CL2023002583A1 - Ligandos peptídicos del receptor 3 de somatostatina restringidos conformacionales y sus conjugados y sus usos. - Google Patents
Ligandos peptídicos del receptor 3 de somatostatina restringidos conformacionales y sus conjugados y sus usos.Info
- Publication number
- CL2023002583A1 CL2023002583A1 CL2023002583A CL2023002583A CL2023002583A1 CL 2023002583 A1 CL2023002583 A1 CL 2023002583A1 CL 2023002583 A CL2023002583 A CL 2023002583A CL 2023002583 A CL2023002583 A CL 2023002583A CL 2023002583 A1 CL2023002583 A1 CL 2023002583A1
- Authority
- CL
- Chile
- Prior art keywords
- somatostatin receptor
- conjugates
- peptide ligands
- conformationally restricted
- somatostatin
- Prior art date
Links
- 102000004117 Somatostatin receptor 3 Human genes 0.000 title abstract 3
- 108090000674 Somatostatin receptor 3 Proteins 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229940075620 somatostatin analogue Drugs 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Las realizaciones de la invención se refieren a péptidos selectivos del receptor de somatostatina para el receptor 3 de somatostatina, métodos para sintetizar análogos de somatostatina y composiciones farmacéuticas y radiofarmacéuticas que comprenden análogos del receptor 3 de somatostatina y métodos para usar tales composiciones para tratamiento y diagnóstico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163156374P | 2021-03-04 | 2021-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023002583A1 true CL2023002583A1 (es) | 2024-01-05 |
Family
ID=83154927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023002583A CL2023002583A1 (es) | 2021-03-04 | 2023-08-31 | Ligandos peptídicos del receptor 3 de somatostatina restringidos conformacionales y sus conjugados y sus usos. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240165282A1 (es) |
| EP (1) | EP4301392A4 (es) |
| JP (1) | JP2024508880A (es) |
| CN (1) | CN117042789A (es) |
| AU (1) | AU2022228766A1 (es) |
| CA (1) | CA3208792A1 (es) |
| CL (1) | CL2023002583A1 (es) |
| IL (1) | IL305248A (es) |
| WO (1) | WO2022185315A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115583989B (zh) * | 2022-12-09 | 2023-02-28 | 烟台蓝纳成生物技术有限公司 | 一种靶向sstr2的化合物及其制备方法和应用 |
| CN118064372B (zh) * | 2024-04-24 | 2024-07-05 | 四川大学华西医院 | 卡波西样血管内皮瘤消化液及其用途、消化方法、原代细胞培养方法和原代细胞 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6579967B1 (en) * | 1999-12-14 | 2003-06-17 | The Salk Institute For Biological Studies | Receptor-selective somatostatin analogs |
| CN101883785B (zh) * | 2007-12-03 | 2014-01-15 | 意大利法尔马科有限公司 | 新的非选择性生长抑素类似物 |
| PL3166967T3 (pl) * | 2014-09-14 | 2023-07-24 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Syntetyczne ligandy receptora somatostatyny |
-
2022
- 2022-03-03 JP JP2023553138A patent/JP2024508880A/ja active Pending
- 2022-03-03 CA CA3208792A patent/CA3208792A1/en active Pending
- 2022-03-03 IL IL305248A patent/IL305248A/en unknown
- 2022-03-03 AU AU2022228766A patent/AU2022228766A1/en active Pending
- 2022-03-03 WO PCT/IL2022/050238 patent/WO2022185315A1/en active Application Filing
- 2022-03-03 EP EP22762741.1A patent/EP4301392A4/en active Pending
- 2022-03-03 CN CN202280018472.2A patent/CN117042789A/zh active Pending
- 2022-03-03 US US18/548,898 patent/US20240165282A1/en active Pending
-
2023
- 2023-08-31 CL CL2023002583A patent/CL2023002583A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4301392A1 (en) | 2024-01-10 |
| EP4301392A4 (en) | 2024-08-21 |
| IL305248A (en) | 2023-10-01 |
| CN117042789A (zh) | 2023-11-10 |
| AU2022228766A1 (en) | 2023-09-07 |
| JP2024508880A (ja) | 2024-02-28 |
| WO2022185315A1 (en) | 2022-09-09 |
| US20240165282A1 (en) | 2024-05-23 |
| CA3208792A1 (en) | 2022-09-09 |
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