dry back implantation rat both sides axillary region is subcutaneous in the baking oven of 50 degrees centigrade of autoclavings.Be divided into 5 groups at random: normal saline, hydrochloric acid prednisone 0.028g/kg, Chinese medicine composition of the present invention 4.35,13.05,39.15g crude drug/kg, each organizes continuous gastric infusion seven days, granulation tissue is peeled off and taken out in rat execution in the 8th day.In 60 degrees centigrade drying in oven, deduct the raw cotton ball weight, be the granuloma net weight.Respectively organize granuloma weight.And calculating suppression ratio.

2.3 experimental result:

Table 3-1. Chinese medicine composition xylol of the present invention causes the influence of mice ear

^*P＜0.05, ^{* *}Compare with the normal saline group p＜0.01.

By table 3-1 as seen: Chinese medicine composition 56.55 of the present invention, 18.85g crude drug/kg can significantly suppress proinflammatory effect (p＜0.05 of the auricle edema that dimethylbenzene causes, p＜0.05), do not observe the proinflammatory effect (p＞0.05) that Chinese medicine composition 6.28g crude drug/kg of the present invention has obvious suppression dimethylbenzene.

Table 3-2. Chinese medicine composition of the present invention is to the bullate influence of rat granuloma (X ± SD)

^{* *}P＜0.05, compare with the normal saline group p＜0.01.

By table 3-2 as seen: Chinese medicine composition 13.05g crude drug/kg of the present invention, 39.15g crude drug/kg can significantly suppress rat granuloma swollen (p＜0.05, p＜0.05), do not observe 4.35g crude drug/kg to the bullate inhibitory action of rat granuloma (p＞0.05).

Following embodiment all can realize above-mentioned experiment purpose, but need to prove that following embodiment only is an optimal way of the present invention, does not limit protection scope of the present invention.

Embodiment 1

Rhizoma Cyperi 10g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 90g, Cortex Moutan 150g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made granule.

Embodiment 2

Rhizoma Cyperi 80g, Cornu Cervi Degelatinatum 100g, Herba Epimedii 10g, Cortex Moutan 30g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made capsule.

Embodiment 3

Rhizoma Cyperi 30g, Cornu Cervi Degelatinatum 10g, Herba Epimedii 50g, Cortex Moutan 80g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, concentrates; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adds ethanol and makes and contain the alcohol amount 70%, left standstill 24 hours, filter, filtrate concentrates, and merges with above-mentioned alcohol extraction concentrated solution, add volatile oil clathrate compound, adding adjuvant technology is routinely made the oral liquid agent.

Embodiment 4

Rhizoma Cyperi 30g, Cornu Cervi Degelatinatum 80g, Herba Epimedii 60g, Cortex Moutan 50g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made Emulsion.

Embodiment 5

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 60g, Herba Epimedii 30g, Cortex Moutan 120g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made masticatory.

Embodiment 6

Rhizoma Cyperi 80g, Cornu Cervi Degelatinatum 30g, Herba Epimedii 80g, Cortex Moutan 80g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made tablet.

Embodiment 7

Rhizoma Cyperi 40g, Cornu Cervi Degelatinatum 70g, Herba Epimedii 70g, Cortex Moutan 80g

Above-mentioned four Chinese medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii adds 5 times of amount ethanol extraction secondaries, refluxes 2 hours at every turn, merges backflow, is concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made pill.

Embodiment 8

Rhizoma Cyperi 60g, Cornu Cervi Degelatinatum 40g, Herba Epimedii 40g, Cortex Moutan 60g

Embodiment 9

Rhizoma Cyperi 10g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 100g, Cortex Moutan 30g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 100g, Semen Vaccariae 10g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adds ethanol and makes and contain the alcohol amount 70%, left standstill 24 hours, filter, filtrate is condensed into extractum, merges with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound; Adding adjuvant technology is routinely made granule.

Embodiment 10

Rhizoma Cyperi 100g, Cornu Cervi Degelatinatum 10g, Herba Epimedii 50g, Cortex Moutan 150g, Radix Salviae Miltiorrhizae 30g, Semen Persicae 50g, Semen Vaccariae 100g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, add ethanol and make and contain alcohol amount, left standstill 24 hours, filter 70%, filtrate is condensed into extractum, merges with above-mentioned alcohol-extracted extract, is spray dried to fine powder, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made capsule.

Embodiment 11

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 100g, Herba Epimedii 10g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 150g, Semen Persicae 10g, Semen Vaccariae 50g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, concentrate; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adds ethanol and makes and contain the alcohol amount 70%, left standstill 24 hours, filter, filtrate concentrates, and merges with above-mentioned alcohol extraction concentrated solution, add volatile oil clathrate compound, adding adjuvant technology is routinely made oral liquid.

Embodiment 12

Rhizoma Cyperi 80g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 30g, Cortex Moutan 120g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 30g, Semen Vaccariae 80g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made Emulsion.

Embodiment 13

Rhizoma Cyperi 30g, Cornu Cervi Degelatinatum 80g, Herba Epimedii 50g, Cortex Moutan 50g, Radix Salviae Miltiorrhizae 120g, Semen Persicae 50g, Semen Vaccariae 30g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made masticatory.

Embodiment 14

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 30g, Herba Epimedii 80g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 80g, Semen Vaccariae 50g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made tablet.

Embodiment 15

Rhizoma Cyperi 40g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 70g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 110g, Semen Persicae 70g, Semen Vaccariae 50g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made pill.

Embodiment 16

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 70g, Herba Epimedii 40g, Cortex Moutan 60g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 40g, Semen Vaccariae 40g.

Above-mentioned seven flavor medicine, Rhizoma Cyperi add 8 times of water gagings, soak 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, and water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Semen Vaccariae three flavor medicines add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Cornu Cervi Degelatinatum and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made granule.

Embodiment 17

Rhizoma Cyperi 10g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 100g, Cortex Moutan 30g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 100g, Semen Vaccariae 10g, Semen Sinapis Albae 50g, Herba Taraxaci 120g, Fructus Crataegi 10g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made granule.

Embodiment 18

Rhizoma Cyperi 100g, Cornu Cervi Degelatinatum 10g, Herba Epimedii 50g, Cortex Moutan 150g, Radix Salviae Miltiorrhizae 30g, Semen Persicae 50g, Semen Vaccariae 100g, Semen Sinapis Albae 10g, Herba Taraxaci 70g, Fructus Crataegi 100g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made capsule.

Embodiment 19

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 100g, Herba Epimedii 10g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 150g, Semen Persicae 10g, Semen Vaccariae 50g, Semen Sinapis Albae 100g, Herba Taraxaci 20g, Fructus Crataegi 50g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, concentrate; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adds ethanol and makes and contain the alcohol amount 70%, left standstill 24 hours, filter, filtrate concentrates, and merges with above-mentioned alcohol extraction concentrated solution, add volatile oil clathrate compound, adding adjuvant technology is routinely made the oral liquid agent.

Embodiment 20

Rhizoma Cyperi 80g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 30g, Cortex Moutan 120g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 30g, Semen Vaccariae 80g, Semen Sinapis Albae 50g, Herba Taraxaci 40g, Fructus Crataegi 80g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made Emulsion.

Embodiment 21

Rhizoma Cyperi 30g, Cornu Cervi Degelatinatum 80g, Herba Epimedii 50g, Cortex Moutan 50g, Radix Salviae Miltiorrhizae 120g, Semen Persicae 50g, Semen Vaccariae 30g, Semen Sinapis Albae 80g, Herba Taraxaci 70g, Fructus Crataegi 30g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made masticatory.

Embodiment 22

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 30g, Herba Epimedii 80g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 80g, Semen Vaccariae 50g, Semen Sinapis Albae 30g, Herba Taraxaci 100g, Fructus Crataegi 50g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made tablet.

Embodiment 23

Rhizoma Cyperi 40g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 70g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 100g, Semen Persicae 50g, Semen Vaccariae 60g, Semen Sinapis Albae 40g, Herba Taraxaci 60g, Fructus Crataegi 60g.

Above-mentioned ten flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks 2 hours, and water vapour distillation 6 hours is collected volatile oil, and Cortex Moutan adds 6 times of water gagings, soaked 1.5 hours, water vapour distillation 6 hours, collection volatile oil, adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum four Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made pill.

Embodiment 24

Rhizoma Cyperi 40g, Cornu Cervi Degelatinatum 40g, Herba Epimedii 50g, Cortex Moutan 40g, Radix Salviae Miltiorrhizae 60g, Semen Persicae 40g, Semen Vaccariae 60g, Semen Sinapis Albae 50g, Herba Taraxaci 80g, Fructus Crataegi 40g.

Embodiment 25

Rhizoma Cyperi 10g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 100g, Cortex Moutan 30g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 100g, Semen Vaccariae 10g, Semen Sinapis Albae 50g, Herba Taraxaci 120g, Fructus Crataegi 10g, Radix Cynanchi Paniculati 50g, Sargassum 100g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made granule.

Embodiment 26

Rhizoma Cyperi 100g, Cornu Cervi Degelatinatum 10g, Herba Epimedii 50g, Cortex Moutan 150g, Radix Salviae Miltiorrhizae 30g, Semen Persicae 50g, Semen Vaccariae 100g, Semen Sinapis Albae 10g, Herba Taraxaci 70g, Fructus Crataegi 100g, Radix Cynanchi Paniculati 10g, Sargassum 50g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made capsule.

Embodiment 27

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 100g, Herba Epimedii 10g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 150g, Semen Persicae 10g, Semen Vaccariae 50g, Semen Sinapis Albae 100g, Herba Taraxaci 20g, Fructus Crataegi 50g, Radix Cynanchi Paniculati 100g, Sargassum 10g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, concentrate; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adds ethanol and makes and contain the alcohol amount 70%, left standstill 24 hours, filter, filtrate concentrates, and merges with above-mentioned alcohol extraction concentrated solution, add volatile oil clathrate compound, adding adjuvant technology is routinely made oral liquid.

Embodiment 28

Rhizoma Cyperi 80g, Cornu Cervi Degelatinatum 50g, Herba Epimedii 30g, Cortex Moutan 120g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 30g, Semen Vaccariae 80g, Semen Sinapis Albae 50g, Herba Taraxaci 40g, Fructus Crataegi 80g, Radix Cynanchi Paniculati 50g, Sargassum 30g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made Emulsion.

Embodiment 29

Rhizoma Cyperi 30g, Cornu Cervi Degelatinatum 80g, Herba Epimedii 50g, Cortex Moutan 50g, Radix Salviae Miltiorrhizae 120g, Semen Persicae 50g, Semen Vaccariae 30g, Semen Sinapis Albae 80g, Herba Taraxaci 70g, Fructus Crataegi 30g, Radix Cynanchi Paniculati 80g, Sargassum 50g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made masticatory.

Embodiment 30

Rhizoma Cyperi 50g, Cornu Cervi Degelatinatum 30g, Herba Epimedii 80g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 80g, Semen Vaccariae 50g, Semen Sinapis Albae 30g, Herba Taraxaci 100g, Fructus Crataegi 50g, Radix Cynanchi Paniculati 30g, Sargassum 80g.

Go up above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made tablet.

Embodiment 31

Rhizoma Cyperi 40g, Herba Epimedii 70g, Cornu Cervi Degelatinatum 50g, Cortex Moutan 80g, Radix Salviae Miltiorrhizae 100g, Semen Persicae 50g, Semen Vaccariae 60g, Semen Sinapis Albae 40g, Herba Taraxaci 60g, Fructus Crataegi 60g, Radix Cynanchi Paniculati 60g, Sargassum 30g.

Above-mentioned 12 flavor medicines, Rhizoma Cyperi adds 8 times of water gagings, soaks water vapour distillation 6 hours 2 hours, collect volatile oil, Cortex Moutan, Radix Cynanchi Paniculati two flavor medicines add 6 times of water gagings, soak 1.5 hours, water vapour distillation 6 hours is collected volatile oil, and adding beta-schardinger dextrin-, to make clathrate standby; Medicinal residues after the distillation and debris device are in addition deposited.Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Vaccariae four Chinese medicine add 5 times of amount ethanol extraction secondaries, reflux 2 hours at every turn, merge backflow, are concentrated into into extractum; Medicinal residues and alcohol extraction medicinal residues merge behind Herba Taraxaci, Semen Sinapis Albae, Semen Persicae, Cornu Cervi Degelatinatum, Sargassum five kinds of Chinese medicine and the extraction volatile oil, add 8 times of water gagings and decoct twice, each 2 hours, merge decoction liquor and extract the volatile oil debris, filter, filtrate is condensed into extractum, adding ethanol makes and contains alcohol amount 70%, left standstill 24 hours, and filtered, filtrate is condensed into extractum, merge with above-mentioned alcohol-extracted extract, be spray dried to fine powder, add volatile oil clathrate compound, adding adjuvant technology is routinely made pill.

Embodiment 32

Rhizoma Cyperi 40g, Herba Epimedii 50g, Cornu Cervi Degelatinatum 40g, Cortex Moutan 40g, Radix Salviae Miltiorrhizae 60g, Semen Persicae 40g, Semen Vaccariae 60g, Semen Sinapis Albae 50g, Herba Taraxaci 80g, Fructus Crataegi 40g, Radix Cynanchi Paniculati 50g, Sargassum 40g.

Claims

1. Chinese medicine composition for the treatment of cyclomastopathy is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion.

2. Chinese medicine composition as claimed in claim 1 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion.

3. Chinese medicine composition as claimed in claim 2 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 70 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions.

4. Chinese medicine composition as claimed in claim 2 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 60 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Herba Epimedii 40 weight portions, Cortex Moutan 60 weight portions.

5. Chinese medicine composition as claimed in claim 1 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion.

6. Chinese medicine composition as claimed in claim 5 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion.

7. Chinese medicine composition as claimed in claim 6 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 110 weight portions, Semen Persicae 70 weight portions, Semen Vaccariae 50 weight portions.

8. Chinese medicine composition as claimed in claim 6 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 50 weight portions, Cornu Cervi Degelatinatum 70 weight portions, Herba Epimedii 40 weight portions, Cortex Moutan 60 weight portions, Radix Salviae Miltiorrhizae 50 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 40 weight portions.

9. Chinese medicine composition as claimed in claim 5 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion, Semen Sinapis Albae 10-100 weight portion, Herba Taraxaci 20-120 weight portion, Fructus Crataegi 10-100 weight portion.

10. Chinese medicine composition as claimed in claim 9 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion, Semen Sinapis Albae 30-80 weight portion, Herba Taraxaci 40-100 weight portion, Fructus Crataegi 30-80 weight portion.

11. Chinese medicine composition as claimed in claim 10 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Herba Epimedii 70 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 100 weight portions, Semen Persicae 50 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 40 weight portions, Herba Taraxaci 60 weight portions, Fructus Crataegi 60 weight portions.

12. Chinese medicine composition as claimed in claim 10 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Herba Epimedii 50 weight portions, Cortex Moutan 40 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 50 weight portions, Herba Taraxaci 80 weight portions, Fructus Crataegi 40 weight portions.

13. Chinese medicine composition as claimed in claim 9 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 10-100 weight portion, Herba Epimedii 10-100 weight portion, Cornu Cervi Degelatinatum 10-100 weight portion, Cortex Moutan 30-150 weight portion, Radix Salviae Miltiorrhizae 30-150 weight portion, Semen Persicae 10-100 weight portion, Semen Vaccariae 10-100 weight portion, Semen Sinapis Albae 10-100 weight portion, Herba Taraxaci 20-120 weight portion, Fructus Crataegi 10-100 weight portion, Radix Cynanchi Paniculati 10-100 weight portion, Sargassum 10-100 weight portion.

14. Chinese medicine composition as claimed in claim 13 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 30-80 weight portion, Herba Epimedii 30-80 weight portion, Cornu Cervi Degelatinatum 30-80 weight portion, Cortex Moutan 50-120 weight portion, Radix Salviae Miltiorrhizae 50-120 weight portion, Semen Persicae 30-80 weight portion, Semen Vaccariae 30-80 weight portion, Semen Sinapis Albae 30-80 weight portion, Herba Taraxaci 40-100 weight portion, Fructus Crataegi 30-80 weight portion, Radix Cynanchi Paniculati 30-80 weight portion, Sargassum 30-80 weight portion.

15. Chinese medicine composition as claimed in claim 14 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Herba Epimedii 70 weight portions, Cornu Cervi Degelatinatum 50 weight portions, Cortex Moutan 80 weight portions, Radix Salviae Miltiorrhizae 100 weight portions, Semen Persicae 50 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 40 weight portions, Herba Taraxaci 60 weight portions, Fructus Crataegi 60 weight portions, Radix Cynanchi Paniculati 60 weight portions, Sargassum 30 weight portions.

16. Chinese medicine composition as claimed in claim 14 is characterized in that it is made by following bulk drugs: Rhizoma Cyperi 40 weight portions, Herba Epimedii 50 weight portions, Cornu Cervi Degelatinatum 40 weight portions, Cortex Moutan 40 weight portions, Radix Salviae Miltiorrhizae 60 weight portions, Semen Persicae 40 weight portions, Semen Vaccariae 60 weight portions, Semen Sinapis Albae 50 weight portions, Herba Taraxaci 80 weight portions, Fructus Crataegi 40 weight portions, Radix Cynanchi Paniculati 50 weight portions, Sargassum 40 weight portions.

17. as the described Chinese medicine composition of arbitrary claim among the claim 1-16, the dosage form that it is characterized by this Chinese medicine composition is: oral liquid, granule, capsule, Emulsion, masticatory, tablet or pill any.

18. Chinese medicine composition as claimed in claim 17, the dosage form that it is characterized by this Chinese medicine composition is a granule.