CL2008001552A1 - Compuestos derivados de piperidina-amida; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso de los compuestos para tratar la hiperglucemia, obesidad, hipertension, hiperlipidemia, aterosclerosis, fallo renal, diabetes. - Google Patents

Compuestos derivados de piperidina-amida; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso de los compuestos para tratar la hiperglucemia, obesidad, hipertension, hiperlipidemia, aterosclerosis, fallo renal, diabetes.

Info

Publication number
CL2008001552A1
CL2008001552A1 CL2008001552A CL2008001552A CL2008001552A1 CL 2008001552 A1 CL2008001552 A1 CL 2008001552A1 CL 2008001552 A CL2008001552 A CL 2008001552A CL 2008001552 A CL2008001552 A CL 2008001552A CL 2008001552 A1 CL2008001552 A1 CL 2008001552A1
Authority
CL
Chile
Prior art keywords
compounds
hyperlipidemia
atherosclerosis
obesity
hypertension
Prior art date
Application number
CL2008001552A
Other languages
English (en)
Inventor
Andjelkovic Mirjana
M Ceccarelli Simone
Chomienne Odila
Mattei Patrizio
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2008001552A1 publication Critical patent/CL2008001552A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Compuestos derivados de piperidina-amida; procedimiento de preparación; composición farmacéutica que comprende a dicho compuesto; y uso de los compuestos para tratar la hiperglucemia, obesidad, hipertensión, hiperlipidemia, aterosclerosis, fallo renal, diabetes.
CL2008001552A 2007-06-01 2008-05-29 Compuestos derivados de piperidina-amida; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso de los compuestos para tratar la hiperglucemia, obesidad, hipertension, hiperlipidemia, aterosclerosis, fallo renal, diabetes. CL2008001552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07109458 2007-06-01

Publications (1)

Publication Number Publication Date
CL2008001552A1 true CL2008001552A1 (es) 2009-05-22

Family

ID=39645621

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008001552A CL2008001552A1 (es) 2007-06-01 2008-05-29 Compuestos derivados de piperidina-amida; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso de los compuestos para tratar la hiperglucemia, obesidad, hipertension, hiperlipidemia, aterosclerosis, fallo renal, diabetes.

Country Status (17)

Country Link
US (1) US8039487B2 (es)
EP (1) EP2155738B1 (es)
JP (1) JP5220848B2 (es)
KR (1) KR101140520B1 (es)
CN (1) CN101679404B (es)
AR (1) AR066759A1 (es)
AT (1) ATE518857T1 (es)
AU (1) AU2008257693B2 (es)
BR (1) BRPI0811978A2 (es)
CA (1) CA2689383C (es)
CL (1) CL2008001552A1 (es)
ES (1) ES2369315T3 (es)
IL (1) IL202159A (es)
MX (1) MX2009013003A (es)
PE (1) PE20090320A1 (es)
TW (1) TW200901997A (es)
WO (1) WO2008145596A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101848908B (zh) * 2007-09-06 2014-07-02 北京强新生物科技有限公司 激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR102151288B1 (ko) 2012-10-10 2020-09-03 이도르시아 파마슈티컬스 리미티드 [오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트
CA2922703A1 (en) * 2013-08-29 2015-03-05 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and body weight related disorders
CA3216365A1 (en) * 2021-05-04 2022-11-10 Venkateswara Rao BODDU Diazepane derivatives, processes for their preparation, and uses thereof for the amelioration, prevention and/or treatment of mental and neurological diseases
WO2023285349A1 (en) * 2021-07-12 2023-01-19 2N Pharma Aps Carnitine-palmitoyl-transferase-1 (cpt-1) inhibitors for use in a method of preventing or treating sepsis in a mammalian subject

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4055400A (en) * 1999-04-02 2000-10-23 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics
FR2865733B1 (fr) * 2004-02-04 2007-10-12 Merck Sante Sas Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine
EP1604989A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft DPP-IV inhibitors
WO2006131452A1 (en) * 2005-06-06 2006-12-14 F. Hoffmann-La Roche Ag SULFONAMIDE DERIVATIVES USEFUL AS LIVER CARNITINE PALMITOYL TRANSFERASE (L-CPTl) INHIBITORS
WO2007031429A1 (en) * 2005-09-15 2007-03-22 F. Hoffmann-La Roche Ag Novel heterobicyclic derivatives useful as inhibitors of liver carnitine palmitoyl transferase
PL1959951T3 (pl) 2005-12-01 2010-06-30 Hoffmann La Roche Heteroarylo-podstawione pochodne piperydyny jako inhibitory l-cpt1
EA018920B1 (ru) * 2008-05-05 2013-11-29 Мерк Патент Гмбх Производные тиазола в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы-1
DE102008029734A1 (de) * 2008-06-23 2009-12-24 Merck Patent Gmbh Thiazolyl-piperidinderivate

Also Published As

Publication number Publication date
IL202159A (en) 2013-07-31
KR20100017976A (ko) 2010-02-16
JP2010529001A (ja) 2010-08-26
US8039487B2 (en) 2011-10-18
ATE518857T1 (de) 2011-08-15
EP2155738A1 (en) 2010-02-24
AU2008257693B2 (en) 2011-01-27
CA2689383C (en) 2013-10-08
CN101679404B (zh) 2012-06-13
AU2008257693A1 (en) 2008-12-04
CA2689383A1 (en) 2008-12-04
BRPI0811978A2 (pt) 2014-11-18
MX2009013003A (es) 2010-01-20
EP2155738B1 (en) 2011-08-03
TW200901997A (en) 2009-01-16
ES2369315T3 (es) 2011-11-29
PE20090320A1 (es) 2009-03-19
IL202159A0 (en) 2010-06-16
WO2008145596A1 (en) 2008-12-04
AR066759A1 (es) 2009-09-09
US20080300279A1 (en) 2008-12-04
CN101679404A (zh) 2010-03-24
KR101140520B1 (ko) 2012-04-30
JP5220848B2 (ja) 2013-06-26

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