CL2019000914A1 - Composiciones de combinaciones que comprenden agonistas de fxr para tratar o prevenir una enfermedad o un trastorno fibrótico o cirrótico. - Google Patents
Composiciones de combinaciones que comprenden agonistas de fxr para tratar o prevenir una enfermedad o un trastorno fibrótico o cirrótico.Info
- Publication number
- CL2019000914A1 CL2019000914A1 CL2019000914A CL2019000914A CL2019000914A1 CL 2019000914 A1 CL2019000914 A1 CL 2019000914A1 CL 2019000914 A CL2019000914 A CL 2019000914A CL 2019000914 A CL2019000914 A CL 2019000914A CL 2019000914 A1 CL2019000914 A1 CL 2019000914A1
- Authority
- CL
- Chile
- Prior art keywords
- treat
- prevent
- cirrhotic
- fibrotic
- compositions
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 230000003176 fibrotic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 abstract 2
- 102100038495 Bile acid receptor Human genes 0.000 abstract 1
- 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCIÓN PROPORCIONA COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN UN AGONISTA DEL RECEPTOR FARNESOIDE X (FXR) Y OTRO AGENTE TERAPÉUTICO, EN PARTICULAR, PARA TRATAR O PREVENIR ENFERMEDADES O TRASTORNOS HEPÁTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662404303P | 2016-10-05 | 2016-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019000914A1 true CL2019000914A1 (es) | 2019-06-14 |
Family
ID=60262958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019000914A CL2019000914A1 (es) | 2016-10-05 | 2019-04-04 | Composiciones de combinaciones que comprenden agonistas de fxr para tratar o prevenir una enfermedad o un trastorno fibrótico o cirrótico. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20190231770A1 (es) |
EP (1) | EP3522883A1 (es) |
JP (1) | JP2019530696A (es) |
KR (1) | KR20190062501A (es) |
CN (1) | CN109789119A (es) |
AR (1) | AR109809A1 (es) |
AU (1) | AU2017339826A1 (es) |
BR (1) | BR112019005985A2 (es) |
CA (1) | CA3039283A1 (es) |
CL (1) | CL2019000914A1 (es) |
IL (1) | IL265817A (es) |
MX (1) | MX2019003889A (es) |
RU (1) | RU2019113150A (es) |
TW (1) | TW201815420A (es) |
WO (1) | WO2018065902A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111093705A (zh) * | 2017-09-13 | 2020-05-01 | 诺华股份有限公司 | 包含fxr激动剂的组合 |
US20220047553A1 (en) * | 2018-09-18 | 2022-02-17 | Metacrine, Inc. | Farnesoid x receptor agonists for the treatment of disease |
AU2020312734A1 (en) * | 2019-07-18 | 2022-01-20 | Enyo Pharma | Improved treatment using EYP001 |
WO2021053618A1 (en) * | 2019-09-19 | 2021-03-25 | Novartis Ag | Treatment comprising fxr agonists |
US20220331341A1 (en) * | 2019-09-30 | 2022-10-20 | Novartis Ag | Treatment comprising the use of fxr agonists |
CN113244281B (zh) * | 2021-06-09 | 2022-11-01 | 贵州医科大学 | 黄水枝醇提物在制备治疗或保护、调节肝纤维化疾病药物中的应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6544951B2 (en) | 1998-07-02 | 2003-04-08 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6559304B1 (en) | 1998-08-19 | 2003-05-06 | Vertex Pharmaceuticals Incorporated | Method for synthesizing caspase inhibitors |
US6201118B1 (en) | 1998-08-19 | 2001-03-13 | Vertex Pharmaceuticals Inc. | Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor |
EP1163208B1 (en) | 1999-08-06 | 2004-05-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
US6790989B2 (en) | 2000-01-13 | 2004-09-14 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
AU4961901A (en) | 2000-03-29 | 2001-10-08 | Vertex Pharma | Carbamate caspase inhibitors and uses thereof |
TR200200767T1 (tr) | 2000-05-23 | 2002-09-23 | Vertex Pharmaceuticals Incorporated | Kaspaz engelleyiciler ve kullanımları |
EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
ATE510837T1 (de) | 2000-09-13 | 2011-06-15 | Vertex Pharma | Caspase inhibitoren und deren verwendung |
US6665495B1 (en) | 2000-10-27 | 2003-12-16 | Yotta Networks, Inc. | Non-blocking, scalable optical router architecture and method for routing optical traffic |
MXPA03009647A (es) | 2001-04-19 | 2004-01-29 | Vertex Pharma | Heterociclildicarbamidas como inhibidores de caspasa. |
JP4428926B2 (ja) | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
EP1539701A1 (en) | 2002-06-28 | 2005-06-15 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
US7612091B2 (en) | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
KR100594544B1 (ko) | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
NZ549665A (en) | 2004-02-27 | 2010-09-30 | Vertex Pharma | Caspase inhibitors and uses thereof |
JP2005319019A (ja) | 2004-05-07 | 2005-11-17 | Bridgestone Sports Co Ltd | ゴルフクラブヘッド |
WO2006017295A2 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
KR101125932B1 (ko) | 2006-12-06 | 2012-03-22 | 아이디유엔 파마슈티칼즈, 인코포레이티드 | (3s)-3-[n-(n'-(2-tert-부틸페닐)옥사밀)알라니닐]아미노-5-(2',3',5',6'-테트라플루오로페녹시)-4-옥소펜탄산의 결정 형태 |
WO2010120880A1 (en) * | 2009-04-14 | 2010-10-21 | Vertex Pharmaceuticals Incorporated | Treatment of liver diseases with a caspase inhibitor |
NZ719078A (en) * | 2013-11-05 | 2018-07-27 | Novartis Ag | Compositions and methods for modulating farnesoid x receptors |
RU2017125365A (ru) * | 2014-12-18 | 2019-01-21 | Новартис Аг | Производные азабициклооктана в качестве агонистов fxr для применения при лечении заболеваний печени и желудочно-кишечных заболеваний |
BR112018013558A2 (pt) * | 2015-12-31 | 2018-12-04 | Conatus Pharmaceuticals Inc | método de tratamento de uma doença hepática em um indivíduo, método de uso de um inibidor de caspase, método para diminuir ou sustentar uma classificação meld ou seus componentes, método para tratar, diminuir ou sustentar uma classificação meld ou seus componentes, método para tratar, diminuir ou sustentar uma classificação de child-pugh ou seus componentes, composição farmacêutica que compreende um inibidor de caspase, kit, método de tratamento, método de tratamento de cirrose hepática e prevenção de uma classificação meld elevada, método de tratamento de cirrose hepática e prevenção de uma classificação de child-pugh elevada |
JP6941109B2 (ja) * | 2016-02-22 | 2021-09-29 | ノバルティス アーゲー | Fxrアゴニストを使用するための方法 |
-
2017
- 2017-10-03 RU RU2019113150A patent/RU2019113150A/ru not_active Application Discontinuation
- 2017-10-03 AU AU2017339826A patent/AU2017339826A1/en not_active Abandoned
- 2017-10-03 CA CA3039283A patent/CA3039283A1/en not_active Abandoned
- 2017-10-03 BR BR112019005985A patent/BR112019005985A2/pt not_active Application Discontinuation
- 2017-10-03 MX MX2019003889A patent/MX2019003889A/es unknown
- 2017-10-03 CN CN201780060152.2A patent/CN109789119A/zh active Pending
- 2017-10-03 WO PCT/IB2017/056099 patent/WO2018065902A1/en unknown
- 2017-10-03 US US16/339,052 patent/US20190231770A1/en not_active Abandoned
- 2017-10-03 JP JP2019518225A patent/JP2019530696A/ja not_active Withdrawn
- 2017-10-03 KR KR1020197012510A patent/KR20190062501A/ko not_active Application Discontinuation
- 2017-10-03 EP EP17794413.9A patent/EP3522883A1/en not_active Withdrawn
- 2017-10-05 TW TW106134302A patent/TW201815420A/zh unknown
- 2017-10-05 AR ARP170102778A patent/AR109809A1/es unknown
-
2019
- 2019-04-03 IL IL265817A patent/IL265817A/en unknown
- 2019-04-04 CL CL2019000914A patent/CL2019000914A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL265817A (en) | 2019-06-30 |
BR112019005985A2 (pt) | 2019-06-25 |
WO2018065902A1 (en) | 2018-04-12 |
RU2019113150A (ru) | 2020-11-06 |
TW201815420A (zh) | 2018-05-01 |
EP3522883A1 (en) | 2019-08-14 |
MX2019003889A (es) | 2019-08-12 |
AU2017339826A1 (en) | 2019-04-04 |
KR20190062501A (ko) | 2019-06-05 |
CA3039283A1 (en) | 2018-04-12 |
AR109809A1 (es) | 2019-01-23 |
CN109789119A (zh) | 2019-05-21 |
JP2019530696A (ja) | 2019-10-24 |
US20190231770A1 (en) | 2019-08-01 |
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