CL2016001100A1 - Formulación compuesta que comprende gránulos húmedos de tadalafilo y lactosa y/o manitol y una mezcla de amlodipina en una cantidad de 6-16 partes de tadalafilo y amlodipina por 100 partes de la composición; método para prepararla; uso para tratar una enfermedad cardiovascular, disfunción eréctil o una combinación de ellas. - Google Patents
Formulación compuesta que comprende gránulos húmedos de tadalafilo y lactosa y/o manitol y una mezcla de amlodipina en una cantidad de 6-16 partes de tadalafilo y amlodipina por 100 partes de la composición; método para prepararla; uso para tratar una enfermedad cardiovascular, disfunción eréctil o una combinación de ellas.Info
- Publication number
- CL2016001100A1 CL2016001100A1 CL2016001100A CL2016001100A CL2016001100A1 CL 2016001100 A1 CL2016001100 A1 CL 2016001100A1 CL 2016001100 A CL2016001100 A CL 2016001100A CL 2016001100 A CL2016001100 A CL 2016001100A CL 2016001100 A1 CL2016001100 A1 CL 2016001100A1
- Authority
- CL
- Chile
- Prior art keywords
- parts
- tadalafil
- amlodipine
- lactose
- prepare
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Abstract
FORMULACIÓN COMPUESTA QUE COMPRENDE GRÁNULOS HÚMEDOS DE TADALAFILO Y LACTOSA Y/O MANITOL Y UNA MEZCLA DE AMLODIPINA EN UNA CANTIDAD DE 6-16 PARTES DE TADALAFILO Y AMLODIPINA POR 100 PARTES DE LA COMPOSICIÓN; MÉTODO PARA PREPARARLA; USO PARA TRATAR UNA ENFERMEDAD CARDIOVASCULAR, DISFUNCIÓN ERÉCTIL O UNA COMBINACIÓN DE ELLAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20130139334 | 2013-11-15 | ||
KR1020140096022A KR20150056443A (ko) | 2013-11-15 | 2014-07-28 | 타다라필 및 암로디핀을 포함하는 복합제제 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016001100A1 true CL2016001100A1 (es) | 2016-11-11 |
Family
ID=53391753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2016001100A CL2016001100A1 (es) | 2013-11-15 | 2016-05-06 | Formulación compuesta que comprende gránulos húmedos de tadalafilo y lactosa y/o manitol y una mezcla de amlodipina en una cantidad de 6-16 partes de tadalafilo y amlodipina por 100 partes de la composición; método para prepararla; uso para tratar una enfermedad cardiovascular, disfunción eréctil o una combinación de ellas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160263040A1 (es) |
EP (1) | EP3068380A4 (es) |
JP (1) | JP2016539934A (es) |
KR (3) | KR101663238B1 (es) |
CN (1) | CN105744930A (es) |
AR (1) | AR098415A1 (es) |
AU (1) | AU2014349417A1 (es) |
CA (1) | CA2927720A1 (es) |
CL (1) | CL2016001100A1 (es) |
HK (1) | HK1221665A1 (es) |
MX (1) | MX2016006292A (es) |
PH (1) | PH12016500865A1 (es) |
RU (1) | RU2016117186A (es) |
TW (1) | TW201605441A (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170113459A (ko) * | 2016-03-31 | 2017-10-12 | 한미약품 주식회사 | 타다라필 및 암로디핀 함유 고형 복합제제 |
JP2019510071A (ja) * | 2016-03-31 | 2019-04-11 | ハンミ ファーマシューティカルズ カンパニー リミテッド | 安定性及び溶出率が改善されたタダラフィル含有及びタムスロシン含有のカプセル複合製剤 |
US10350171B2 (en) * | 2017-07-06 | 2019-07-16 | Dexcel Ltd. | Celecoxib and amlodipine formulation and method of making the same |
JP7334144B2 (ja) * | 2018-03-16 | 2023-08-28 | 日本新薬株式会社 | 口腔内崩壊錠 |
CN109528675B (zh) * | 2018-12-31 | 2020-12-22 | 杭州康本医药科技有限公司 | 一种他达拉非肠溶片剂及其制备方法 |
KR102195162B1 (ko) | 2019-01-30 | 2020-12-24 | 단국대학교 천안캠퍼스 산학협력단 | 타다라필 함유 고체분산체 및 이의 제조방법 |
CN110638768B (zh) * | 2019-10-25 | 2024-04-16 | 株洲千金药业股份有限公司 | 一种治疗男性勃起功能障碍药物的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0001632A3 (en) | 1999-04-30 | 2001-12-28 | Lilly Icos Llc Wilmington | Pharmaceutical compositions comprising selective phosphodiestherase inhibitors |
AU2002350719A1 (en) * | 2002-11-29 | 2004-06-23 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
DE102005016981A1 (de) * | 2005-04-13 | 2006-10-19 | Bayer Healthcare Ag | Kombination zur Therapie bei benigner Prostatahyperplasie |
KR20100012867A (ko) * | 2007-04-25 | 2010-02-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 타다라필을 포함하는 고체 제형 |
EP2167048B1 (en) * | 2007-05-30 | 2016-10-26 | Wockhardt Limited | A novel tablet dosage form |
US20100316711A1 (en) * | 2007-10-25 | 2010-12-16 | Bayer Yakuhin ,Ltd. | Nifedipine containing opress coated tablet and method of preparing same |
CA2749903C (en) * | 2009-01-23 | 2016-09-06 | Jae Hyun Park | Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same |
EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
EP2672959A1 (en) * | 2011-02-10 | 2013-12-18 | Synthon BV | Granulated composition comprising tadalafil and a disintegrant |
-
2014
- 2014-07-28 KR KR1020140096023A patent/KR101663238B1/ko active IP Right Grant
- 2014-07-28 KR KR1020140096022A patent/KR20150056443A/ko not_active Application Discontinuation
- 2014-11-03 KR KR1020140151219A patent/KR101665641B1/ko active IP Right Grant
- 2014-11-06 US US15/034,269 patent/US20160263040A1/en not_active Abandoned
- 2014-11-06 AU AU2014349417A patent/AU2014349417A1/en not_active Abandoned
- 2014-11-06 RU RU2016117186A patent/RU2016117186A/ru unknown
- 2014-11-06 JP JP2016528844A patent/JP2016539934A/ja active Pending
- 2014-11-06 MX MX2016006292A patent/MX2016006292A/es unknown
- 2014-11-06 CN CN201480062583.9A patent/CN105744930A/zh active Pending
- 2014-11-06 EP EP14861867.1A patent/EP3068380A4/en not_active Withdrawn
- 2014-11-06 CA CA2927720A patent/CA2927720A1/en not_active Abandoned
- 2014-11-11 TW TW103139057A patent/TW201605441A/zh unknown
- 2014-11-14 AR ARP140104278A patent/AR098415A1/es unknown
-
2016
- 2016-05-06 CL CL2016001100A patent/CL2016001100A1/es unknown
- 2016-05-10 PH PH12016500865A patent/PH12016500865A1/en unknown
- 2016-08-19 HK HK16109954.7A patent/HK1221665A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20160263040A1 (en) | 2016-09-15 |
KR101665641B1 (ko) | 2016-10-13 |
CA2927720A1 (en) | 2015-05-21 |
CN105744930A (zh) | 2016-07-06 |
AR098415A1 (es) | 2016-05-26 |
AU2014349417A1 (en) | 2016-05-05 |
KR20150056461A (ko) | 2015-05-26 |
EP3068380A4 (en) | 2017-06-28 |
PH12016500865A1 (en) | 2016-06-20 |
KR20150056444A (ko) | 2015-05-26 |
JP2016539934A (ja) | 2016-12-22 |
EP3068380A1 (en) | 2016-09-21 |
KR20150056443A (ko) | 2015-05-26 |
HK1221665A1 (zh) | 2017-06-09 |
TW201605441A (zh) | 2016-02-16 |
RU2016117186A (ru) | 2017-12-18 |
KR101663238B1 (ko) | 2016-10-14 |
MX2016006292A (es) | 2016-09-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2016001100A1 (es) | Formulación compuesta que comprende gránulos húmedos de tadalafilo y lactosa y/o manitol y una mezcla de amlodipina en una cantidad de 6-16 partes de tadalafilo y amlodipina por 100 partes de la composición; método para prepararla; uso para tratar una enfermedad cardiovascular, disfunción eréctil o una combinación de ellas. | |
CL2019000473A1 (es) | Compuestos de pirrolizina sustituida y usos de los mismos. | |
HK1251901A1 (zh) | 烯基取代的2,5-哌嗪二酮和其在組合物中用於向個體或細胞遞送藥劑的用途 | |
CL2015002860A1 (es) | Antagonistas de la alfa-v-beta-6 integrina | |
AR107303A1 (es) | Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit | |
CL2014003444A1 (es) | Compuestos derivados tienopirimidina; proceso de preparacion; composicion farmaceutica que los comprende; combinacion farmaceutica; uso en el tratamiento de canceres y enfermedades autoinmunes. | |
BR112018005892A2 (pt) | composições para higiene bucal e métodos de uso. | |
CL2015001055A1 (es) | Composiciones para lavado de ropa; y uso de dicha composicion. | |
CO6831975A2 (es) | Inmunoconjugados, composiciones para prepararlos, métodos para prepararlos y uso | |
AR108507A1 (es) | Un dispositivo de vaporización, método de uso del dispositivo, un estuche de carga, un kit y un ensamblaje de vibración | |
BR112015015891A8 (pt) | Composição farmacêutica de solução sólida, e, uso de uma composição farmacêutica | |
CL2015002733A1 (es) | Composición farmacéutica de clorhidrato de s-cetamina. | |
BR112018005753A2 (pt) | composições para higiene bucal e métodos de uso. | |
BR112016025910A2 (pt) | uso de uma quantidade eficaz de glyx-13, uso de glyx-13 e um antagonista de nmdar e composição farmaceuticamente aceitável compreendendo os mesmos | |
ECSP16012582A (es) | Compuestos heterocíclicos y métodos de uso | |
PE20151759A1 (es) | Imidazopiridazinas sustituidas | |
DOP2012000279A (es) | Composiciones farmaceuticas que comprenden hidromorfona y naloxona | |
MX2017006464A (es) | Combinaciones de inhibidor de tlr e inhibidor de tirosina cinasa de bruton. | |
ECSP16058769A (es) | Composicion para la administracion oral de agente bioactivos | |
GT201200304A (es) | Composiciones farmacéuticas que comprenden hidromorfona y naloxona | |
BR112014003040A2 (pt) | mistura de polímero em uma forma sólida ou aquosa, composição, e, uso de misturas de polímero. | |
UY35835A (es) | Anticuerpos específicos para FcRn. | |
CL2014003525A1 (es) | Composicion farmaceutica que comprende fimasartan, hidroclorotiazida y un aglutinante; procedimiento de preparacion; su uso en el tratamiento de hipertension. | |
CO2017001601A2 (es) | Derivados de 1-acetil-4-((pirazin-2-il) amino)-1,2,3,4-tetrahydroquinolina-6 carboxamida como inhibidores de bromodominio | |
CL2016000998A1 (es) | Composición herbaria, procedimiento para su preparación y uso de la misma |