CL2023002879A1 - Emulsiones para anestésicos locales - Google Patents
Emulsiones para anestésicos localesInfo
- Publication number
- CL2023002879A1 CL2023002879A1 CL2023002879A CL2023002879A CL2023002879A1 CL 2023002879 A1 CL2023002879 A1 CL 2023002879A1 CL 2023002879 A CL2023002879 A CL 2023002879A CL 2023002879 A CL2023002879 A CL 2023002879A CL 2023002879 A1 CL2023002879 A1 CL 2023002879A1
- Authority
- CL
- Chile
- Prior art keywords
- emulsion
- local anesthetic
- emulsions
- local anesthetics
- oil
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 6
- 239000003589 local anesthetic agent Substances 0.000 title abstract 4
- 229960005015 local anesthetics Drugs 0.000 title 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una emulsión y el uso de una emulsión para el alivio del dolor que comprende un anestésico local, lecitina, aceite y una fase acuosa, en donde el anestésico local no es covalente unido a las gotas de aceite de la emulsión y la emulsión es física y químicamente estable y la emulsión proporciona una mejor seguridad, farmacocinética de liberación prolongada y una duración prolongada de la acción del anestésico local.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163169121P | 2021-03-31 | 2021-03-31 | |
US17/369,369 US11992483B2 (en) | 2021-03-31 | 2021-07-07 | Emulsions for local anesthetics |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023002879A1 true CL2023002879A1 (es) | 2024-02-09 |
Family
ID=83450711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023002879A CL2023002879A1 (es) | 2021-03-31 | 2023-09-27 | Emulsiones para anestésicos locales |
Country Status (12)
Country | Link |
---|---|
US (1) | US11992483B2 (es) |
EP (1) | EP4313018A1 (es) |
JP (1) | JP2024512704A (es) |
KR (1) | KR20230163543A (es) |
CN (1) | CN117412743A (es) |
AU (1) | AU2022249201A1 (es) |
BR (1) | BR112023019572A2 (es) |
CA (1) | CA3212259A1 (es) |
CL (1) | CL2023002879A1 (es) |
CO (1) | CO2023012680A2 (es) |
MX (1) | MX2023011487A (es) |
WO (1) | WO2022212166A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
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US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
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US5693337A (en) | 1994-07-13 | 1997-12-02 | Wakamoto Pharmaceutical Co., Ltd. | Stable lipid emulsion |
BR9907832A (pt) | 1998-02-10 | 2000-10-31 | Sicor Inc | Composição de propofol contendo sulfito |
BE1011899A6 (fr) | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
DE69940735D1 (de) | 1998-07-17 | 2009-05-28 | Pacira Pharmaceuticals Inc | Biologisch abbaubare anordnungen zur kontrollierten freigabe eingeschlossener substanzen |
US7261903B1 (en) | 1999-02-22 | 2007-08-28 | Guy Weinberg | Lipid emulsions in the treatment of systemic poisoning |
US6100302A (en) | 1999-04-05 | 2000-08-08 | Baxter International Inc. | Propofol formulation with enhanced microbial characteristics |
US7476400B2 (en) | 2001-11-13 | 2009-01-13 | Ferndale Ip, Inc. | High-concentration lidocaine compositions and methods for their preparation |
WO2003105817A1 (en) | 2002-05-02 | 2003-12-24 | Fdl, Inc. | Novel parenteral composition comprising propofol |
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US8476010B2 (en) | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
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US20090192230A1 (en) | 2004-01-14 | 2009-07-30 | Koichi Takeda | Propofol-containing fat emulsion preparation |
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JP2008502690A (ja) | 2004-06-15 | 2008-01-31 | アンドリュー シァン チェン, | リン脂質組成物ならびにその調製方法および使用方法 |
WO2007000662A2 (en) | 2005-02-03 | 2007-01-04 | Taro Pharmaceuticals U.S.A., Inc. | Novel propofol composition comprising ascorbic acid or pharmaceutically acceptable salts thereof |
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US20090131538A1 (en) | 2005-05-27 | 2009-05-21 | Taro Pharmaceuticals North America, Inc. c/o Taro Pharmaceuticals U.S.A., Inc. | Novel propofol composition comprising a pharmaceutically acceptable salt of formaldehyde sulfoxylate |
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EP2034961A1 (de) | 2006-06-30 | 2009-03-18 | Gertrud Langhoff | Solubilisatformulierungen |
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US20100105125A1 (en) | 2008-10-24 | 2010-04-29 | Bioprocessh20 Llc | Systems, apparatuses and methods for cultivating microorganisms and mitigation of gases |
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US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
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-
2021
- 2021-07-07 US US17/369,369 patent/US11992483B2/en active Active
-
2022
- 2022-03-24 MX MX2023011487A patent/MX2023011487A/es unknown
- 2022-03-24 WO PCT/US2022/021721 patent/WO2022212166A1/en active Application Filing
- 2022-03-24 JP JP2023560488A patent/JP2024512704A/ja active Pending
- 2022-03-24 CN CN202280038196.6A patent/CN117412743A/zh active Pending
- 2022-03-24 BR BR112023019572A patent/BR112023019572A2/pt unknown
- 2022-03-24 CA CA3212259A patent/CA3212259A1/en active Pending
- 2022-03-24 KR KR1020237037464A patent/KR20230163543A/ko unknown
- 2022-03-24 EP EP22781919.0A patent/EP4313018A1/en active Pending
- 2022-03-24 AU AU2022249201A patent/AU2022249201A1/en active Pending
-
2023
- 2023-09-26 CO CONC2023/0012680A patent/CO2023012680A2/es unknown
- 2023-09-27 CL CL2023002879A patent/CL2023002879A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2022249201A1 (en) | 2023-09-21 |
US20220313669A1 (en) | 2022-10-06 |
EP4313018A1 (en) | 2024-02-07 |
JP2024512704A (ja) | 2024-03-19 |
KR20230163543A (ko) | 2023-11-30 |
MX2023011487A (es) | 2023-10-04 |
US11992483B2 (en) | 2024-05-28 |
BR112023019572A2 (pt) | 2023-11-14 |
WO2022212166A1 (en) | 2022-10-06 |
CO2023012680A2 (es) | 2023-11-20 |
CN117412743A (zh) | 2024-01-16 |
CA3212259A1 (en) | 2022-10-06 |
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