CH231833A - Process for the preparation of the calcium salt of 4-aminobenzenesulfonacetamide. - Google Patents

Process for the preparation of the calcium salt of 4-aminobenzenesulfonacetamide.

Info

Publication number
CH231833A
CH231833A CH231833DA CH231833A CH 231833 A CH231833 A CH 231833A CH 231833D A CH231833D A CH 231833DA CH 231833 A CH231833 A CH 231833A
Authority
CH
Switzerland
Prior art keywords
calcium salt
aminobenzenesulfonacetamide
preparation
compounds
salt
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Schering
Original Assignee
Ag Schering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag Schering filed Critical Ag Schering
Publication of CH231833A publication Critical patent/CH231833A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

      Verfahren    zur Herstellung des     Caleinmsalzes    des     4-Aminobenzolsulfonaeetamids.       Es wurde gefunden,     .dass    man durch     Um-          ,setzun,g    von an der     Sulfonamidgrup.pe        acy-          lierten    Verbindungen mit Metalloxyden,       -hydroxyden    oder     -carbonaten    oder derglei  chen die entsprechenden Metallverbindungen  erhalten kann.

   So ist es leicht, die     Alkaliver-          bindungen    durch Behandlung dieser Verbin  dungen mit der berechneten Menge Alkali  hydroxydlösung oder     Natriumearbonat    her  zustellen, und wenn nötig, die     Alkalisalze          auszusalzen    oder durch Zusatz     wassermisch-          barer    organischer Lösungsmittel auszufällen.       Selbstverstä.nglich    kann man die Salze aus  ihren Lösungen auch durch einfaches Ein  dampfen zur Trockne     isolieren,.     



  Es ist auch möglich, andere Metallverbin  dungen, wie die Erdalkali-, Gold-, Kupfer-,  Quecksilber, .Silber-, Aluminium-,     Magcie-          sium-    und dergleichen Verbindungen herzu  stellen, die ebenfalls praktische Bedeutung  besitzen.

   Zur Herstellung dieser Salze eignet  .sich insbesondere die     bekannte        Methode    der  doppelten Umsetzung, gemäss welcher zum         Beispiel    -die     Erdalkalimetallsalze    der     acylier-          ten        Sulfonamide    mit     löslichen        Schwermetull-          sulfaten    umgesetzt weiden.

   Hierbei fallen die       schwerlöslichen        Erdalkalisulfate    aus, wäh  rend das lösliche     Schwermetallsalz    des     acy-          lierten        .Sulfonamids        in,    Lösung bleibt und aus       ,dieser        isoliert    werden kann.

   Zur Salzbildung  kann man auch organische Basen, wie zum  Beispiel     Alkylamine,        Alkanolamine,    wie       Athanolamine,        Pyridin.    Anilin,     1-Phenyl-          2    .     3,--dimethyl-4-dimethylamino-5-pyrazolon,     Chinin: und andere, verwenden.  



       Gegenstand    des     vorliegenden.        Patentes    ist  nun     ein    Verfahren zur     Herstellung    des     Cal-          ZiumsaIzes    des     4-Aminobenzolsulfo.nacet-          amids,    das dadurch gekennzeichnet ist, dass  man,     4-Aminobenzol.sulfonacetamid    mit einem  das     Calciumsalz        -bildenden    Mittel umsetzt.  



  Die neue Verbindung soll als Arzneimit  tel sowie als     Zwischenprodukt    zur Herstel  lung von     Arzneimitteln    und andern technisch  wertvollen     Produkten    Verwendung finden.      <I>Beispiel:</I>       21,4b    4     Aminobenzolsulfonacetamid    wer  den unter Erhitzen in 100     emd    Wasser ge  löst. Zu dieser     Lösunb    gibt man 5     o-        Caleium-          carbonat.    'Nach kurzem     Kochen    wird filtriert.  und das Filtrat zur Trockne verdampft.

   Der       Rückstand    wird aus verdünntem     Alkohol    um  kristallisiert.     llan    erhält ein     weisses    in Was  ser leicht lösliches Pulver.



      Process for the preparation of the caleinm salt of 4-aminobenzene sulfonaeetamide. It has been found that one can obtain the corresponding metal compounds by reacting, g of compounds acylated on the sulfonamide group with metal oxides, hydroxides or carbonates or the like.

   It is easy to prepare the alkali compounds by treating these compounds with the calculated amount of alkali hydroxide solution or sodium carbonate and, if necessary, to salt out the alkali salts or to precipitate them by adding water-miscible organic solvents. Of course, the salts can also be isolated from their solutions by simply evaporating them to dryness.



  It is also possible to produce other metal compounds, such as alkaline earth, gold, copper, mercury, silver, aluminum, magnesium and the like compounds, which are also of practical importance.

   The known method of double conversion is particularly suitable for preparing these salts, according to which, for example, the alkaline earth metal salts of the acylated sulfonamides are reacted with soluble heavy metal sulfates.

   Here, the poorly soluble alkaline earth metal sulfates precipitate, while the soluble heavy metal salt of the acylated sulfonamide remains in solution and can be isolated.

   Organic bases such as alkylamines, alkanolamines such as ethanolamines, pyridine can also be used for salt formation. Aniline, 1-phenyl-2. 3, - dimethyl-4-dimethylamino-5-pyrazolone, quinine: and others, use.



       Subject of the present. Patent is now a process for the preparation of the calcium salt of 4-aminobenzene sulfonacetamide, which is characterized in that 4-aminobenzene sulfonacetamide is reacted with an agent which forms the calcium salt.



  The new compound is to be used as a drug and as an intermediate for the manufacture of drugs and other technically valuable products. <I> Example: </I> 21,4b 4 aminobenzenesulfonacetamide are dissolved in 100 emd water while being heated. 50% calcium carbonate is added to this solution. 'After a short boil, it is filtered. and the filtrate evaporated to dryness.

   The residue is recrystallized from dilute alcohol. llan is given a white powder that is easily soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahrun zur Herstellunb des Calcium- alzes des 4-Aminolxnzolsulfonacetamids, da durch bekennzeiehnet, dass man 4-Aminoben- zolsulfonacetamid mit einem das Calcium- salz bildenden Mittel umsetzt. Die neue Verbindung ist ein weisses in Wasser leicht lösliches Pulver. PATENT CLAIM: Process for the production of the calcium salt of 4-aminolxnzenesulfonacetamide, as it denotes that 4-aminobenzenesulfonacetamide is reacted with an agent that forms the calcium salt. The new compound is a white powder that is easily soluble in water.
CH231833D 1939-01-19 1939-01-19 Process for the preparation of the calcium salt of 4-aminobenzenesulfonacetamide. CH231833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH220209T 1939-01-19

Publications (1)

Publication Number Publication Date
CH231833A true CH231833A (en) 1944-04-15

Family

ID=4451533

Family Applications (1)

Application Number Title Priority Date Filing Date
CH231833D CH231833A (en) 1939-01-19 1939-01-19 Process for the preparation of the calcium salt of 4-aminobenzenesulfonacetamide.

Country Status (1)

Country Link
CH (1) CH231833A (en)

Similar Documents

Publication Publication Date Title
CH231833A (en) Process for the preparation of the calcium salt of 4-aminobenzenesulfonacetamide.
DE675817C (en) Process for the preparation of readily water-soluble salts of diarylaminoalkylcarbinoln
CH231834A (en) Process for the preparation of the magnesium salt of 4-aminobenzenesulfonacetamide.
CH231835A (en) Process for the preparation of the diaethanolamine salt of 4-aminobenzenesulfonacetamide.
CH231839A (en) Process for the preparation of the quinine salt of 4-aminobenzenesulfonacetamide.
DE374097C (en) Process for the production of double compounds from caffeine which are easily soluble in water
DE411956C (en) Process for the production of soluble acidic calcium or calcium-magnesium salts of inositol phosphoric acid
DE734957C (en) Process for the production of p-aminobenzenesulfonamide pellets
CH220209A (en) Process for the preparation of the sodium salt of 4-aminobenzenesulfonacetamide.
DE874309C (en) Process for the production of sulfamic acids and their salts
DE411051C (en) Process for the preparation of derivatives of 2-phenylquinoline-4-carboxylic acid
DE810027C (en) Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols
AT63835B (en) Process for the preparation of N-monoalkyl derivatives of p-aminophenol.
AT216671B (en) Process for the preparation of compounds of various penicillins with sulfonamides
AT120405B (en) Process for the preparation of auromercaptocarboxylic acids.
DE545915C (en) Process for the preparation of compounds of 7-iodo-8-oxyquinoline-5-sulfonic acid which are easily soluble in water
DE661554C (en) Production of alkali nitrates
DE363268C (en) Process for the production of a non-hygroscopic iron salt, particularly suitable for tanning purposes
AT159318B (en) Process for the preparation of readily water-soluble compounds of dialkylaminoalkyldiarylcarbinols.
DE817754C (en) Process for the isolation of piperazine from reaction mixtures containing it
CH242493A (en) Process for the preparation of a new benzenesulfonamide derivative.
AT119962B (en) Process for the preparation of N-chloroiodine compounds of α-aminopyridine and its derivatives.
DE720937C (en) Process for the production of therapeutically valuable gold compounds from keratin breakdown products
DE467627C (en) Process for the preparation of N-methanesulfinic acid salts of secondary aromatic-aliphatic amines
CH231840A (en) Process for the preparation of the pyramidone salt of 4-aminobenzenesulfonacetamide.