CH370416A - Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline - Google Patents

Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline

Info

Publication number
CH370416A
CH370416A CH6554058A CH6554058A CH370416A CH 370416 A CH370416 A CH 370416A CH 6554058 A CH6554058 A CH 6554058A CH 6554058 A CH6554058 A CH 6554058A CH 370416 A CH370416 A CH 370416A
Authority
CH
Switzerland
Prior art keywords
carboxylic acid
choline
uracil
preparation
therapeutically useful
Prior art date
Application number
CH6554058A
Other languages
German (de)
Inventor
Hirt Emil Dr Chem
Original Assignee
Galactina & Biomalz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galactina & Biomalz Ag filed Critical Galactina & Biomalz Ag
Priority to CH6554058A priority Critical patent/CH370416A/en
Publication of CH370416A publication Critical patent/CH370416A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  
 



  Verfahren zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins, welches dadurch gekennzeichnet ist, dass Uracil-6-carbonsäure (2,4-Dioxy-pyrimidin-6-carbonsäure) mit Cholin umgesetzt wird.



  Beispiel
Cholinchlorid, gelöst in Wasser, wird mittels eines geeigneten Anionenaustauschers in die freie Base überführt und hierauf mit der äquivalenten Menge Uracil-6-carbonsäure das Salz gebildet. Das erhaltene uracilcarbonsaure Cholin ist ein weisses, körniges, vollständig in Wasser lösliches Produkt mit einem Cholingehalt (als Cholin-Reineckat bestimmt), der praktisch dem theoretischen Wert entspricht. Das Salz hat die Formel:
EMI1.1     
   PATENTANSPRUCH 40    Verfahren    zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins, dadurch gekennzeichnet, dass   Uracyl-6-carbonsäure    mit Cholin umgesetzt wird. 

**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.



   



  
 



  Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline
The present invention relates to a process for the preparation of the therapeutically usable uracil-6-carboxylic acid choline, which is characterized in that uracil-6-carboxylic acid (2,4-dioxy-pyrimidine-6-carboxylic acid) is reacted with choline.



  example
Choline chloride, dissolved in water, is converted into the free base using a suitable anion exchanger and the salt is then formed with the equivalent amount of uracil-6-carboxylic acid. The uracilcarboxylic acid choline obtained is a white, granular, completely water-soluble product with a choline content (determined as pure choline) that practically corresponds to the theoretical value. The salt has the formula:
EMI1.1
   PATENT CLAIM 40 Process for the preparation of the therapeutically usable uracil-6-carboxylic acid choline, characterized in that uracyl-6-carboxylic acid is reacted with choline.

** WARNING ** End of DESC field could overlap beginning of CLMS **.

Claims (1)

**WARNUNG** Anfang CLMS Feld konnte Ende DESC uberlappen **. ** WARNING ** Beginning of CLMS field could overlap end of DESC **. Verfahren zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins, welches dadurch gekennzeichnet ist, dass Uracil-6-carbonsäure (2,4-Dioxy-pyrimidin-6-carbonsäure) mit Cholin umgesetzt wird. Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline The present invention relates to a process for the preparation of the therapeutically usable uracil-6-carboxylic acid choline, which is characterized in that uracil-6-carboxylic acid (2,4-dioxy-pyrimidine-6-carboxylic acid) is reacted with choline. Beispiel Cholinchlorid, gelöst in Wasser, wird mittels eines geeigneten Anionenaustauschers in die freie Base überführt und hierauf mit der äquivalenten Menge Uracil-6-carbonsäure das Salz gebildet. Das erhaltene uracilcarbonsaure Cholin ist ein weisses, körniges, vollständig in Wasser lösliches Produkt mit einem Cholingehalt (als Cholin-Reineckat bestimmt), der praktisch dem theoretischen Wert entspricht. Das Salz hat die Formel: EMI1.1 PATENTANSPRUCH 40 Verfahren zur Herstellung des therapeutisch verwendbaren uracil-6-carbonsauren Cholins, dadurch gekennzeichnet, dass Uracyl-6-carbonsäure mit Cholin umgesetzt wird. example Choline chloride, dissolved in water, is converted into the free base using a suitable anion exchanger and the salt is then formed with the equivalent amount of uracil-6-carboxylic acid. The uracilcarboxylic acid choline obtained is a white, granular, completely water-soluble product with a choline content (determined as pure choline) that practically corresponds to the theoretical value. The salt has the formula: EMI1.1 PATENT CLAIM 40 Process for the preparation of the therapeutically usable uracil-6-carboxylic acid choline, characterized in that uracyl-6-carboxylic acid is reacted with choline.
CH6554058A 1958-10-29 1958-10-29 Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline CH370416A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH6554058A CH370416A (en) 1958-10-29 1958-10-29 Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH6554058A CH370416A (en) 1958-10-29 1958-10-29 Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline

Publications (1)

Publication Number Publication Date
CH370416A true CH370416A (en) 1963-07-15

Family

ID=4526464

Family Applications (1)

Application Number Title Priority Date Filing Date
CH6554058A CH370416A (en) 1958-10-29 1958-10-29 Process for the preparation of the therapeutically useful uracil-6-carboxylic acid choline

Country Status (1)

Country Link
CH (1) CH370416A (en)

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