CL2014000469A1 - Compuestos derivados del acido 2-oxo-6-(aril/heteroaril)-1,2-dihidropiridin-3-carboxilico; composicion farmaceutica; tratamiento combinado; y un metodo de tratamiento de una infeccion bacteriana. - Google Patents
Compuestos derivados del acido 2-oxo-6-(aril/heteroaril)-1,2-dihidropiridin-3-carboxilico; composicion farmaceutica; tratamiento combinado; y un metodo de tratamiento de una infeccion bacteriana.Info
- Publication number
- CL2014000469A1 CL2014000469A1 CL2014000469A CL2014000469A CL2014000469A1 CL 2014000469 A1 CL2014000469 A1 CL 2014000469A1 CL 2014000469 A CL2014000469 A CL 2014000469A CL 2014000469 A CL2014000469 A CL 2014000469A CL 2014000469 A1 CL2014000469 A1 CL 2014000469A1
- Authority
- CL
- Chile
- Prior art keywords
- dihydropyridine
- heteroaryl
- oxo
- aryl
- treating
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528599P | 2011-08-29 | 2011-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000469A1 true CL2014000469A1 (es) | 2014-11-14 |
Family
ID=47756844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000469A CL2014000469A1 (es) | 2011-08-29 | 2014-02-26 | Compuestos derivados del acido 2-oxo-6-(aril/heteroaril)-1,2-dihidropiridin-3-carboxilico; composicion farmaceutica; tratamiento combinado; y un metodo de tratamiento de una infeccion bacteriana. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9409905B2 (https=) |
| EP (1) | EP2750504A4 (https=) |
| JP (1) | JP2014525453A (https=) |
| KR (1) | KR20140097118A (https=) |
| CN (1) | CN103889224B (https=) |
| AU (1) | AU2012301953C1 (https=) |
| BR (1) | BR112014004515A2 (https=) |
| CA (1) | CA2846663A1 (https=) |
| CL (1) | CL2014000469A1 (https=) |
| HK (1) | HK1199693A1 (https=) |
| IL (1) | IL231060A (https=) |
| MX (1) | MX2014002298A (https=) |
| WO (1) | WO2013033258A1 (https=) |
| ZA (1) | ZA201402248B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1199792A1 (en) * | 2011-08-29 | 2015-07-24 | Ptc Therapeutics, Inc. | Antibacterial compounds and methods for use |
| WO2014139388A1 (en) * | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2014157382A1 (ja) * | 2013-03-29 | 2014-10-02 | 味の素株式会社 | スフィンゴシンキナーゼ阻害剤 |
| WO2016039939A1 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Bicyclic and tricyclic substituted 2-pyridinone antibacterial compounds |
| WO2016039937A1 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Bicyclic and tricyclic substituted 2-pyridinone antibacterial compounds |
| WO2016109706A1 (en) * | 2014-12-31 | 2016-07-07 | Ptc Therapeutics, Inc. | Fused polycyclic 2-pyridinone antibacterial compounds |
| WO2018200571A1 (en) | 2017-04-25 | 2018-11-01 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1h-indene analogs and methods using same |
| JP7153645B2 (ja) * | 2017-06-08 | 2022-10-14 | 三井化学アグロ株式会社 | ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤 |
| CN107325080B (zh) * | 2017-08-30 | 2020-05-12 | 延边大学 | 含三嗪或氨基胍结构的咔唑类衍生物的制备方法及其抗菌应用 |
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| CN108659091B (zh) * | 2018-05-24 | 2020-07-03 | 烟台大学 | 夫西地酸衍生物及其合成制备方法和应用 |
| JP2021534246A (ja) * | 2018-08-16 | 2021-12-09 | レクレオ ファーマシューティカルス アイエヌシー | １，３，４，９−テトラヒドロ−２ｈ−ピリド［３，４−ｂ］インドール誘導体化合物及びその使用 |
| CN109329290A (zh) * | 2018-10-11 | 2019-02-15 | 四川省兰月科技有限公司 | 防治猕猴桃、柑橘黄化病的农药组合物 |
| CN109485601B (zh) * | 2018-12-23 | 2020-06-30 | 沧州普瑞东方科技有限公司 | 2,6-二卤吡啶-3-羧酸的合成方法 |
| CN111521706A (zh) * | 2020-05-11 | 2020-08-11 | 苏州必宜生物科技有限公司 | 一种快速检测血浆中头孢克肟浓度的方法 |
| AU2022424463A1 (en) * | 2021-12-28 | 2024-07-18 | Adeka Corporation | Aryl tetrahydropyridine derivative or salt thereof, pest control agent containing same, and method for use thereof |
| CN115960031B (zh) * | 2023-01-06 | 2024-09-10 | 暨南大学 | 一种四氢异吲哚酮类化合物及其制备方法和应用 |
| CN119569650A (zh) * | 2024-12-05 | 2025-03-07 | 凯美克(上海)医药科技有限公司 | 一种7-溴-2-氯喹啉-4-醇的合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3703582A (en) | 1970-04-20 | 1972-11-21 | Merck & Co Inc | Aryl pyridine carboxylic acids in the treatment of inflammation |
| US3948903A (en) * | 1972-12-15 | 1976-04-06 | Parke, Davis & Company | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins |
| US3954734A (en) | 1974-01-21 | 1976-05-04 | Parke, Davis & Company | Novel antibacterial amide compounds and process means for producing the same |
| JPS5643288A (en) | 1979-09-18 | 1981-04-21 | Meiji Seika Kaisha Ltd | Cephalosporin derivative and its preparation |
| JPS5651488A (en) | 1979-10-02 | 1981-05-09 | Meiji Seika Kaisha Ltd | Penicillin derivative and its preparation |
| DE3338846A1 (de) * | 1982-10-29 | 1984-05-03 | Toyama Chemical Co. Ltd., Tokyo | Neue 4-oxo-1,4-dihydronicotinsaeurederivate und salze derselben, verfahren zu ihrer herstellung und antibakterielle mittel mit einem gehalt derselben |
| EP0308020A3 (en) | 1987-09-18 | 1990-12-05 | Merck & Co. Inc. | 5-(aryl and heteroaryl)-6-(aryl and heteroaryl)-1,2-dihydro-2-oxo 3-pyridinecarboxylic acids and derivatives thereof |
| GB8809481D0 (en) | 1988-04-21 | 1988-05-25 | Smith Kline French Lab | Chemical compounds |
| IE911704A1 (en) * | 1990-05-21 | 1991-12-04 | Smith Kline French Lab | Chemical compounds |
| DE19639817A1 (de) * | 1996-09-27 | 1998-04-02 | Hoechst Ag | Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von Hautinfektionen |
| CN1231161A (zh) | 1998-07-07 | 1999-10-13 | 邱泽国 | 全自动多功能超声波洗碗机 |
| EP1343763A1 (en) | 2000-11-20 | 2003-09-17 | Bristol-Myers Squibb Company | Pyrodone derivatives as ap2 inhibitors |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| ATE448784T1 (de) * | 2002-02-14 | 2009-12-15 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| CN101531631B (zh) | 2002-02-14 | 2011-09-28 | 法玛西雅公司 | 作为p38map激酶调节剂的取代吡啶酮类 |
| CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| TWI360539B (en) | 2004-10-28 | 2012-03-21 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| CN101171247A (zh) * | 2005-03-04 | 2008-04-30 | 阿斯利康(瑞典)有限公司 | 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物 |
| WO2006117762A2 (en) | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Antimicrobial agents |
| CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| HK1199792A1 (en) * | 2011-08-29 | 2015-07-24 | Ptc Therapeutics, Inc. | Antibacterial compounds and methods for use |
| CA2846655A1 (en) * | 2011-08-29 | 2013-03-07 | Arthur Branstrom | Antibacterial compounds and methods for use |
-
2012
- 2012-08-29 AU AU2012301953A patent/AU2012301953C1/en not_active Ceased
- 2012-08-29 KR KR1020147008210A patent/KR20140097118A/ko not_active Withdrawn
- 2012-08-29 CA CA2846663A patent/CA2846663A1/en not_active Abandoned
- 2012-08-29 JP JP2014528562A patent/JP2014525453A/ja not_active Ceased
- 2012-08-29 WO PCT/US2012/052922 patent/WO2013033258A1/en not_active Ceased
- 2012-08-29 BR BR112014004515A patent/BR112014004515A2/pt not_active IP Right Cessation
- 2012-08-29 US US14/241,506 patent/US9409905B2/en not_active Expired - Fee Related
- 2012-08-29 HK HK15100101.9A patent/HK1199693A1/xx unknown
- 2012-08-29 CN CN201280051906.5A patent/CN103889224B/zh not_active Expired - Fee Related
- 2012-08-29 MX MX2014002298A patent/MX2014002298A/es unknown
- 2012-08-29 EP EP12828218.3A patent/EP2750504A4/en not_active Withdrawn
-
2014
- 2014-02-20 IL IL231060A patent/IL231060A/en not_active IP Right Cessation
- 2014-02-26 CL CL2014000469A patent/CL2014000469A1/es unknown
- 2014-03-26 ZA ZA2014/02248A patent/ZA201402248B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9409905B2 (en) | 2016-08-09 |
| NZ623063A (en) | 2016-04-29 |
| CA2846663A1 (en) | 2013-03-07 |
| AU2012301953C1 (en) | 2016-11-03 |
| EP2750504A4 (en) | 2015-03-11 |
| CN103889224A (zh) | 2014-06-25 |
| ZA201402248B (en) | 2016-06-29 |
| EP2750504A1 (en) | 2014-07-09 |
| CN103889224B (zh) | 2017-05-24 |
| JP2014525453A (ja) | 2014-09-29 |
| WO2013033258A1 (en) | 2013-03-07 |
| AU2012301953A1 (en) | 2014-03-13 |
| BR112014004515A2 (pt) | 2017-03-28 |
| IL231060A0 (en) | 2014-03-31 |
| US20150038437A1 (en) | 2015-02-05 |
| IL231060A (en) | 2017-01-31 |
| MX2014002298A (es) | 2014-07-22 |
| KR20140097118A (ko) | 2014-08-06 |
| HK1199693A1 (en) | 2015-07-17 |
| AU2012301953B2 (en) | 2016-05-12 |
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