CH285675A - Process for preparing the salt of para-chlorophenyl-cyanamide and isopropylguanidine. - Google Patents
Process for preparing the salt of para-chlorophenyl-cyanamide and isopropylguanidine.Info
- Publication number
- CH285675A CH285675A CH285675DA CH285675A CH 285675 A CH285675 A CH 285675A CH 285675D A CH285675D A CH 285675DA CH 285675 A CH285675 A CH 285675A
- Authority
- CH
- Switzerland
- Prior art keywords
- cyanamide
- chlorophenyl
- para
- salt
- isopropylguanidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Procédé de préparation du sel de la para#chlorophényl#cyanamide et de l'isopropylguanidine. On a décrit au brevet principal un pro cédé de préparation du sel de la para-chloro- phényl-cyanamide et de l'isopropylguanidine, qui consiste à faire réagir à température mo dérée de la para-chlorophényl-cyanamide et de l'isopropylguanidine et à séparer le sel obtenu du mélange réactionnel. On a décrit plus particulièrement un mode opératoire avantageux consistant à opérer en milieu aqueux.
On a trouvé maintenant que la réaction peut également être conduite en milieu anhydre.
La présente invention a donc pour objet un procédé de préparation du sel de la para- chlorophényl-cyanamide et de l'isopropyl- guanidine, caractérisé en ce que l'on fait réagir en milieu anhydre et à température modérée, de la parachlorophényl-cyanamide et de l'isopropylguanidine et en ce que l'on sé pare le sel obtenu du mélange réactionnel.
Voici, à titre d'exemple, comment le pro cédé de l'invention peut être réalisé en pra tique; les parties s'entendent. en poids. On dissout 7,5 parties de sodium dans 95 parties d'alcool méthylique anhydre. On ajoute successivement, vers 22 , 49 parties de sulfate d'isopropylguanidine sec et 50 parties de para-chlorophényl-cyanamide sèche. Il pré cipite du sulfate de soude qu'on élimine par centrifugation et lave au méthanol anhydre. Les solutions réunies sont concentrées dans le vide à température inférieure à 35 C.
On obtient 77 parties de sel d'isopropylguanidine et de para-chlorophényl-cyanamide impur fon dant à 98 C; par recristallisation dans l'eau glacée, on obtient le produit pur avec un ren dement de 88%.
Process for the preparation of the salt of para # chlorophenyl # cyanamide and isopropylguanidine. The main patent describes a process for the preparation of the salt of para-chlorophenyl-cyanamide and isopropylguanidine, which consists in reacting at moderate temperature para-chlorophenyl-cyanamide and isopropylguanidine and in separating the salt obtained from the reaction mixture. There has been described more particularly an advantageous procedure consisting in operating in an aqueous medium.
It has now been found that the reaction can also be carried out in an anhydrous medium.
The subject of the present invention is therefore a process for preparing the salt of parachlorophenyl-cyanamide and of isopropyl-guanidine, characterized in that parachlorophenyl-cyanamide is reacted in an anhydrous medium and at moderate temperature. and isopropylguanidine and in that the salt obtained is separated from the reaction mixture.
Here is, by way of example, how the process of the invention can be carried out in practice; the parties agree. in weight. 7.5 parts of sodium are dissolved in 95 parts of anhydrous methyl alcohol. At about 22, 49 parts of dry isopropylguanidine sulfate and 50 parts of dry para-chlorophenyl-cyanamide are added successively. It precipitates sodium sulfate which is removed by centrifugation and washed with anhydrous methanol. The combined solutions are concentrated in vacuum at a temperature below 35 ° C.
77 parts of isopropylguanidine salt and of impure para-chlorophenyl-cyanamide are obtained, melting at 98 C; by recrystallization from ice-cold water, the pure product is obtained with a yield of 88%.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR285675X | 1949-01-26 | ||
| CH277982T | 1949-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH285675A true CH285675A (en) | 1952-09-15 |
Family
ID=25731795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH285675D CH285675A (en) | 1949-01-26 | 1949-07-08 | Process for preparing the salt of para-chlorophenyl-cyanamide and isopropylguanidine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH285675A (en) |
-
1949
- 1949-07-08 CH CH285675D patent/CH285675A/en unknown
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