CH242522A - Process for the preparation of an acylated sulfonamide. - Google Patents

Process for the preparation of an acylated sulfonamide.

Info

Publication number
CH242522A
CH242522A CH242522DA CH242522A CH 242522 A CH242522 A CH 242522A CH 242522D A CH242522D A CH 242522DA CH 242522 A CH242522 A CH 242522A
Authority
CH
Switzerland
Prior art keywords
amino
preparation
sulfonamide
benzene
dihydrocinnamoyl
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242522A publication Critical patent/CH242522A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines     acylierten    Sulfonamides.    Gegenstand     vorliegenden    Patentes ist ein  Verfahren zur Herstellung eines     acylierten     Sulfonamides. Das Verfahren ist dadurch         gekennzeichnet,    dass man ein substituiertes       4-Amino-benzolsulfonamid    der Formel  
EMI0001.0006     
    in der     R        einen    durch     hydrolysierende        Mittel          abspaltbaren    Rest bedeutet, durch     Verseifung     in     4-Amina-benzol-N.,-(dihydrocinuamoyl)

  -          sulfonamid    überführt.    Die neue Verbindung bildet farblose Kri  stalle vom Schmelzpunkt 160-161 . Sie soll  als Arzneimittel     Verwendung        finden.       <I>Beispiel:</I>  10     Teile        N-(4-Amino-benzolsulfonyl)-dihydrozimtsäureamidin    von der     Formel     
EMI0001.0020     
    werden mit 100 Teilen 3,5     %iger    Salzsäure  4 Stunden auf 90-100  erhitzt. Nach dem  Erkalten     wird        sodaalkali        ch    gestellt, filtriert       und    mit Essigsäure angesäuert.

   Man erhält    das     4-Amino-benzol-Nx-(dihydrocinnamoyl)-          sulfonamid.    Aus Alkohol umkristallisiert  bildet es farblose Kristalle vom Schmelz  punkt     160-161 .  



  Process for the preparation of an acylated sulfonamide. The present patent relates to a process for the preparation of an acylated sulfonamide. The process is characterized in that a substituted 4-amino-benzenesulfonamide of the formula
EMI0001.0006
    in which R means a residue that can be split off by hydrolyzing agents, by saponification in 4-aminobenzene-N., - (dihydrocinuamoyl)

  - sulfonamide transferred. The new compound forms colorless crystals with a melting point of 160-161. It should be used as a medicine. <I> Example: </I> 10 parts of N- (4-Amino-benzenesulfonyl) -dihydrocinnamic acid amidine of the formula
EMI0001.0020
    are heated to 90-100 for 4 hours with 100 parts of 3.5% hydrochloric acid. After cooling, soda-alkali is made, filtered and acidified with acetic acid.

   The 4-amino-benzene-Nx- (dihydrocinnamoyl) sulfonamide is obtained. Recrystallized from alcohol, it forms colorless crystals with a melting point of 160-161.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines acy fier- ten Sulfonamides, dadurch gekennzeichnet, dass man ein substituiertes 4-Amino-benzol- sulfonamid der Formel EMI0002.0009 in der R einen durch hydrolysierende Mittel absTaltbaren Rest bedeutet, durch Verseifung in 4-Amino--benzol-N,-(dihydrocinnamoyl) PATENT CLAIM: Process for the preparation of an acylated sulfonamide, characterized in that a substituted 4-amino-benzenesulfonamide of the formula EMI0002.0009 in which R denotes a residue that can be eliminated by hydrolyzing agents, by saponification in 4-amino-benzene-N, - (dihydrocinnamoyl) - sulfonamid überführt. Die neue Verbindung- bildet farblose Kri stalle vom Schmelzpunkt 160-161 . Sie soll als Arzneimittel Verwendung finden. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man N-(4-Amino-benzol- sulfo@nyl)-dihydrozimtsäureamidin durch hy- drolytische Spaltung in 4-Amino-benzol-N,- (dihydrocinnamoyl)-sulfonamid überführt. - sulfonamide transferred. The new compound forms colorless crystals with a melting point of 160-161. It should be used as a medicine. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that N- (4-amino-benzene-sulfo @ nyl) -dihydrocinnamic acid amidine is converted into 4-amino-benzene-N, - (dihydrocinnamoyl) -sulphonamide by hydrolytic cleavage.
CH242522D 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide. CH242522A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242522T 1943-05-21
CH239850T 1944-03-16

Publications (1)

Publication Number Publication Date
CH242522A true CH242522A (en) 1946-05-15

Family

ID=25728451

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242522D CH242522A (en) 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide.

Country Status (1)

Country Link
CH (1) CH242522A (en)

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