CH613706A5 - Process for the preparation of new imidazolobenzodiazepines and of their salts - Google Patents
Process for the preparation of new imidazolobenzodiazepines and of their saltsInfo
- Publication number
- CH613706A5 CH613706A5 CH180876A CH180876A CH613706A5 CH 613706 A5 CH613706 A5 CH 613706A5 CH 180876 A CH180876 A CH 180876A CH 180876 A CH180876 A CH 180876A CH 613706 A5 CH613706 A5 CH 613706A5
- Authority
- CH
- Switzerland
- Prior art keywords
- salts
- imidazolobenzodiazepines
- preparation
- new
- halogen
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical class C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- -1 hypnotic Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000005891 transamination reaction Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6509/75A GB1496426A (en) | 1975-02-15 | 1975-02-15 | 1,2-dihydro-4h-imidazo(1,2-alpha)(1,4)benzodiazepin-1-ones processes for their preparation and compositions incorporating them |
| GB4580075 | 1975-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH613706A5 true CH613706A5 (en) | 1979-10-15 |
Family
ID=26240753
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH180876A CH613706A5 (en) | 1975-02-15 | 1976-02-13 | Process for the preparation of new imidazolobenzodiazepines and of their salts |
| CH1131378A CH618171A5 (en) | 1975-02-15 | 1978-11-02 | Process for the preparation of new imidazolobenzodiazepines and of their salts |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1131378A CH618171A5 (en) | 1975-02-15 | 1978-11-02 | Process for the preparation of new imidazolobenzodiazepines and of their salts |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5914034B2 (fr) |
| AR (1) | AR225721A1 (fr) |
| AT (1) | AT351030B (fr) |
| CA (1) | CA1073454A (fr) |
| CH (2) | CH613706A5 (fr) |
| DE (1) | DE2605652A1 (fr) |
| DK (1) | DK141250B (fr) |
| EG (1) | EG12462A (fr) |
| ES (1) | ES445188A1 (fr) |
| FI (1) | FI62090C (fr) |
| FR (1) | FR2300569A1 (fr) |
| GR (1) | GR60028B (fr) |
| HK (1) | HK47379A (fr) |
| HU (1) | HU173109B (fr) |
| IE (1) | IE43791B1 (fr) |
| IL (1) | IL48888A (fr) |
| IT (1) | IT8047823A0 (fr) |
| LU (1) | LU74341A1 (fr) |
| MX (1) | MX3327E (fr) |
| NL (1) | NL171585C (fr) |
| NO (1) | NO146201C (fr) |
| NZ (1) | NZ179990A (fr) |
| PH (3) | PH14669A (fr) |
| PT (1) | PT64796B (fr) |
| SE (1) | SE422686B (fr) |
| YU (1) | YU42471B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| FR2502621B1 (fr) * | 1981-03-27 | 1983-10-28 | Roussel Uclaf |
-
1976
- 1976-01-21 IL IL48888A patent/IL48888A/xx unknown
- 1976-02-09 FR FR7603457A patent/FR2300569A1/fr active Granted
- 1976-02-10 AR AR261199A patent/AR225721A1/es active
- 1976-02-12 SE SE7601592A patent/SE422686B/xx not_active IP Right Cessation
- 1976-02-12 NZ NZ179990A patent/NZ179990A/xx unknown
- 1976-02-12 FI FI760347A patent/FI62090C/fi not_active IP Right Cessation
- 1976-02-12 DE DE19762605652 patent/DE2605652A1/de active Granted
- 1976-02-13 LU LU74341A patent/LU74341A1/xx unknown
- 1976-02-13 IE IE298/76A patent/IE43791B1/en not_active IP Right Cessation
- 1976-02-13 CH CH180876A patent/CH613706A5/xx not_active IP Right Cessation
- 1976-02-13 PH PH18091A patent/PH14669A/en unknown
- 1976-02-13 PT PT64796A patent/PT64796B/fr unknown
- 1976-02-13 DK DK58776AA patent/DK141250B/da not_active IP Right Cessation
- 1976-02-13 NL NLAANVRAGE7601492,A patent/NL171585C/xx not_active IP Right Cessation
- 1976-02-13 HU HU76RO879A patent/HU173109B/hu unknown
- 1976-02-13 JP JP51014122A patent/JPS5914034B2/ja not_active Expired
- 1976-02-13 YU YU345/76A patent/YU42471B/xx unknown
- 1976-02-13 NO NO760468A patent/NO146201C/no unknown
- 1976-02-14 EG EG77/76A patent/EG12462A/xx active
- 1976-02-14 GR GR50055A patent/GR60028B/el unknown
- 1976-02-14 ES ES445188A patent/ES445188A1/es not_active Expired
- 1976-02-16 CA CA245,850A patent/CA1073454A/fr not_active Expired
- 1976-02-16 AT AT107376A patent/AT351030B/de not_active IP Right Cessation
- 1976-02-16 MX MX176D patent/MX3327E/es unknown
-
1978
- 1978-07-24 PH PH21416A patent/PH15282A/en unknown
- 1978-11-02 CH CH1131378A patent/CH618171A5/fr not_active IP Right Cessation
-
1979
- 1979-01-26 PH PH22113A patent/PH16286A/en unknown
- 1979-07-12 HK HK473/79A patent/HK47379A/xx unknown
-
1980
- 1980-02-06 IT IT8047823A patent/IT8047823A0/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |