CL2023003730A1 - Proteina de fusion entre pd-1 e il-2 y métodos de uso de las mismas. - Google Patents

Proteina de fusion entre pd-1 e il-2 y métodos de uso de las mismas.

Info

Publication number
CL2023003730A1
CL2023003730A1 CL2023003730A CL2023003730A CL2023003730A1 CL 2023003730 A1 CL2023003730 A1 CL 2023003730A1 CL 2023003730 A CL2023003730 A CL 2023003730A CL 2023003730 A CL2023003730 A CL 2023003730A CL 2023003730 A1 CL2023003730 A1 CL 2023003730A1
Authority
CL
Chile
Prior art keywords
methods
fusion protein
same
moiety
antigen
Prior art date
Application number
CL2023003730A
Other languages
English (en)
Spanish (es)
Inventor
Lin Chia-Yang
Wu Jiaxi
Bloch Nicolin
Zhang Tong
Davis Samuel
Smith Eric
Ullman Erica
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of CL2023003730A1 publication Critical patent/CL2023003730A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CL2023003730A 2021-06-14 2023-12-13 Proteina de fusion entre pd-1 e il-2 y métodos de uso de las mismas. CL2023003730A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163210111P 2021-06-14 2021-06-14
US202263365375P 2022-05-26 2022-05-26

Publications (1)

Publication Number Publication Date
CL2023003730A1 true CL2023003730A1 (es) 2024-07-05

Family

ID=82361286

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2023003730A CL2023003730A1 (es) 2021-06-14 2023-12-13 Proteina de fusion entre pd-1 e il-2 y métodos de uso de las mismas.
CL2024003382A CL2024003382A1 (es) 2021-06-14 2024-11-05 Proteína de fusión que comprende un resto de anti-pd-1 y un resto de il2, y su uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2024003382A CL2024003382A1 (es) 2021-06-14 2024-11-05 Proteína de fusión que comprende un resto de anti-pd-1 y un resto de il2, y su uso.

Country Status (12)

Country Link
US (1) US12528851B2 (https=)
EP (1) EP4355427A1 (https=)
JP (1) JP2024521472A (https=)
KR (1) KR20240021194A (https=)
AU (1) AU2022292792A1 (https=)
BR (1) BR112023023787A2 (https=)
CL (2) CL2023003730A1 (https=)
CO (1) CO2023015593A2 (https=)
IL (1) IL308369A (https=)
MX (1) MX2023014905A (https=)
TW (1) TW202317623A (https=)
WO (1) WO2022266598A1 (https=)

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WO2025080538A1 (en) 2023-10-09 2025-04-17 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a combination of a pd1 inhibitor and a targeted immunocytokine
US20250114469A1 (en) 2023-10-09 2025-04-10 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING CANCER WITH A COMBINATION OF A TAAxCD3 BISPECIFIC ANTIBODY AND A TARGETED IMMUNOCYTOKINE
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Also Published As

Publication number Publication date
CL2024003382A1 (es) 2025-03-28
IL308369A (en) 2024-01-01
US12528851B2 (en) 2026-01-20
WO2022266598A1 (en) 2022-12-22
KR20240021194A (ko) 2024-02-16
AU2022292792A1 (en) 2024-01-04
US20220402989A1 (en) 2022-12-22
EP4355427A1 (en) 2024-04-24
JP2024521472A (ja) 2024-05-31
MX2023014905A (es) 2024-02-14
TW202317623A (zh) 2023-05-01
BR112023023787A2 (pt) 2024-02-20
CO2023015593A2 (es) 2023-11-30

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