CH607585A5 - Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine - Google Patents

Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine

Info

Publication number
CH607585A5
CH607585A5 CH1263576A CH1263576A CH607585A5 CH 607585 A5 CH607585 A5 CH 607585A5 CH 1263576 A CH1263576 A CH 1263576A CH 1263576 A CH1263576 A CH 1263576A CH 607585 A5 CH607585 A5 CH 607585A5
Authority
CH
Switzerland
Prior art keywords
cyanop
yridine
hydroxypropoxy
ethylamino
dimethoxy
Prior art date
Application number
CH1263576A
Other languages
English (en)
Inventor
Joerg Dr Frei
Knut A Dr Jaeggi
Franz Dr Ostermayer
Herbert Dr Schroeter
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH1263576A priority Critical patent/CH607585A5/xx
Priority to DE19772740678 priority patent/DE2740678A1/de
Priority to AT648777A priority patent/AT358037B/de
Priority to DK402877A priority patent/DK402877A/da
Priority to NO773125A priority patent/NO773125L/no
Priority to FI772681A priority patent/FI772681A/fi
Priority to SE7710250A priority patent/SE7710250L/xx
Priority to ES462389A priority patent/ES462389A1/es
Priority to FR7728037A priority patent/FR2367065A1/fr
Priority to PT67048A priority patent/PT67048B/pt
Priority to JP11169877A priority patent/JPS5350177A/ja
Priority to BE181044A priority patent/BE858867A/xx
Priority to GB39204/77A priority patent/GB1591723A/en
Priority to IE1938/77A priority patent/IE45692B1/en
Priority to NL7710394A priority patent/NL7710394A/xx
Priority to ZA00775698A priority patent/ZA775698B/xx
Priority to CA287,391A priority patent/CA1105021A/en
Priority to NZ185267A priority patent/NZ185267A/xx
Priority to AU29125/77A priority patent/AU514676B2/en
Priority to IL53013A priority patent/IL53013A/xx
Priority to GR54455A priority patent/GR71677B/el
Publication of CH607585A5 publication Critical patent/CH607585A5/xx
Priority to AT337979A priority patent/AT358586B/de
Priority to AT338079A priority patent/AT358042B/de
Priority to AT338179A priority patent/AT360021B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH1263576A 1976-10-05 1976-10-05 Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine CH607585A5 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
CH1263576A CH607585A5 (en) 1976-10-05 1976-10-05 Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine
DE19772740678 DE2740678A1 (de) 1976-10-05 1977-09-09 1-amino-2-hydroxy-3-heterocycloxypropane
AT648777A AT358037B (de) 1976-10-05 1977-09-09 Verfahren zur herstellung neuer 1-amino-2- hydroxy-3-heterocyclyloxy-propane und ihrer salze
DK402877A DK402877A (da) 1976-10-05 1977-09-09 1-amino-2-hydroxy-3-heterocyclyloxy-propansalte deraf samt fremgangsmaade til fremstilling deraf
NO773125A NO773125L (no) 1976-10-05 1977-09-09 Fremgangsmaate til fremstilling av 1-amino-2-hydroksy-3-heterocykloksypropan
FI772681A FI772681A (fi) 1976-10-05 1977-09-12 1-amino-2-hydroxi-3-heterocyklyloxipropaner
SE7710250A SE7710250L (sv) 1976-10-05 1977-09-13 Propanderivat
ES462389A ES462389A1 (es) 1976-10-05 1977-09-15 Procedimiento para la obtencion de 1-amino-2-hidroxi-3-hete-rocicliloxi-propanos.
FR7728037A FR2367065A1 (fr) 1976-10-05 1977-09-16 Nouveaux composes du type 1-amino-2-hydroxy-3-heterocyclyloxy-propane utiles en tant que medicaments et leur procede de preparation
PT67048A PT67048B (de) 1976-10-05 1977-09-19 Verfahren zur herstellung von 1-amino-2-hydroxy-3-heterocyclyloxy-propanen
JP11169877A JPS5350177A (en) 1976-10-05 1977-09-19 11aminoo22hydroxyy33 heterocyllyloxyypropane
BE181044A BE858867A (fr) 1976-10-05 1977-09-20 Nouveaux composes du type 1-amino-2-hydroxy-3-heterocycly-loxy-propane et procede pour leur preparation
GB39204/77A GB1591723A (en) 1976-10-05 1977-09-20 1-amino-2-hydroxy-3-heterocyclyloxy-propanes
IE1938/77A IE45692B1 (en) 1976-10-05 1977-09-22 1-amino-2-hydroxy-3-heterocyclyloxy-propanes
NL7710394A NL7710394A (nl) 1976-10-05 1977-09-22 1-amino-2-hydroxy-3-heterocycloxypropanen.
ZA00775698A ZA775698B (en) 1976-10-05 1977-09-23 1-amino-2-hydroxy-3-heterocyclyloxy-propanes
CA287,391A CA1105021A (en) 1976-10-05 1977-09-23 Process for the manufacture of new 1-amino-2-hydroxy- 3-heterocyclyloxy-propanes
AU29125/77A AU514676B2 (en) 1976-10-05 1977-09-26 1-amino-2-hydroxy-3-heterocycloxy-propanes
NZ185267A NZ185267A (en) 1976-10-05 1977-09-26 Derivatives of 1-amino-2hydroxy-3-heterocycloxy-propanes, and pharmaceutical compositions containing them
IL53013A IL53013A (en) 1976-10-05 1977-09-28 1-phehethylamino-2-hydroxy-3-pyridyloxy-(or pyrazinyloxy) propanes,their production and pharmaceutical compositions containing them
GR54455A GR71677B (no) 1976-10-05 1977-09-29
AT337979A AT358586B (de) 1976-10-05 1979-05-07 Verfahren zur herstellung neuer 1-amino-2- hydroxy-3-heterocyclyloxy-propane und ihrer salze
AT338079A AT358042B (de) 1976-10-05 1979-05-07 Verfahren zur herstellung neuer 1-amino-2- -hydroxy-3-heterocyclyloxy-propane und ihrer salze
AT338179A AT360021B (de) 1976-10-05 1979-05-07 Verfahren zur herstellung neuer 1-amino-2- hydroxy-3-heterocyclyloxy-propane und ihrer salze

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1263576A CH607585A5 (en) 1976-10-05 1976-10-05 Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine

Publications (1)

Publication Number Publication Date
CH607585A5 true CH607585A5 (en) 1978-09-15

Family

ID=4384944

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1263576A CH607585A5 (en) 1976-10-05 1976-10-05 Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine

Country Status (21)

Country Link
JP (1) JPS5350177A (no)
AT (1) AT358037B (no)
AU (1) AU514676B2 (no)
BE (1) BE858867A (no)
CA (1) CA1105021A (no)
CH (1) CH607585A5 (no)
DE (1) DE2740678A1 (no)
DK (1) DK402877A (no)
ES (1) ES462389A1 (no)
FI (1) FI772681A (no)
FR (1) FR2367065A1 (no)
GB (1) GB1591723A (no)
GR (1) GR71677B (no)
IE (1) IE45692B1 (no)
IL (1) IL53013A (no)
NL (1) NL7710394A (no)
NO (1) NO773125L (no)
NZ (1) NZ185267A (no)
PT (1) PT67048B (no)
SE (1) SE7710250L (no)
ZA (1) ZA775698B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK267779A (da) * 1978-06-27 1979-12-28 Merck & Co Inc Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
GB8510146D0 (en) * 1985-04-20 1985-05-30 Smith Kline French Lab Chemical compounds & processes
EP0252670B1 (en) * 1986-06-30 1992-01-15 Toyo Jozo Kabushiki Kaisha 2-substituted alkoxy-3-substituted-pyrazines
WO2001036412A1 (en) * 1999-11-15 2001-05-25 Eli Lilly And Company Process for the preparation of aryloxy propanolamines

Also Published As

Publication number Publication date
BE858867A (fr) 1978-03-20
FR2367065A1 (fr) 1978-05-05
IE45692B1 (en) 1982-10-20
CA1105021A (en) 1981-07-14
GB1591723A (en) 1981-06-24
AT358037B (de) 1980-08-11
FI772681A (fi) 1978-04-06
JPS5350177A (en) 1978-05-08
NZ185267A (en) 1979-07-11
DK402877A (da) 1978-04-06
ES462389A1 (es) 1978-07-01
AU514676B2 (en) 1981-02-19
ATA648777A (de) 1980-01-15
NO773125L (no) 1978-04-06
SE7710250L (sv) 1978-04-06
GR71677B (no) 1983-06-21
PT67048B (de) 1979-02-16
ZA775698B (en) 1978-05-30
DE2740678A1 (de) 1978-04-06
NL7710394A (nl) 1978-04-07
IL53013A0 (en) 1977-11-30
FR2367065B1 (no) 1980-10-10
IE45692L (en) 1978-04-05
AU2912577A (en) 1979-04-05
PT67048A (de) 1977-10-01
IL53013A (en) 1981-09-13

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Legal Events

Date Code Title Description
PL Patent ceased