CH602723A5 - - Google Patents

Info

Publication number
CH602723A5
CH602723A5 CH1549273A CH1549273A CH602723A5 CH 602723 A5 CH602723 A5 CH 602723A5 CH 1549273 A CH1549273 A CH 1549273A CH 1549273 A CH1549273 A CH 1549273A CH 602723 A5 CH602723 A5 CH 602723A5
Authority
CH
Switzerland
Application number
CH1549273A
Inventor
Burton Grant Christensen
Ronald William Ratcliffe
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH602723A5 publication Critical patent/CH602723A5/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58Preparation of carboxylic acid halides
    • C07C51/60Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02Preparation
    • C07D463/06Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D505/00Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568Four-membered rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1549273A 1972-11-06 1973-11-02 CH602723A5 (US07935154-20110503-C00018.png)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30390572A 1972-11-06 1972-11-06
US39566273A 1973-09-18 1973-09-18

Publications (1)

Publication Number Publication Date
CH602723A5 true CH602723A5 (US07935154-20110503-C00018.png) 1978-07-31

Family

ID=26973713

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1549273A CH602723A5 (US07935154-20110503-C00018.png) 1972-11-06 1973-11-02

Country Status (11)

Country Link
JP (1) JPS5632993B2 (US07935154-20110503-C00018.png)
AT (1) AT340590B (US07935154-20110503-C00018.png)
BE (1) BE806921A (US07935154-20110503-C00018.png)
CH (1) CH602723A5 (US07935154-20110503-C00018.png)
DE (1) DE2355209A1 (US07935154-20110503-C00018.png)
ES (1) ES420271A1 (US07935154-20110503-C00018.png)
FR (1) FR2205313B1 (US07935154-20110503-C00018.png)
GB (1) GB1455016A (US07935154-20110503-C00018.png)
HK (1) HK86679A (US07935154-20110503-C00018.png)
NL (1) NL178005C (US07935154-20110503-C00018.png)
SE (1) SE417205B (US07935154-20110503-C00018.png)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4172199A (en) * 1975-01-02 1979-10-23 Bristol-Myers Company O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
US4012383A (en) * 1975-01-02 1977-03-15 Bristol-Myers Company Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US4166905A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4171439A (en) * 1975-04-11 1979-10-16 Bristol-Myers Company Antibacterial analogs of isocephalosporins
US4166906A (en) * 1975-04-11 1979-09-04 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4108992A (en) 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4171438A (en) * 1975-07-23 1979-10-16 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
CA1085392A (en) 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
CY1158A (en) * 1976-03-25 1983-01-28 Shionogi & Co Arylmalonamido-1-oxadethiacephalosporins
JPS607635B2 (ja) * 1976-04-27 1985-02-26 塩野義製薬株式会社 オキサゾリジン化合物
JPS604811B2 (ja) * 1976-07-28 1985-02-06 塩野義製薬株式会社 メチルケトンのハロゲン化
JPS609515B2 (ja) * 1976-08-09 1985-03-11 塩野義製薬株式会社 3′−ノルオキサセファロスポリン類
CA1076125A (en) * 1976-08-09 1980-04-22 Masayuki Narisada Intermediates for cephalosporin analogues
JPS5331690A (en) * 1976-09-01 1978-03-25 Shionogi & Co Ltd Oxadithiacephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
JPS5398951A (en) 1977-02-08 1978-08-29 Shionogi & Co Ltd Azetidinone derivatives and process for their preparation
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
JPS53105491A (en) 1977-02-25 1978-09-13 Shionogi & Co Ltd Oxazolinoazethidinylbutyrylic acid derivatives
CA1100962A (en) * 1977-04-28 1981-05-12 Yoshio Hamashima Haloarylmalonamidooxacephalosporins
JPS53149991A (en) * 1977-06-01 1978-12-27 Shionogi & Co Ltd Preparation of 3-heterothiomethyl-1-oxadethia-3-cephem-4-carboxylic acid
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS609718B2 (ja) * 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
IT1102408B (it) * 1977-12-23 1985-10-07 Fujisawa Pharmaceutical Co Composti analoghi della cefalosforina e procedimenti per la loro preparazione
DE2961633D1 (en) * 1978-03-04 1982-02-18 Beecham Group Plc Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation
JPS5936914B2 (ja) * 1978-06-24 1984-09-06 協和醗酵工業株式会社 セフアロスポリン類縁体
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
DE3069524D1 (en) * 1979-12-20 1984-11-29 Hoechst Uk Ltd Penem derivatives
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound
US4304774A (en) * 1980-09-17 1981-12-08 Eli Lilly And Company Bis-tetrazolmethyl substituted β-lactam antibiotics
DE3225269A1 (de) * 1982-07-06 1984-01-12 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 7-amino-1-dethia-1-oxa-3-hydroxymethyl-cephem-4-carbonsaeuren
JPS59104389A (ja) * 1982-12-06 1984-06-16 Shionogi & Co Ltd オキサセファム誘導体
US4717722A (en) * 1984-05-07 1988-01-05 Merck & Co., Inc. Substituted 1-oxa-dethiacephalosporins as anti-inflammatory and antidegenerative agents
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
US5019571A (en) * 1988-01-25 1991-05-28 Eli Lilly And Company 1-carbacephalosporin antibiotics
JP2004168775A (ja) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd オキサセファロスポリンの改良合成法
CA2833121A1 (en) 2011-04-28 2012-11-01 Shionogi & Co., Ltd. Novel cephem compound having catechol or pseudo-catechol structure
CN103254215B (zh) * 2013-05-24 2015-06-03 浙江东邦药业有限公司 一种烯丙基氯代氧头孢化合物的制备方法

Also Published As

Publication number Publication date
NL7314711A (US07935154-20110503-C00018.png) 1974-05-08
NL178005C (nl) 1986-01-02
FR2205313B1 (US07935154-20110503-C00018.png) 1976-07-02
AT340590B (de) 1977-12-27
DE2355209A1 (de) 1974-05-16
ES420271A1 (es) 1976-07-01
JPS5632993B2 (US07935154-20110503-C00018.png) 1981-07-31
NL178005B (nl) 1985-08-01
JPS49133594A (US07935154-20110503-C00018.png) 1974-12-21
GB1455016A (en) 1976-11-10
ATA491775A (de) 1977-04-15
SE417205B (sv) 1981-03-02
FR2205313A1 (US07935154-20110503-C00018.png) 1974-05-31
BE806921A (fr) 1974-05-06
HK86679A (en) 1979-12-28

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Legal Events

Date Code Title Description
PL Patent ceased