CL2021003034A1 - Métodos de tratamiento del síndrome de sjögren utilizando un inhibidor de la tirosina quinasa de bruton - Google Patents

Métodos de tratamiento del síndrome de sjögren utilizando un inhibidor de la tirosina quinasa de bruton

Info

Publication number
CL2021003034A1
CL2021003034A1 CL2021003034A CL2021003034A CL2021003034A1 CL 2021003034 A1 CL2021003034 A1 CL 2021003034A1 CL 2021003034 A CL2021003034 A CL 2021003034A CL 2021003034 A CL2021003034 A CL 2021003034A CL 2021003034 A1 CL2021003034 A1 CL 2021003034A1
Authority
CL
Chile
Prior art keywords
sjögren
treatment
methods
syndrome
bruton
Prior art date
Application number
CL2021003034A
Other languages
English (en)
Spanish (es)
Inventor
Souvik Bhattacharya
Bruno Bieth
Maciej Cabanski
Bruno Cenni
Buck Stefan De
Martin Kaul
Arvind Kinhikar
Andrijana Radivojevic
Garami Alessandra Vitaliti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2021003034A1 publication Critical patent/CL2021003034A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2021003034A 2019-05-23 2021-11-17 Métodos de tratamiento del síndrome de sjögren utilizando un inhibidor de la tirosina quinasa de bruton CL2021003034A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962851994P 2019-05-23 2019-05-23

Publications (1)

Publication Number Publication Date
CL2021003034A1 true CL2021003034A1 (es) 2022-09-09

Family

ID=70918750

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021003034A CL2021003034A1 (es) 2019-05-23 2021-11-17 Métodos de tratamiento del síndrome de sjögren utilizando un inhibidor de la tirosina quinasa de bruton

Country Status (23)

Country Link
US (2) US12383556B2 (enExample)
EP (2) EP3972603B1 (enExample)
JP (2) JP7765970B2 (enExample)
KR (1) KR20220011652A (enExample)
CN (1) CN113811301A (enExample)
AU (2) AU2020278236C1 (enExample)
BR (1) BR112021023110A2 (enExample)
CA (1) CA3137271A1 (enExample)
CL (1) CL2021003034A1 (enExample)
DK (1) DK3972603T3 (enExample)
ES (1) ES3004516T3 (enExample)
FI (1) FI3972603T3 (enExample)
HR (1) HRP20241584T1 (enExample)
HU (1) HUE069020T2 (enExample)
IL (1) IL287745B2 (enExample)
LT (1) LT3972603T (enExample)
MX (1) MX2021014161A (enExample)
PL (1) PL3972603T3 (enExample)
PT (1) PT3972603T (enExample)
RS (1) RS66195B1 (enExample)
SI (1) SI3972603T1 (enExample)
TW (1) TWI857060B (enExample)
WO (1) WO2020234781A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12383556B2 (en) 2019-05-23 2025-08-12 Novartis Ag Methods of treating Sjögren's syndrome using a Bruton's tyrosine kinase inhibitor
EP4284344A1 (en) * 2021-01-26 2023-12-06 Novartis AG Pharmaceutical composition
IL310975A (en) 2021-09-03 2024-04-01 Novartis Ag LOU064 for the treatment of multiple sclerosis
CA3239276A1 (en) 2021-12-14 2023-06-22 Novartis Ag Methods of treatment using lou064
TW202342048A (zh) 2022-02-28 2023-11-01 瑞士商諾華公司 使用ｌｏｕ０６４治療化膿性汗腺炎之方法
KR102875105B1 (ko) 2023-04-03 2025-10-21 주식회사 사이알바이오 재조합 세마포린 4d 차단항체를 유효성분으로 포함하는 쇼그렌 증후군 예방 또는 치료용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213100A (pt) 2001-10-05 2004-11-30 Combinatorx Inc Combinações para o tratamento de distúrbios imuniinflamatórios
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
HRP20211845T1 (hr) 2015-12-16 2022-03-04 Boehringer Ingelheim International Gmbh Derivati bipirazolila korisni za liječenje autoimunih bolesti
US10570118B2 (en) * 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
US10874741B2 (en) 2017-08-28 2020-12-29 Spectrix Therapeutics, LLC Compound to treat Sjogren's syndrome
EP3704158A1 (en) 2017-11-03 2020-09-09 Novartis AG Anti-cd40 antibodies for use in treatment of sjögren's syndrome
TWI694995B (zh) * 2017-11-06 2020-06-01 美商美國禮來大藥廠 Btk抑制劑化合物
US12383556B2 (en) 2019-05-23 2025-08-12 Novartis Ag Methods of treating Sjögren's syndrome using a Bruton's tyrosine kinase inhibitor

Also Published As

Publication number Publication date
PL3972603T3 (pl) 2025-02-03
BR112021023110A2 (pt) 2022-04-12
IL287745A (en) 2021-12-01
DK3972603T3 (da) 2024-12-02
EP4442321A2 (en) 2024-10-09
SI3972603T1 (sl) 2025-02-28
MX2021014161A (es) 2022-01-04
AU2020278236B2 (en) 2025-08-07
RS66195B1 (sr) 2024-12-31
EP4442321A3 (en) 2025-01-01
JP2022533968A (ja) 2022-07-27
PT3972603T (pt) 2024-11-26
FI3972603T3 (fi) 2024-12-04
US20220175772A1 (en) 2022-06-09
JP7765970B2 (ja) 2025-11-07
TW202110451A (zh) 2021-03-16
AU2020278236C1 (en) 2026-02-26
WO2020234781A1 (en) 2020-11-26
TWI857060B (zh) 2024-10-01
KR20220011652A (ko) 2022-01-28
EP3972603B1 (en) 2024-09-04
EP3972603A1 (en) 2022-03-30
HRP20241584T1 (hr) 2025-01-31
HUE069020T2 (hu) 2025-02-28
US12383556B2 (en) 2025-08-12
JP2025165957A (ja) 2025-11-05
CN113811301A (zh) 2021-12-17
US20250339428A1 (en) 2025-11-06
AU2020278236A1 (en) 2022-01-06
IL287745B2 (en) 2026-02-01
IL287745B1 (en) 2025-10-01
CA3137271A1 (en) 2020-11-26
ES3004516T3 (en) 2025-03-12
AU2020278236A8 (en) 2022-04-28
LT3972603T (lt) 2024-12-10
AU2025263830A1 (en) 2025-11-27

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