CH639244A5 - SUBSTITUTE FOOD FOR BREAST MILK AND VACCINE MILK. - Google Patents

Description

The present invention relates to a substitute food for breast milk and cow's milk containing the nutrients essential for ensuring a healthy and harmonious growth for infants of first and second childhood.

As early as 1929 Hill L. W. and Stuart H. C. ["A soy bean preparation for feeding infants with milk idiosyncrasy" J. A. M. A. 93 985, (1929)] had suggested feeding children suffering from intolerance to cow's milk with liquid preparations derived from soybeans.

Previous experiments, as the Authors themselves report, made with milk-free diets administered to infants with eczema, had given very bad results, given that the children improved yes from the skin manifestations, but they faced serious digestive disorders that ended up being much more dangerous of the eczema itself.

Soy milk preparations for feeding the baby are also on sale in Italy; these preparations are both of foreign origin and of Italian manufacture. These soybean preparations are not always well tolerated by all children suffering from intestinal malabsorption disorders and are not decisive in re-feeding after gastroenteritis, so in practice they have not become common use. The existence of documented cases (see Mendoza J. et al. Pediatrica, Vol. 16, No. 5-1970) of soy intolerance means that the use of these foods may not be followed by success.

Also the preparations of calcium caseinate and chemically acidified milks have been - in recent years - abandoned due to the emergence of notions concerning the allergy to milk proteins of which these products are made and to the secondary lactase deficiency that is established in malabsorption from any specific cause and which therefore does not stop chronic diarrhea since lactose is still contained, albeit in a reduced dose, in acidified milks.

It is therefore an object of the present invention to provide a milk substitute food capable of constituting a global, pre-dosed, sterile food system, suitable for first and second childhood, ready for use and free from the drawbacks of known food preparations.

It is also an object of the present invention to provide a milk substitute food for first and second childhood particularly suitable for administration in the following cases:

- food recovery after diarrheal episodes;

- intestinal malabsorption syndrome from any cause;

- intolerance to cow's milk and beef proteins;

- lactose intolerance and other disaccharides;

- soy intolerance;

- allergic skin manifestations (infantile eczema);

- allergic respiratory manifestations (bronchial asthma;

5 state of asthmatic illness; intractable bronchial asthma and so on);

- iron anemia;

- poor growth in statistics;

- anorexia;

I - normal subjects especially in emergency situations such as travel, stays outside the usual environment with problems of supply of food ingredients and so on.

These and other purposes are achieved with the food according to the invention, containing lamb meat 150 - 200 g rice cream 150 - 200 g olive oil 10 - 30 g fine salt (NaCl) 0.5 - 2 g 20 water to taste a l'OOO mi.

Lamb meat must be lean, without bands, tendons, connective tissue and reduced to a homogeneous puree by passing it to the homogenizer; rice cream 25 must not have additives and must be cooked for twenty minutes; then the homogenised lamb meat and the cooked rice cream are added, the salt and oil are added, it is brought to a volume of 1 liter with sterile water and is distributed in 100 ml glass containers. Naturally, the glass must be of such a position that it does not release dangerous elements. The hermetic seal is of the known type.

Colloidal calcium phosphate could be added in a dose of 20 mg per 100 ml of food, that is, 200 mg in 1000 ml, so it would ensure a daily intake of 35 120-200 mg per day of calcium and phosphorus, as recommended. However this addition is not essential; vitamins should be administered to the child as usual, in the form of drop mixtures such as Protovit® (1>, Abi-dec® ((2), Idroplurivit® (3), and so on). or two daily spoons of a calcium phosphate-based product (for example Ca-Steorgyl® (4); Calci-oste-lin B12® (5) and so on) preferably which do not contain lactose.

For children particularly accustomed to the sweet taste of 45 baby food and who therefore could refuse the salty food object of the present invention, 20 to 30 g of rice cream can be replaced with glucose in the form, for example of Dextropur® (6).

In its preferred embodiment the food of the present invention contains:

lamb meat 180 g rice cream 180 g olive oil 15 g

55 fine salt (NaCl) 1 g water to taste a l'OOO mi.

The food of the present invention has a composition equal to: 72% carbohydrates; proiteine 14.4%; fats 60 13.5%.

<!> Hoffmann La Roche, Basel (Ch).

<2> Parke Davis, Detroit (U.S.A.).

65 (S) Menarini A. S.a.S., Florence.

<4> Roussel Maestretti, S.p.A., Mileno.

<5ì Glaxo Laboratories Ltd., Greenford (Great Britain).

<6> Monda, S.p.A., Milan.

3

639244

Since 18 g of rice cream provides 72 calories, 18 g of lean lamb about 15 calories and 1.5 g of oil about 13 calories, 100 ml of food provide 100 calories. This identity between volume and calories allows to facilitate and simplify the setting of the food ration in the young child. For each kg of the child's body weight, a minimum ration of 100 daily calories is given, which corresponds to 100 ml of food. To do this, it is sufficient to know the weight of the child in grams and give him the quantity of food corresponding to the first three figures rounded to the immediately higher round ones; this quantity of homogenate must be diluted with half the overall volume of water. For example, a child of 5,700 kg should be given 570 ml of food of the present invention which, in practice, can be rounded to 600 ml, to which 300 ml of water (i.e. 600: 2) must be added. For a single meal, if the child is at 6 meals, he will receive 100 ml of food of the present invention diluted with 50 ml of water, that is, six 150 ml meals; if instead the child is at 5 meals he will receive 120 ml of food from the present invention to which 60 ml of water will be added, that is a total of 180 ml.

If the child does not become satiated, or should gain little weight (less than 25-30 g per day, depending on age), the total calorie intake must be increased to 110 or even 120 calories per kg per day. To obtain the grams of food to be given, just multiply the first three digits of the weight in grams by 1.1 and you will have the quantities equal to 120 cal / kg / day. To ensure the water requirement, 150-160 ml / kg / day must be added. The amount already suggested can be valid, i.e. an amount of water expressed in ml equal to half the volume of food of the present invention. For each kg of body weight of the child, 3.6 g of protein, 1.5 g of fat and 18 g of carbon hydrates are given with the food of the present invention and adding half the volume of water 150 I of water itself.

The food of the present invention has also been successfully given to children of very low weight, i.e. 2.5 kg.

By feeding children with the food of the present invention, there is an excellent appetite, the emission of 0-3 discharges per day, formed, alkaline, brownish in color. In addition, the children treated in this way are also in a good mood, do not have abdominal pain, show greater energy in motor and relationship life responses and have normal or even accelerated weight and stat growth. Even their bleeding-

tion improves in a surprising way, perhaps because they receive a large amount of iron bound to the proteins of lamb.

The food of the present invention has proven to be particularly useful in cases of acute gastroenteritis, malabsorption syndrome, bronchopulmonary infections, rickets, psychomotor retardation.

33 children aged between 1 and 24 months, some of whom were hospitalized several times for various causes, for me a total of 41 hospital stays, were treated with a diet containing the food of the present invention.

These hospitalizations originated in 23 cases from acute gastroenteritis, in 9 from malabsorption syndrome and in 9 from various pathologies (bronchopulmonary infections, rickets, 15 psychomotor retardation, see attached table).

The diet containing the food of the present invention has been used both as a dietary treatment during re-feeding in subjects suffering from acute gastroenteritis with severe weight loss, and as a basic diet for the feeding of children suffering from intestinal malabsorption or other morbid conditions.

To evaluate the effectiveness of this diet, the following parameters were taken into consideration:

25 1) normalization time of the alve in subjects with diarrhea;

2) daily increase in weight.

The normalization time of the alvo was varied, ranging from a minimum of 24 hours to a maximum of 12 30 days with an average value per subject of 2.5 days, equal to 60 hours. It should be noted that in 9 subjects (32% of cases) the alve regularized within 24 hours and in 17 subjects (60%) in 48 hours; in one case, this diet therapy does not seem to have had any immediate effect since the normalization 35 of the alvo occurred only after 12 days, but since it is a small patient suffering from a serious malformation syndrome such as "Incontinentia pigmenti", it does not seem that this case is paradigmatic to evaluate the effect of this diet.

Also for the daily weight gain, the data were 40 various states ranging from a minimum of 10 g to a maximum of 100 g with an average value of 40 g per day per subject.

The average daily weight increase was:

45 for people with gastroenteritis: 42 g per day;

for subjects with malabsorption: 40 g per day;

for subjects suffering from other pathology: 40 g per day.

Child N.

AGE months

DIAGNOSIS

FEBRE for days

COPROCOLT.

NORMAL, alvo in days

Antibiot.

First Kg.

P E S

^ '

• d

U,

<L>

to.

OR

Output Kg.

Incr./die gr-

1

13

G.E. M.

6

E. Coli

Salmonella

3

Gental. Colim.

7.0

9.2

7.1

44

2

8

G.E. B.

11

E. Coli Salmonella

-

Gentai. Colim.

00 co

3.0

co co

20

3

9

G.E.

3

E. Coli Proteus

3

Gental. Colim.

6.9

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6.7

100

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Child N.

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DIAGNOSIS

no no

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I

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!

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FEBRE for days

E- Coli i

E. Coli Salmonella

E. Coli

E. Coli Entero-bact;

'IS. Coli ■ S almo-nella

E. Coli Proteus mirab.

E. Coli neg.

E. Coli S almo-nella

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E. Coli Proteus mirabilis

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COPROCOLT.

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Colim. Gental

Colim.

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Gental. Colim.

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G.E.

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DIAGNOSIS

THE

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C3 O

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s or s o

FEBRE for days

Proteus E. Coli

E. Coli Citrobacter.

E. Coli Proteus

E. Coli Proteus

E. Coli

Klebs.

Enterob.

E. Coli Proteus Klebs.

E. Coli Proteus Citrob.

1

E. Coli Proteus

E. Coli;

E. Coli Enterobacter.

E. Coli Enterobacter.

E. Coli Klebs.

E. Coli Enterob.

the

COPROCOLT.

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I

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the

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CO

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the

NORMAL, alvo in days

Colim.

the

Colim. Gental.

Colim.

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SJ Q h- m ir> Ö r + ÇL £ U H

Colim. Gental

Kanam.

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639244 6

Child N.

AGE months

DIAGNOSIS

FEBRE for days

COPROCOLT.

NORMAL, alvo in days

Antibiot.

First Kg.

WEIGHTS -a u <

the

CU

I-I

Output Kg.

Incr./die gr.

32

22

G.E.

1

Salmonella

2

Colim. Gental.

10.7

-

11, 0

30

33

6

G.E.

no

E. Coli

Enterob.

cloacae

3

-

7.0

-

7.1

20

34

9

M.

2

E. Coli

Enterob.

cloacae

2

-

6.8

-

7.1

60

35

4

S.A.L.V.

no

E. Coli Enterobacter

1

-

8.8

-

8.9

30

36

2

S.A.L.V. M.

no

E. Coli

Enterob,

cloacae

-

-

4.2

-

4.3

33

37

20

M.

no

E. Coli

-

-

13.6

-

13.8

22

38

11

M.

4

E. Coli Salmonella

2

Large.

9.7

-

9.9

15

39

13

E.P.M.

3

-

-

Large. Gental.

7.8

-

8.0

33

40

9

M.

-

E. Coli Proteus Mirab.

1

-

8.1

-

8.3

80

41

15

M.

-

E. Coli Pseudomonas

-

-

9.8

-

10.0

25

Diagnosis: G. E. = gastro enteritis; M. = intestinal malabsorption; B. = bronchitis; C. = convulsions;

R. P. M. = psycho-motor delay; Permanent Disability = in- Antibiotics:

continentia pigmenti and C3 deficiency; 55 C. L. = milky crust; Bt. = Bronchiolitis;

Re = rickets; I.V.U. = urinary tract infection;

S. A. L. V. = suspected allergy to cow's milk proteins.

Colim. = Colimicine; Gental. = Gentalyn (Gentamicina); Large. = Amplital (Ampicilline); Rifad. = Rifadin (Rifamycin); Eritr. = Erythrocin (Erythromycin); Kanam. = Kanami-china.

v

Claims (2)

639244 2 CLAIMS 1. Replacement food for breast milk and cow's milk containing: lamb meat 150 - 200 g rice cream 150 - 200 g olive oil 10 - 30 g fine salt (NaCl) 0.5 - 2 g water to taste a l'OOO mi. 2. Substituted food according to claim 1 containing: lamb meat 180 g rice cream 180 g olive oil 15 g fine salt (NaCl) 1 g water to taste a l'OOO mi.