CL2021000002A1 - Método para la detección y el recuento epigenético de células inmunitarias en muestras de sangre humana para inmunodiagnóstico y exploración neonatal - Google Patents

Método para la detección y el recuento epigenético de células inmunitarias en muestras de sangre humana para inmunodiagnóstico y exploración neonatal

Info

Publication number
CL2021000002A1
CL2021000002A1 CL2021000002A CL2021000002A CL2021000002A1 CL 2021000002 A1 CL2021000002 A1 CL 2021000002A1 CL 2021000002 A CL2021000002 A CL 2021000002A CL 2021000002 A CL2021000002 A CL 2021000002A CL 2021000002 A1 CL2021000002 A1 CL 2021000002A1
Authority
CL
Chile
Prior art keywords
epigenetic
detection
immune cells
immunodiagnosis
count
Prior art date
Application number
CL2021000002A
Other languages
English (en)
Inventor
Sven Olek
Original Assignee
Prec For Medicine Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prec For Medicine Gmbh filed Critical Prec For Medicine Gmbh
Publication of CL2021000002A1 publication Critical patent/CL2021000002A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a métodos mejorados para la detección y el recuento epigenético de células sanguíneas e inmunitarias, y sus respectivos usos y kits.
CL2021000002A 2018-07-05 2021-01-04 Método para la detección y el recuento epigenético de células inmunitarias en muestras de sangre humana para inmunodiagnóstico y exploración neonatal CL2021000002A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102018116353.3A DE102018116353B4 (de) 2018-07-05 2018-07-05 Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening

Publications (1)

Publication Number Publication Date
CL2021000002A1 true CL2021000002A1 (es) 2021-07-30

Family

ID=67514540

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021000002A CL2021000002A1 (es) 2018-07-05 2021-01-04 Método para la detección y el recuento epigenético de células inmunitarias en muestras de sangre humana para inmunodiagnóstico y exploración neonatal

Country Status (12)

Country Link
US (1) US12006546B2 (es)
EP (1) EP3818178A1 (es)
CN (1) CN112400027A (es)
BR (1) BR112020026951A2 (es)
CA (1) CA3105679A1 (es)
CL (1) CL2021000002A1 (es)
CO (1) CO2020016598A2 (es)
DE (1) DE102018116353B4 (es)
EC (1) ECSP20084782A (es)
MX (1) MX2020014237A (es)
PE (1) PE20210631A1 (es)
WO (1) WO2020007928A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024073508A2 (en) * 2022-09-27 2024-04-04 Guardant Health, Inc. Methods and compositions for quantifying immune cell dna
CN116949156B (zh) * 2023-09-19 2023-12-08 美迪西普亚医药科技(上海)有限公司 一种基于核酸变体的通用型检测人t细胞的分析方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2199411T3 (en) 2008-12-16 2015-08-03 Epiontis Gmbh Epigenetic markers for the identification of CD3-positive T lymphocytes
US20170233807A1 (en) * 2008-12-16 2017-08-17 Epiontis Gmbh Epigenetic Markers for the Identification of Blood Sub-cells of Type 1
EP2625288B1 (en) * 2010-10-08 2016-05-25 Epiontis GmbH Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes
US20130296328A1 (en) * 2011-01-20 2013-11-07 Université Libre de Bruxelles Epigenetic portraits of human breast cancers
DK2788510T3 (en) * 2012-03-12 2017-03-20 Epiontis Gmbh Epigenetic marker for identification of CD3CD4-positive T lymphocytes
GB201221133D0 (en) * 2012-11-23 2013-01-09 Epiontis Gmbh Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes
CA2904658C (en) 2013-04-19 2023-10-17 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample
GB201516972D0 (en) * 2015-09-25 2015-11-11 Epiontis Gmbh LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells
GB201516971D0 (en) * 2015-09-25 2015-11-11 Epiontis Gmbh MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells
EP3360971A1 (en) * 2017-02-09 2018-08-15 Epiontis GmbH Improved method for epigenetic immune cell counting

Also Published As

Publication number Publication date
DE102018116353B4 (de) 2020-06-10
ECSP20084782A (es) 2021-05-31
DE102018116353A1 (de) 2020-01-09
MX2020014237A (es) 2021-05-27
US20220090196A1 (en) 2022-03-24
US12006546B2 (en) 2024-06-11
CO2020016598A2 (es) 2021-03-19
WO2020007928A1 (en) 2020-01-09
EP3818178A1 (en) 2021-05-12
CN112400027A (zh) 2021-02-23
CA3105679A1 (en) 2020-01-09
PE20210631A1 (es) 2021-03-23
BR112020026951A2 (pt) 2021-04-13

Similar Documents

Publication Publication Date Title
BR112017010268A2 (pt) agente de ligação; composição de diagnóstico; kit de diagnóstico; métodos de diagnóstico de uma infecção bacteriana ou de diferenciação entre uma infecção bacteriana e uma infecção de viral; para descartar uma infecção bacteriana em um indivíduo; para descartar uma infecção viral em um indivíduo; para considerar uma infecção bacteriana em um indivíduo; para considerar uma infecção viral em um indivíduo; para distinguir entre uma infecção bacteriana ou mista e uma infecção viral em um indivíduo; para fornecer uma recomendação de tratamento para um indivíduo; para fornecer uma recomendação de teste de diagnóstico para um indivíduo; para descartar uma doença infecciosa; para identificação do tipo de infecção; e dispositivo para o diagnóstico de infecções bacterianas
PH12019501146A1 (en) Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
CL2021000002A1 (es) Método para la detección y el recuento epigenético de células inmunitarias en muestras de sangre humana para inmunodiagnóstico y exploración neonatal
AR110645A1 (es) Anticuerpos anti-hla-g y uso de los mismos
CY1121916T1 (el) Βιοδεικτες micro-rna για την ταυτοποιηση του κινδυνου και/ή τη διαγνωση του ογκου στον πνευμονα
BR112016029583A2 (pt) ?kit ou dispositivo para a detecção de câncer esofágico e método de detecção?
MX2016014769A (es) Dispositivo de diagnostico a base de orina, flexible, integrado.
BR112016029521A2 (pt) ?kit, dispositivo e método para a detecção de câncer de estômago?
AR093984A1 (es) Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
CO2019008675A2 (es) Anticuerpos anti-lag3 radiomarcados para la obtención de imágenes mediante inmuno-pet
BR112018010764A2 (pt) método para detectar atividade bacteriana em uma amostra biológica e unidade de detecção correspondente
AR087363A1 (es) Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
WO2015189591A3 (en) Method and arrays for use in diagnosing early breast cancer
CY1123112T1 (el) Διαγνωστικη δοκιμη για ανοσολογικη τροφικη ευαισθησια
UY37082A (es) Anticuerpos monoclonales específicos para el antígeno piii de adenovirus humano (adv), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnóstico de la infección causada por adv
WO2013167727A3 (en) Method for determining arthritis relapse risk
TR201900550T4 (tr) İnsan p53'ünün bir lineer epitopunu bağlayan antikor ve bunun tanısal uygulamaları.
WO2015166353A3 (en) Early detection of preeclampsia
BR112016017926A2 (pt) ensaio para detectar periostina humana
EA201691091A1 (ru) Диагностические реагенты для улучшенной in vivo или in vitro клеточно-опосредованной иммунологической диагностики туберкулеза
BR112016030008A2 (pt) método para a detecção de infecção por pegivirus humano 2 em um indivíduo, para a detecção de ácido nucleico de pegivirus humano 2 e para a detecção de pegivirus humano 2 em uma amostra, e, composição
SG10201907690TA (en) Device and method for detecting target molecules
RU2014113841A (ru) Способ ранней диагностики эндогенной интоксикации
PL406989A1 (pl) Profil mikro RNA we krwi jako test wykrywania raka płuca
CY1122873T1 (el) Διαγνωστικη δοκιμη για την ανοσολογικη τροφικη ευαισθησια σε κυνας