CH271520A - Process for the preparation of a derivative of 2-benzylaminopyrimidine. - Google Patents
Process for the preparation of a derivative of 2-benzylaminopyrimidine.Info
- Publication number
- CH271520A CH271520A CH271520DA CH271520A CH 271520 A CH271520 A CH 271520A CH 271520D A CH271520D A CH 271520DA CH 271520 A CH271520 A CH 271520A
- Authority
- CH
- Switzerland
- Prior art keywords
- pyrimidine
- amino
- preparation
- benzyl
- derivative
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
Verfahren zur Herstellung eines Derivates des 2-Benzylamino-pyrimidins Das Hauptpatent Nr.265663 betrifft ein Verfahren zur Herstellung einer netten Sub stanz mit Antihistaminaktivität, nämlich des 2 - (p - llethoxy - benzyl - dimethy laminoäthy 1 amino)-pyrimidins, welches mit Säuren leicht lösliche Additionsprodukte bildet. Zur kli nischen Verwendung eignet sich besonders das Hydrochlorid.
Gegenstand des vorliegenden Patentes ist nun ein Verfahren zur Herstellung dieses Hydrochlorids, welches dadurch gekennzeich net ist, dass das 2-(p-hlethoxy-benzyl-dimethyl- aminoäthyl-amino)-py ridin, gelöst in einem organischen Lösungsmittel, mit konzentrierter Salzsäure behandelt und das gebildete Hydro- chlorid durch Abkühlen des Reaktions gemisches zum Auskristallisieren gebracht, ab filtriert, mit Aceton gewaschen und getrocknet wird.
Das so erhaltene 2-(p-llethoxy-benzyl- dimethylaminoäthyl - amino) - pyrimidin-hydro- chlorid bildet kubische Kristalle mit. einem Schmelzpunkt von 173 bis 176 C, die in Was ser leicht löslich sind.
Das auf die genannte Weise erhaltene Hydrochlorid kann durch Umkristallisation einer weiteren Reinigung unterzogen werden. Beispiel.: Zu 1000g 2-(p-3lethoxy-benzyl-dimethyl.- aminoätliyl-amino)-pyrimidin wurden 2250 eins Aceton und 406 g konzentrierte Salzsäure (36 % HCl) hinzugefügt. Das Reaktionsge- misch wurde gut abgekühlt und das auskri stallisierte Hydrochlorid auf einem Filter ge sammelt und mit Aceton gewaschen und so dann getrocknet.
Das Filtrat wurde hierauf alkalisch ge stellt, die freie Base mit Äther aufgenommen, das Lösungsmittel abgetrieben und der Rück stand nochmals wie beschrieben behandelt.
Process for the preparation of a derivative of 2-benzylamino-pyrimidine The main patent No. 265663 relates to a process for the preparation of a nice substance with antihistamine activity, namely 2 - (p - llethoxy - benzyl - dimethy laminoäthy 1 amino) -pyrimidine, which with acids forms easily soluble addition products. Hydrochloride is particularly suitable for clinical use.
The subject of the present patent is a process for the production of this hydrochloride, which is characterized in that the 2- (p-ethoxy-benzyl-dimethyl-aminoethyl-amino) -pyridine, dissolved in an organic solvent, is treated with concentrated hydrochloric acid and the hydrochloride formed is brought to crystallize out by cooling the reaction mixture, filtered off, washed with acetone and dried.
The 2- (p-llethoxy-benzyl-dimethylaminoethyl-amino) -pyrimidine hydrochloride obtained in this way also forms cubic crystals. a melting point of 173 to 176 C, which are easily soluble in what water.
The hydrochloride obtained in this way can be subjected to further purification by recrystallization. Example .: To 1000 g of 2- (p-3lethoxy-benzyl-dimethyl-aminoethyl-amino) -pyrimidine, 2250 g of acetone and 406 g of concentrated hydrochloric acid (36% HCl) were added. The reaction mixture was cooled well and the hydrochloride which had crystallized out was collected on a filter and washed with acetone and then dried in this way.
The filtrate was then made alkaline, the free base was taken up with ether, the solvent was driven off and the residue was treated again as described.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US271520XA | 1946-06-26 | 1946-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH271520A true CH271520A (en) | 1950-10-31 |
Family
ID=21836004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH271520D CH271520A (en) | 1946-06-26 | 1946-10-17 | Process for the preparation of a derivative of 2-benzylaminopyrimidine. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH271520A (en) |
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1946
- 1946-10-17 CH CH271520D patent/CH271520A/en unknown
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