CH517690A - Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern - Google Patents

Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern

Info

Publication number
CH517690A
CH517690A CH38468A CH38468A CH517690A CH 517690 A CH517690 A CH 517690A CH 38468 A CH38468 A CH 38468A CH 38468 A CH38468 A CH 38468A CH 517690 A CH517690 A CH 517690A
Authority
CH
Switzerland
Prior art keywords
naphthyl
methyl
preparation
acetic acid
alkyl esters
Prior art date
Application number
CH38468A
Other languages
English (en)
Inventor
Hans Dr Fried John
Thomas Dr Harrison Ian
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Corp filed Critical Syntex Corp
Priority to CH1871770A priority Critical patent/CH520644A/de
Priority to CH437471A priority patent/CH537369A/de
Priority to CH1871870A priority patent/CH520645A/de
Publication of CH517690A publication Critical patent/CH517690A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/35Formation of carbon-to-carbon triple bonds only
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33Polycyclic acids
    • C07C63/337Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH38468A 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern CH517690A (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH1871770A CH520644A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-(2-Naphtyl)- bzw. a-(3,4-Dihydro-2-naphthyl)-a-methyl-essigsäuren
CH437471A CH537369A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung neuer a-substituierter 2-(6-Cyano-2-naphthyl)- und 2-(6-Cyano-3,4-dihydro-2-naphthyl)-essigsäuren
CH1871870A CH520645A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-(2-Naphthyl)- bzw. a-(3,4-Dihydro-2-naphthyl)-a-difluormethylessigsäuren

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60899767A 1967-01-13 1967-01-13
US69477167A 1967-12-07 1967-12-07
ZA677597 1967-12-18

Publications (1)

Publication Number Publication Date
CH517690A true CH517690A (de) 1972-01-15

Family

ID=27417009

Family Applications (1)

Application Number Title Priority Date Filing Date
CH38468A CH517690A (de) 1967-01-13 1968-01-11 Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern

Country Status (9)

Country Link
BE (1) BE751445Q (de)
CA (1) CA960689A (de)
CH (1) CH517690A (de)
ES (1) ES349061A1 (de)
FR (3) FR8487M (de)
GB (1) GB1211134A (de)
HK (1) HK26776A (de)
NL (2) NL147129B (de)
SE (1) SE352069B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA7068B (en) * 1969-09-30 1971-08-25 Syntex Corp Preparation of 2-(6-methoxy-2-naphrthyl)propionic acid
DE2039639C2 (de) * 1970-08-10 1982-08-05 Syntex Corp., Panama-City Verfahren zur Herstellung von l-2-(6-Methoxy-2-naphthyl)-1-propanol
US4048331A (en) * 1974-10-15 1977-09-13 The Upjohn Company Process of treatment
IT1100784B (it) * 1978-12-06 1985-09-28 Ibis Ist Biochim Speriment Prodotto ad attivita' coleretica e composizioni terapeutiche che lo cmprendno come principio attivo
IT1109200B (it) * 1979-02-20 1985-12-16 Montedison Spa Processo per la preparazione di esteri di acidi arilacetici da alfa-alo-alchilarilchetoni
AT370721B (de) * 1981-02-24 1983-04-25 Ciba Geigy Ag Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
GB9314693D0 (en) * 1993-07-15 1993-08-25 Smithkline Beecham Plc Naphthyl derivatives for treatment method
CN1675154A (zh) * 2002-06-07 2005-09-28 科蒂科股份有限公司 抑制巨噬细胞移动抑制因子(mif)的细胞因子或生物活性的萘衍生物

Also Published As

Publication number Publication date
FR8487M (de) 1973-07-27
NL147129B (nl) 1975-09-15
NL7512107A (nl) 1976-01-30
ES349061A1 (es) 1969-08-16
CA960689A (en) 1975-01-07
HK26776A (en) 1976-05-21
FR1587861A (de) 1970-04-03
FR8494M (de) 1973-07-27
GB1211134A (en) 1970-11-04
SE352069B (de) 1972-12-18
BE751445Q (fr) 1970-11-16
NL6800251A (de) 1968-07-15

Similar Documents

Publication Publication Date Title
CH491113A (de) Verfahren zur Herstellung von Polycarbonsäureestern
CH495994A (de) Verfahren zur Herstellung von Polycarbonsäureestern
CH507984A (de) Verfahren zur Herstellung von 7-Acylaminocephalosporansäuren
CH517690A (de) Verfahren zur Herstellung von a-Methyl-2-naphthyl-essigsäurealkylestern
CH494205A (de) Verfahren zur Herstellung von Carbonsäure-2-aryloxyäthylestern
CH489478A (de) Verfahren zur Herstellung von Indanyl-N-methylcarbaminsäureestern
CH492669A (de) Verfahren zur Herstellung von p-Hydroxybenzoesäure
CH500935A (de) Verfahren zur Herstellung von Phenylsalicylsäure-Verbindungen
AT299447B (de) Verfahren zur Herstellung von 7-Aminocephalosporansäure
CH500936A (de) Verfahren zur Herstellung von Carbonsäureestern
CH498874A (de) Verfahren zur Herstellung von B-Halogenäthylphosphonsäuren
CH508666A (de) Verfahren zur Herstellung von Phosphonsäureestern
CH513104A (de) Verfahren zur Herstellung von Diameisensäureestern
AT277960B (de) Verfahren zur Herstellung von N-Hydroxyimidothiocarbonsäureestern
CH495381A (de) Verfahren zur Herstellung von Thionothiolphosphor-, -phosphon- oder -phosphin-säureestern
CH499483A (de) Verfahren zur Herstellung von Phenoxyphthalsäureester
CH510059A (de) Verfahren zur Herstellung von Amidothionophosphorsäurephenylestern
CH495940A (de) Verfahren zur Herstellung von Carbonsäureestern
CH463485A (de) Verfahren zur Herstellung von Phenyl-benzolsulfon-säureestern
CH481933A (de) Verfahren zur Herstellung von 4-Methyl-oxazol-5-carbonsäureestern
CH491961A (de) Verfahren zur Herstellung von Thio-Phosphor- oder Thio-Phosphonsäureestern
CH485641A (de) Verfahren zur Herstellung von Acetessigsäureestern
CH542170A (de) Verfahren zur Herstellung von 3-Acetoxy-2-methylen-propionsäurealkylestern
AT274851B (de) Verfahren zur Herstellung von Amidophosphorsäureestern
CH508589A (de) Verfahren zur Herstellung von B-Aminocarbonsäurederivaten

Legal Events

Date Code Title Description
PUE Assignment

Owner name: SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

PL Patent ceased