CN100340249C - Medicine with chondriomere distortion preventing function - Google Patents
Medicine with chondriomere distortion preventing function Download PDFInfo
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- CN100340249C CN100340249C CNB2005100345991A CN200510034599A CN100340249C CN 100340249 C CN100340249 C CN 100340249C CN B2005100345991 A CNB2005100345991 A CN B2005100345991A CN 200510034599 A CN200510034599 A CN 200510034599A CN 100340249 C CN100340249 C CN 100340249C
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Abstract
The present invention discloses a medicine for preventing teratospermia. The medicine of the present invention comprises the following components measured by parts of weight: 2000 to 8000 of caterpillar fungus spore powder, 80 to 120 of zinc and 2 to 3 of selenium. The medicine of the present invention can effectively prevent teratospermia induced by cyclophosphamide monohydrate, the lower distortion rate can be lowered by 20 to 25%, the stage number of a+b sperms is kept at more than 60 %, the sperm survival rate is larger than 68%, the sperm density is at 2 to 3*10<7>/ml, and the sperms with straight-line motion speed of larger than 60 mu m/s reach from 30% to 40%.
Description
Technical field
The present invention relates to field of medicinal compositions, relate in particular to a kind of new pharmaceutical composition.
Background technology
According to society and medical department feedback opinion, the male sterility situation is on the rise at present.Occur the decline of sperm quality and quantity in nearly 20～30 years and become clinically the particularly common disease of Andriatrics Dept..According to The World Health Organization's statistics in 1987, wife's side factor accounts for 39% in infertility, and male factor accounts for 20%, and has 40% to belong to cacospermia among the sterile male approximately.Human sperm quantity on average descends with 2% speed over nearly 20 years, according to Britain's data report, because the electromagnetic wave that environmental pollution, drug influence, various household electrical appliance and kind difference, intensity are different and the influence of ray, the man that gets involved accounts for male 66%, thereby causes the sterile or miscarriage of a large amount of of the right age spouses.
Treatment to azoospermia or azoospermia does not both at home and abroad all have effective medicine, is main means with hormone replacement therapy mainly abroad, is exactly in addition to solve sterile by sperm injection technology such as (ICSI) in external fertilization (IVF) and the ovum.Though pregnancy rate is very high, and significant limitation is arranged.Domestic divided by outside the hormone therapy, mostly use the herb mixture and the acupuncture and moxibustion treatment of YIN nourishing, tonifying YANG, the kidney invigorating.These all can not be at the preventive and therapeutic effect of chondriomere distortion preventing function.In addition, engineered cytokine such as bFGF etc. are in conceptual phase as medicine, do not report clinically, and there is certain reproduction insecurity in this class somatomedin.
Summary of the invention
The objective of the invention is to a treatment difficult problem, a kind of medicine that can prevent and treat sperm distortion is provided at above-mentioned male sterility.
The medicine of chondriomere distortion preventing function of the present invention, component calculates and is made up of following by weight:
Cordyceps spore powder 2000～8000
Zinc 80～120
Selenium 2～3
The medicine of above-mentioned chondriomere distortion preventing function, component calculates and is made up of following by weight:
Cordyceps spore powder 4000～5000
Zinc 100～120
Selenium 2～3
Above-mentioned Cordyceps spore powder is that Hepialus armorieanus Oberthur belongs to Cordyceps spore powder.
It is principal agent that the present invention belongs to Cordyceps spore powder with Hepialus armorieanus Oberthur, and according to record and the research of the pharmacological effect in the present age that ancient Chinese prose is offered, Cordyceps spore powder has tonifying YANG, the kidney invigorating and strong smart effect.The used Cordyceps spore powder of the present invention, its manufacture method: be inoculated in broth bouillon in right amount with the Cordyceps spore, 20～30 ℃, concussion was cultivated 12～48 hours, wherein preferably 22 ℃ cultivated 24 hours; Spill in solid medium in the shop then, under aseptic condition, cultivated 20～30 days, dry and be broken into Cordyceps spore powder.
The used trace elements zn of medicine of the present invention (zinc) relates to nucleic acid and proteinic biosynthesis in the spermatogenesis process, its key enzyme is zinciferous metalloenzyme, and scarce Zn can influence the activity of a series of enzymes of spermatogenesis process, causes spermatogenesis process obstacle.Zn can influence the sex gland hormones level.Contain a certain amount of Zn in the refining, after fertilization, the zinc in the refining plays an important role to the activation of endometrium hormone receptor, and embryo nidation and offspring's growth thereof are all had material impact.The trace elements zn that the present invention added also can be that zinc compound adds, as zinc gluconate, zinc sulfate or the like.
The used trace element Se of medicine of the present invention (selenium), Se in refining within the specific limits with the motility of sperm positive correlation, it is the important composition of mitochondria of sperms adventitia.Mitochondrion is cell " energy ", the kinestate of the suitable concn decision sperm of Se.The trace element Se that the present invention added can be that the selenium-containing compound form is added, and as sodium selenite and Selenomethionine, also can be the yeast selenium of biological extraction, biosynthetic selenic ester polysaccharide or the like; Yeast selenium preferably wherein.
The medicine of chondriomere distortion preventing function of the present invention can also add Herba Epimedii.In the Chinese medicine medical material, Herba Epimedii is a medea.For example, the effect of Herba Epimedii extract is equivalent to the androgen effect, can increase blood plasma testosterone content.Herba Epimedii is the Berberidaceae medicinal plants, and its effective ingredient is an icariin.Experiment showed, and get the injection of Herba Epimedii extract mouse peritoneal, its effect is equivalent to androgen, and can increase mice plasma testosterone content.Wherein, the Herba Epimedii that the present invention added is an extract extractum.Wherein, the weight of Herba Epimedii extract extractum is 7～8 times of Cordyceps spore powder weight.
With above-mentioned mentioned Cordyceps spore powder, zinc, selenium uniform mixing in proportion, be prepared into medicine dry powder, further be distributed into capsule, or be prepared into tablet or granule, or directly be prepared into extractum.
With above-mentioned mentioned Cordyceps spore powder, zinc, selenium uniform mixing in proportion, be prepared into medicine dry powder, be mixed in proportion with Herba Epimedii extract extractum again, further be distributed into capsule, or be prepared into tablet or granule, or directly be prepared into extractum.Wherein, the weight of Herba Epimedii extract extractum is 7～8 times of Cordyceps spore powder weight.
Beneficial effect of the present invention:
Medicine of the present invention can effectively prevent the sperm distortion that cyclophosphamide brings out, and aberration rate can reduce by 20～25%, and a+b sperm progression remains on more than 60%, sperm survival rate＞68%; Sperm concentration 2～3 * 10
7/ ml, the sperm of point-to-point speed＞60 μ m/s reaches 30%～40%.
The present invention adds Herba Epimedii can more effectively prevent the sperm distortion that cyclophosphamide brings out, and aberration rate can further reduce by 25～30%, and a+b sperm progression remains on more than 66%, sperm survival rate＞70%; Sperm concentration 3 * 10
7/ ml, the sperm of point-to-point speed＞60 μ m/s reaches 32%～40%.
The specific embodiment
The preparation of embodiment 1 medicine
Be inoculated in broth bouillon in right amount with the Cordyceps spore, 22 ℃ of concussions were cultivated 24 hours, spill in solid medium in the shop then, under aseptic condition, cultivated 25 days, dry and be broken into Cordyceps spore powder, with 300 milligrams of Cordyceps spore powders, 65 milligrams of zinc gluconate (containing 8.45 milligrams on zinc), 300 milligrams of yeast selenium (containing 0.15 milligram on selenium) uniform mixing, be prepared into medicine dry powder then, with 2.25 gram Herba Epimedii extractum mix homogeneously, be prepared into pharmaceutical composition again.Further be distributed into capsule again.
The proof experiment 1 of embodiment 2 drug effect effects
The preparation method of medicine such as embodiment 1.According to the difference of prescription, every kind of capsule contains things such as not commensurability Cordyceps spore powder, zinc, selenium or Herba Epimedii extractum.See table 1 prescription hurdle for details.
Get 70 of male mices, be divided into 7 groups at random, 10 every group, one group of negative matched group, feed conventional feed every day, in addition 6 groups of disposable celiacs injection cyclophosphamide 2.4mg/ only, induce sperm distortion after, wherein 1 group of positive controls is fed conventional feed every day, 5 groups is to be measured group in addition, except that feeding every day the conventional feed, by the heavy 25g of every mice, gavage pharmaceutical composition dry powder capsule of the present invention every day, the every group to be measured amount that contains effective medicine in the capsule that gavages prescription hurdle of seeing attached list.Raise after 30 days, disconnected neck is put to death mice, gets the epididymis tissue, collects seminal fluid, redyes analyzing samples with Yihong and Jim Sa (Giemsa) dyestuff.
Rate of teratosperm is measured: the sperm suspension after dye with ultramicroscopic observation (1), and according to the sperm morphology abnormal shape, the statistics aberration rate; (2) utilize the computer software of WLJY-9000 type mighty force sperm quality detector to discern sperm deformity.With these two kinds of method references each other.
The mensuration of motility of sperm: utilize mighty force sperm instrument that motility of sperm such as sperm survival rate, movement velocity, rectilinear motion are detected.
Experimental result: compare medicine of the present invention with matched group and can effectively prevent the sperm distortion that cyclophosphamide brings out, aberration rate can reduce by 22%, and a+b sperm progression remains on 65%, sperm motility rate 70%; Sperm concentration=2.6 * 10
7/ ml, the sperm of point-to-point speed＞60 μ m/s reaches 32%.See table 1 for details.
The experimental result of each prescription of table 1
Claims (4)
1, a kind of medicine of chondriomere distortion preventing function is characterized in that being made up of the component of following parts by weight:
Cordyceps spore powder 2000～8000
Zinc 80～120
Selenium 2～3
Described Cordyceps spore powder is that Hepialus armorieanus Oberthur belongs to Cordyceps spore powder.
2, medicine as claimed in claim 1 is characterized in that being made up of the component of following parts by weight:
Cordyceps spore powder 4000～5000
Zinc 100～120
Selenium 2～3.
3, a kind of medicine of chondriomere distortion preventing function is characterized in that being made up of the component of following parts by weight:
Cordyceps spore powder 2000～8000
Zinc 80～120
Selenium 2～3
Herba Epimedii extract extractum weight is 7～8 times of Cordyceps spore weight
Described Cordyceps spore powder is that Hepialus armorieanus Oberthur belongs to Cordyceps spore powder.
4, medicine as claimed in claim 3 is characterized in that being made up of the component of following parts by weight:
Cordyceps spore powder 4000～5000
Zinc 100～120
Selenium 2～3
Herba Epimedii extract extractum weight is 7～8 times of Cordyceps spore weight
Described Cordyceps spore powder is that Hepialus armorieanus Oberthur belongs to Cordyceps spore powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100345991A CN100340249C (en) | 2005-05-12 | 2005-05-12 | Medicine with chondriomere distortion preventing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100345991A CN100340249C (en) | 2005-05-12 | 2005-05-12 | Medicine with chondriomere distortion preventing function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698857A CN1698857A (en) | 2005-11-23 |
| CN100340249C true CN100340249C (en) | 2007-10-03 |
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| CNB2005100345991A Active CN100340249C (en) | 2005-05-12 | 2005-05-12 | Medicine with chondriomere distortion preventing function |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104366119A (en) * | 2014-11-28 | 2015-02-25 | 广西商大科技有限公司 | Premix improving sexual desire of service boars |
| CN106074598A (en) * | 2016-06-14 | 2016-11-09 | 奥格生物技术（六安）有限公司 | A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof |
| CN109007857A (en) * | 2018-08-29 | 2018-12-18 | 苏州佩普肽康生物科技有限公司 | Improve the food formula of special diet and preparation method thereof of mankind spermatozoon quality |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546645A (en) * | 2003-12-15 | 2004-11-17 | 田敬华 | Northern Chinese caterpillar fungus culture liquid |
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2005
- 2005-05-12 CN CNB2005100345991A patent/CN100340249C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546645A (en) * | 2003-12-15 | 2004-11-17 | 田敬华 | Northern Chinese caterpillar fungus culture liquid |
Non-Patent Citations (2)
| Title |
|---|
| 冬虫夏草是国宝 取而代之金水宝 范赋胜，中国中医药报 2004 * |
| 锌硒宝治疗男性不育患者精浆锌离子与超氧化物歧化酶含量的研究 魏鸿蔼，王良圣，蔡岳斌，生殖与避孕，第23卷第3期 2003 * |
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| CN1698857A (en) | 2005-11-23 |
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| C14 | Grant of patent or utility model | ||
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Assignee: Zhuhai Ansheng Fenghuang Pharmaceutical Co., Ltd. Assignor: Li Guocheng Contract fulfillment period: 2008.1.1 to 2013.1.1 contract change Contract record no.: 2009440001630 Denomination of invention: Medicine with chondriomere distortion preventing function Granted publication date: 20071003 License type: Exclusive license Record date: 20091021 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.1.1 TO 2013.1.1; CHANGE OF CONTRACT Name of requester: ZHUHAI ANSHENG FENGHUANG PHARMACY CO., LTD. Effective date: 20091021 |