CL2021001416A1 - Inhibidor de 15-pgdh - Google Patents

Inhibidor de 15-pgdh

Info

Publication number
CL2021001416A1
CL2021001416A1 CL2021001416A CL2021001416A CL2021001416A1 CL 2021001416 A1 CL2021001416 A1 CL 2021001416A1 CL 2021001416 A CL2021001416 A CL 2021001416A CL 2021001416 A CL2021001416 A CL 2021001416A CL 2021001416 A1 CL2021001416 A1 CL 2021001416A1
Authority
CL
Chile
Prior art keywords
pgdh inhibitor
pgdh
compound
general formula
solution
Prior art date
Application number
CL2021001416A
Other languages
English (en)
Inventor
Shigeki Seto
Hitomi Yamada
Yoshifumi Saito
Haruaki Kurasaki
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of CL2021001416A1 publication Critical patent/CL2021001416A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

[Problema] Para proporcionar un compuesto que tiene un efecto inhibidor de 15- PGDH. [Solución] Un compuesto representado por la fórmula general (1) o una sal farmacológicamente aceptable del mismo.
CL2021001416A 2019-01-08 2021-05-28 Inhibidor de 15-pgdh CL2021001416A1 (es)

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JP2019000915 2019-01-08

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CL2021001416A1 true CL2021001416A1 (es) 2021-12-24

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CL2021001416A CL2021001416A1 (es) 2019-01-08 2021-05-28 Inhibidor de 15-pgdh

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US (1) US20230082516A1 (es)
EP (1) EP3922247A4 (es)
JP (1) JPWO2020145250A1 (es)
KR (1) KR20210113598A (es)
CN (1) CN113226310B (es)
AR (1) AR119672A1 (es)
AU (1) AU2020207089A1 (es)
BR (1) BR112021013105A2 (es)
CA (1) CA3125900A1 (es)
CL (1) CL2021001416A1 (es)
CO (1) CO2021008681A2 (es)
EA (1) EA202191286A1 (es)
IL (1) IL283608A (es)
MA (1) MA54901A (es)
MX (1) MX2021007017A (es)
SG (1) SG11202106564XA (es)
WO (1) WO2020145250A1 (es)

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WO2023078461A1 (zh) * 2021-11-08 2023-05-11 武汉人福创新药物研发中心有限公司 杂环类化合物及其制备方法和用途
TW202325292A (zh) * 2021-11-18 2023-07-01 大陸商武漢人福創新藥物研發中心有限公司 15-pgdh抑制劑及用途
WO2023143432A1 (zh) * 2022-01-28 2023-08-03 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
TW202346303A (zh) * 2022-04-13 2023-12-01 大陸商賽諾哈勃藥業（成都）有限公司 一種調控15-pgdh活性的化合物、包含其的藥物組合物及其用途
WO2024017366A1 (zh) * 2022-07-22 2024-01-25 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法
WO2024067463A1 (zh) * 2022-09-27 2024-04-04 苏州阿尔脉生物科技有限公司 苯并[7]环烯类衍生物、包含其的药物组合物及其医药用途
WO2024099429A1 (zh) * 2022-11-11 2024-05-16 赛诺哈勃药业（成都）有限公司 一种调控15-pgdh活性的化合物及其制备方法

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JP4340545B2 (ja) 2002-04-23 2009-10-07 ロレアル 毛髪の成長を促進し及び／又は抜毛を防止又は遅延化するための化粧品組成物
EP1594438B1 (fr) 2003-02-12 2013-07-17 L'Oréal Utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour favoriser la pigmentation de la peau ou des phanères
CA2598956A1 (en) * 2005-02-24 2006-08-31 Pfizer Products Inc. Bicyclic heteroaromatic derivatives useful as anticancer agents
FR2891457B1 (fr) 2005-10-05 2007-11-23 Oreal Utilisation de composes phenyl-furyl-methyl-thiazolidine-2,4 dione ou phenyl-thienyl-methyl-thiazolidine-2,4-diones pour favoriser et/ou induire et/ou stimuler la pigmentation des matieres keratiniques et/ou limiter leur depigmentation et/
EP2035436B1 (en) * 2006-06-26 2011-05-25 UCB Pharma S.A. Fused thiazole derivatives as kinase inhibitors
US8232287B2 (en) * 2007-10-16 2012-07-31 Daiichi Sankyo Company, Limited Pyrimidyl indoline compound
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
JP5980812B2 (ja) * 2011-01-05 2016-08-31 バイオエナジェニックス Ｐａｓｋの阻害のための複素環化合物
DK2838533T3 (da) 2012-04-16 2017-11-27 Univ Case Western Reserve Sammensætninger og fremgangsmåder til at modulere 15-pgdh-aktivitet
RU2637945C2 (ru) 2012-06-04 2017-12-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы
US11690847B2 (en) * 2016-11-30 2023-07-04 Case Western Reserve University Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof

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EP3922247A1 (en) 2021-12-15
EA202191286A1 (ru) 2021-11-19
JPWO2020145250A1 (ja) 2021-11-18
CN113226310A (zh) 2021-08-06
WO2020145250A1 (ja) 2020-07-16
MX2021007017A (es) 2021-07-21
IL283608A (en) 2021-07-29
CN113226310B (zh) 2024-03-19
KR20210113598A (ko) 2021-09-16
US20230082516A1 (en) 2023-03-16
SG11202106564XA (en) 2021-07-29
TW202043206A (zh) 2020-12-01
AU2020207089A1 (en) 2021-06-24
AR119672A1 (es) 2022-01-05
CO2021008681A2 (es) 2021-07-19
BR112021013105A2 (pt) 2021-09-21
EP3922247A4 (en) 2022-10-12
MA54901A (fr) 2021-12-15
CA3125900A1 (en) 2020-07-16

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