CL2004000628A1 - Uso de un androgeno natural o sintetico definido en combinacion con un gestageno definido para preparar un medicamento util en el tratamiento de deficit total o parcial de testosterona y profilaxis simultanea de hiperplasia prostatica benigna y carci - Google Patents

Uso de un androgeno natural o sintetico definido en combinacion con un gestageno definido para preparar un medicamento util en el tratamiento de deficit total o parcial de testosterona y profilaxis simultanea de hiperplasia prostatica benigna y carci

Info

Publication number
CL2004000628A1
CL2004000628A1 CL200400628A CL2004000628A CL2004000628A1 CL 2004000628 A1 CL2004000628 A1 CL 2004000628A1 CL 200400628 A CL200400628 A CL 200400628A CL 2004000628 A CL2004000628 A CL 2004000628A CL 2004000628 A1 CL2004000628 A1 CL 2004000628A1
Authority
CL
Chile
Prior art keywords
gestagen
testosterone
simultaneous
natural
combination
Prior art date
Application number
CL200400628A
Other languages
English (en)
Inventor
Doris Hubler
Lothar Sobek
Michael Oettel
Walter Elger
Abdul -Abbas Al-Mudhaffar
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7870308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2004000628(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of CL2004000628A1 publication Critical patent/CL2004000628A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

USO DE UN ANDROGENO NATURAL O SINTETICO EN COMBINACION CON UN COMPONENTE DEL GRUPO DE LOS GESTAGENOS, QUE SIRVE PARA OBTENER UN PREPARADO COMBINADO DESTINADO COMPENSAR UN DEFICIT ABSOLUTO O PARCIAL DE TESTOSTERONA CON PROFILAXISS SIMULTANEA DE LA FORMACION DE HIPERPLASIA PROSTATICA BENIGNA (BPH) O CARCINOMA DE PROSTATA.
CL200400628A 1998-06-09 2004-03-24 Uso de un androgeno natural o sintetico definido en combinacion con un gestageno definido para preparar un medicamento util en el tratamiento de deficit total o parcial de testosterona y profilaxis simultanea de hiperplasia prostatica benigna y carci CL2004000628A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19825591A DE19825591A1 (de) 1998-06-09 1998-06-09 Pharmazeutische Kombinationen zum Ausgleich eines Testosteron-Defizits beim Mann mit gleichzeitigem Schutz der Prostata

Publications (1)

Publication Number Publication Date
CL2004000628A1 true CL2004000628A1 (es) 2005-01-07

Family

ID=7870308

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400628A CL2004000628A1 (es) 1998-06-09 2004-03-24 Uso de un androgeno natural o sintetico definido en combinacion con un gestageno definido para preparar un medicamento util en el tratamiento de deficit total o parcial de testosterona y profilaxis simultanea de hiperplasia prostatica benigna y carci

Country Status (11)

Country Link
US (1) US20070078091A1 (es)
EP (1) EP1084569B1 (es)
JP (1) JP3645489B2 (es)
AT (1) ATE233976T1 (es)
AU (1) AU5277599A (es)
CL (1) CL2004000628A1 (es)
DE (2) DE19825591A1 (es)
DK (1) DK1084569T3 (es)
ES (1) ES2194495T3 (es)
PT (1) PT1084569E (es)
WO (1) WO1999065228A2 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003534375A (ja) * 2000-05-26 2003-11-18 フィッチ，ハリー 選択性抗エストロゲン薬を用いた男性におけるアンドロゲン欠乏症の治療法
EP1210951B1 (en) * 2000-11-30 2005-02-02 Pfizer Products Inc. Composition containing estrogen agonists/antagonists and testosterone for treating a decline in the level of the hormone testosterone
US7019012B2 (en) * 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
DE10221018A1 (de) * 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
WO2005066195A1 (de) * 2004-01-02 2005-07-21 Pharmacon Forschung Und Beratung Gmbh Verfahren zur herstellung von 1,2-ungesättigten azasteroiden
US7138389B2 (en) 2004-02-09 2006-11-21 University Of Washington Oral androgen therapy using modulators of testosterone bioavailability
EP2305352A1 (en) * 2004-04-02 2011-04-06 Merck Sharp & Dohme Corp. 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders
EP2371367A1 (en) * 2005-03-25 2011-10-05 Merck Sharp & Dohme (I.A.) Corp. Method of treating men with testosterone supplement and 5alpha reductase inhibitor
CA2629244C (en) 2005-11-11 2014-08-05 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
EP1968705A1 (en) * 2005-12-21 2008-09-17 Pfizer Products Incorporated Pharmaceutical combination of a pde-5 inhibitor and a 5-alpha reductase inhibitor
US20110092470A1 (en) * 2006-03-21 2011-04-21 Alan Meehan Method of treating men with erectile dysfunction
ES2385613T3 (es) 2006-09-18 2012-07-27 Boehringer Ingelheim International Gmbh Método para tratar cánceres que portan mutaciones de EGFR
JP5553767B2 (ja) * 2008-11-07 2014-07-16 大日本住友製薬株式会社 新規で有用な下部尿路症状治療剤
EP2266567A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
EP2266568A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
WO2011003853A2 (en) 2009-07-06 2011-01-13 Boehringer Ingelheim International Gmbh Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
WO2011082384A2 (en) 2009-12-31 2011-07-07 Differential Drug Development Associates, Llc Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
US20130303495A1 (en) * 2009-12-31 2013-11-14 Sov Therapeutics Emulsion formulations
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
NZ631833A (en) 2013-03-15 2017-06-30 Differential Drug Dev Ass Llc Emulsion formulations
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
RU2018133932A (ru) 2016-04-01 2020-05-12 Терапьютиксмд, Инк. Фармацевтическая композиция стероидного гормона
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
BE1028115B1 (fr) * 2020-03-02 2021-09-27 Georges Debled Composition pour le traitement des cancers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423507A (en) * 1966-02-25 1969-01-21 Schering Corp Method of treating benign prostratic hypertrophy
DE2817157A1 (de) * 1978-04-17 1979-10-25 Schering Ag Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie
DE3121152A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung der kombination eines aromatase-hemmers mit einem antiandrogen zur prophylaxe und therapie der prostatahyperplasie"
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
GB8506027D0 (en) * 1985-03-08 1985-04-11 Efamol Ltd Pharmaceutical & dietary compositions
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
IN171596B (es) * 1989-06-27 1992-11-21 Cohen Michael
ATE177949T1 (de) * 1989-07-07 1999-04-15 Endorecherche Inc Kombinationstherapie zur prophylaxe und/oder behandlung benigner prostatahyperplasie
DE4312034A1 (de) * 1993-04-13 1994-10-20 Hesch Rolf Dieter Prof Dr Med Neuartige Androgene und Anabolika
DE4318371A1 (de) * 1993-05-28 1994-12-01 Schering Ag Mittel, enthaltend eine Verbindung mit antiandrogener sowie eine Verbindung mit kompetitiver, progesteronantagonistischer Wirkung
ATE215826T1 (de) * 1993-11-19 2002-04-15 Jenapharm Gmbh Karzinostatisches mittel für hormontherapie, das dienogest als wirksamer bestandteil enthält
US5609617A (en) * 1995-02-21 1997-03-11 C. Norman Shealy Method for enhancement of dehydroepiandrosterone
US5599822A (en) * 1995-06-06 1997-02-04 Eli Lilly And Company Methods for minimizing bone loss
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
WO1999046279A2 (en) * 1998-03-11 1999-09-16 Endorecherche, Inc. INHIBITORS OF TYPE 5 AND TYPE 3 17β-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE

Also Published As

Publication number Publication date
AU5277599A (en) 1999-12-30
US20070078091A1 (en) 2007-04-05
EP1084569B1 (de) 2003-03-05
PT1084569E (pt) 2003-07-31
DE19825591A1 (de) 1999-12-23
WO1999065228A2 (de) 1999-12-16
ATE233976T1 (de) 2003-03-15
JP3645489B2 (ja) 2005-05-11
JP2002518294A (ja) 2002-06-25
EP1084569A2 (de) 2001-03-21
DK1084569T3 (da) 2003-06-30
DE59904462D1 (de) 2003-04-10
ES2194495T3 (es) 2003-11-16
WO1999065228A3 (de) 2000-09-14

Similar Documents

Publication Publication Date Title
CL2004000628A1 (es) Uso de un androgeno natural o sintetico definido en combinacion con un gestageno definido para preparar un medicamento util en el tratamiento de deficit total o parcial de testosterona y profilaxis simultanea de hiperplasia prostatica benigna y carci
CL2004000675A1 (es) Uso de una combinacion de androgeno de origen biogenico o sintetico y un estrogeno de origen biogenico o sintetico para preparar un medicamento util en el tratamiento del hipogonadismo y enfermedades hipofisis o glandula pituitaria en hombres, para e
ES2115572T1 (es) Procedimiento y producto para el teñido del cabello.
PL349028A1 (en) Cancer treatment composition and method using natural plant essential oils
ATE380552T1 (de) Pharmazeutische zusammensetzung enthältend estetrolderivate und anwendung in der krebsbehandlung
ES2150050T3 (es) Polisacaridos injertados con antioxidantes y su utilizacion.
ES2163293T3 (es) Combinacion de un inhibidor de tirosina quinasas y castracion quimica para tratar el cancer de prostata.
AR018240A1 (es) Composiciones de tinte de fibras queratinicas que contienen derivados de pirazolo-[1,5-a]-pirimidina, procedimiento de tinte, nuevos derivados depirazolo-[1,5-a]-pirimidina y su procedimiento de preparacion
ES2157027T3 (es) Oxazolidinonas sustituidas y su uso como farmacos antibacterianos.
SE9700642D0 (sv) Medel och sätt för förebyggande och behandling av det metabola syndromet
HUP0000261A2 (hu) Módszer prosztatatúltengés és prosztatarák kezelésére
CL2004000026A1 (es) Uso de una composicion que comprende 0 a alrededor de 29% de cis-clomifeno y de alrededor de 100 a alrededor de 71% de trans-clomifeno para preparar un medicamento util para aumentar los niveles de testosterona en suero en un mamifero masculino.
AR039987A1 (es) Utilizacion de inhibidores de la transduccion de senales inducida por egfr para el tratamiento de la hiperplasia de la prostata benigna (hpb)/hipertrofia de la prostata
PT1109571E (pt) Metodos de tratamento da hipertensao e composicoes para utilizacao nesses metodos
AR016981A2 (es) Polipeptidos sinteticos
NZ508299A (en) Testosterone derivative
MX9806082A (es) Preparacion farmaceutica combinada de analogos de lhrh y antiestrogenos para el tratamiento de trastornos ginecologicos.
ES2177811T3 (es) Uso de nitroflavonoides para el tratamiento de la ansiedad.
ES2188936T3 (es) Antagonistas del receptor alfa-q-adrenergico.
EP0369216A3 (en) Pharmaceutical preparation based on ester derivatives of hecogenine, and their use in treating benign prostatic hyperplasia
UY26431A1 (es) Quimioterapia de combinación
BR0108951A (pt) Uso de exemestano, e método para o tratamento de primeira linha de c ncer de mama
DE69905392D1 (de) Verwendung von einer pharmazeutischen zusammensetzung enthaltende ein antikrebs mittel und mindestens ein peptid
EP0975629A4 (en) TREATMENT OR PROPHYLAXIS OF PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA USING SELECTIVE MODULATORS OF ESTROGEN RECEPTORS
ZA991315B (en) Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia.