CL2021003468A1 - Una formulación de un conjugado de un análogo de tubulisina con una molécula de unión celular - Google Patents
Una formulación de un conjugado de un análogo de tubulisina con una molécula de unión celularInfo
- Publication number
- CL2021003468A1 CL2021003468A1 CL2021003468A CL2021003468A CL2021003468A1 CL 2021003468 A1 CL2021003468 A1 CL 2021003468A1 CL 2021003468 A CL2021003468 A CL 2021003468A CL 2021003468 A CL2021003468 A CL 2021003468A CL 2021003468 A1 CL2021003468 A1 CL 2021003468A1
- Authority
- CL
- Chile
- Prior art keywords
- tubulisin
- formulation
- binding molecule
- cell binding
- conjugate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Communicable Diseases (AREA)
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Abstract
Una formulación de conjugados de los análogos de tubulisina con una molécula de unión celular que tiene una estructura representada por la Fórmula (I), en donde T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 y R13 son como se define en la presente, se pueden usar para el tratamiento dirigido para el cáncer, la enfermedad autoinmunitaria y la enfermedad infecciosa
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2019/092614 WO2020257998A1 (en) | 2019-06-24 | 2019-06-24 | A conjugate of a cytotoxic agent to a cell binding molecule with branched linkers |
PCT/CN2019/093946 WO2021000067A1 (zh) | 2019-06-29 | 2019-06-29 | 一种细胞结合分子-Tubulysin衍生物偶联物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021003468A1 true CL2021003468A1 (es) | 2022-10-07 |
Family
ID=74061434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021003468A CL2021003468A1 (es) | 2019-06-24 | 2021-12-24 | Una formulación de un conjugado de un análogo de tubulisina con una molécula de unión celular |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220249594A1 (es) |
EP (1) | EP3986476A4 (es) |
JP (2) | JP2022544442A (es) |
KR (1) | KR20220024915A (es) |
CN (1) | CN114040781A (es) |
AU (1) | AU2020301115B2 (es) |
BR (1) | BR112021026009A2 (es) |
CA (1) | CA3142960C (es) |
CL (1) | CL2021003468A1 (es) |
IL (1) | IL288954A (es) |
MX (1) | MX2021015878A (es) |
SG (1) | SG11202113022UA (es) |
TW (1) | TW202144009A (es) |
WO (1) | WO2020258893A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2872157T3 (pl) | 2012-07-12 | 2020-07-13 | Hangzhou Dac Biotech Co., Ltd | Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi |
US11873281B2 (en) | 2012-07-12 | 2024-01-16 | Hangzhou Dac Biotech Co., Ltd. | Conjugates of cell binding molecules with cytotoxic agents |
WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
CA3108168A1 (en) * | 2020-02-05 | 2021-08-05 | Yue Zhang | Conjugates of cell-binding molecules with cytotoxic agents |
MX2022015769A (es) * | 2020-06-24 | 2023-01-19 | Regeneron Pharma | Tubulisinas y conjugados de proteina-tubulisina. |
CN112924588A (zh) * | 2021-01-27 | 2021-06-08 | 浙江公正检验中心有限公司 | 一种畜禽产品中氯霉素类、五氯酚同时测定的检测方法 |
CN114213540B (zh) * | 2022-02-22 | 2022-07-01 | 北京大学人民医院 | 一组用于髓系肿瘤免疫分型的抗体组合物及其应用 |
CN115124570B (zh) * | 2022-08-11 | 2024-06-25 | 万华化学集团股份有限公司 | 一种c3膦盐的制备方法 |
CN116239513B (zh) * | 2023-05-05 | 2023-08-18 | 天津凯莱英制药有限公司 | Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2872157T3 (pl) * | 2012-07-12 | 2020-07-13 | Hangzhou Dac Biotech Co., Ltd | Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi |
US10077287B2 (en) * | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
US9839687B2 (en) * | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
US10292961B2 (en) * | 2015-07-15 | 2019-05-21 | Hangzhou Dac Biotech Co., Ltd. | Disulfur bridge linkers for conjugation of a cell-binding molecule |
AU2016363013B2 (en) * | 2015-12-04 | 2022-03-10 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
JP2019518013A (ja) * | 2016-05-10 | 2019-06-27 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 安定性が向上したツブリシン類似体の抗体薬物結合体 |
CN109912683B (zh) * | 2017-12-13 | 2023-01-06 | 杭州多禧生物科技有限公司 | 一种细胞毒素分子、偶联物及其制备方法和应用 |
CN111093707A (zh) * | 2017-12-31 | 2020-05-01 | 杭州多禧生物科技有限公司 | 含支链连接体的Tubulysin同系物偶联物 |
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2020
- 2020-02-18 AU AU2020301115A patent/AU2020301115B2/en active Active
- 2020-02-18 CA CA3142960A patent/CA3142960C/en active Active
- 2020-02-18 EP EP20831886.5A patent/EP3986476A4/en active Pending
- 2020-02-18 US US17/596,956 patent/US20220249594A1/en active Pending
- 2020-02-18 BR BR112021026009A patent/BR112021026009A2/pt unknown
- 2020-02-18 SG SG11202113022UA patent/SG11202113022UA/en unknown
- 2020-02-18 CN CN202080032694.0A patent/CN114040781A/zh active Pending
- 2020-02-18 MX MX2021015878A patent/MX2021015878A/es unknown
- 2020-02-18 WO PCT/CN2020/075709 patent/WO2020258893A1/en unknown
- 2020-02-18 JP JP2021576898A patent/JP2022544442A/ja active Pending
- 2020-02-18 KR KR1020227002437A patent/KR20220024915A/ko active Search and Examination
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2021
- 2021-02-09 TW TW110104872A patent/TW202144009A/zh unknown
- 2021-12-13 IL IL288954A patent/IL288954A/en unknown
- 2021-12-24 CL CL2021003468A patent/CL2021003468A1/es unknown
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2023
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Publication number | Publication date |
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EP3986476A1 (en) | 2022-04-27 |
JP2022544442A (ja) | 2022-10-19 |
TW202144009A (zh) | 2021-12-01 |
AU2020301115B2 (en) | 2024-05-23 |
WO2020258893A1 (en) | 2020-12-30 |
CA3142960A1 (en) | 2020-12-30 |
EP3986476A4 (en) | 2023-11-15 |
AU2020301115A1 (en) | 2022-02-10 |
MX2021015878A (es) | 2022-03-22 |
US20220249594A1 (en) | 2022-08-11 |
BR112021026009A2 (pt) | 2022-02-08 |
CN114040781A (zh) | 2022-02-11 |
CA3142960C (en) | 2024-02-13 |
KR20220024915A (ko) | 2022-03-03 |
SG11202113022UA (en) | 2021-12-30 |
IL288954A (en) | 2022-02-01 |
JP2024028815A (ja) | 2024-03-05 |
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