CH482691A - Procédé de préparation de pipérazines 1,4-disubstituées - Google Patents

Procédé de préparation de pipérazines 1,4-disubstituées

Info

Publication number
CH482691A
CH482691A CH1141863A CH1141863A CH482691A CH 482691 A CH482691 A CH 482691A CH 1141863 A CH1141863 A CH 1141863A CH 1141863 A CH1141863 A CH 1141863A CH 482691 A CH482691 A CH 482691A
Authority
CH
Switzerland
Prior art keywords
preparing
disubstituted piperazines
piperazines
disubstituted
Prior art date
Application number
CH1141863A
Other languages
English (en)
French (fr)
Inventor
Stephen Tomcufcik Andrew
Frank Fabio Paul
May Hoffman Arlene
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to CH1174870A priority Critical patent/CH514608A/fr
Priority to CH735968A priority patent/CH484160A/fr
Priority to CH842566A priority patent/CH499524A/fr
Publication of CH482691A publication Critical patent/CH482691A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B43/00—Preparation of azo dyes from other azo compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH1141863A 1963-04-04 1963-09-16 Procédé de préparation de pipérazines 1,4-disubstituées CH482691A (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH1174870A CH514608A (fr) 1963-04-04 1963-09-16 Procédé de préparation de pipérazines 1,4-disubstituées
CH735968A CH484160A (fr) 1963-04-04 1963-09-16 Procédé de préparation de pipérazines 1,4-disubstituées
CH842566A CH499524A (fr) 1963-04-04 1963-09-16 Procédé de préparation de pipérazines 1,4-disubstituées

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US27053663A 1963-04-04 1963-04-04
US27053463A 1963-04-04 1963-04-04
US27053763A 1963-04-04 1963-04-04
US37971464A 1964-07-01 1964-07-01
US468142A US3331843A (en) 1963-04-04 1965-06-29 1-substituted-4-substituted aminoalkylene piperazines
US468143A US3331830A (en) 1963-04-04 1965-06-29 1-substituted-4-substituted aminoalkylene piperazines

Publications (1)

Publication Number Publication Date
CH482691A true CH482691A (fr) 1969-12-15

Family

ID=27559486

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1141863A CH482691A (fr) 1963-04-04 1963-09-16 Procédé de préparation de pipérazines 1,4-disubstituées

Country Status (13)

Country Link
US (2) US3331843A (enExample)
BE (1) BE637271A (enExample)
BR (1) BR6352303D0 (enExample)
CH (1) CH482691A (enExample)
DE (1) DE1445425A1 (enExample)
FI (2) FI41280C (enExample)
FR (1) FR3708M (enExample)
GB (1) GB1047935A (enExample)
LU (1) LU44424A1 (enExample)
MC (1) MC435A1 (enExample)
NL (1) NL297170A (enExample)
NO (1) NO117694B (enExample)
SE (2) SE320667B (enExample)

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US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
GB1279843A (en) * 1969-05-23 1972-06-28 Science Union & Cie Benzamidoethyl-piperazines and process for their preparation
US4081542A (en) * 1975-04-21 1978-03-28 Merck & Co., Inc. Piperazinylpyrazines
CH653021A5 (fr) * 1981-04-24 1985-12-13 Delalande Sa Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
US4457931A (en) * 1982-09-27 1984-07-03 Selvi & C. S.P.A. Piperazine derivatives with anticholinergic and/or antihistaminic activity
HUT43600A (en) * 1985-06-22 1987-11-30 Sandoz Ag Process for production of new thiazole derivatives and medical compound containing those
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US4977156A (en) * 1988-07-26 1990-12-11 The Dow Chemical Company Amino piperazine esters showing biocidal activity
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
JP3193560B2 (ja) * 1993-04-16 2001-07-30 明治製菓株式会社 新規ベンゾオキサゾール誘導体
US6358956B1 (en) 1999-03-03 2002-03-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6355643B1 (en) 1999-03-03 2002-03-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU5567000A (en) 1999-06-24 2001-01-09 Toray Industries, Inc. Alpha1b-adrenergic receptor antagonists
WO2001014331A2 (en) * 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
HRP20040804A2 (en) * 2002-03-13 2005-02-28 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
KR20040094672A (ko) 2002-03-13 2004-11-10 얀센 파마슈티카 엔.브이. 히스톤 디아세틸라제의 신규한 저해제로서의설포닐아미노-유도체
CN100503599C (zh) 2002-03-13 2009-06-24 詹森药业有限公司 作为组蛋白脱乙酰酶的新颖抑制剂的羰基氨基衍生物
WO2003076400A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. New inhibitors of histone deacetylase
US8193205B2 (en) * 2004-07-28 2012-06-05 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (es) * 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
WO2006089076A2 (en) 2005-02-18 2006-08-24 Neurogen Corporation Thiazole amides, imidazole amides and related analogues
EP1885710B1 (en) 2005-05-18 2015-08-19 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
US8101616B2 (en) * 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
PT1981874E (pt) * 2006-01-19 2009-09-02 Janssen Pharmactuica N V Derivados de aminofenil como novos inibidores de histonadesacetilase
ES2396986T3 (es) * 2006-01-19 2013-03-01 Janssen Pharmaceutica N.V. Derivados de piridina y pirimidina como inhibidores de histona desacetilasa
CA2635015C (en) * 2006-01-19 2014-06-03 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
FI3719018T3 (fi) 2006-04-25 2025-10-07 Astex Therapeutics Ltd Puriini- ja deatsapuriinijohdannaisia farmaseuttisina yhdisteinä
KR20100033544A (ko) * 2007-07-19 2010-03-30 에프. 호프만-라 로슈 아게 신규한 헤테로사이클일 화합물 및 이의 케모카인 길항제로서의 용도
BRPI0815591B8 (pt) * 2007-08-22 2021-05-25 Astrazeneca Ab composto, composição farmacêutica, e, uso de um composto.
MX2010003927A (es) 2007-10-11 2010-04-30 Astrazeneca Ab Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b.
EP2212310A4 (en) * 2007-10-15 2011-04-20 Elder Pharmaceuticals Ltd INDUSTRIALLY MANUFACTURED PROCESS FOR THE PRODUCTION OF BISQUINOLINE DERIVATIVES USING SUBSTANTIALLY PURE N-MONOSUBSTITUTED PIPERAZINES
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
FR2945289A1 (fr) * 2009-05-11 2010-11-12 Sanofi Aventis Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
WO2011095885A1 (en) * 2010-02-08 2011-08-11 Matrix Laboratories Ltd. An improved process for the preparation of piperaquine
WO2011102793A1 (en) * 2010-02-18 2011-08-25 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
AU2011218492B2 (en) * 2010-02-18 2014-11-13 Astrazeneca Ab New crystalline form of a cyclopropyl benzamide derivative
KR101851820B1 (ko) 2011-04-01 2018-06-04 아스트라제네카 아베 치료적 요법
CA2835344A1 (en) 2011-06-06 2012-12-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline
SG11201401471PA (en) 2011-11-30 2014-08-28 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
CN113750101A (zh) 2015-12-10 2021-12-07 Ptc医疗公司 用于治疗亨廷顿病的方法
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
CA3067591A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
EP3645121B8 (en) 2017-06-28 2025-06-18 PTC Therapeutics, Inc. Methods for treating huntington's disease
KR20210005559A (ko) 2018-03-27 2021-01-14 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
CN110606830B (zh) * 2018-06-14 2022-03-18 珠海润都制药股份有限公司 一种哌嗪套用生产磷酸哌喹中间体喹啉哌嗪盐酸盐的方法
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
LT3814357T (lt) 2018-06-27 2024-06-25 Ptc Therapeutics, Inc. Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui
WO2020005877A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease

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US2513026A (en) * 1950-06-27 Process for preparing same
BE485737A (enExample) * 1947-11-12
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
US2794804A (en) * 1955-03-24 1957-06-04 American Cyanamid Co Substituted piperazines and method of preparing the same
US2949431A (en) * 1957-07-17 1960-08-16 Mobay Chemical Corp Preparation of cellular polyurethanes using piperazine catalysts
US3098066A (en) * 1960-03-04 1963-07-16 Ciba Geigy Corp Diaza-heterocyclic guanidine compounds
US3015657A (en) * 1959-05-28 1962-01-02 Charles F Geschickter 1-carbalkoxy-4-(aminoalkanol) piperazines
US3030366A (en) * 1961-01-25 1962-04-17 Lakeside Lab Inc Piperazinoalkyl glycolamides
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
US3190883A (en) * 1962-10-05 1965-06-22 Geschickter Fund Med Res Aminoalkanol derivatives of piperazines
US3184382A (en) * 1963-08-12 1965-05-18 Pure Oil Co Method of producing tranquilization by hydroxy-loweralkyl-n-substituted carbamic acid esters

Also Published As

Publication number Publication date
LU44424A1 (enExample) 1963-11-11
FI41280B (enExample) 1969-06-30
FI42440B (enExample) 1970-04-30
SE320667B (enExample) 1970-02-16
GB1047935A (en) 1966-11-09
BR6352303D0 (pt) 1973-07-17
DE1445425A1 (de) 1968-10-31
MC435A1 (fr) 1964-07-06
SE346316B (enExample) 1972-07-03
FI41280C (fi) 1969-10-10
FI42440C (fi) 1970-08-10
BE637271A (enExample) 1900-01-01
NL297170A (enExample) 1900-01-01
NO117694B (enExample) 1969-09-15
US3331843A (en) 1967-07-18
US3331830A (en) 1967-07-18
FR3708M (fr) 1965-11-29

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