CH383984A - Process for the preparation of a therapeutically useful product - Google Patents

Process for the preparation of a therapeutically useful product

Info

Publication number
CH383984A
CH383984A CH1115860A CH1115860A CH383984A CH 383984 A CH383984 A CH 383984A CH 1115860 A CH1115860 A CH 1115860A CH 1115860 A CH1115860 A CH 1115860A CH 383984 A CH383984 A CH 383984A
Authority
CH
Switzerland
Prior art keywords
preparation
therapeutically useful
useful product
choline
carboxylic acid
Prior art date
Application number
CH1115860A
Other languages
German (de)
Inventor
Hirt Emil Dr Chem
Original Assignee
Galactina & Biomalz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galactina & Biomalz Ag filed Critical Galactina & Biomalz Ag
Priority to CH1115860A priority Critical patent/CH383984A/en
Priority to FR875008A priority patent/FR1386M/en
Publication of CH383984A publication Critical patent/CH383984A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines therapeutisch verwendbaren Produktes    Gegenstand der vorliegenden     Erfindung    ist     ein.     Verfahren     zur    Herstellung eines therapeutisch ver  wendbaren Produktes, welches dadurch gekennzeich-         net    ist, dass     Uracil-4-carbonsäure        (2,6-Dioxy-pyrimi-          din-4-carbonsäure)    mit     Cholin        zum        uracilcarbon-          sauren        Cholin    vereinigt wird.

      <I>Beispiel</I>         Cholinchlorid,    gelöst in Wasser, wird mittels eines  geeigneten     Anionenaustauschers    in die freie Base       übergeführt    und hierauf mit der äquivalenten Menge       Uracilcarbonsäure    das     Salz    gebildet. Das erhaltene       uracilcarbonsaure        Cholin    ist ein weisses,     körniges,       vollständig in Wasser lösliches Produkt     mit    einem       Cholingehalt    (als     Cholin-Reineckat    bestimmt), der  praktisch dem theoretischen Wert entspricht.  



  Das     Salz    hat die Formel:  
EMI0001.0025     




  Process for the preparation of a therapeutically useful product The present invention is a. Process for the production of a therapeutically usable product, which is characterized in that uracil-4-carboxylic acid (2,6-dioxy-pyrimidine-4-carboxylic acid) is combined with choline to form uracil-carboxylic acid choline.

      <I> Example </I> Choline chloride, dissolved in water, is converted into the free base using a suitable anion exchanger and the salt is then formed with the equivalent amount of uracilic acid. The uracilcarboxylic acid choline obtained is a white, granular, completely water-soluble product with a choline content (determined as pure choline) that practically corresponds to the theoretical value.



  The salt has the formula:
EMI0001.0025

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung eines therapeutisch verwendbaren Produktes, dadurch gekennzeichnet, dass Uracil-4-carbonsäure (2,6-Dioxy-pyrimidin-4- carbonsäure) mit Cholin zum uracilcarbonsauren Cholin vereinigt wird. PATENT CLAIM A process for the production of a therapeutically usable product, characterized in that uracil-4-carboxylic acid (2,6-dioxy-pyrimidine-4-carboxylic acid) is combined with choline to form the uracil-carboxylic acid choline.
CH1115860A 1960-10-05 1960-10-05 Process for the preparation of a therapeutically useful product CH383984A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH1115860A CH383984A (en) 1960-10-05 1960-10-05 Process for the preparation of a therapeutically useful product
FR875008A FR1386M (en) 1960-10-05 1961-10-04 New derivative of choline and its use in therapy, in particular as a lipotropic agent.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1115860A CH383984A (en) 1960-10-05 1960-10-05 Process for the preparation of a therapeutically useful product

Publications (1)

Publication Number Publication Date
CH383984A true CH383984A (en) 1964-11-15

Family

ID=4370651

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1115860A CH383984A (en) 1960-10-05 1960-10-05 Process for the preparation of a therapeutically useful product

Country Status (2)

Country Link
CH (1) CH383984A (en)
FR (1) FR1386M (en)

Also Published As

Publication number Publication date
FR1386M (en) 1962-07-02

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