CH614704A5 - Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamids - Google Patents
Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamidsInfo
- Publication number
- CH614704A5 CH614704A5 CH369979A CH369979A CH614704A5 CH 614704 A5 CH614704 A5 CH 614704A5 CH 369979 A CH369979 A CH 369979A CH 369979 A CH369979 A CH 369979A CH 614704 A5 CH614704 A5 CH 614704A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- novel
- fluorobenzoylpropyl
- carried out
- case
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel N-(p-fluorobenzoylpropyl)-4-piperidyl-amides of the formula I shown, wherein R denotes a hydrogen atom, a straight-chain or branched alkyl radical having 1 to 15 carbon atoms, or a tetrahydrofuryl, furyl, thienyl, phenyl or adamantyl radical, are prepared by reacting 4-(4'-aminopiperidino)-p-fluorobutyrophenone with a carboxylic acid which introduces the group R, or with a functional derivative of such an acid, preferably an acid halide, especially the acid chloride, or an acid anhydride. In the case of the functional derivatives, the reaction is advantageously carried out in the presence of an acid-binding agent and in the case of the free carboxylic acid it is preferably carried out in the presence of a dehydrating condensation agent. The products of the process can be converted into their physiologically harmless acid addition salts. The novel compounds show the typical pattern of action of neuroleptics and can therefore be employed as central nervous system-damping (suppressing) agents, sedatives and tranquillisers. <IMAGE>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2423897A DE2423897C3 (en) | 1974-05-16 | 1974-05-16 | N- (p-FluorobenzoyIpropyl) -4piperidylamides, process for their preparation and pharmaceutical preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH614704A5 true CH614704A5 (en) | 1979-12-14 |
Family
ID=5915760
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH612075A CH613445A5 (en) | 1974-05-16 | 1975-05-13 | Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamides |
| CH369979A CH614704A5 (en) | 1974-05-16 | 1979-04-19 | Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamids |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH612075A CH613445A5 (en) | 1974-05-16 | 1975-05-13 | Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamides |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS50160281A (en) |
| AT (2) | AT342591B (en) |
| BE (1) | BE829140A (en) |
| CH (2) | CH613445A5 (en) |
| DE (1) | DE2423897C3 (en) |
| DK (1) | DK213675A (en) |
| ES (2) | ES437080A1 (en) |
| FI (1) | FI59400C (en) |
| FR (1) | FR2270877B1 (en) |
| GB (1) | GB1500973A (en) |
| NL (1) | NL7505710A (en) |
| NO (1) | NO144671C (en) |
| SE (1) | SE416129B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| DE19952146A1 (en) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkanes, arylalkenes and aryl-azaalkanes, medicaments containing these compounds and process for their preparation |
-
1974
- 1974-05-16 DE DE2423897A patent/DE2423897C3/en not_active Expired
-
1975
- 1975-04-23 AT AT310275A patent/AT342591B/en not_active IP Right Cessation
- 1975-04-28 ES ES437080A patent/ES437080A1/en not_active Expired
- 1975-05-05 FI FI751317A patent/FI59400C/en not_active IP Right Cessation
- 1975-05-13 CH CH612075A patent/CH613445A5/en not_active IP Right Cessation
- 1975-05-15 NL NL7505710A patent/NL7505710A/en not_active Application Discontinuation
- 1975-05-15 JP JP50057905A patent/JPS50160281A/ja active Pending
- 1975-05-15 GB GB20708/75A patent/GB1500973A/en not_active Expired
- 1975-05-15 DK DK213675A patent/DK213675A/en unknown
- 1975-05-15 SE SE7505587A patent/SE416129B/en unknown
- 1975-05-15 NO NO751724A patent/NO144671C/en unknown
- 1975-05-15 BE BE156408A patent/BE829140A/en not_active IP Right Cessation
- 1975-05-16 FR FR7515385A patent/FR2270877B1/fr not_active Expired
- 1975-10-30 ES ES441383A patent/ES441383A1/en not_active Expired
-
1977
- 1977-01-07 AT AT4077A patent/AT342594B/en not_active IP Right Cessation
-
1979
- 1979-04-19 CH CH369979A patent/CH614704A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE416129B (en) | 1980-12-01 |
| GB1500973A (en) | 1978-02-15 |
| FI751317A (en) | 1975-11-17 |
| FI59400B (en) | 1981-04-30 |
| FI59400C (en) | 1981-08-10 |
| FR2270877A1 (en) | 1975-12-12 |
| FR2270877B1 (en) | 1978-10-06 |
| DE2423897A1 (en) | 1975-11-27 |
| DE2423897B2 (en) | 1978-12-21 |
| DK213675A (en) | 1975-11-17 |
| ATA310275A (en) | 1977-08-15 |
| SE7505587L (en) | 1975-11-17 |
| JPS50160281A (en) | 1975-12-25 |
| BE829140A (en) | 1975-11-17 |
| AT342591B (en) | 1978-04-10 |
| NO144671B (en) | 1981-07-06 |
| NO144671C (en) | 1981-10-14 |
| NO751724L (en) | 1975-11-18 |
| DE2423897C3 (en) | 1979-09-06 |
| CH613445A5 (en) | 1979-09-28 |
| ES437080A1 (en) | 1977-02-01 |
| AU8119575A (en) | 1976-11-18 |
| ATA4077A (en) | 1977-08-15 |
| NL7505710A (en) | 1975-11-18 |
| AT342594B (en) | 1978-04-10 |
| ES441383A1 (en) | 1977-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |