CN100366288C - Dental ulcerative glue - Google Patents
Dental ulcerative glue Download PDFInfo
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- CN100366288C CN100366288C CNB2005100944220A CN200510094422A CN100366288C CN 100366288 C CN100366288 C CN 100366288C CN B2005100944220 A CNB2005100944220 A CN B2005100944220A CN 200510094422 A CN200510094422 A CN 200510094422A CN 100366288 C CN100366288 C CN 100366288C
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- ulcerative
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- glue
- gum
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Abstract
The present invention relates to gum for treating oral ulcer, which belongs to the field of medicine preparation. The gum for treating oral ulcer uses a high molecular polymer material as a carrier, uses an oil medium as a solvent, and contains antibiotic (such as metronidazole, fasigyn, etc.), hormone (such as dexamethasone, cortisone, etc.), polydocanol (such as amethacaine, aethocaine, etc.), borneol, peppermint oil, etc. The gum can slowly release a medicine partially. The gum has long residence time in the mouth cavity, and a preferable therapeutic effect on oral ulcer, and is an ideal preparation for the department of stomatology.
Description
Technical field
The present invention relates to a kind of medical field, be specifically related to a kind of preparation for the treatment of oral ulcer, i.e. dental ulcerative glue.
Background technology
Oral ulcer is the higher a kind of disease of sickness rate in the disease of cari oris mucosa, good sending out in positions such as lip, cheek, lingual margins, and the age is regardless of, and all can fall ill throughout the year, influences the healthy and physically and mentally healthy of people.But never have a kind of easy, ideal medicine and method now.Present therapeutic scheme is based on topical therapeutic, and main purpose is antiinflammatory, pain relieving, promotes ulcer healing, and employed medicine mainly contains: 1, gargarism: 1: 5000 hibitane liquor hibitane, furacilin solution etc.; 2, buccal tablet: oradol buccal tablet, lysozyme buccal tablet, hibitane buccal tablet etc.; 3, powder: BINGPENG SAN, XILEI SAN, Pulvis Indigo Naturalis, watermelon crystal are loose etc.; 4, medicine film: contain medicines such as antibiotic and cortisone in its substrate; 5, analgesic: Anuject, dyclonine solution is used for the preceding temporary transient pain relieving of feed; 6, paste: oral ulcer paste etc.
In the above-mentioned existing therapeutic scheme, having some defectives more or less, is that medicine holdup time in the oral cavity is short as the shortcoming of gargarism, buccal tablet, paste, and duration of efficacy is short, and administration number of times is more, and patient dependence is relatively poor; The shortcoming of medicine film is a poor adhesion, comes off easily; The shortcoming of powder is difficulty of administration location; Analgesic is disposable, weak curative effect.In order to solve above-mentioned shortcoming, the present invention becomes liquid paraffin to solvent water on the basis that oral ulcer is stuck with paste, make medicine holdup time significant prolongation in the oral cavity like this, and easy to use, and curative effect is better.
Summary of the invention
The object of the invention provide a kind of in the oral cavity holdup time longer, can discharge medicine in local slow, oral ulcer is had the medicine for treating oral cavity ulcer (being dental ulcerative glue) of better curative effect, to improve the effect of treatment oral ulcer.
For achieving the above object, the technical solution used in the present invention is: a kind of dental ulcerative glue, and the effective ingredient of its pharmaceutical preparation includes:
Gelatin 5%～50% weight;
Sodium carboxymethyl cellulose (CMC-Na) 5%～50% weight;
Metronidazole or tinidazole 5%～20% weight;
Tetracaine or procaine 0.05%～0.5% weight;
Dexamethasone or cortisone 0.05%～0.5% weight;
Polyvinyl alcohol is or/and Borneolum Syntheticum, Oleum menthae, and wherein, polyvinyl alcohol is 5%～50% weight, and Borneolum Syntheticum is 0.5%～5% weight, and Oleum menthae is 0.5%～5% weight;
The liquid paraffin surplus.
Related content in the technique scheme is explained as follows:
1, such scheme increases " polyvinyl alcohol ", " Borneolum Syntheticum " reaches " Oleum menthae " afterwards, and the content of effective of pharmaceutical preparation is:
Gelatin 10%～30% weight;
Sodium carboxymethyl cellulose (CMC-Na) 10%～30% weight;
Polyvinyl alcohol 5%～20% weight;
Metronidazole or tinidazole 5%～15% weight;
Tetracaine or procaine 0.1%～0.2% weight;
Dexamethasone or cortisone 0.1%～0.2% weight;
Borneolum Syntheticum 0.5%～2% weight;
Oleum menthae 0.5%～2% weight;
The liquid paraffin surplus.
2, such scheme increases " polyvinyl alcohol ", " Borneolum Syntheticum " reaches " Oleum menthae " afterwards, and the optimum content of the effective ingredient of pharmaceutical preparation is:
Gelatin 15%～25% weight;
Sodium carboxymethyl cellulose (CMC-Na) 15%～25% weight;
Polyvinyl alcohol 10%～15% weight;
Metronidazole or tinidazole 7.5%～15% weight;
Tetracaine or procaine 0.1%～0.15% weight;
Dexamethasone or cortisone 0.1%～0.15% weight;
Borneolum Syntheticum 1%～2% weight;
Oleum menthae 1%～2% weight;
The liquid paraffin surplus.
5, about the preparation technology of dental ulcerative glue of the present invention
Above all raw materials are worn into fine powder, cross 200 mesh sieves, press recipe quantity, add the neither too hard, nor too soft colloid of appropriate amount of fluid paraffin furnishing and get final product.
6, about the using method of dental ulcerative glue of the present invention
With clear water that oral rinse is clean, colloid is coated in the affected part, every day is for several times.
7, dental ulcerative glue treatment mechanism of the present invention
This preparation utilizes the hydrophilic of macromolecular material, and preparation itself is anhydrous, and the moisture content that runs in the oral cavity expands rapidly, is adsorbed on to suffer from the district, and adhesion is stronger, thereby the holdup time of prolong drug in the oral cavity guarantees that drug slow discharges, and improves curative effect.
8, innovative point of the present invention: this ulcer glue is to be carrier with the macromolecule polymer material, do solvent with oil medium, include antibiotic (as metronidazole, tinidazole etc.), hormone (as dexamethasone, cortisone etc.), topical anesthetic cream (as tetracaine, procaine etc.), Borneolum Syntheticum, Herba Menthae wet goods medicine.Hydrophilic high molecular polymer grinds to form colloid with liquid paraffin (oil medium).This colloid runs into moisture content and is adsorbed on the oral mucosa rapidly in the oral cavity, so sodium carboxymethyl cellulose, gelatin, polyvinyl alcohol can change other hydrophilic high molecular polymers with certain viscosity in the prescription.Antibiotic metronidazole in the prescription can change other antibiotic into, and as tinidazole etc., the hormone dexamethasone also can change other hormone into, as cortisone etc., so the key point application of this carrier in the department of stomatology that be colloid.
Because the technique scheme utilization, the present invention compared with prior art has following advantage and effect:
1, advantage: 1) effect is rapid, and duration of efficacy is long, and effect is remarkable;
2) easy to use, patient dependence is good;
3) low price helps alleviating medical burden.
2, effect
Select oral ulcer patient's 30 examples at 18～60 years old age, male's 16 examples, women's 14 examples are used dental ulcerative glue by last method, and three days cure rate is 96.7%, and effective percentage 100% is not seen untoward reaction in the medication process.
The specific embodiment
Below in conjunction with embodiment the present invention is further described:
Embodiment one: a kind of dental ulcerative glue, and the effective ingredient of its pharmaceutical preparation consists of:
Gelatin 25g
Sodium carboxymethyl cellulose (CMC-Na) 25g
Metronidazole 10g
Tetracaine 0.1g
Dexamethasone 0.1g
Borneolum Syntheticum 1g
Oleum menthae 1g
Liquid paraffin 37.8g
Preparation technology: above all raw materials are worn into fine powder, cross 200 mesh sieves, press recipe quantity, add the neither too hard, nor too soft colloid of appropriate amount of fluid paraffin furnishing and get final product.
Embodiment two: a kind of dental ulcerative glue, and the effective ingredient of its pharmaceutical preparation consists of:
Gelatin 15g
Sodium carboxymethyl cellulose (CMC-Na) 20g
Polyvinyl alcohol 15g
First nitre 10g
Tetracaine 0.1g
Dexamethasone 0.1g
Liquid paraffin 39.8g
Preparation technology: above all raw materials are worn into fine powder, cross 200 mesh sieves, press recipe quantity, add the neither too hard, nor too soft colloid of appropriate amount of fluid paraffin furnishing and get final product.
Embodiment three: a kind of dental ulcerative glue, and the effective ingredient of its pharmaceutical preparation consists of:
Gelatin 15g
Sodium carboxymethyl cellulose (CMC-Na) 15g
Polyvinyl alcohol 10g
Metronidazole 15g
Tetracaine 0.1g
Dexamethasone 0.1g
Borneolum Syntheticum 1g
Oleum menthae 2g
Liquid paraffin 41.8g
Preparation technology: above all raw materials are worn into fine powder, cross 200 mesh sieves, press recipe quantity, add the neither too hard, nor too soft colloid of appropriate amount of fluid paraffin furnishing and get final product.
Embodiment four: a kind of dental ulcerative glue, and the effective ingredient of its pharmaceutical preparation consists of:
Gelatin 15g
Sodium carboxymethyl cellulose (CMC-Na) 15g
Polyvinyl alcohol 10g
Tinidazole 15g
Procaine 0.1g
Cortisone 0.1g
Borneolum Syntheticum 1g
Oleum menthae 2g
Liquid paraffin 41.8g
Preparation technology: above all raw materials are worn into fine powder, cross 200 mesh sieves, press recipe quantity, add the neither too hard, nor too soft colloid of appropriate amount of fluid paraffin furnishing and get final product.
Model case:
Example one: Wang; the man, 31 years old, from October, 2003 oral ulcer increase the weight of to be persistence outbreak; 2～3 of general the lip of the tongue; 4～5 at other position, gingiva, maxillary, lip swelling, oral vitamin and detoxicating tablet of cow-bezoar poor effect; through treating with dental ulcerative glue; be applied to the affected part three times every day, pain obviously alleviated in first day, ulcer surface healing in the 3rd day.
Example two: Liu, the woman, 40 years old, patient's symptom showed as lip two cheeks and all sees white curing ulcer erosion, and red swelling of gingiva, can't be taken food at the heat that occurs together, halitosis, pain, and just can take food the same day after with dental ulcerative glue, and ulcer surface heals after three days, the pain disappearance.
The foregoing description only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (3)
1. dental ulcerative glue, it is characterized in that: the effective ingredient of pharmaceutical preparation includes:
Gelatin 5%～50% weight;
Sodium carboxymethyl cellulose 5%～50% weight;
Metronidazole or tinidazole 5%～20% weight;
Tetracaine or procaine 0.05%～0.5% weight;
Dexamethasone or cortisone 0.05%～0.5% weight;
Polyvinyl alcohol is or/and Borneolum Syntheticum, Oleum menthae, and wherein, polyvinyl alcohol is 5%～50% weight, and Borneolum Syntheticum is 0.5%～5% weight, and Oleum menthae is 0.5%～5% weight;
The liquid paraffin surplus.
2. dental ulcerative glue according to claim 1 is characterized in that: the content of effective of pharmaceutical preparation is:
Gelatin 10%～30% weight;
Sodium carboxymethyl cellulose 10%～30% weight;
Polyvinyl alcohol 5%～20% weight;
Metronidazole or tinidazole 5%～15% weight;
Tetracaine or procaine 0.1%～0.2% weight;
Dexamethasone or cortisone 0.1%～0.2% weight;
Borneolum Syntheticum 0.5%～2% weight;
Oleum menthae 0.5%～2% weight;
The liquid paraffin surplus.
3. dental ulcerative glue according to claim 2 is characterized in that: the content of effective of pharmaceutical preparation is:
Gelatin 15%～25% weight;
Sodium carboxymethyl cellulose 15%～25% weight;
Polyvinyl alcohol 10%～15% weight;
Metronidazole or tinidazole 7.5%～15% weight;
Tetracaine or procaine 0.1%～0.15% weight;
Dexamethasone or cortisone 0.1%～0.15% weight;
Borneolum Syntheticum 1%～2% weight;
Oleum menthae 1%～2% weight;
The liquid paraffin surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100944220A CN100366288C (en) | 2005-09-14 | 2005-09-14 | Dental ulcerative glue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100944220A CN100366288C (en) | 2005-09-14 | 2005-09-14 | Dental ulcerative glue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1745846A CN1745846A (en) | 2006-03-15 |
| CN100366288C true CN100366288C (en) | 2008-02-06 |
Family
ID=36165664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100944220A Expired - Fee Related CN100366288C (en) | 2005-09-14 | 2005-09-14 | Dental ulcerative glue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100366288C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291754C (en) * | 2005-07-12 | 2006-12-27 | 李赴朝 | Localized anesthesia synergistic delay agent |
| CN102488698A (en) * | 2011-12-02 | 2012-06-13 | 河南科技大学第一附属医院 | Oral treatment water |
| CN102935088A (en) * | 2012-10-25 | 2013-02-20 | 祁建春 | Injection therapy and drug constitutes for curing recurrent aphthous ulcer |
| CA2979554C (en) * | 2015-10-22 | 2023-03-14 | Colgate-Palmolive Company | Oral care compositions |
| CN110448688A (en) * | 2019-09-11 | 2019-11-15 | 徐州生物工程职业技术学院 | A kind of lysozyme formulation, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076338A (en) * | 1992-03-13 | 1993-09-22 | 李震超 | The production method of health-care chewing gum |
| CN1165675A (en) * | 1997-02-26 | 1997-11-26 | 王庆书 | Drug for treating pharyngitis, laryngitis and psora |
-
2005
- 2005-09-14 CN CNB2005100944220A patent/CN100366288C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076338A (en) * | 1992-03-13 | 1993-09-22 | 李震超 | The production method of health-care chewing gum |
| CN1165675A (en) * | 1997-02-26 | 1997-11-26 | 王庆书 | Drug for treating pharyngitis, laryngitis and psora |
Non-Patent Citations (1)
| Title |
|---|
| 自制复方甲硝唑口腔膜治疗牙周脓肿. 王爱莲.山东医药，第40卷第16期. 2000 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1745846A (en) | 2006-03-15 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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Granted publication date: 20080206 Termination date: 20091014 |