MX2019011620A - Dosis y regimen para un inhibidor de la interaccion de hdm2-p53 en tumores hematologicos. - Google Patents
Dosis y regimen para un inhibidor de la interaccion de hdm2-p53 en tumores hematologicos.Info
- Publication number
- MX2019011620A MX2019011620A MX2019011620A MX2019011620A MX2019011620A MX 2019011620 A MX2019011620 A MX 2019011620A MX 2019011620 A MX2019011620 A MX 2019011620A MX 2019011620 A MX2019011620 A MX 2019011620A MX 2019011620 A MX2019011620 A MX 2019011620A
- Authority
- MX
- Mexico
- Prior art keywords
- hdm2
- regimen
- hematological tumors
- dose
- interaction inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente invención se refiere a un inhibidor de la interacción de HDM2-p53 (S)-5-(5-Cloro-1-metil-2-oxo-1,2-dihidro-piridin-3-il) -6-(4-cloro-fenil)-2-(2,4-dimetoxi-pirimidin-5-il)-1-isopropil-5, 6-dihidro-1H-pirrolo[3,4-d]imidazol-4-ona (HDM201), o un derivado no covalente farmacéuticamente aceptable del mismo, para uso en el tratamiento de pacientes con tumores hematológicos, en donde el fármaco se administra siguiendo un régimen prolongado de dosificación baja.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762479397P | 2017-03-31 | 2017-03-31 | |
PCT/IB2018/052187 WO2018178925A1 (en) | 2017-03-31 | 2018-03-29 | Dose and regimen for an hdm2-p53 interaction inhibitor in hematological tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019011620A true MX2019011620A (es) | 2019-12-05 |
Family
ID=62025902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019011620A MX2019011620A (es) | 2017-03-31 | 2018-03-29 | Dosis y regimen para un inhibidor de la interaccion de hdm2-p53 en tumores hematologicos. |
Country Status (13)
Country | Link |
---|---|
US (2) | US20200281925A1 (es) |
EP (1) | EP3600326B1 (es) |
JP (1) | JP6617208B2 (es) |
KR (1) | KR20190129889A (es) |
CN (1) | CN110392573A (es) |
AU (1) | AU2018242612B2 (es) |
CA (1) | CA3052543A1 (es) |
ES (1) | ES2942419T3 (es) |
IL (1) | IL268993A (es) |
MX (1) | MX2019011620A (es) |
RU (1) | RU2753527C2 (es) |
TW (1) | TWI771398B (es) |
WO (1) | WO2018178925A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
CA3043004A1 (en) | 2016-11-15 | 2018-05-24 | Novartis Ag | Dose and regimen for hdm2-p53 interaction inhibitors |
AU2019400978A1 (en) | 2018-12-20 | 2021-06-24 | Novartis Ag | Extended low dose regimens for MDM2 inhibitors |
EP4031139A1 (en) | 2019-09-16 | 2022-07-27 | Novartis AG | Use of an mdm2 inhibitor for the treatment of myelofibrosis |
KR20220098755A (ko) | 2019-11-05 | 2022-07-12 | 애브비 인코포레이티드 | 나비토클락스를 사용한 골수섬유증 및 mpn 관련 장애 치료에 사용하기 위한 투약 레지멘 |
WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY34591A (es) * | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
US20130245089A1 (en) | 2012-03-19 | 2013-09-19 | Hoffmann-La Roche Inc. | Method for administration |
MX2015016344A (es) * | 2013-05-27 | 2016-03-01 | Novartis Ag | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. |
WO2015084804A1 (en) * | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
ES2785203T3 (es) * | 2013-12-05 | 2020-10-06 | Hoffmann La Roche | Tratamiento de combinación novedoso para leucemia mielógena aguda (LMA) |
CN105848682A (zh) * | 2013-12-23 | 2016-08-10 | 诺华股份有限公司 | 药物组合 |
US9290505B2 (en) * | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
TW201613576A (en) * | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
JP6823587B2 (ja) * | 2015-04-13 | 2021-02-03 | 第一三共株式会社 | Mdm2阻害剤とbtk阻害剤との併用治療法 |
TWI750129B (zh) * | 2015-08-03 | 2021-12-21 | 瑞士商諾華公司 | 作為血液學毒性生物標記之gdf-15 |
AU2016314082B2 (en) * | 2015-08-28 | 2019-07-25 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
CA3043004A1 (en) * | 2016-11-15 | 2018-05-24 | Novartis Ag | Dose and regimen for hdm2-p53 interaction inhibitors |
-
2018
- 2018-03-29 KR KR1020197028073A patent/KR20190129889A/ko not_active Application Discontinuation
- 2018-03-29 EP EP18718926.1A patent/EP3600326B1/en active Active
- 2018-03-29 WO PCT/IB2018/052187 patent/WO2018178925A1/en active Application Filing
- 2018-03-29 AU AU2018242612A patent/AU2018242612B2/en active Active
- 2018-03-29 US US16/494,927 patent/US20200281925A1/en not_active Abandoned
- 2018-03-29 ES ES18718926T patent/ES2942419T3/es active Active
- 2018-03-29 RU RU2019130325A patent/RU2753527C2/ru active
- 2018-03-29 JP JP2018560565A patent/JP6617208B2/ja active Active
- 2018-03-29 MX MX2019011620A patent/MX2019011620A/es unknown
- 2018-03-29 CN CN201880015785.6A patent/CN110392573A/zh not_active Withdrawn
- 2018-03-29 CA CA3052543A patent/CA3052543A1/en active Pending
- 2018-03-30 TW TW107111106A patent/TWI771398B/zh active
-
2019
- 2019-08-29 IL IL26899319A patent/IL268993A/en unknown
-
2021
- 2021-08-13 US US17/401,600 patent/US20220031697A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3600326A1 (en) | 2020-02-05 |
EP3600326B1 (en) | 2023-01-25 |
IL268993A (en) | 2019-10-31 |
RU2019130325A (ru) | 2021-04-30 |
WO2018178925A1 (en) | 2018-10-04 |
AU2018242612B2 (en) | 2020-05-21 |
US20200281925A1 (en) | 2020-09-10 |
ES2942419T3 (es) | 2023-06-01 |
JP6617208B2 (ja) | 2019-12-11 |
TW201841639A (zh) | 2018-12-01 |
AU2018242612A1 (en) | 2019-08-22 |
CN110392573A (zh) | 2019-10-29 |
US20220031697A1 (en) | 2022-02-03 |
JP2019515018A (ja) | 2019-06-06 |
CA3052543A1 (en) | 2018-10-04 |
KR20190129889A (ko) | 2019-11-20 |
RU2019130325A3 (es) | 2021-04-30 |
TWI771398B (zh) | 2022-07-21 |
RU2753527C2 (ru) | 2021-08-17 |
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