CH240460A - Process for the preparation of di- (p-ethoxyphenyl) -benzyl-carbinol. - Google Patents
Process for the preparation of di- (p-ethoxyphenyl) -benzyl-carbinol.Info
- Publication number
- CH240460A CH240460A CH240460DA CH240460A CH 240460 A CH240460 A CH 240460A CH 240460D A CH240460D A CH 240460DA CH 240460 A CH240460 A CH 240460A
- Authority
- CH
- Switzerland
- Prior art keywords
- benzyl
- carbinol
- preparation
- ethoxyphenyl
- decomposition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von Di-(p-äthoayphenyl)-benzyl-earbinol. Die Erfindung bezieht sich auf die Her stellung von Di-(p-äthogyphenyl)-benzyl- carbinol,
EMI0001.0004
Gemäss dem Verfahren der Erfindung wird diese Substanz in guter Ausbeute durch Einwirkung eines Benzyl-Metallderivates, wie z.
B. Benzyl-Magnesiumchlorid oder -bromid oder Benzyl-Lithium, auf 4,4'-Diäthogybenzo- phenon und anschliessende Zersetzung der entstandenen Verbindung hergestellt. Für die Zersetzung verwendet man vorzugsweise Wasser, das Salze, wie @ Ammoniumohlorid oder Säuren, wie Schwefelsäure enthält.
Die so erhaltene Carbinolverbindung ist ein wertvolles Zwischenprodukt für die Her stellung von therapeutisch wirksamen Ver bindungen.
Das nachstehende Beispiel zeigt wie die Erfindung praktisch durchgeführt werden kann. Beispiel: 95 g 4,4'-Diäthogybenzophenon werden einem Grignard-Reagens zugesetzt, das er halten wurde aus 14 g Magnesium, 85 g Benzylchlorid und 400 cm' trockenem Äther. Nach zweistündigem Rühren wird die Lösung über Nacht stehengelassen und dann mit kal ter, wässriger Ammoniumchloridlösung zer setzt.
Das Carbinol wird mit einer Benzol- Äther-Mischung extrahiert, und aus Benzin vom Siedepunkt 100-110 C oder 100 bis 150 C zur Reinigung umkristallisiert. Es scheidet sich in farblosen Kristallen vom Smp. 124 C ab. Ausbeute: etwa 90 % der Theorie.
Process for the preparation of di- (p-ethiophenyl) -benzyl-earbinol. The invention relates to the Her position of di- (p-ethogyphenyl) -benzyl-carbinol,
EMI0001.0004
According to the method of the invention, this substance is in good yield by the action of a benzyl metal derivative, such as.
B. benzyl magnesium chloride or bromide or benzyl lithium, on 4,4'-diethogybenzo- phenone and subsequent decomposition of the compound produced. For the decomposition, preference is given to using water which contains salts such as ammonium chloride or acids such as sulfuric acid.
The carbinol compound thus obtained is a valuable intermediate product for the preparation of therapeutically effective compounds.
The following example shows how the invention can be put into practice. Example: 95 g of 4,4'-diethogybenzophenone are added to a Grignard reagent, which he was kept from 14 g of magnesium, 85 g of benzyl chloride and 400 cm 'of dry ether. After stirring for two hours, the solution is left to stand overnight and then decomposed with cold, aqueous ammonium chloride solution.
The carbinol is extracted with a benzene-ether mixture and recrystallized from gasoline with a boiling point of 100-110 C or 100 to 150 C for purification. It separates out in colorless crystals with a melting point of 124 ° C. Yield: about 90% of theory.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB240460X | 1943-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH240460A true CH240460A (en) | 1945-12-31 |
Family
ID=10205504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH240460D CH240460A (en) | 1943-01-28 | 1944-06-22 | Process for the preparation of di- (p-ethoxyphenyl) -benzyl-carbinol. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH240460A (en) |
-
1944
- 1944-06-22 CH CH240460D patent/CH240460A/en unknown
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