CH517690A - Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern - Google Patents

Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern

Info

Publication number
CH517690A
CH517690A CH38468A CH38468A CH517690A CH 517690 A CH517690 A CH 517690A CH 38468 A CH38468 A CH 38468A CH 38468 A CH38468 A CH 38468A CH 517690 A CH517690 A CH 517690A
Authority
CH
Switzerland
Prior art keywords
naphthyl
methyl
preparation
acetic acid
alkyl esters
Prior art date
Application number
CH38468A
Other languages
German (de)
English (en)
Inventor
Hans Dr Fried John
Thomas Dr Harrison Ian
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Corp filed Critical Syntex Corp
Priority to CH1871770A priority Critical patent/CH520644A/de
Priority to CH1871870A priority patent/CH520645A/de
Priority to CH437471A priority patent/CH537369A/de
Publication of CH517690A publication Critical patent/CH517690A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/35—Formation of carbon-to-carbon triple bonds only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH38468A 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern CH517690A (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH1871770A CH520644A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-(2-Naphtyl)- bzw. a-(3,4-Dihydro-2-naphthyl)-a-methyl-essigsäuren
CH1871870A CH520645A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-(2-Naphthyl)- bzw. a-(3,4-Dihydro-2-naphthyl)-a-difluormethylessigsäuren
CH437471A CH537369A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung neuer a-substituierter 2-(6-Cyano-2-naphthyl)- und 2-(6-Cyano-3,4-dihydro-2-naphthyl)-essigsäuren

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60899767A 1967-01-13 1967-01-13
US69477167A 1967-12-07 1967-12-07
ZA677597 1967-12-18

Publications (1)

Publication Number Publication Date
CH517690A true CH517690A (de) 1972-01-15

Family

ID=27417009

Family Applications (1)

Application Number Title Priority Date Filing Date
CH38468A CH517690A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern

Country Status (9)

Country Link
BE (1) BE751445Q (xx)
CA (1) CA960689A (xx)
CH (1) CH517690A (xx)
ES (1) ES349061A1 (xx)
FR (3) FR8487M (xx)
GB (1) GB1211134A (xx)
HK (1) HK26776A (xx)
NL (2) NL147129B (xx)
SE (1) SE352069B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA7068B (en) * 1969-09-30 1971-08-25 Syntex Corp Preparation of 2-(6-methoxy-2-naphrthyl)propionic acid
DE2039639C2 (de) * 1970-08-10 1982-08-05 Syntex Corp., Panama-City Verfahren zur Herstellung von l-2-(6-Methoxy-2-naphthyl)-1-propanol
US4048331A (en) * 1974-10-15 1977-09-13 The Upjohn Company Process of treatment
IT1100784B (it) * 1978-12-06 1985-09-28 Ibis Ist Biochim Speriment Prodotto ad attivita' coleretica e composizioni terapeutiche che lo cmprendno come principio attivo
IT1109200B (it) * 1979-02-20 1985-12-16 Montedison Spa Processo per la preparazione di esteri di acidi arilacetici da alfa-alo-alchilarilchetoni
AT370721B (de) * 1981-02-24 1983-04-25 Ciba Geigy Ag Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
GB9314693D0 (en) * 1993-07-15 1993-08-25 Smithkline Beecham Plc Naphthyl derivatives for treatment method
AU2003229142A1 (en) * 2002-06-07 2003-12-22 Cortical Pty Ltd Naphthalene derivatives which inhibit the cytokine or biological activity of macrophage inhibitory factor (MIF)

Also Published As

Publication number Publication date
FR8487M (xx) 1973-07-27
BE751445Q (fr) 1970-11-16
SE352069B (xx) 1972-12-18
ES349061A1 (es) 1969-08-16
NL7512107A (nl) 1976-01-30
NL6800251A (xx) 1968-07-15
CA960689A (en) 1975-01-07
FR8494M (xx) 1973-07-27
GB1211134A (en) 1970-11-04
NL147129B (nl) 1975-09-15
FR1587861A (xx) 1970-04-03
HK26776A (en) 1976-05-21

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Legal Events

Date Code Title Description
PUE Assignment

Owner name: SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

PL Patent ceased