CN106074598A - A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof - Google Patents
A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof Download PDFInfo
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- CN106074598A CN106074598A CN201610413483.7A CN201610413483A CN106074598A CN 106074598 A CN106074598 A CN 106074598A CN 201610413483 A CN201610413483 A CN 201610413483A CN 106074598 A CN106074598 A CN 106074598A
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- peptide chelated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof.Its primary raw material forms and quality proportion is: small-peptide chelated zinc 30～120, small-peptide chelated manganese 12～60, small-peptide chelated copper 2～10, small peptide chelated iron@20～60, albumen selenium is 0.5～5.The present invention is remarkably improved the amount retained of trace element in sperm, improves semen quality；The organic chelated microelement composition of compound recipe of the present invention, clinic application proves that it can improve the quality of sperm, makes sperm quantity increase, and spermatozoon activity strengthens, and survival rate improves, and can be greatly improved pregnancy rate, for prevention and the treatment of male infertility.
Description
Technical field
The present invention relates to a kind of organic chelated microelement composition of compound recipe, specially one and treat dysspermatism male not
Organic chelated microelement composition of compound recipe educating disease and preparation method thereof.
Background technology
At present, due to the aggravation of social competition, male is faced with increasing operating pressure, adds plus environmental pollution again
Play, more affects sperm generation and ripe chemical substance is absorbed by male through various approach, causes male to produce spermatogenic
Quantity declines, the activity reduction of sperm, and this Sha's Bark of Denmark's scholar's Neil analyzes 1,938 21 countries in the nineteen ninety whole world
Finding after the semen quality report of nearly 1.5 ten thousand people, mankind spermatozoon number reduced more than 40% in 50 years, and wherein semen volume subtracts
Having lacked 20%, sperm concentration is then reduced to 66,000,000,2003 of nineteen ninety from every milliliter 1.13 hundred million of 1940, defends in the world
In raw " environment international symposium to procreative effect " organized, scientists the most seriously gives a warning: global human
Sperm quality the most constantly declines the sperm concentration of every milliliter of seminal fluid and is dropped to 0.5 hundred million by 1.13 hundred million, have dropped
62%, National Population and Family Planning Commission's Institute Of Science And Technology is to 1981 to 1996 Nian Jian39Ge cities and counties totally 11726
The sperm of people finds after being analyzed, and the semen quality of China male just declines with the speed of annual 1%, decreases by more than 40%.
Scientific investigations showed that, the reason of injury male fertility function increases day by day, and it includes that various sexually transmitted disease (STD), environmental pollution cause people
Heavy metal of body, chemical substance even radioactive substance exceeds standard, long campaigns hot operation, operating pressure are excessive, cigarette, wine and medicine
The impact of thing, obesity, bad life habits etc., society occurs increasing because male's aspect reason cause infertile
Disease.
Summary of the invention
Present invention aims to the above male infertility sickness rate gradually rise, the quantity of mankind spermatozoon and
Quality occurs in that the trend being decreased obviously, and male reproductive health is just by serious threat, and the deficiency that existing curative effect of medication is the best,
There is provided one safely, have no adverse reaction, and to semen abnormal such as azoospermia, lack essence, azoospermia etc. and symptom can not be given birth to and have
Organic chelated microelement composition of compound recipe of the treatment male sterility of significant curative effect and preparation method thereof.
The technical problem to be solved realizes by the following technical solutions:
A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease, its primary raw material composition and matter
Amount proportion is: small-peptide chelated zinc 30～120, small-peptide chelated manganese 12～60, small-peptide chelated copper 2～10, small peptide chelated iron@20～60,
Albumen selenium is 0.5～5.
Preferably, described small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper and small peptide chelated iron@are containing 2～3
Individual amino acid whose small-peptide chelated type organic trace element.
A kind of compound recipe organic chelated microelement composition preparation method treating unusual semen and male infertility disease, its basis
Finished product difference to be made be divided into following some:
(1) capsule is made: by small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper, small peptide chelated iron@, albumen selenium for according to joining
Ratio mixes, and mixs homogeneously with quantitative carrier lactose or corn starch, the most encapsulated makes capsule；
(2) tablet is made: by small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper, small peptide chelated iron@, albumen selenium and carrier breast
Sugar or corn starch mix homogeneously, add magnesium stearate lubricant, mix homogeneously, pelletize when needing, then tablet made by tabletting；
(3) make other dosage forms to prepare by pharmacopeia conventional method.
The invention has the beneficial effects as follows: zinc is a kind of trace element necessary to spermiogenesis tail, and research shows zinc and seminal fluid
Quality is relevant, zinc concentration appreciable impact sperm concentration, motility of sperm in refining.Selenium is indispensable trace in animal body
One of element, as the important composition composition of glutathion peroxidase (GSH-Px), can eliminate the free radical that body produces；
Sperm is the most extremely sensitive to free radical, and scarce selenium can cause motility of sperm decline, mitochondria development and paramophia；Small-peptide chelated micro-
Secondary element and albumen selenium, absorption rate is high, is remarkably improved the amount retained of trace element in sperm, improves semen quality；This
The organic chelated microelement composition of compound recipe of invention, clinic application proves that it can improve the quality of sperm, makes sperm quantity
Increasing, spermatozoon activity strengthens, and survival rate improves, and can be greatly improved pregnancy rate, for prevention and the treatment of male infertility.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment
It is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under not making creative work premise, broadly falls into the model of present invention protection
Enclose.
Embodiment 1:
A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease, its primary raw material composition and matter
Amount proportion is: small-peptide chelated zinc 60, small-peptide chelated manganese 20, small-peptide chelated copper 5, small peptide chelated iron@30, albumen selenium is 3.
Described each raw material and carrier corn starch 120 parts is mixed homogeneously, the most encapsulated makes capsule.
Embodiment 2:
A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease, its primary raw material composition and matter
Amount proportion is: small-peptide chelated zinc 80, small-peptide chelated manganese 30, small-peptide chelated copper 6, small peptide chelated iron@40, albumen selenium is 4.
Described each raw material and carrier corn starch 160 parts is mixed homogeneously, the most encapsulated makes capsule.
Embodiment 3:
A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease, described in be that small-peptide chelated type has
Organic microelement and the compositions of albumen selenium, be made up of following component, and its primary raw material forms and quality proportion is: small-peptide chelated
Zinc 50, small-peptide chelated manganese 20, small-peptide chelated copper 4, small peptide chelated iron@30, albumen selenium is 2.
Described each raw material and carrier corn starch 100 parts is mixed homogeneously, the most encapsulated makes capsule.
Model case:
Lee, man, 35 years old, within 2 years after marriage, not educate, sexual life is normal, and on inspection, spouse is normal, diagnosis: row's essence one hour after essence
Sub-survival rate is 20%.Taking capsule of the present invention 10 days, living spermatozoa percentage reaches 75%.
Chen, man, 32 years old, within 1 year after marriage, not educate, sexual life is normal, and on inspection, spouse is normal, Sperm recovery: essence
Sub-vigor is 0, takes capsule of the present invention 10 days, and motility of sperm reaches 60%.
Wu, man, 38 years old, within 5 years after marriage, not educate, sexual life is normal, and on inspection, spouse is normal, and diagnosis: azoospermia is taken
This capsule 30 days, motility of sperm reaches 65%.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent,
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's
Within protection domain.
Claims (3)
1. treat the organic chelated microelement composition of compound recipe of unusual semen and male infertility disease, its primary raw material composition and
Quality proportion is: small-peptide chelated zinc 30～120, small-peptide chelated manganese 12～60, small-peptide chelated copper 2～10, small peptide chelated iron@20～
60, albumen selenium is 0.5～5.
A kind of organic chelated trace and REE elements of compound recipe treating unusual semen and male infertility disease the most according to claim 1
Thing, it is characterised in that described small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper and small peptide chelated iron@are containing 2～3
Individual amino acid whose small-peptide chelated type organic trace element.
3. treating a compound recipe organic chelated microelement composition preparation method for unusual semen and male infertility disease, its feature exists
In, its according to finished product difference to be made be divided into following some:
(1) capsule is made: by small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper, small peptide chelated iron@, albumen selenium for according to joining
Ratio mixes, and mixs homogeneously with quantitative carrier lactose or corn starch, the most encapsulated makes capsule；
(2) tablet is made: by small-peptide chelated zinc, small-peptide chelated manganese, small-peptide chelated copper, small peptide chelated iron@, albumen selenium and carrier breast
Sugar or corn starch mix homogeneously, add magnesium stearate lubricant, mix homogeneously, pelletize when needing, then tablet made by tabletting；
(3) make other dosage forms to prepare by pharmacopeia conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610413483.7A CN106074598A (en) | 2016-06-14 | 2016-06-14 | A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610413483.7A CN106074598A (en) | 2016-06-14 | 2016-06-14 | A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106074598A true CN106074598A (en) | 2016-11-09 |
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| CN201610413483.7A Pending CN106074598A (en) | 2016-06-14 | 2016-06-14 | A kind of organic chelated microelement composition of compound recipe treating unusual semen and male infertility disease and preparation method thereof |
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Citations (10)
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|---|---|---|---|---|
| JP2001314175A (en) * | 2000-05-05 | 2001-11-13 | Bio Venture Bank Kk | New nutritional supplementary food |
| CN1457799A (en) * | 2002-05-12 | 2003-11-26 | 中山市三才医药集团有限公司 | Compound composition for curing male's sterility |
| CN1698857A (en) * | 2005-05-12 | 2005-11-23 | 李国成 | Medicine with chondriomere distortion preventing function |
| CN101057677A (en) * | 2007-04-27 | 2007-10-24 | 李卫平 | Xinxi nutrient supplement |
| CN101167735A (en) * | 2006-10-27 | 2008-04-30 | 黄胜先 | Medicine for improving sperm quality and treating man's sterility |
| CN101953844A (en) * | 2010-02-28 | 2011-01-26 | 黄胜先 | Medicament for improving sperm quality and treating male sterility |
| CN102846673A (en) * | 2012-03-21 | 2013-01-02 | 陈浩 | Composition for improving human sperm motility and quality |
| US20130295068A1 (en) * | 2006-02-03 | 2013-11-07 | Fapa Vital Anstalt | Combination preparation for improving sperm quality |
| CN104041811A (en) * | 2014-06-13 | 2014-09-17 | 沈阳农业大学 | Taurine compound preparation for improving sexual function and semen quality of male |
| CN104664404A (en) * | 2013-12-02 | 2015-06-03 | 林南 | Zinc and selenium contained health care drug |
-
2016
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Patent Citations (10)
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|---|---|---|---|---|
| JP2001314175A (en) * | 2000-05-05 | 2001-11-13 | Bio Venture Bank Kk | New nutritional supplementary food |
| CN1457799A (en) * | 2002-05-12 | 2003-11-26 | 中山市三才医药集团有限公司 | Compound composition for curing male's sterility |
| CN1698857A (en) * | 2005-05-12 | 2005-11-23 | 李国成 | Medicine with chondriomere distortion preventing function |
| US20130295068A1 (en) * | 2006-02-03 | 2013-11-07 | Fapa Vital Anstalt | Combination preparation for improving sperm quality |
| CN101167735A (en) * | 2006-10-27 | 2008-04-30 | 黄胜先 | Medicine for improving sperm quality and treating man's sterility |
| CN101057677A (en) * | 2007-04-27 | 2007-10-24 | 李卫平 | Xinxi nutrient supplement |
| CN101953844A (en) * | 2010-02-28 | 2011-01-26 | 黄胜先 | Medicament for improving sperm quality and treating male sterility |
| CN102846673A (en) * | 2012-03-21 | 2013-01-02 | 陈浩 | Composition for improving human sperm motility and quality |
| CN104664404A (en) * | 2013-12-02 | 2015-06-03 | 林南 | Zinc and selenium contained health care drug |
| CN104041811A (en) * | 2014-06-13 | 2014-09-17 | 沈阳农业大学 | Taurine compound preparation for improving sexual function and semen quality of male |
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Application publication date: 20161109 |
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