CL2023000992A1 - Procedimiento para racemizar y aislar atropisómeros de 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidin-2,4(1h,3h)-diona - Google Patents
Procedimiento para racemizar y aislar atropisómeros de 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidin-2,4(1h,3h)-dionaInfo
- Publication number
- CL2023000992A1 CL2023000992A1 CL2023000992A CL2023000992A CL2023000992A1 CL 2023000992 A1 CL2023000992 A1 CL 2023000992A1 CL 2023000992 A CL2023000992 A CL 2023000992A CL 2023000992 A CL2023000992 A CL 2023000992A CL 2023000992 A1 CL2023000992 A1 CL 2023000992A1
- Authority
- CL
- Chile
- Prior art keywords
- isolating
- procedure
- racemizing
- atropisomers
- methylpyridin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- OXJTVPMAMRSGNT-UHFFFAOYSA-N 7-chloro-6-fluoro-1-(4-methyl-2-propan-2-ylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4-dione Chemical compound ClC=1C(=CC2=C(N(C(NC2=O)=O)C=2C(=NC=CC=2C)C(C)C)N=1)F OXJTVPMAMRSGNT-UHFFFAOYSA-N 0.000 title 1
- 229940126062 Compound A Drugs 0.000 abstract 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 3
- 229940095064 tartrate Drugs 0.000 abstract 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporciona en el presente documento un procedimiento que comprende calentar una composición que comprende el (P)-compuesto A o una sal del mismo y un disolvente hasta una temperatura de 250 grados Celsius a 350 grados Celsius para formar el compuesto A racemizado. También se proporciona un procedimiento para aislar el (P)-compuesto A de una composición que comprende el (P)-compuesto A y un tartrato, tal como se describe en el presente documento. Se proporciona además en el presente documento, un procedimiento para aislar un ácido libre de un tartrato o a hidrato del mismo de una composición que comprende un tartrato, (P)-compuesto A, y un disolvente orgánico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063088848P | 2020-10-07 | 2020-10-07 | |
US202163162278P | 2021-03-17 | 2021-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023000992A1 true CL2023000992A1 (es) | 2023-09-15 |
Family
ID=78500740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023000992A CL2023000992A1 (es) | 2020-10-07 | 2023-04-05 | Procedimiento para racemizar y aislar atropisómeros de 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidin-2,4(1h,3h)-diona |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230391771A1 (es) |
EP (1) | EP4225755A1 (es) |
JP (1) | JP2023544775A (es) |
KR (1) | KR20230083318A (es) |
CN (1) | CN116323611A (es) |
AU (1) | AU2021357815A1 (es) |
CA (1) | CA3196612A1 (es) |
CL (1) | CL2023000992A1 (es) |
IL (1) | IL301517A (es) |
MX (1) | MX2023003983A (es) |
TW (1) | TW202229276A (es) |
WO (1) | WO2022076623A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022246069A1 (en) | 2021-05-19 | 2022-11-24 | Teva Pharmaceuticals International Gmbh | Process for preparation of sotorasib and solid state form thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2382074A (en) * | 2001-11-14 | 2003-05-21 | Basf Ag | Recovery of chiral tartaric acid resolving agents |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
JP2020090482A (ja) * | 2018-11-16 | 2020-06-11 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
-
2021
- 2021-10-06 JP JP2023520495A patent/JP2023544775A/ja active Pending
- 2021-10-06 KR KR1020237015187A patent/KR20230083318A/ko unknown
- 2021-10-06 EP EP21802088.1A patent/EP4225755A1/en active Pending
- 2021-10-06 US US18/030,685 patent/US20230391771A1/en active Pending
- 2021-10-06 CN CN202180068032.3A patent/CN116323611A/zh active Pending
- 2021-10-06 MX MX2023003983A patent/MX2023003983A/es unknown
- 2021-10-06 WO PCT/US2021/053859 patent/WO2022076623A1/en active Application Filing
- 2021-10-06 CA CA3196612A patent/CA3196612A1/en active Pending
- 2021-10-06 AU AU2021357815A patent/AU2021357815A1/en active Pending
- 2021-10-06 IL IL301517A patent/IL301517A/en unknown
- 2021-10-07 TW TW110137330A patent/TW202229276A/zh unknown
-
2023
- 2023-04-05 CL CL2023000992A patent/CL2023000992A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP4225755A1 (en) | 2023-08-16 |
IL301517A (en) | 2023-05-01 |
US20230391771A1 (en) | 2023-12-07 |
CA3196612A1 (en) | 2022-04-14 |
MX2023003983A (es) | 2023-04-24 |
CN116323611A (zh) | 2023-06-23 |
WO2022076623A1 (en) | 2022-04-14 |
KR20230083318A (ko) | 2023-06-09 |
TW202229276A (zh) | 2022-08-01 |
JP2023544775A (ja) | 2023-10-25 |
AU2021357815A1 (en) | 2023-04-20 |
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