CN100372553C - Tranquilizing and blood nourishing oral liquid - Google Patents

Abstract

The present invention provides tranquilizing and blood nourishing oral liquid, which is prepared from seven kinds of traditional Chinese medicine, such as fleece-flower root prepared from raw materials of traditional Chinese medicine, spatholobus stem, caulis polygoni multiflori, pine needle, uncaria, rehmannia root, stephania sinica, etc. After the raw materials are decocted, a small amount of preservative, corrigent and water are used for preparing the oral liquid. The present invention has the efficiency of nourishing blood and tranquilization, clearing heat and relieving fidgetiness, can be used for treating symptoms, such as insomnia caused by deficiency of liver blood, amnesia, etc.; the present invention has the advantages of obvious effect, convenient medicine taking, comfort mouth feel, safe clinical use, no adverse reaction and no toxic side effect.

Description

Tranquilizing and blood nourishing oral liquid

Technical field

The present invention relates to a kind of Chinese medicine preparation, especially a kind of tranquilizing and blood nourishing oral liquid.

Background technology

Disharmony between the liver and spleen, deficiency of liver-blood often causes insomnia, disease such as forgetful, clinical treatment stable and barbiturate commonly used, such medicine all is a chemicals, though therapeutical effect is arranged, side effect is too big, dry mouth and tougue appears in majority after patient's medication, gastrointestinal reaction is classified taboo as to liver, kidney, cardio-cerebral diseases, hypertension, glaucoma, and can cause dependency, the addiction of medicine.

Summary of the invention

The purpose of this invention is to provide the preparation of the pure Chinese medicine of a kind of employing, have the nourishing blood to tranquillize the mind effect, the insomnia that is caused by deficiency of liver-blood in treatment, disease such as forgetful have obvious effect, no dependence, the tranquilizing and blood nourishing oral liquid that has no side effect.

The selected Chinese prescription of the present invention is (in a weight portion):

75 parts of 100 parts of Caulis Polygoni Multiflori of 116.7 portions of Caulis Spatholobis of Radix Polygoni Multiflori Preparata

25 parts of 150 portions of Radix Rehmanniae of 54.3 parts of Ramulus Uncariae Cum Uncis of Folium Pini

25 parts of Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae)

Manufacturing technique method:

Take by weighing above-mentioned seven flavor Chinese crude drugs (by producing the 1000ml oral liquid, middle dose is g), decoct with water secondary, add 6 times of amounts of water for the first time, decocted 2 hours, for the second time add 4 times of amounts of water, decocted collecting decoction 1.5 hours, filter, it is 1.03～1.06 (60 ℃) that filtrate is concentrated into relative density, filters filtrate for later use; Other gets correctives such as protein sugar 4g, is dissolved in water, and adds in the above-mentioned solution; Add preservative sodium benzoate 2g, ethyl hydroxybenzoate a small amount of (dissolving with small amount of ethanol), mixing adds water and adjusts total amount to 1000ml, shakes up, and fill is through being up to the standards promptly.

Pharmacological effect: tranquilizing and blood nourishing.

Purposes: be used for insomnia that deficiency of liver-blood causes, disease such as forgetful.

Effective dose and using method: oral, a 30ml, a twice-daily.

Clinical drug of the present invention uses the result to show to have following advantage:

The present invention is the pure Chinese medicinal preparation according to traditional Chinese medical theory and experience development, effect with nourishing blood to tranquillize the mind, clearing heat and relieving fidgetness, be used for the treatment of that the insomnia that deficiency of liver-blood causes is insomnia, disease such as forgetful, effect is remarkable, taking convenience, comfortable taste, clinical safe in utilization, have no adverse reaction and toxic and side effects.

For show medicine of the present invention to the insomnia that is used for the treatment of deficiency of liver-blood and causes be insomnia, the therapeutic effect of disease such as forgetful, the present invention selects inpatient's 54 examples and training door exanthema people 68 examples, wherein male 52 examples, woman's 70 examples, 18～65 years old age, the course of disease is more than 1 month, and totally 122 examples are through system's clinical observation, and selects medical history, the state of an illness, age, sex and the suitable insomnia of former Therapeutic Method is insomnia, amesiac's 60 examples are matched group.Test group: use medicine of the present invention; Matched group: use TIANTIANLE KOUFUYE.Before experimental period the experimenter was made detailed physical examination, meet case choice criteria person and promptly include the object of observation in.The situation of taking medicine was inquired with examining 1 time, the record state of an illness and side effect in per 5 days in the test back.Viewing duration is without other similar medicines.15 days observation periods, 5 days is a course of treatment, totally 3 courses of treatment.

Instructions of taking: the treatment group is taken the each 30ml of medicine of the present invention, every day 2 times; Matched group is taken the each 10ml of TIANTIANLE KOUFUYE, every day 3 times.Clinical test results such as table 1, table 2.

Compare before and after table 1, the treatment of witness integration (X ± SD)

	The treatment group			Matched group
							n	Before the treatment	After the treatment	n	Before the treatment	After the treatment
	Dizziness and blurred vision	115	3.61±0.74	1.18±1.41	56	4.27±0.87							1.90±0.74
Two dryness and uneasy feeling of the eye							91	2.71±0.61	0.63±0.68	43	2.75±0.68	1.07±0.81
	The fidgets due to deficiency insomnia	122	4.88±0.68	1.70±0.71	60	5.05±0.70							2.50±1.00
Numb limbs and tense tendons							60	2.71±0.63	1.54±0.63	22	3.29±0.81	1.80±1.40
	Dysphoria with feverish sensation in the chest palms and soles	98	3.21±0.59	0.70±0.62	49	3.36±0.65							0.70±0.78
Dryness of the mouth and throat							111	3.10±0.64	0.65±0.68	58	3.18±0.72	1.18±0.74
	Hectic fever night sweat	42	2.98±0.69	0.56±0.59	20	2.61±0.44							0.60±0.54

Annotate: relatively, the P value all＜0.01 before and after the treatment

Table 1 data show, medicine of the present invention to the insomnia that deficiency of liver-blood causes be insomnia, forgetful etc. improving significantly, witness integrations such as treatment fidgets due to deficiency insomnia, dizziness and blurred vision, two dryness and uneasy feeling of the eye, numb limbs and tense tendons, dysphoria with feverish sensation in the chest palms and soles, dryness of the mouth and throat, the hectic fever night sweat equal highly significant (P＜0.01) that descends proves that medicine of the present invention has the effect of nourishing blood to tranquillize the mind, clearing heat and relieving fidgetness.

Table 2, treatment group and matched group curative effect be (Ridid analysis) relatively

	n	Cure	Produce effects	Effectively	Invalid	R	U	P
									The treatment group	122	14	57	40	11	0.5216	1.4368	>0.05
Matched group	60	4	34	35	7	0.4567

Test statistics shows: with medicine of the present invention to the insomnia that 122 routine deficiency of liver-blood cause be insomnia, disease patient such as forgetful does therapeutic test, that obtains significant curative effect accounts for 58%, substantially effectively accounts for 33%, invalid accounts for 9%, total effective rate reaches 91%.

The specific embodiment

Production instance: get Radix Polygoni Multiflori Preparata 84kg (through the Radix Polygoni Multiflori of concocting, pharmacy is on sale), Caulis Spatholobi 72kg, Caulis Polygoni Multiflori 54kg, Folium Pini 39kg, Ramulus Uncariae Cum Uncis 72kg, Radix Rehmanniae 18kg, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 18kg decocts with water secondary, adds water 2140kg for the first time, decocts 2 hours; For the second time add water 1430kg, decocted 1.5 hours, collecting decoction filters, and filtrate is concentrated into relative density 1.03～1.06 (60 ℃), filters filtrate for later use; Other gets protein sugar 2.88kg, is dissolved in water, and adds in the above-mentioned solution, adds sodium benzoate 1.44kg, ethyl hydroxybenzoate a small amount of (dissolving with small amount of ethanol) again, mixing adds water and adjusts total amount to 720000ml, shakes up, fill, outer package promptly gets product through being up to the standards.

Model case:

1. thank certain, the woman, 60 years old, showed effect repeatedly 4 years because of having a sleepless night easily to wake up, recurrence increases the weight of to go to a doctor after 1 month.Card is seen: fidgets due to deficiency is insomnia, and easily wakes up, only fell asleep 2～3 hours every night, and with dizziness and blurred vision, two dryness and uneasy feeling of the eye, numb limbs and tense tendons, dryness of the mouth and throat, body of the tongue is dim red, stringy and thready pulse.Tcm diagnosis: be insomnia (liver-yin deficient syndrome).Western medicine diagnose: neurasthenia.Give the tranquilizing and blood nourishing oral liquid treatment, each 30ml, respectively obey 1 time every day sooner or later.Medication can be slept 3 hours after 5 days every night; Can sleep 4～5 hours other sxs after 10 days every night; After the medication to 15 day, can sleep every night 6～7 hours, feel other transference cures, hale and hearty.Efficacy evaluation: clinical recovery.

2. Chen, the man, 48 years old, because of insomnia, two dryness and uneasy feeling of the eye go to a doctor over the past half year.Card is seen: night difficulty falling asleep, easily wake up in the back of sleeping, difficult more sleeping after waking up, daytime lethargic and drowsy state, listlessness; With dizziness and blurred vision, two dryness and uneasy feeling of the eye, numb limbs and tense tendons, dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, hectic fever night sweat; Red tongue with a little fluid, tongue is few, wiry and frequent pulse.Tcm diagnosis: be insomnia (syndrome of deficiency of liver yin).Western medicine diagnose: neurasthenia.Give the tranquilizing and blood nourishing oral liquid treatment, each 30ml, respectively obey 1 time every day sooner or later.Medication is dysphoria with feverish sensation in the chest palms and soles, fiery dry dry pharynx disappearance after 5 days, and insomnia improves; After continuing medication to 15 day, insomnia disappears, and spirit is clearly better, and all the other each diseases disappear.Efficacy evaluation: clinical recovery.

Claims (2)

1. tranquilizing and blood nourishing oral liquid, the crude drug that it is characterized in that making the medicine active ingredient are formed:

75 parts of 100 parts of Caulis Polygoni Multiflori of 116.7 portions of Caulis Spatholobis of Radix Polygoni Multiflori Preparata

25 parts of 150 portions of Radix Rehmanniae of 54.3 parts of Ramulus Uncariae Cum Uncis of Folium Pini

25 parts of Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae).

2. tranquilizing and blood nourishing oral liquid according to claim 1 is characterized in that: be aided with a small amount of antiseptic, correctives and water again after above raw material is decocted and make oral liquid.