CL2007003472A1 - Sal fumarato de (alfa s,beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol; proceso de preparacion; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamie - Google Patents

Sal fumarato de (alfa s,beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol; proceso de preparacion; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamie

Info

Publication number
CL2007003472A1
CL2007003472A1 CL200703472A CL2007003472A CL2007003472A1 CL 2007003472 A1 CL2007003472 A1 CL 2007003472A1 CL 200703472 A CL200703472 A CL 200703472A CL 2007003472 A CL2007003472 A CL 2007003472A CL 2007003472 A1 CL2007003472 A1 CL 2007003472A1
Authority
CL
Chile
Prior art keywords
alfa
beta
pharmaceutical composition
preparation process
quinolinaethanol
Prior art date
Application number
CL200703472A
Other languages
English (en)
Spanish (es)
Inventor
Jean Francois Alexandre Hegyi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37983588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007003472(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2007003472A1 publication Critical patent/CL2007003472A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL200703472A 2006-12-05 2007-12-03 Sal fumarato de (alfa s,beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol; proceso de preparacion; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamie CL2007003472A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06125443 2006-12-05

Publications (1)

Publication Number Publication Date
CL2007003472A1 true CL2007003472A1 (es) 2008-08-22

Family

ID=37983588

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200703472A CL2007003472A1 (es) 2006-12-05 2007-12-03 Sal fumarato de (alfa s,beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol; proceso de preparacion; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamie

Country Status (34)

Country Link
US (1) US8546428B2 (cg-RX-API-DMAC7.html)
EP (1) EP2086940B1 (cg-RX-API-DMAC7.html)
JP (2) JP2010511663A (cg-RX-API-DMAC7.html)
KR (1) KR101514700B1 (cg-RX-API-DMAC7.html)
CN (2) CN101547904A (cg-RX-API-DMAC7.html)
AP (1) AP2498A (cg-RX-API-DMAC7.html)
AR (1) AR064149A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007328945B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719693A2 (cg-RX-API-DMAC7.html)
CA (1) CA2668512C (cg-RX-API-DMAC7.html)
CL (1) CL2007003472A1 (cg-RX-API-DMAC7.html)
CY (1) CY1113594T1 (cg-RX-API-DMAC7.html)
DK (1) DK2086940T3 (cg-RX-API-DMAC7.html)
EA (1) EA017091B9 (cg-RX-API-DMAC7.html)
ES (1) ES2387923T3 (cg-RX-API-DMAC7.html)
HK (1) HK1214513A1 (cg-RX-API-DMAC7.html)
HR (1) HRP20120639T1 (cg-RX-API-DMAC7.html)
IL (1) IL199077A (cg-RX-API-DMAC7.html)
JO (1) JO2973B1 (cg-RX-API-DMAC7.html)
ME (1) ME01456B (cg-RX-API-DMAC7.html)
MX (1) MX2009005909A (cg-RX-API-DMAC7.html)
MY (1) MY148844A (cg-RX-API-DMAC7.html)
NO (1) NO342773B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ576485A (cg-RX-API-DMAC7.html)
PE (1) PE20081350A1 (cg-RX-API-DMAC7.html)
PL (1) PL2086940T3 (cg-RX-API-DMAC7.html)
PT (1) PT2086940E (cg-RX-API-DMAC7.html)
RS (1) RS52408B (cg-RX-API-DMAC7.html)
SI (1) SI2086940T1 (cg-RX-API-DMAC7.html)
TW (1) TWI417098B (cg-RX-API-DMAC7.html)
UA (1) UA97813C2 (cg-RX-API-DMAC7.html)
UY (1) UY30762A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008068231A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200903907B (cg-RX-API-DMAC7.html)

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US20120010216A1 (en) * 2010-07-06 2012-01-12 Brown Arthur M Pharmaceutical compositions containing vanoxerine
CZ2014708A3 (cs) * 2014-10-16 2016-04-27 Zentiva, K.S. Soli Bedaquilinu
CN114129526A (zh) * 2015-01-27 2022-03-04 詹森药业有限公司 可分散组合物
CN106279017A (zh) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 贝达喹啉晶型、组合物及其制备方法
CZ2015391A3 (cs) * 2015-06-09 2016-12-21 Zentiva, K.S. Sůl bedaquilinu s kyselinou citronovou
WO2017066926A1 (zh) * 2015-10-20 2017-04-27 浙江海正药业股份有限公司 富马酸贝达喹啉的晶型及其制备方法
PT3971177T (pt) * 2016-07-20 2024-07-30 Novartis Ag Derivados de aminopiridina e a sua utilização como inibidores seletivos de alk-2
CN106316943A (zh) * 2016-07-27 2017-01-11 重庆华邦制药有限公司 富马酸贝达喹啉晶型化合物的精制方法
PE20200336A1 (es) 2017-07-14 2020-02-14 Janssen Pharmaceutica Nv Formulaciones a largo plazo
US20220023282A1 (en) * 2018-12-13 2022-01-27 Mannkind Corporation Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
CN113271930A (zh) 2019-01-09 2021-08-17 詹森药业有限公司 治疗非结核分枝杆菌疾病的组合
WO2020161743A1 (en) * 2019-02-08 2020-08-13 Mylan Laboratories Limited Process for the preparation of bedaquiline fumarate
KR102303635B1 (ko) * 2020-07-01 2021-09-17 동아에스티 주식회사 (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법
CN111888477B (zh) * 2020-09-15 2023-03-07 北京福元医药股份有限公司 一种贝达喹啉药物制剂
JP2023549605A (ja) 2020-11-12 2023-11-28 ヤンセン ファーマシューティカ エヌ．ベー． 非結核性マイコバクテリア疾患の治療におけるベダキリン、エタンブトール、及びマクロライドの組合せ
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
WO2023232838A1 (en) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bedaquiline for use in the treatment of leprosy
CN117399070B (zh) * 2022-07-07 2025-06-24 上海交通大学 含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用

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DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
GB8824392D0 (en) * 1988-10-18 1988-11-23 Ciba Geigy Ag Dispersible formulation
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
CA2270123A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
CZ300261B6 (cs) * 1996-10-30 2009-04-01 Eli Lilly And Company Použití hydrochloridové soli raloxifenu pro prípravu léciva pro prevenci rakoviny prsu
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AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
AU2005249231B2 (en) * 2004-05-28 2010-11-11 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases
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BG66437B1 (bg) * 2004-12-24 2014-07-31 Janssen Pharmaceutica N.V. Използване на хинолинови съединения за лечение на латентна туберкулоза

Also Published As

Publication number Publication date
TWI417098B (zh) 2013-12-01
PL2086940T3 (pl) 2012-10-31
JO2973B1 (en) 2016-03-15
PE20081350A1 (es) 2008-09-18
CA2668512A1 (en) 2008-06-12
MX2009005909A (es) 2009-06-16
HRP20120639T1 (hr) 2012-08-31
KR20090087020A (ko) 2009-08-14
CN101547904A (zh) 2009-09-30
HK1214513A1 (zh) 2016-07-29
ES2387923T3 (es) 2012-10-04
UA97813C2 (uk) 2012-03-26
CY1113594T1 (el) 2016-06-22
AU2007328945B2 (en) 2014-04-03
WO2008068231A1 (en) 2008-06-12
ZA200903907B (en) 2013-08-28
IL199077A (en) 2016-09-29
EP2086940B1 (en) 2012-05-16
AU2007328945A1 (en) 2008-06-12
RS52408B (sr) 2013-02-28
JP2010511663A (ja) 2010-04-15
JP5894239B2 (ja) 2016-03-23
AP2498A (en) 2012-10-19
DK2086940T3 (da) 2012-08-20
EA017091B9 (ru) 2014-10-30
TW200838527A (en) 2008-10-01
US20100028428A1 (en) 2010-02-04
JP2015028049A (ja) 2015-02-12
UY30762A1 (es) 2008-07-03
SI2086940T1 (sl) 2012-09-28
CN105012303A (zh) 2015-11-04
US8546428B2 (en) 2013-10-01
NO20092535L (no) 2009-08-06
PT2086940E (pt) 2012-08-09
EA017091B1 (ru) 2012-09-28
NO342773B1 (no) 2018-08-06
NZ576485A (en) 2012-01-12
ME01456B (me) 2014-04-20
EA200970532A1 (ru) 2009-10-30
AP2009004870A0 (en) 2009-06-30
BRPI0719693A2 (pt) 2013-12-24
CA2668512C (en) 2015-03-24
AR064149A1 (es) 2009-03-18
EP2086940A1 (en) 2009-08-12
MY148844A (en) 2013-06-14
KR101514700B1 (ko) 2015-04-24

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