CN100355358C - Additives of fodder for improving intestines function of piglings - Google Patents
Additives of fodder for improving intestines function of piglings Download PDFInfo
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- CN100355358C CN100355358C CNB2005100970475A CN200510097047A CN100355358C CN 100355358 C CN100355358 C CN 100355358C CN B2005100970475 A CNB2005100970475 A CN B2005100970475A CN 200510097047 A CN200510097047 A CN 200510097047A CN 100355358 C CN100355358 C CN 100355358C
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Abstract
The present invention discloses a feed additive for improving the intestinal function of piglings, which is prepared by proportionally mixing and processing at least three of glutamine, glycyl-L-glutamine, sodium butanoate, vitamin C and glucose. When 0.05 to 2% of feed additive for improving the intestine function of piglings of the present invention is added to compound feed for feeding, a product can obviously reduce the diarrhea rate of piglings, increase daily gain and improve the conversion rate of feed. Because the feed additive for improving the intestine function of piglings of the present invention can be used for replacing plasma protein powder, the biosafety problem caused by the application of plasma protein powder is solved. A plurality of experiments and lab detection prove that the feed additive has the advantages of high efficiency, safety and no toxicity, and fed animal products accord with the requirement of food sanitation.
Description
Technical field
The present invention relates to a kind of feed addictive of promoting intestines function of piglings.
Background technology
In the Swine Production, the key link is weanling pig production, early weaning piglet is the advanced technology of common concern during domestic and international intensive pig production is produced, early weaning can improve the breeding potential of sow, can increase the year litter size of sow, minimizing is by the transmission of parent to piglet, and can improve production performance and the carcass quality of growth pig, and usage ratio of equipment such as delivery room is improved.The country of pig industry prosperity has at present begun to apply l4 age in days ultra-early weaning technology.But the major issue that early weaning brings is how to improve the growth performance of weanling pig, because the growth performance of weanling pig not only is related to the level of production and the economic benefit in piglet stage, and be related to the production performance and the economic benefit in the whole growth stage of pig, the raising of piglet early growth performance can make the growth of later stage performance be greatly improved, and the marketing time of shortening pork pig, bring bigger economic benefit thereby give to raise pigs to produce.But the raising of the growth performance of weanling pig also is the most scabrous ring in the whole link of raising pigs.Because during the piglet birth, its alimentary canal fails fully to adapt to the digestion and the utilization (Rhoads of breast milk, 1990), great change has taken place in the character of daily ration behind the weaned piglet, and piglet alimentary canal zoon not as yet, the digestive enzyme activity deficiency, immunologic function is undeveloped mature (Aumaitre andCorring still also, 1978), and wean not only is related to physiological variation, psychology, variation has also taken place in environment and nutrition condition, thereby it is poor often to show as appetite, the disorders of digestion, diarrhoea, growthing lag, efficiency of feed utilization is low etc. so-called " early weaning piglet syndrome ".
The research that solves " early weaning piglet syndrome " is scientific worker's the research focus of raising pigs at present, for example, utilize the pig blood resource of large-scale slaughterhouse health, adopt advanced separation, modified, spray-drying blood plasma (ball) albumen powder that drying process with atomizing is produced, because of it has good palatability, the protein content height, amino acid balance and kept characteristics such as immune globulin activity in the blood plasma and be used as the technical measures of solution " early weaning piglet syndrome ".But owing to the use that is under an embargo of bio-safety problem.
Studies show that in a large number glutamine (GLN) is the fuel of intestinal cell, it is the precursor that synthetic cell breaks up necessary purine and pyrimidine nucleotide, be mesenterium lymph and last theliolymphocyte and significant energy substrate, be to keep the adenoid essential composition relevant with enteron aisle, it also is the essential material of synthetic intestinal secretion immune globulin white matter, keeping the enteron aisle normal function and improving play an important role aspect the intestine immunity power (James, 1998).And GLN is the rich in amino acid of pig Ruzhong content, and it is the underlying cause (Alverdy, 1990) that the early weaning piglet syndrome produces that wean back GLN supply reduces.GLN, glucose, butyrate, propionate and acetate all are energy sources of intestinal mucosa cell, and wherein GLN is the energy source of most important intestinal mucosa cell, and glucose takes second place.GLN dipeptides (as Gly-L-Gln) main form with dipeptides in small intestine absorbs, the absorptivity height, being decomposed into the amino acid of its composition after absorbing by the dipeptidase in the histoorgans such as small intestine, can overcoming the thermal instability and the low solubility of GLN monomer, also is effective addition manner of a kind of GLN.
Summary of the invention
The invention provides a kind of feed addictive of promoting intestines function of piglings.
The feed addictive of promoting intestines function of piglings is formulated in proportion by the material more than three kinds or three kinds in glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose.
Various material proportionings are as follows in the feed addictive of enhancement intestines function of piglings:
1) glutamine: sodium butyrate: the vitamin C ratio is 1: 0.05～10: 0.1～10.
2) glutamine: sodium butyrate: the glucose ratio is 1: 0.05～10: 1～100.
3) glutamine: vitamin C: the glucose ratio is 1: 0.1～10: 1～100.
4) glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.05～1 0: 0.1～10: 1～100.
5) glycyl-L-glutamine: sodium butyrate: the vitamin C ratio is 1: 0.1～10: 0.1～10.
6) glycyl-L-glutamine: sodium butyrate: the glucose ratio is 1: 0.1～10: 1～100.
7) glycyl-L-glutamine: vitamin C: the glucose ratio is 1: 0.1～10: 1～100.
8) glycyl-L-glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.1～10: 0.1～10: 1～100.
9) glutamine: glycyl-L-glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.1～10: 0.1～10: 0.1～10: 1～100.
Above-mentioned compound is mixed, promoted the feed addictive of intestines function of piglings accordingly.
The present invention starts with from the digestive physiology development characteristics of piglet, applied nutrition and immunoregulation means, multiple active material with raising function of intestinal canal, enhancing digestive enzyme activity and raising immunity is carried out the reasonable compatibility combination, successfully developed a kind of feed addictive of promoting intestines function of piglings.Use the feed addictive of enhancement intestines function of piglings of the present invention, can prevent the intensification of the excessive atrophy of intestinal mucosa fine hair in 1～7 day and crypts behind the weaned piglet, can significantly improve 8～14 days intestinal mucosa height of naps in wean back, weanling pig duodenum content total protease activity can be significantly improved, the amylase activity of back 14 days weanling pigs of wean can be significantly improved.Use the feed addictive of enhancement intestines function of piglings of the present invention, can significantly improve the average daily gain of weanling pig, reduce the post-weaning diarrhea in piglet rate, shorten the diarrhoea cycle.Promote the complete replacement blood slurry protein powder of feed addictive energy of intestines function of piglings, have remarkable economic efficiency and social benefit, market prospects are wide.
The feed addictive that adds 0.05～2% enhancement intestines function of piglings of the present invention on the basis of mixed feed is fed, and can obviously reduce the diarrhea rate of piglet, improves daily gain, improves food conversion ratio.The alternative SDPP of the feed addictive of enhancement intestines function of piglings of the present invention is avoided in response to the bio-safety problem that causes with SDPP.Detect through Multitest and laboratory, the not only efficient and safety non-toxic of this additive, the animal product of being fed meets the food hygiene requirement.
The specific embodiment
The feed addictive of promoting intestines function of piglings is Powdered, be that compound with this powdery adds in mixed feed, concentrated feed, premix or the additive during application, and evenly mix, its addition is amounted in the mixed feed content and is counted 0.05～2%.
Embodiment 1
Glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 0.05: 10 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 2
Glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 10: 0.1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 3
Glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 5: 5.05 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 4
Glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 0.05: 100 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 5
Glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 10: 1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 6
Glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 5.03: 50.5 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 7
Glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 0.1: 100 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 8
Glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 10: 1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 9
Glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 5.05: 50.5 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 10
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.05: 10: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 11
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 0.1: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 12
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 5.03: 5.05: 50.5 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 13
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 0.1: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 14
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.05: 10: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 15
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 10: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 16
With glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.05: 0.1: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 17
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 0.1: 10 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 18
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 10: 0.1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 19
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of vitamin C are made up with 1: 5.05: 5.05 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 20
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 0.1: 100 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 21
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 10: 1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 22
Glycyl-L-glutamine, sodium butyrate and three kinds of materials of glucose are made up with 1: 5.05: 50.5 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 23
Glycyl-L-glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 0.1: 100 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 24
Glycyl-L-glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 10: 1 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 25
Glycyl-L-glutamine, vitamin C and three kinds of materials of glucose are made up with 1: 5.05: 50.5 ratio, and above-mentioned compound is mixed, obtain a kind of feed addictive of promoting intestines function of piglings.
Embodiment 26
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.1: 10: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 27
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 0.1: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 28
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 0.1: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 29
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.1: 10: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 30
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 10: 10: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 31
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 0.1: 0.1: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 32
With glycyl-L-glutamine, sodium butyrate, vitamin C and four kinds of materials of glucose with 1: 5.05: 5.05: 50.5 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 33
With GLN, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 0.1: 10: 10: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 34
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 10: 0.1: 0.1: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 35
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 10: 0.1: 10: 100 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 36
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 0.1: 10: 0.1: 1 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 37
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 10: 10: 0.1: 100 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 38
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 0.1: 0.1: 10: 1 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 39
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 10: 10: 10: 1 ratios combination, and above-mentioned compound mixed obtains-kind promotes the feed addictive of intestines function of piglings.
Embodiment 40
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 0.1: 0.1: 0.1: 100 ratio combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Embodiment 41
With glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose with 1: 5.05: 5.05: 5.05: 50.5 ratios combination, and above-mentioned compound mixed obtains a kind of feed addictive of promoting intestines function of piglings.
Application Example 1
In 28 age in days weanling pig daily rations, add the feed addictive of 0.5% enhancement intestines function of piglings of the present invention, the influence of diarrhea of weaned piglets rate is seen Table-1.
Table-1 function of intestinal canal conditioning agent is to the influence of diarrhea rate
| The piglet age in days | Control group | Test group |
| 28～35d 35～42d 42～49d | 24.60±3.64 A 27.73±4.96 A 6.34±1.37 A | 7.14±2.38 B 7.14±2.38 B 0.79±1.37 B |
Add the feed addictive of 0.5% enhancement intestines function of piglings of the present invention in the daily ration, 28～35 age in days stage of piglet diarrhea rate is than control group low by 70.98% (P＜0.0 1); 35～42 age in days stage of piglet diarrhea rate is than control group low by 73.28% (P＜0.01); 42～49 age in days stage of piglet diarrhea rate is than control group low by 87.54% (P＜0.01).
Application Example 2
Add the feed addictive of 0.75% enhancement intestines function of piglings of the present invention in 28 age in days weanling pig daily rations, the influence of 28～42 age in days stages to weanling pig daily gain, material anharmonic ratio sees Table-2.
Table-2 function of intestinal canal conditioning agents are to the influence of weanling pig daily gain, material anharmonic ratio
| Project | Control group | Test group |
| Heavy (Kg) average daily gains of starting weight (Kg) 42 ages in days (g) material anharmonic ratio | 7.99±0.84 11.45±1.42a 246.7±10.1A 1.58±0.11a | 7.88±0.81 12.31±1.29b 316.4±8.1B 1.38±0.07b |
Add the feed addictive of 0.75% enhancement intestines function of piglings of the present invention in 28 age in days weanling pig daily rations, 28～42 age in days stages were improved 28.25% (P＜0.01) to the weanling pig daily gain, material anharmonic ratio 12.66% (P＜0.05).
Application Example 3
The feed addictive of interpolation 1% enhancement intestines function of piglings of the present invention sees Table-3 to the influence of the back serum xylose concentration that weans in 21 age in days weanling pig daily rations.
Table-3 function of intestinal canal conditioning agents are to the influence (mmol/L) of serum xylose concentration
| Date 0d 7d 14d 21d | Control group 0.826 ± 0.043 0.153 ± 0.013A, 0.288 ± 0.033A, 0.447 ± 0.018A | Test II 0.826 ± 0.043 0.345 ± 0.019B, 0.583 ± 0.018B, 0.930 ± 0.044B |
In 21 age in days weanling pig daily rations, add the feed addictive of 1% enhancement intestines function of piglings of the present invention, wean back 1 all serum xylose concentrations are than control group high by 125.49% (P＜0.01), wean back 2 all serum xylose concentrations are than control group high by 102.43% (P＜0.01), and wean back 3 all serum xylose concentrations are than control group high by 108.05% (P＜0.01).
Claims (1)
1. feed addictive of promoting intestines function of piglings, it is characterized in that by the material more than three kinds or three kinds in glutamine, glycyl-L-glutamine, sodium butyrate, vitamin C and five kinds of materials of glucose formulatedly in following ratio, described ratio is as follows:
Glutamine: sodium butyrate: the vitamin C ratio is 1: 0.05～10: 0.1～10;
Or glutamine: sodium butyrate: the glucose ratio is 1: 0.05～10: 1～100;
Or glutamine: vitamin C: the glucose ratio is 1: 0.1～10: 1～100;
Or glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.05～10: 0.1～10: 1～100;
Or glycyl-L-glutamine: sodium butyrate: the vitamin C ratio is 1: 0.1～10: 0.1～10;
Or glycyl-L-glutamine: sodium butyrate: the glucose ratio is 1: 0.1～10: 1～100;
Or glycyl-L-glutamine: vitamin C: the glucose ratio is 1: 0.1～10: 1～100;
Or glycyl-L-glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.1～10: 0.1～10: 1～100;
Or glutamine: glycyl-L-glutamine: sodium butyrate: vitamin C: the glucose ratio is 1: 0.1～10: 0.1～10: 0.1～10: 1～100.
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| CN102919581A (en) * | 2012-10-30 | 2013-02-13 | 浙江科盛饲料股份有限公司 | Feed additive, functional feed, and preparation method and application of functional feed |
| CN103070295B (en) * | 2013-01-31 | 2015-05-27 | 武汉工业学院 | Feed additive for improving intestinal barrier function of livestock and poultry and application of feed additive |
| CN103636943A (en) * | 2013-11-26 | 2014-03-19 | 大连创达技术交易市场有限公司 | Feed additive |
| CN104996781A (en) * | 2015-06-25 | 2015-10-28 | 安徽省正大源饲料集团有限公司 | Compound feed for anthony pigs |
| CN105285399A (en) * | 2015-11-16 | 2016-02-03 | 通威股份有限公司 | Liquid state composite microecological preparation for pigling and preparation method thereof |
| CN106561998A (en) * | 2016-11-14 | 2017-04-19 | 赵清国 | Micro-capsule coating sodium butyrate and preparation method thereof |
| CN110506853A (en) * | 2018-05-22 | 2019-11-29 | 广州英赛特生物技术有限公司 | Application of the N- glycyl glutamine in animal feed additive |
| CN109463352B (en) * | 2018-11-29 | 2020-08-07 | 深圳农畉农产品有限公司 | Method for reducing skatole in live pigs |
| US11964929B2 (en) * | 2018-12-18 | 2024-04-23 | Wisorig Technologies Pte. Limited | Application of glutamine derivative in preparation of animal feed additive |
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