CN100381121C - New use of linolenic acid in preparation of anti arthrolithiasis medicine or health care food - Google Patents
New use of linolenic acid in preparation of anti arthrolithiasis medicine or health care food Download PDFInfo
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- CN100381121C CN100381121C CNB2005100206490A CN200510020649A CN100381121C CN 100381121 C CN100381121 C CN 100381121C CN B2005100206490 A CNB2005100206490 A CN B2005100206490A CN 200510020649 A CN200510020649 A CN 200510020649A CN 100381121 C CN100381121 C CN 100381121C
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Abstract
The present invention discloses new purposes of linolenic acid in preparing antigout drugs or in health foods and also discloses an antigout drug or a health food prepared from the linolenic acid as a raw material. The antigout drug or the health food comprises effective dosage of linolenic acid and various carriers adacceptable in medicines and foods; a certain amount of vitamin E as an oxidation inhibitor can also be added in a formula; the proportioning dosage of the linolenic acid and the vitamin E can be the compounding of the effective dosage of linolenic acid and the vitamin E usable medically, but the proportioning dosage of the linolenic acid and the vitamin E is preferably 90 to 99.5% of linolenic acid and 0.5 to 10% of vitamin E. the antigout drug or the health food of the present invention has the advantages of simple preparation process, low cost, notable antigout effect, short course of treatment, difficult recurrence and extremely convenience for people to take without toxic and side effect.
Description
(1) technical field:
The present invention relates to linolenic new purposes, particularly linolenic acid in the medicine of preparation gout or the new purposes in the health food; The invention still further relates to the linolenic acid medicine or the health food of the gout that is Main Ingredients and Appearance.
(2) background technology:
Gout is the disease that purine metabolic disturbance causes, it is too much to show as in the blood uric acid, cause urate deposition in the joint, kidney and connective tissue, cause joint deformity, nephropathy and concurrent renal calculus.The acute attack of gout is to cause the pain that granulocyte local infiltration and inflammatory reaction are followed owing to be deposited on the urate crystal in joint.The medicine of doctor trained in Western medicine gout can be divided into: suppress the uricopoiesis medicine, as allopurinol; Promote the urate excretion medicine, as probenecid, sulfinpyrazone, benzbromarone; Treatment acute gout medicine is as colchicine and some anti-inflammatory analgesic such as indomethacin, Phenylbutazone and naproxen etc.But the said medicine toxic and side effects is big, causes side effect such as allergy, bone marrow depression as allopurinol; Probenecid can cause gastrointestinal disturbance, renal colic and bring out the gout acute attack; The toxicity of colchicine is very big, can cause nausea,vomiting,diarrhea, occurs pharyngeal causalgia, bloody diarrhea, hematuria, shock during acute poisoning, can suppress hemopoietic function of bone marrow, and long-time medication can cause granulocyte and thrombocytopenia, aplastic anemia.Because above-mentioned drug side effect is very big, the patient often can not adhere to taking for a long time, makes gout be difficult to radical cure.The traditional Chinese medical science thinks that then gout belongs to categories such as arthromyodynia, gout, severe and migratory arthralgia, be exopathogen retardance meridians, coagulation of QI-blood, the pain of joint muscle numbness that Liver and kidney two void cause, weighing, the disease of joint stuffiness, chronic patient has that joint deformity is stiff more, tophus, nephropathy etc.Chinese medical discrimination can be divided into the hot and suffocating card of rheumatism, blockage of phlegm and blood stasis card, the positive deficiency syndrome of lingering arthralgia again, and clinical treatment often adopts sides such as clearing heat and expelling damp, disperse blood stasis and dredge collateral, supplementing QI and nourishing YIN.For example the Chinese medicine of clearing away heat-damp and promoting diuresis comprises Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Rhizoma Alismatis, Herba Artemisiae Annuae, Herba Hedyotidis Diffusae etc., and the Chinese medicine of blood circulation promoting and blood stasis dispelling comprises Herba sambuci chinensis, Caulis Spatholobi, Semen Persicae, Flos Carthami etc.Because the treatment by Chinese herbs gout is all based on compound recipe, the side effect of various degrees, its curative effect is not remarkable, takes inconvenient yet.Therefore, all difficult therapeutic effect that makes patient satisfaction that reaches of the anti-gout drugs of the existing doctor trained in Western medicine and the traditional Chinese medical science.
Linolenic acid claims alpha-linolenic acid again, and its structural formula is:
CH
3CH
2CH＝CHCH
2CH＝CHCH
2CH＝CH(CH
2)
7COOH
Linolenic acid is the fatty acid of needed by human, be that N-3 is the parent that fatty acid is closed in insatiable hunger in the formation human body, but metabolism produces multiple important active substances such as DHA, EPA in human body.Modern science research thinks that linolenic acid is to maintain the core substance that human brain is evolved, and its final metabolite EPA and DHA are the important component of forming neuron membrane.Modern medicine and threpsology also confirm: alpha-linolenic acid not only has effects such as the central nervous system of adjusting, improving memory, nootropics and visual function, also have the sleep of improvement, control cardiovascular and cerebrovascular disease, improve blood vessel elasticity, two-ways regulation blood pressure, blood fat, cholesterol, prevention myocardial infarction and cerebral embolism, reach the promotion insulin secretion, prolong hypoglycemic effect, suppress physiological functions such as complication.In a single day human body lacks alpha-linolenic acid promptly can cause the body metabolism disorder of blood lipid, causes hyperlipidemia, high blood viscosity, atherosclerosis; Also can cause immunity reduction, forgetful, tired, visual deterioration; If especially infant, teenager lack the normal development that will have a strong impact on its intelligence and vision.Therefore, alpha-linolenic acid is preparation prevention and treatment hyperlipidemia, high blood viscosity, coronary heart disease, diabetes, fatty liver, senile dementia and improves the medicine of brain effect or the important source material of health food.For example application number is: 00109537.4, name is called: the Chinese invention patent of " a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease ", disclose a kind of medicine of preventing and treating cardiovascular and cerebrovascular disease, it is to be the capsule made of raw material and the compositions of soft capsule with the total Saponin powder of Herba Gynostemmatis, nucleic acid powder, soybean lecithin powder, tea polyphenols, Eriocheir sinensis powder, linolenic acid, fish oil, Oleum sesami; This medicine has better curative effect to cardiovascular and cerebrovascular disease such as treatment hyperlipidemia, atherosclerosis, hypertension, coronary heart disease, myocardial infarction, cerebral infarction.But not finding as yet so far linolenic acid is applied to gout or occurs with the linolenic acid is the anti-gout drugs or the health food of feedstock production.
(3) summary of the invention:
The present invention will disclose linolenic new purposes, promptly in the medicine of preparation gout or the new purposes in the health food.The applicant finds with the linolenic acid to be that the medicine or the health food of feedstock production can play the gout effect, for constitutional and secondary hyperuricemia, and the hyperuricemia that too much causes of uricopoiesis especially; Take place repeatedly or chronic gout; Tophus; Uric acid renal calculus and/or urate nephropathy; The hyperuricemia that renal insufficiency is arranged; The acute attack of the acute attack of gouty arthritis and prevention of recurrence gouty arthritis all can be played excellent prevention or therapeutic effect.
The present invention is directed to the doctor trained in Western medicine and the traditional Chinese medical science deficiency aspect gout, disclosing a kind of is the medicine or the health food of the gout of feedstock production with the linolenic acid, and this medicine or health food comprise acceptable carrier on the linolenic acid of effective dose and various medicine and the food; Certainly can also in prescription, add a certain amount of antioxidant vitamin E; The proportional quantity of linolenic acid and vitamin E can be the linolenic acid of effective dose be equipped with medically can use amount vitamin E, but the proportioning between them is preferably by weight percentage: linolenic acid 90～99.5%; Vitamin E 0.5～10%; Wherein said linolenic acid can certainly be selected other the higher material of linolenic acid content for containing linolenic oils and fats or free fatty or ethyl linolenate; And containing in the linolenic material of selecting for use, linolenic content should be 10～99%, and its preferred content is 60～80%; Preferably then be 70%.
According to above-mentioned prescription, can be directly with each component fill soft capsule; Or be processed into microscapsule powder, further be processed into tablet or fill hard capsule, or make other medicine or food on acceptable forms.Made contain linolenic anti-gout drugs or health food should be oral, one after each meal, adult's usual amounts contains 1～2 linolenic medicine of gram or health food, 2 times on the one for take at every turn.
The applicant has found and linolenic acid can be applied to gout, and to have developed be the medicine or the health food of the gout of feedstock production with the linolenic acid, this production technology is simple, with low cost, the gout effect is remarkable, and short treating period is difficult for recurrence, and without any side effects, take also very convenient.
(4) specific embodiment:
Embodiment one:
Get ethyl linolenate (linolenic acid content 70%) 99.5 grams, vitamin E 0.5 gram uniform mixing, the fill soft capsule promptly obtains the gout capsule.
Embodiment two:
It is fully emulsified to get Oleum Perillae (linolenic acid content 55%) 50 gram, carboxylated dextrin 150 grams, water 300 grams, spends spray dryinges in inlet temperature 90 degree and outlet temperature 40, makes Powdered Oleum Perillae microcapsule.This product can be used for producing health foods such as cookies, bread, dessert, ice cream, soup stock, sauce, milk product; Also direct fill hard capsule obtains the gout capsule.
Embodiment three:
Get Semen Lini oil (linolenic acid content 40%) 90 gram, vitamin E 10 grams, prepare Powdered microcapsule, can be used for producing various health foods according to the method for embodiment two; Or direct fill hard capsule, obtain the gout capsule.
Test example one:
Mr. Zheng, the man in year surplus in the of 50, suffers from gout for many years, toe joint, finger and elbow joint pain, it is weak to feel tired, adhere to taking every day contain 1 the gram linolenic embodiment one described gout capsule, took in 1st 2 times, take one week of this capsule back gout transference cure, feel energetic, exceed half a year so far and do not recur.
Test example two:
Mr. Wang, the man, 40 years old, suffer from gout for many years, toe joint has an intense pain down to difficulty in walking, adheres to taking every day containing the linolenic embodiment one described gout capsule of 2 grams, took 2 times in 1st, transference cure after the week, three wheat harvesting periods do not recur so far.
Test example three:
Mr. Huang, the man, in year surplus in the of 40, the trouble gout is pointed and elbow joint pain for many years, adheres to taking every day containing the linolenic embodiment one described gout capsule of 1.5 grams, took 2 times in 1st, two all backs transference cures, four wheat harvesting periods do not recur so far.
Claims (1)
1. alpha-linolenic acid is in the medicine of preparation gout or the new purposes in the health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100206490A CN100381121C (en) | 2005-03-30 | 2005-03-30 | New use of linolenic acid in preparation of anti arthrolithiasis medicine or health care food |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100206490A CN100381121C (en) | 2005-03-30 | 2005-03-30 | New use of linolenic acid in preparation of anti arthrolithiasis medicine or health care food |
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| Publication Number | Publication Date |
|---|---|
| CN1686101A CN1686101A (en) | 2005-10-26 |
| CN100381121C true CN100381121C (en) | 2008-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100206490A Expired - Fee Related CN100381121C (en) | 2005-03-30 | 2005-03-30 | New use of linolenic acid in preparation of anti arthrolithiasis medicine or health care food |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113812614A (en) * | 2021-03-04 | 2021-12-21 | 孙晓辉 | Uric acid resistant functional food |
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2005
- 2005-03-30 CN CNB2005100206490A patent/CN100381121C/en not_active Expired - Fee Related
Non-Patent Citations (5)
| Title |
|---|
| Suppression of acute and chronic inflammation by dietarygamma linolenic acid. Tate,-G ET AL.J-Rheumatol.,Vol.16 No.6. 1989 * |
| Suppression of monosodium urate crystal-inducedacuteinflammation by diets enriched with gamma-linolenic acidandeicosapentaenoic acid. Tate,-G-A 等.Arthritis-Rheum. ,Vol.31 No.12. 1988 * |
| Suppression of monosodium urate crystal-inducedinflammation by black currant seed oil. Tate,-G-A 等.Agents-Actions.,Vol.43 No.1-2. 1994 * |
| 亚麻籽油降脂作用的实验研究. 黄庆德等.营养卫生，第25卷第3期. 2004 * |
| 桑蚕蛹油对大鼠血脂水平及血小板功能的影响. 杨雪锋等.卫生研究，第31卷第4期. 2002 * |
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| CN1686101A (en) | 2005-10-26 |
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Granted publication date: 20080416 |