CN105194066A - Medicament for preventing and treating senile dementia - Google Patents

Abstract

The invention discloses a medicament for preventing and treating senile dementia. Components of the medicament comprise prepared fleeceflower root, caulis spatholobi, caulis polygoni multiflori, matsuba, uncaria tomentosa, rehmannia glutinosa and stephania sinica diels. The medicament has a remarkable therapeutic effect on senile dementia.

Description

A kind of medicine of prevention and therapy alzheimer disease

Technical field

The present invention relates to medical art, be specifically related to a kind of novelty teabag of compound preparation.

Background technology

Senile dementia is the nervous system degenerative disease of the Progressive symmetric erythrokeratodermia development of a kind of onset concealment.Show as feature with dysmnesia, aphasia, apraxia, agnosia, the infringement of visual space technical ability, n-back test obstacle and the generalized dementia such as personality and behavior change clinically, the cause of disease is not bright so far.General Symptoms last progress, the course of disease is 5-10 normally, therefore answers and early treatment.But the treatment of its early memory obstacle is clinical comparatively stubborn problem, current drug application is based on cholinergic preparation and non-cholinergic preparation, wherein cholinesterase inhibitor uses more with donepezil, Exelon abroad, what domestic application was more is huperzine A, but its treatment use excessive cycle, somewhat expensive, many side effect make its clinical practice produce little effect, particularly to the severe dementia found not in time.

The patent CN200510019447.4 tranquilizing and blood nourishing oral liquid in our unit early stage, because of the insomnia that it causes at deficiency of liver-blood, forgetful aspect has significant curative effect and is subject to patient and uses widely.Carrying out it in degree of depth R&D process, finding, used as treatment senile dementia field, have outstanding effect.

Summary of the invention

The present invention discloses a kind of medicine being used for the treatment of senile dementia, has following technical scheme to realize:

Treat a medicine for senile dementia, be made up of the Chinese prescription of following parts by weight:

Radix Polygoni Multiflori Preparata 116.7 parts, Caulis Spatholobi 100 parts, Caulis Polygoni Multiflori 75 parts, Folium Pini 54.3 parts, Ramulus Uncariae Cum Uncis 150 parts, Radix Rehmanniae 25 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25 parts, is characterized in that the application of this medicine in treatment senile dementia.

Manufacturing technique method is identical with patent CN200510019447.4 tranquilizing and blood nourishing oral liquid:

Take above-mentioned seven flavor medicine material (by production 1000ml oral liquid, middle dose is g), decocts with water secondary, and add water 6 times amount for the first time, decoct 2 hours, add water 4 times amount for the second time, decocts 1.5 hours, collecting decoction, filter, it is 1.03 ~ 1.06(60 DEG C that filtrate is concentrated into relative density), filter, filtrate is for subsequent use; Separately get correctives as protein sugar 4g, be dissolved in water, add in above-mentioned solution; Add preservative sodium benzoate 2g, ethyl hydroxybenzoate a small amount of (using a small amount of dissolve with ethanol), mixing, the adjustment total amount that adds water, to 1000ml, shakes up, fill, through being up to the standards and get final product.

Effective dose and using method: oral, a 30ml, 2 times on the one.

Through test, the present invention proves that it has good curative effect to patients with Alzheimer disease, be not " the kidney invigorating gas " in general sense, and stress to fill out marrow effect, and include consciousness-restoring and orifice-opening effects such as invigorating blood circulation, reduce phlegm, the reasonable application of this medicine has been hited, and the brain of alzheimer disease morbidity is hollow, the key pathological link of expectorant stasis blocking key, likely block the pathogenesis of alzheimer disease, improve its dysfunction, give full play to the curative effect advantage of Chinese medicine treatment senile dementia.

Detailed description of the invention

Specifically can be obtained by the method for making of patent CN200510019447.4 tranquilizing and blood nourishing oral liquid.

Embodiment 1

Radix Polygoni Multiflori Preparata 116.7g, Caulis Spatholobi 100g, Caulis Polygoni Multiflori 75g, Folium Pini 54.3g, Ramulus Uncariae Cum Uncis 150g, Radix Rehmanniae 25g, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25g, take above-mentioned seven flavor medicine material and decoct with water secondary, add water 6 times amount for the first time, decocts 2 hours, and add water 4 times amount for the second time, decoct 1.5 hours, collecting decoction, filter, it is 1.03(60 DEG C that filtrate is concentrated into relative density), filter, filtrate is for subsequent use; Separately get correctives as protein sugar 4g, be dissolved in water, add in above-mentioned solution; Add preservative sodium benzoate 2g, ethyl hydroxybenzoate a small amount of (using a small amount of dissolve with ethanol), mixing, the adjustment total amount that adds water, to 1000ml, shakes up, fill, through being up to the standards and get final product.

Below in conjunction with test, effect of the present invention is set forth.

1. the affect result of the present invention on senile dementia rats ability of learning and memory shows that low middle high dose group rat all finds the time of platform short (P<0.05) than model group rats, points out it can improve learning and memory in rats ability.

Each group of treated rats in Morris water maze performance compares (x ± s, unit: second)

Note: * compares P<0.05 with model group; Δ compares P<0.05 with taponin group; U compares P<0.05 with normal group.

Dosage group 5ml/kg, high dose group 10ml/kg of the present invention in low dose group 2ml/kg of the present invention, the present invention, taponin group 24mg/kg.

2. the present invention is on the impact of senile dementia rats cerebral tissue SOD activity.

Ge Zu rat cerebral tissue SOD expression activitiy (x ± s, unit: U/mgprot)

Note: * compares P<0.05 with model group; Δ compares P<0.05 with taponin group; U compares P<0.05 with normal group.

Result shows the present invention's middle and high dosage group rat cerebral tissue SOD activity all high than model group (P<0.05), and with normal group without significant difference, points out it can improve rat cerebral tissue's oxidation and removing free radicals ability.

Claims (1)

1. treat a medicine for senile dementia, be made up of the Chinese prescription of following parts by weight:

Radix Polygoni Multiflori Preparata 116.7 parts, Caulis Spatholobi 100 parts, Caulis Polygoni Multiflori 75 parts, Folium Pini 54.3 parts, Ramulus Uncariae Cum Uncis 150 parts, Radix Rehmanniae 25 parts, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 25 parts, is characterized in that the application of this medicine in treatment senile dementia.