CL2023002578A1 - Derivados de alfa-d-galatopiranosido triazolil-metil sustituidos - Google Patents

Derivados de alfa-d-galatopiranosido triazolil-metil sustituidos

Info

Publication number
CL2023002578A1
CL2023002578A1 CL2023002578A CL2023002578A CL2023002578A1 CL 2023002578 A1 CL2023002578 A1 CL 2023002578A1 CL 2023002578 A CL2023002578 A CL 2023002578A CL 2023002578 A CL2023002578 A CL 2023002578A CL 2023002578 A1 CL2023002578 A1 CL 2023002578A1
Authority
CL
Chile
Prior art keywords
galatopyranoside
triazolyl
derivatives
methyl substituted
substituted alpha
Prior art date
Application number
CL2023002578A
Other languages
English (en)
Inventor
Grisostomi Corinna
Sager Christoph
Zumbrunn Cornelia
Bolli Martin
Gatfield John
Remen Lubos
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2023002578A1 publication Critical patent/CL2023002578A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06Heterocyclic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a los compuestos de la Fórmula (I), en donde A, R1, R2, RP2, RP3 y RP4 son como se describe en la descripción, su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de la fórmula (I), y especialmente a su uso como inhibidores de Galectina-3.
CL2023002578A 2021-03-03 2023-08-31 Derivados de alfa-d-galatopiranosido triazolil-metil sustituidos CL2023002578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2021055348 2021-03-03

Publications (1)

Publication Number Publication Date
CL2023002578A1 true CL2023002578A1 (es) 2024-03-22

Family

ID=80682779

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002578A CL2023002578A1 (es) 2021-03-03 2023-08-31 Derivados de alfa-d-galatopiranosido triazolil-metil sustituidos

Country Status (13)

Country Link
US (1) US20240109930A1 (es)
EP (1) EP4301748A1 (es)
JP (1) JP2024509421A (es)
KR (1) KR20230154221A (es)
CN (1) CN116888113A (es)
AU (1) AU2022228660A1 (es)
BR (1) BR112023017624A2 (es)
CA (1) CA3209917A1 (es)
CL (1) CL2023002578A1 (es)
IL (1) IL305581A (es)
MX (1) MX2023010241A (es)
TW (1) TW202300146A (es)
WO (1) WO2022184755A1 (es)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100172D0 (sv) 2001-01-22 2001-01-22 Ulf Nilsson New inhibitors against galectins
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
SE0401301D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
CA2926917C (en) 2012-10-10 2021-01-05 Galectin Therapeutics, Inc. Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders
ES2817888T3 (es) 2012-10-31 2021-04-08 Galecto Biotech Ab Inhibidor de galactósido de galectina-3 y su uso para tratar fibrosis pulmonar
WO2014078655A1 (en) 2012-11-15 2014-05-22 Tufts University Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor
CN107406478B (zh) 2015-01-30 2021-07-27 格莱克特生物技术公司 半乳糖凝集素的α-D-半乳糖苷抑制剂
JP6430060B2 (ja) 2015-07-06 2018-11-28 ギリアード サイエンシーズ, インコーポレイテッド Cotモジュレーターおよびその使用方法
CA3062648A1 (en) 2017-05-12 2018-11-15 Galectin Sciences, Llc Compounds for the prevention and treatment of diseases and the use thereof
CA3062649A1 (en) 2017-05-12 2018-11-15 Galectin Sciences, Llc Compounds for the treatment of systemic insulin resistance disorders and the use thereof
WO2019067702A1 (en) 2017-09-27 2019-04-04 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
WO2019075045A1 (en) 2017-10-11 2019-04-18 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
CN111527097A (zh) 2017-10-31 2020-08-11 卡莱克汀科学有限责任公司 用于治疗全身性胰岛素抵抗障碍的硒代半乳糖苷化合物及其用途
JP7486484B2 (ja) 2018-11-21 2024-05-17 ガレクト バイオテック エービー ガレクチンのα-D-ガラクトシド阻害剤
WO2020210308A1 (en) * 2019-04-10 2020-10-15 Bristol-Myers Squibb Company Small molecule inhibitors of galectin-3
CA3141436A1 (en) 2019-07-03 2021-01-07 Fredrik Zetterberg Novel galactoside inhibitor of galectins
EP3994135A1 (en) 2019-07-05 2022-05-11 Galecto Biotech AB Novel galactoside inhibitor of galectins
TW202120102A (zh) 2019-08-09 2021-06-01 瑞士商愛杜西亞製藥有限公司 (雜)芳基-甲基-硫代-β-D-吡喃半乳糖苷衍生物
WO2021028323A1 (en) 2019-08-09 2021-02-18 Idorsia Pharmaceuticals Ltd (2-acetamidyl)thio-beta-d-galactopyranoside derivatives
WO2021028570A1 (en) 2019-08-15 2021-02-18 Idorsia Pharmaceuticals Ltd 2-hydroxycycloalkane-1-carbamoyl derivatives
RS65294B1 (sr) 2019-08-29 2024-04-30 Idorsia Pharmaceuticals Ltd Derivati alfa-d-galaktopiranozida

Also Published As

Publication number Publication date
WO2022184755A1 (en) 2022-09-09
EP4301748A1 (en) 2024-01-10
TW202300146A (zh) 2023-01-01
JP2024509421A (ja) 2024-03-01
CA3209917A1 (en) 2022-09-09
MX2023010241A (es) 2023-09-12
AU2022228660A1 (en) 2023-10-19
IL305581A (en) 2023-10-01
CN116888113A (zh) 2023-10-13
KR20230154221A (ko) 2023-11-07
BR112023017624A2 (pt) 2023-10-10
US20240109930A1 (en) 2024-04-04

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