CL2011000093A1 - Compuestos derivados de un ester piperidinilico del acido bifenil-2-ilcarbamico; composicion farmaceutica; combinacion farmaceutica; y su uso para broncoconstriccion, enfermedades obstructivas o inflamatorias de las vias respiratorias. - Google Patents

Compuestos derivados de un ester piperidinilico del acido bifenil-2-ilcarbamico; composicion farmaceutica; combinacion farmaceutica; y su uso para broncoconstriccion, enfermedades obstructivas o inflamatorias de las vias respiratorias.

Info

Publication number
CL2011000093A1
CL2011000093A1 CL2011000093A CL2011000093A CL2011000093A1 CL 2011000093 A1 CL2011000093 A1 CL 2011000093A1 CL 2011000093 A CL2011000093 A CL 2011000093A CL 2011000093 A CL2011000093 A CL 2011000093A CL 2011000093 A1 CL2011000093 A1 CL 2011000093A1
Authority
CL
Chile
Prior art keywords
bronchoconstriction
obstructive
biphenyl
inflammatory diseases
respiratory tract
Prior art date
Application number
CL2011000093A
Other languages
English (en)
Spanish (es)
Inventor
Paul Alan Lane Charlotte Alice Louise Glossop
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CL2011000093A1 publication Critical patent/CL2011000093A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2011000093A 2008-07-15 2011-01-14 Compuestos derivados de un ester piperidinilico del acido bifenil-2-ilcarbamico; composicion farmaceutica; combinacion farmaceutica; y su uso para broncoconstriccion, enfermedades obstructivas o inflamatorias de las vias respiratorias. CL2011000093A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8072608P 2008-07-15 2008-07-15

Publications (1)

Publication Number Publication Date
CL2011000093A1 true CL2011000093A1 (es) 2011-05-06

Family

ID=41139473

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000093A CL2011000093A1 (es) 2008-07-15 2011-01-14 Compuestos derivados de un ester piperidinilico del acido bifenil-2-ilcarbamico; composicion farmaceutica; combinacion farmaceutica; y su uso para broncoconstriccion, enfermedades obstructivas o inflamatorias de las vias respiratorias.

Country Status (28)

Country Link
US (1) US20100016366A1 (fr)
EP (1) EP2328868A1 (fr)
JP (1) JP2011528346A (fr)
KR (1) KR20110017452A (fr)
CN (1) CN102099334A (fr)
AP (1) AP2010005512A0 (fr)
AR (1) AR072802A1 (fr)
AU (1) AU2009272303B2 (fr)
BR (1) BRPI0915753A2 (fr)
CA (1) CA2727769A1 (fr)
CL (1) CL2011000093A1 (fr)
CO (1) CO6321246A2 (fr)
CR (1) CR11828A (fr)
DO (1) DOP2011000017A (fr)
EA (1) EA201001842A1 (fr)
EC (1) ECSP11010753A (fr)
HN (1) HN2009001330A (fr)
IL (1) IL210293A0 (fr)
MA (1) MA32479B1 (fr)
MX (1) MX2011000588A (fr)
NI (1) NI201100015A (fr)
NZ (1) NZ589934A (fr)
PE (1) PE20110312A1 (fr)
SV (1) SV2011003808A (fr)
TW (1) TW201006799A (fr)
UY (1) UY31980A (fr)
WO (1) WO2010007552A1 (fr)
ZA (1) ZA201100841B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011083387A1 (fr) * 2010-01-07 2011-07-14 Pfizer Limited Sel de chlorhydrate du biphényl-2-yl-carbamate de 1-{9-[(3-fluoro-4-hydroxy-benzoyl)-méthyl-amino]-nonyl}-pipéridin-4-yle
MX2012011395A (es) * 2010-04-01 2013-02-26 Theravida Inc Metodos de mejoramiento de la calidad del sueño.
CN107074816B (zh) * 2015-03-27 2020-07-17 四川海思科制药有限公司 一种杂环衍生物及其制备方法和在医药上的用途
WO2016180348A1 (fr) * 2015-05-14 2016-11-17 四川海思科制药有限公司 Dérivé spiro-hétérocyclique contenant de l'azote présentant des activités d'excitation de récepteur bêta2 et des activités antagonistes au récepteur m et son application dans un médicament
CN106336406B (zh) * 2015-07-10 2020-01-03 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的八氢并环戊二烯衍生物及其在医药上的用途
WO2019071147A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 réduisant l'expression du gène dux4 et des gènes aval pour le traitement de la fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP2009534463A (ja) * 2006-04-24 2009-09-24 アストラゼネカ・アクチエボラーグ 例えば慢性気管支閉塞、喘息および過活動膀胱の処置に有用な、ムスカリンｍ３受容体アンタゴニスト活性を有する環状アミノアルコールの新規アルキルエステル

Also Published As

Publication number Publication date
AU2009272303A1 (en) 2010-01-21
MA32479B1 (fr) 2011-07-03
AR072802A1 (es) 2010-09-22
BRPI0915753A2 (pt) 2015-11-03
CN102099334A (zh) 2011-06-15
DOP2011000017A (es) 2011-02-15
KR20110017452A (ko) 2011-02-21
NI201100015A (es) 2011-08-05
HN2009001330A (es) 2012-04-02
ECSP11010753A (es) 2011-02-28
US20100016366A1 (en) 2010-01-21
MX2011000588A (es) 2011-03-01
EA201001842A1 (ru) 2011-08-30
JP2011528346A (ja) 2011-11-17
CA2727769A1 (fr) 2010-01-21
WO2010007552A1 (fr) 2010-01-21
ZA201100841B (en) 2011-10-26
SV2011003808A (es) 2011-03-23
CR11828A (es) 2011-01-10
AU2009272303B2 (en) 2011-12-22
IL210293A0 (en) 2011-03-31
PE20110312A1 (es) 2011-06-25
CO6321246A2 (es) 2011-09-20
NZ589934A (en) 2012-06-29
EP2328868A1 (fr) 2011-06-08
AP2010005512A0 (en) 2010-12-31
UY31980A (es) 2010-02-26
TW201006799A (en) 2010-02-16

Similar Documents

Publication Publication Date Title
CL2011000093A1 (es) Compuestos derivados de un ester piperidinilico del acido bifenil-2-ilcarbamico; composicion farmaceutica; combinacion farmaceutica; y su uso para broncoconstriccion, enfermedades obstructivas o inflamatorias de las vias respiratorias.
CY2020032I2 (el) Παραγωγα πλευρομουτιλινης για τη θεραπεια ασθενειων που προκαλουνται απο μικροβια
CL2008003940A1 (es) Compuestos derivados de morfolino pirimidina sustituida; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de cancer, enfermedades inflamatorias, enfermedades obstructivas de las vias aereas, enfermedades inmunes o enfermedades cardiovasculares.
EP2418200A4 (fr) Dérivés phtalimidiques de composés antiinflammatoires non stéroïdiens et/ou de modulateurs du tnf- , procédé pour leur obtention, compositions pharmaceutiques les contenant et leurs utilisations dans le traitement de maladies inflammatoires
IN2014CN04907A (fr)
BRPI1015569A2 (pt) compostos úteis para o tratamento de doenças degenerativas e inflamatórias.
NI200700296A (es) Imidazoquinolinas como inhibidores de cinasa de lipido
CL2014000630A1 (es) Una composicion que comprende 1) un compuesto derivado de nucleosido denominado como compuesto 10 y 2) un compuesto derivado de acido 5-tiofeno-2-carboxilico denominado como compuesto 5 o un compuesto derivado del ester metilico del acido carbamico denominado como compuesto 6; y su uso para el tratamiento profilactico o terapeutico de una infeccion por vhc.
PT2470546E (pt) Compostos de hexa-hidrooxazinopteridina para serem utilizados como inibidores de mtor
DK2114886T3 (da) Fremgangsmåde til fremstilling af visse substituerede sulfiliminer
WO2011153157A3 (fr) Inhibiteurs benzoquinolone de vmat2
CO6430427A2 (es) Derivados de benzofuranilo
GEP20135863B (en) Substituted piperidines as ccr3 antagonists
GEP20186885B (en) Novel compounds
MX2011011776A (es) Nuevos profarmacos de triptolite.
MA33948B1 (fr) Dérivés d'acide 3-hétéroaroylamino-propionique substitues par oxygène et leur utilisation en tant qu'agents pharmaceutiques.
CL2007003875A1 (es) Compuestos derivados de amidas del acido 3-amino tetrahidrofurano-3-carboxilico; procedimiento de preparacion de dichos compuestos.
IL199829A0 (en) Use of substituted pyranone acid derivatives for the treatment of metabolic syndrome
DK2493312T3 (da) Farmaceutiske faststofsammensætninger, der indeholder en integrase- hæmmer
CL2014002318A1 (es) Procedimiento para la separación de ésteres de alquilo (divisional de solicitud n° 1387-2010)
WO2009118589A3 (fr) Compositions orodispersibles de rhéine ou de diacéréine
EE201300004A (et) Kombineeritud ravimkoostis sdame-veresoonkonnaga seotud haiguste v?i seisundite raviks
CL2013002629A1 (es) Compuestos derivados de isoxazolidina; composicion y combinacion farmaceutica que los comprende, util para la prevencion y/o el tratamiento de las enfermedades relacionadas con la reduccion en la cantidad, la actividad o el movimiento de las celulas que participan en la inflamacion, enfermedades respiratorias, asma y epoc.
WO2010102154A3 (fr) Composés acides biaryl oxyacétiques
WO2011123524A3 (fr) Macrolides inhibiteurs de mtor