CN100344624C - 含有精氨酰胺类的医药制剂 - Google Patents

含有精氨酰胺类的医药制剂 Download PDF

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Publication number
CN100344624C
CN100344624C CNB2004800076128A CN200480007612A CN100344624C CN 100344624 C CN100344624 C CN 100344624C CN B2004800076128 A CNB2004800076128 A CN B2004800076128A CN 200480007612 A CN200480007612 A CN 200480007612A CN 100344624 C CN100344624 C CN 100344624C
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CN
China
Prior art keywords
solution
pharmaceutical composition
argatroban
pharmaceutical preparation
pharmaceutical
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB2004800076128A
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English (en)
Chinese (zh)
Other versions
CN1761661A (zh
Inventor
尾崎和彦
平宫真奈美
吉泽胜芳
山田孝志
广川毅
菅原浩一
来栖克典
山田昇
梶原健一
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Tanabe Pharma Corp
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Mitsubishi Pharma Corp
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Publication date
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Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of CN1761661A publication Critical patent/CN1761661A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB2004800076128A 2003-03-20 2004-03-19 含有精氨酰胺类的医药制剂 Expired - Lifetime CN100344624C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP077125/2003 2003-03-20
JP2003077125 2003-03-20

Publications (2)

Publication Number Publication Date
CN1761661A CN1761661A (zh) 2006-04-19
CN100344624C true CN100344624C (zh) 2007-10-24

Family

ID=33027937

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800076128A Expired - Lifetime CN100344624C (zh) 2003-03-20 2004-03-19 含有精氨酰胺类的医药制剂

Country Status (5)

Country Link
JP (1) JP3781308B2 (https=)
KR (1) KR101010547B1 (https=)
CN (1) CN100344624C (https=)
TW (1) TW200505422A (https=)
WO (1) WO2004083201A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤
IN2015DN03947A (https=) * 2005-09-01 2015-10-02 Baxter Int
JP5438999B2 (ja) * 2009-03-19 2014-03-12 テルモ株式会社 アルガトロバン注射液製剤
CN102120026A (zh) * 2011-03-03 2011-07-13 天津市炜杰科技有限公司 以醇作为增溶剂的21(s)阿加曲班静脉注射液
CN102228426A (zh) * 2011-06-17 2011-11-02 天津市炜杰科技有限公司 以醇作为增溶剂的21(r)阿加曲班静脉注射液
CN104098647B (zh) * 2014-06-24 2017-12-08 安徽省逸欣铭医药科技有限公司 阿加曲班类似物及其制备方法和医药用途
CN114689768A (zh) * 2020-12-31 2022-07-01 汉寿康运医药科技有限公司 一种阿加曲班一水合物中杂质含量的分离检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214052A (en) * 1987-07-28 1993-05-25 Mitsubishi Kasei Corporation Method for dissolving arginineamides and pharmaceutical compositions containing them
CN1109754A (zh) * 1994-02-03 1995-10-11 合成实验室公司 阿尔加特罗邦浓缩水溶液
JP2002241284A (ja) * 2001-02-16 2002-08-28 Towa Yakuhin Kk 全身投与用アルガトロバン注射液

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6431727A (en) * 1987-07-28 1989-02-02 Mitsubishi Chem Ind Dissolution of argininamide and drug composition containing argininamides
JP3530542B2 (ja) * 1992-03-18 2004-05-24 三菱化学株式会社 眼科用アルガトロバン製剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214052A (en) * 1987-07-28 1993-05-25 Mitsubishi Kasei Corporation Method for dissolving arginineamides and pharmaceutical compositions containing them
CN1109754A (zh) * 1994-02-03 1995-10-11 合成实验室公司 阿尔加特罗邦浓缩水溶液
JP2002241284A (ja) * 2001-02-16 2002-08-28 Towa Yakuhin Kk 全身投与用アルガトロバン注射液

Also Published As

Publication number Publication date
KR101010547B1 (ko) 2011-01-24
TWI327910B (https=) 2010-08-01
JP3781308B2 (ja) 2006-05-31
WO2004083201A1 (ja) 2004-09-30
TW200505422A (en) 2005-02-16
CN1761661A (zh) 2006-04-19
KR20060002825A (ko) 2006-01-09
JPWO2004083201A1 (ja) 2006-06-22

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210811

Address after: Osaka, Japan

Patentee after: MITSUBISHI TANABE PHARMA Corp.

Address before: Osaka, Japan

Patentee before: MITSUBISHI PHARMA Corp.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20071024