CL2023001392A1 - Anticuerpo biespecífico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8 - Google Patents

Anticuerpo biespecífico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8

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Publication number
CL2023001392A1
CL2023001392A1 CL2023001392A CL2023001392A CL2023001392A1 CL 2023001392 A1 CL2023001392 A1 CL 2023001392A1 CL 2023001392 A CL2023001392 A CL 2023001392A CL 2023001392 A CL2023001392 A CL 2023001392A CL 2023001392 A1 CL2023001392 A1 CL 2023001392A1
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CL
Chile
Prior art keywords
tspan8
antibody
cancer cell
peritoneal
antibodies
Prior art date
Application number
CL2023001392A
Other languages
English (en)
Inventor
Yoshiyuki Tenda
Masatoshi Yuri
Daisuke Yamajuku
Takeshi Tsutsumi
Yuko Kusuzaki
Hiroki Sasaki
Fumiko Chiwaki
Masayuki Komatsu
Original Assignee
Astellas Pharma Inc
Nat Cancer Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Astellas Pharma Inc, Nat Cancer Ct filed Critical Astellas Pharma Inc
Publication of CL2023001392A1 publication Critical patent/CL2023001392A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

Un objetivo de la presente invención es proporcionar un anticuerpo anti-TSPAN8/antiCD3 específico y un anticuerpo anti-TSPAN8 utilizable en el tratamiento o prevención en un ser humano. Se inmunizó un ratón productor de anticuerpos monoclonales humanos con una célula cancerosa diseminada peritoneal aislada de un paciente, para obtener un anticuerpo 16B11 y un anticuerpo 16B12 que se unen selectivamente a una célula cancerosa diseminada peritoneal. Estos anticuerpos eran anticuerpos anti-TSPAN8 que se unen a la región de las posiciones de aminoácidos 126 a 155 de TSPAN8 y mostraron una fuerte actividad de unión a TSPAN8 expresada en la célula cancerosa diseminada peritoneal. Además, un anticuerpo biespecífico anti-TSPAN8 (16B11) -anti-CD3 producido sobre la base de la secuencia de 16B11 exhibió una actividad citotóxica contra la célula cancerosa que expresa TSPAN8 in vitro, ejerció una acción antitumoral en ratones portadores de células cancerosas que expresan TSPAN in vivo, y prolongaron la vida útil de los ratones modelo de diseminación peritoneal.
CL2023001392A 2020-11-16 2023-05-15 Anticuerpo biespecífico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8 CL2023001392A1 (es)

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JP2020189988 2020-11-16

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CL2023001392A1 true CL2023001392A1 (es) 2023-10-13

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US (2) US11897954B2 (es)
EP (1) EP4245855A1 (es)
JP (2) JP7078237B1 (es)
KR (1) KR20230108288A (es)
CN (1) CN116635071A (es)
AR (1) AR124063A1 (es)
AU (1) AU2021378575A1 (es)
CA (1) CA3200860A1 (es)
CL (1) CL2023001392A1 (es)
CO (1) CO2023007734A2 (es)
CR (1) CR20230244A (es)
DO (1) DOP2023000096A (es)
EC (1) ECSP23034684A (es)
IL (1) IL302544A (es)
MX (1) MX2023005346A (es)
PE (1) PE20240224A1 (es)
TW (1) TW202229353A (es)
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TW202404638A (zh) * 2022-04-13 2024-02-01 日商安斯泰來製藥股份有限公司 抗ｔｓｐａｎ８－抗ｃｄ３雙特異性抗體之與ｐｄ－１訊息抑制劑之組合在癌治療的用途
WO2023219121A1 (ja) * 2022-05-12 2023-11-16 アステラス製薬株式会社 抗ｔａａ－抗ｃｄ３多重特異性抗体

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JP6159010B2 (ja) 2013-03-15 2017-07-05 ザ・トランスレーショナル・ジェノミクス・リサーチ・インスティチュート テトラスパニン８に対するハイブリドーマクローンおよびモノクローナル抗体
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KR20150130115A (ko) 2014-05-13 2015-11-23 연세대학교 산학협력단 상온 대기압 플라즈마를 이용한 치은 섬유아세포의 세포활성도 촉진 방법
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JP7072792B2 (ja) 2017-12-11 2022-05-23 国立大学法人神戸大学 二重特異性抗体

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US11897954B2 (en) 2024-02-13
JPWO2022102768A1 (es) 2022-05-19
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US20230348587A1 (en) 2023-11-02
JP2022079486A (ja) 2022-05-26
AU2021378575A1 (en) 2023-06-22
CN116635071A (zh) 2023-08-22
MX2023005346A (es) 2023-05-22
CO2023007734A2 (es) 2023-06-30
ECSP23034684A (es) 2023-06-30
IL302544A (en) 2023-07-01
DOP2023000096A (es) 2023-06-15
PE20240224A1 (es) 2024-02-16
CR20230244A (es) 2023-07-12
US20240166736A1 (en) 2024-05-23
CA3200860A1 (en) 2022-05-19
AR124063A1 (es) 2023-02-08
TW202229353A (zh) 2022-08-01
EP4245855A1 (en) 2023-09-20
WO2022102768A1 (ja) 2022-05-19

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