CH665127A5 - COUPLING PART FOR INJECTION SYRINGES. - Google Patents
COUPLING PART FOR INJECTION SYRINGES. Download PDFInfo
- Publication number
- CH665127A5 CH665127A5 CH6469/83A CH646983A CH665127A5 CH 665127 A5 CH665127 A5 CH 665127A5 CH 6469/83 A CH6469/83 A CH 6469/83A CH 646983 A CH646983 A CH 646983A CH 665127 A5 CH665127 A5 CH 665127A5
- Authority
- CH
- Switzerland
- Prior art keywords
- flange
- syringes
- intended
- microcapsules
- end pieces
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
- B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2044—Separating means having slits
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
DESCRIPTION DESCRIPTION
La présente invention se rapporte au domaine des accessoires pour instruments médicaux, plus précisément à une pièce d'accouplement pour seringues à injection. The present invention relates to the field of accessories for medical instruments, more specifically to a coupling part for injection syringes.
Actuellement, de nombreuses préparations pharmaceutiques se présentent sous une forme enrobée par micro-encapsulation; il s'agit notamment de médicaments à effet retard ou à action prolongée que l'on administre le plus généralement par injection. Currently, many pharmaceutical preparations are in a coated form by microencapsulation; these include delayed-release or long-acting drugs that are most commonly administered by injection.
Divers problèmes se posent, tant au niveau de la manipulation des microcapsules en vue de leur emploi que de leur mise en suspension. On est toujours à la recherche d'opérations les plus simples et les plus sûres possibles quant au maintien de la stérilité, et permettant également d'éviter des pertes de produit actif avant injection. Various problems arise, both in terms of handling the microcapsules with a view to their use and their suspension. We are always looking for the simplest and safest possible operations for maintaining sterility, and also making it possible to avoid losses of active product before injection.
Pour la préparation de suspensions de microcapsules, les techniques actuelles consistent à introduire la dose prévue de microcapsules dans une première seringue, de préférence obturée à l'extrémité munie de l'embout destiné à recevoir par la suite une aiguille, à stériliser ensuite celle-ci à l'aide d'une méthode appropriée, puis à transférer d'une seconde seringue le liquide stérile de la suspension. Les seringues du commerce sont munies d'une pièce d'obturation de forme allongée, le plus souvent tronconique, provisoirement placée sur l'embout : de telles pièces garantissent la stérilité du volume interne de la seringue, mais agrandissent d'autant l'espace clos hors du cylindre de ladite seringue. Lors de l'introduction de matière solide telles des microscapsules, une perte plus ou moins importante de produit actif est constatée. For the preparation of microcapsule suspensions, current techniques consist in introducing the intended dose of microcapsules into a first syringe, preferably closed at the end provided with the end piece intended to receive a needle thereafter, then sterilizing the latter. this using an appropriate method, then transferring the sterile liquid from the suspension from a second syringe. Commercial syringes are provided with an elongated closure piece, most often frustoconical, temporarily placed on the tip: such pieces guarantee the sterility of the internal volume of the syringe, but enlarge the space as much closed outside the cylinder of said syringe. During the introduction of solid matter such as microscapsules, a more or less significant loss of active product is noted.
Lors de la préparation de la suspension de microcapsules proprement dite, le transfert de liquide d'une seringue à l'autre s'effectue par l'entremise d'un tuyau souple, de longueur variable, réunissant chacune des deux seringues par leur embout respectif, l'homogénéisation de la suspension s'effectuant par transferts successifs au mélange hétérogène, d'une seringue dans l'autre. De tels transferts doivent être nombreux et, une fois l'homogénéisation réalisée, on observe une perte importante de produit actif dans le tuyau souple reliant les deux seringues, pertes pouvant aller parfois jusqu'à 20% en poids de produit actif, compte tenu des volumes morts des embouts de chacune desdites seringues. On utilise aussi un robinet 5 dit à trois voies en lieu et place du tuyau souple, deux des branches dudit robinet coopérant avec l'embout de chacune des seringues. Outre le danger accru de pertes de produit due à une manipulation erronée (ouverture sur la troisième voie libre), ce type d'accessoire nécessite également un nombre élevé de transferts successifs pour io parvenir à l'homogénéisation souhaitée, et l'on observe des pertes du produit actif du même ordre que ci-dessus. Un tel accessoire est en outre fort cher et renchérit d'autant le coût d'une injection de microcapsules en suspension. During the preparation of the suspension of microcapsules proper, the transfer of liquid from one syringe to the other is carried out by means of a flexible tube, of variable length, joining each of the two syringes by their respective nozzle. , the homogenization of the suspension being carried out by successive transfers to the heterogeneous mixture, from one syringe to the other. Such transfers must be numerous and, once homogenization has been carried out, there is a significant loss of active product in the flexible tube connecting the two syringes, losses which can sometimes go up to 20% by weight of active product, taking into account the dead volumes of the tips of each of said syringes. One also uses a tap 5 called three-way instead of the flexible hose, two of the branches of said tap cooperating with the tip of each of the syringes. In addition to the increased danger of product loss due to incorrect handling (opening on the third free way), this type of accessory also requires a high number of successive transfers to achieve the desired homogenization, and losses of the active product of the same order as above. Such an accessory is also very expensive and increases the cost of injecting microcapsules in suspension all the more.
L'invention a pour but de remédier aux défauts des instruments 15 actuels en proposant des accessoires pour seringues à injection réduisant au minimum le volume mort des seringues utilisées et permettant également de préparer des suspensions de microcapsules dans les meilleures conditions de stérilité, sans perte excessive de temps ni de produit actif. L'invention a pour objet une pièce d'ac-20 couplement pour seringues selon la revendication 1, de même que des ensembles destinés à l'accouplement et à l'obturation de telles seringues, tels que définis aux revendications 5 et 6. The object of the invention is to remedy the shortcomings of current instruments by proposing accessories for injection syringes which minimize the dead volume of the syringes used and also make it possible to prepare suspensions of microcapsules under the best sterility conditions, without excessive loss. time or active product. The subject of the invention is a coupling piece for syringes according to claim 1, as well as assemblies intended for coupling and for closing such syringes, as defined in claims 5 and 6.
Les figures décrites ci-après illustrent certaines des exécutions de l'invention. Elles ne sont données qu'à titre indicatif. Dans lesdites 25 figures, les seringues ont été représentées opaques, contrairement à la réalité dans la plupart des cas. The figures described below illustrate some of the embodiments of the invention. They are given for information only. In the said 25 figures, the syringes have been shown to be opaque, contrary to reality in most cases.
La fig. 1 représente, vue de profil, une exécution de la pièce d'accouplement selon l'invention; Fig. 1 shows a side view of an embodiment of the coupling part according to the invention;
la fig. 2 est une vue de face de la pièce représentée par la fig. 1 ; 30 la fig. 3 est une vue en coupe, légèrement agrandie, de la pièce représentée par la fig. 1 ; fig. 2 is a front view of the part shown in FIG. 1; 30 fig. 3 is a sectional view, slightly enlarged, of the part shown in FIG. 1;
la fig. 4 représente, vue partiellement en coupe, la pièce d'accouplement illustrée par la fig. 1, fixée sur l'embout d'une seringue; la fig. 5 représente, vues de profil, deux seringues accouplées à 35 l'aide de la pièce illustrée par la fig, 1, et la fig. 6 représente, vu de profil, un bouchon destiné à coopérer avec la pièce d'accouplement illustrée par la fig. 1 en vue de former une pièce d'obturation telle que représentée par la fig. 3. fig. 4 shows, partly in section, the coupling part illustrated in FIG. 1, attached to the tip of a syringe; fig. 5 shows, in profile views, two syringes coupled using the part illustrated in FIG, 1, and FIG. 6 shows, seen in profile, a plug intended to cooperate with the coupling part illustrated in FIG. 1 with a view to forming a closure part as shown in FIG. 3.
La pièce selon l'invention est destinée à l'accouplement de serin-40 gues à injection comportant un embout tronconique 1 placé à l'intérieur d'une douille filetée 2. Selon l'invention, elle se compose de deux embouts creux communicants 3, 4 disposés coaxialement, tous deux solidaires d'une bride intermédiaire 5 et de forme intérieure tronconique, la grande base du tronc de cône se situant à chacune 45 des extrémités de ladite pièce. De fait, la forme intérieure des embouts 3, 4 est aménagée de façon à assurer un contact le plus * étroit possible avec l'embout correspondant de la seringue. Comme illustré, ladite forme est le plus généralement tronconique, tout comme celle des embouts 1. La longueur desdits embouts 3, 4 est en 50 outre calculée de façon telle qu'elle soit pratiquement égale à celle des embouts 1 : on réduit ainsi à sa valeur minimum le volume mort inhérent à toute seringue à injection, ce qui réduit d'autant les pertes intervenant au cours des opérations. The part according to the invention is intended for coupling canary-40 injection lines comprising a frustoconical end piece 1 placed inside a threaded sleeve 2. According to the invention, it consists of two hollow communicating end pieces 3 , 4 arranged coaxially, both integral with an intermediate flange 5 and of frustoconical interior shape, the large base of the truncated cone being located at each 45 of the ends of said part. In fact, the internal shape of the tips 3, 4 is arranged so as to ensure the closest * contact possible with the corresponding tip of the syringe. As illustrated, said shape is most generally frustoconical, just like that of the end pieces 1. The length of said end pieces 3, 4 is furthermore calculated in such a way that it is practically equal to that of the end pieces 1: this reduces to its minimum value the dead volume inherent in any injection syringe, thereby reducing the losses occurring during operations.
Selon l'invention, chacun desdits embouts 3,4 présente à son ex-55 trémité opposée à la bride 5 un rebord 6, 7 destiné à coopérer avec le filetage de la douille 2. On assure de cette façon la solidarisation de la pièce d'accouplement 11 à chacune des seringues qui y sont connectées, renforçant simultanément le contact étroit des embouts 1,3 et 4 et garantissant ainsi la stérilité des opérations de transfert de 60 produit d'une seringue à l'autre. According to the invention, each of said end pieces 3,4 has at its ex-55 end opposite to the flange 5 a flange 6, 7 intended to cooperate with the thread of the sleeve 2. In this way, the part d is secured. coupling 11 to each of the syringes connected thereto, simultaneously strengthening the close contact of the tips 1, 3 and 4 and thus guaranteeing the sterility of the operations for transferring 60 product from one syringe to another.
Selon l'invention en outre, la pièce d'accouplement 11 se caractérise par le fait que la bride 5 se prolonge à l'intérieur de l'espace creux 8 commun aux embouts 3,4 pour délimiter un orifice 9 de diamètre sensiblement inférieur à celui de l'espace 8. Cet agencement 65 particulier a principalement pour effet de provoquer un régime turbulent lors du transfert de liquide d'une seringue à l'autre et de promouvoir ainsi une homogénéisation rapide de la suspension. Dans la plupart des cas, 5 à 10 transferts au plus sont suffisants. Les dimen According to the invention, moreover, the coupling piece 11 is characterized in that the flange 5 extends inside the hollow space 8 common to the end pieces 3,4 to delimit an orifice 9 of diameter substantially less than that of space 8. This particular arrangement 65 has the main effect of causing a turbulent regime during the transfer of liquid from one syringe to another and thus promoting rapid homogenization of the suspension. In most cases, no more than 5-10 transfers are sufficient. The dimen
3 3
665 127 665,127
sions de l'orifice 9 seront bien entendu telles qu'elles en éviteront l'obturation accidentelle par des matières solides, telles des microcapsules par exemple. sions of the orifice 9 will of course be such that they will avoid accidental obstruction by solid materials, such as microcapsules for example.
La pièce 11 peut être réalisée en un matériau rigide, par exemple thermoformable, usuel dans l'art médical. On peut citer, à titre 5 d'exemple, les polymères tels que le Nylon, le Téflon, le Makrolon, le polystyrène, le polypropylène ou le polyéthylène. Un tel matériau doit en outre, de préférence, supporter une stérilisation à l'aide de rayons gamma. The part 11 can be made of a rigid material, for example thermoformable, customary in the medical art. By way of example, mention may be made of polymers such as Nylon, Teflon, Makrolon, polystyrene, polypropylene or polyethylene. In addition, such a material should preferably withstand sterilization using gamma rays.
La pièce 11 peut être avantageusement utilisée pour réaliser l'ac- 10 couplement de deux seringues, l'une d'entre elles contenant une préparation pharmaceutique sous forme de microcapsules stériles, Part 11 can advantageously be used to couple two syringes, one of which contains a pharmaceutical preparation in the form of sterile microcapsules,
l'autre un solvant stérile destiné à mettre en suspension lesdites microcapsules. Après le transfert de la totalité du mélange dans l'une des deux seringues, la pièce 11 est déconnectée de celle-ci, une ai- 15 guille à injection étant alors placée sur l'embout 1 ainsi libéré. Ladite seringue est alors prête pour l'injection d'une suspension de microcapsules. Dans la pratique, on a observé que les pertes en produit actif étaient inférieures à 5% en poids environ. the other a sterile solvent intended to suspend said microcapsules. After the entire mixture has been transferred to one of the two syringes, the part 11 is disconnected therefrom, an injection needle being then placed on the end piece 1 thus released. Said syringe is then ready for the injection of a suspension of microcapsules. In practice, it has been observed that the losses of active product are less than approximately 5% by weight.
Selon l'invention, la bride 5 est le plus généralement de forme polygonale et fait office d'organe de manipulation de la pièce 11. En fait, toute forme adaptée à la préhension de ladite bride peut être envisagée. On peut ainsi réaliser des objets de petite taille demeurant aisément manipulables. According to the invention, the flange 5 is most generally of polygonal shape and acts as a member for handling the part 11. In fact, any shape suitable for gripping said flange can be envisaged. It is thus possible to produce small objects that remain easy to handle.
Selon l'invention en outre, l'un des embouts 3, 4 peut être muni d'un bouchon 10 dont une partie 12 au moins est de forme complémentaire à celle de l'espace intérieur desdits embouts, le plus généralement de forme tronconique. Ladite partie 12 présente en outre une protubérance 13, destinée à coopérer avec l'orifice 3 défini plus haut. Un tel ensemble, connecté par son embout libre à une seringue, constitue une pièce d'obturation dans laquelle l'espace mort inhérent à l'agencement des seringues actuellement connues (embout 1 et douille filetée 2) est réduit à son volume minimum. Un tel ensemble convient particulièrement bien à l'obturation de seringues destinées à recevoir des matières pulvérulentes, telles des microcapsules par exemple. According to the invention, moreover, one of the end pieces 3, 4 can be provided with a plug 10, at least part 12 of which is of shape complementary to that of the interior space of said end pieces, most generally of frustoconical shape. Said part 12 also has a protrusion 13, intended to cooperate with the orifice 3 defined above. Such an assembly, connected by its free tip to a syringe, constitutes a closure piece in which the dead space inherent in the arrangement of the syringes currently known (tip 1 and threaded sleeve 2) is reduced to its minimum volume. Such an assembly is particularly suitable for closing syringes intended to receive pulverulent materials, such as microcapsules for example.
Le bouchon 10 sera de préférence réalisé dans des matériaux du même type que celui utilisé pour la pièce d'accouplement 11. The plug 10 will preferably be made of materials of the same type as that used for the coupling part 11.
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1 feuille dessins 1 sheet of drawings
Claims (7)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6469/83A CH665127A5 (en) | 1983-12-02 | 1983-12-02 | COUPLING PART FOR INJECTION SYRINGES. |
| EP84810571A EP0148116A1 (en) | 1983-12-02 | 1984-11-23 | Coupling piece for an injection syringe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6469/83A CH665127A5 (en) | 1983-12-02 | 1983-12-02 | COUPLING PART FOR INJECTION SYRINGES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH665127A5 true CH665127A5 (en) | 1988-04-29 |
Family
ID=4310129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH6469/83A CH665127A5 (en) | 1983-12-02 | 1983-12-02 | COUPLING PART FOR INJECTION SYRINGES. |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP0148116A1 (en) |
| CH (1) | CH665127A5 (en) |
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| US11471610B1 (en) | 2018-10-18 | 2022-10-18 | Robert Banik | Asymmetrical closure for a medical device |
| USD903865S1 (en) | 2018-11-19 | 2020-12-01 | International Medical Industries, Inc. | Self-righting tip cap |
| US11911339B1 (en) | 2019-08-15 | 2024-02-27 | Peter Lehel | Universal additive port cap |
| US11697527B1 (en) | 2019-09-11 | 2023-07-11 | Logan Hendren | Tamper evident closure assembly |
| US11357588B1 (en) | 2019-11-25 | 2022-06-14 | Patrick Vitello | Needle packaging and disposal assembly |
| TWI731660B (en) * | 2020-04-24 | 2021-06-21 | 透策生技股份有限公司 | Processing method for accelerating the dispersion of injection-type fillers by means of pressurization |
| US11523970B1 (en) | 2020-08-28 | 2022-12-13 | Jonathan Vitello | Tamper evident shield |
| US11872187B1 (en) | 2020-12-28 | 2024-01-16 | Jonathan Vitello | Tamper evident seal for a vial cover |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1961790A1 (en) * | 1969-12-10 | 1971-06-16 | Sander Beuermann Karl Heinz | Closing plug for container openings |
| FR2279378A1 (en) * | 1974-07-22 | 1976-02-20 | Chibret Laboratoires | Flask for mixing powders and solvents esp for pharmaceutical compsns - has screw-cap with perforated tube which pierces seal between two containers |
| US4172457A (en) * | 1977-10-06 | 1979-10-30 | American Hospital Supply Corporation | Plural component mixing system and method |
| SU792092A1 (en) * | 1978-12-20 | 1980-12-30 | Минский Ордена Трудового Красного Знамени Государственный Медицинский Институт | Apparatus for determining tracer amounts of gas dissolved in liquids |
| FR2446114A1 (en) * | 1979-01-15 | 1980-08-08 | Hyco Et Aulas | Powered syringe actuator partic, for intravenous injections - can be readily adapted to operate any selected syringe |
| US4237882A (en) * | 1979-09-27 | 1980-12-09 | Sherwood Medical Industries Inc. | Needle sheath |
-
1983
- 1983-12-02 CH CH6469/83A patent/CH665127A5/en not_active IP Right Cessation
-
1984
- 1984-11-23 EP EP84810571A patent/EP0148116A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0148116A1 (en) | 1985-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |